Advanced Science
·
2022
·Vol. 9
·期 12
·2102220
·
IF 17.521
Chenle Dong,Chen Yang,Muhammad Rizwan Younis,Jing Zhang,Gang He,Xingdi Qiu,Lian-Hua Fu,Dong-Yang Zhang,Hao Wang,Wenli Hong,Jing Lin,Xueqing Wu,Peng Huang
Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near-infrared (NIR-II) light-responsive shape memory composite based on the combination of cuprorivaite (CaCuSi 4 O 10 ) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly( d , l -lactide- co -trimethylene carbonate) (PT) as shape memory building blocks is developed. The as-prepared CUP/PT composite possesses excellent shape memory performance under NIR-II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Huan Liu,Aminov Nail,Decheng Meng,Liran Zhu,Xiaohan Guo,Cong Li,Xiaoqing Ye,Huanjun Li
Infected wound healing remains a significant clinical challenge, demanding innovative therapeutic strategies to simultaneously address bacterial elimination, tissue regeneration, and controlled drug delivery. Inspired by the hierarchical structure of crocodile teeth, a bioinspired, 3D-printed microneedle patch integrating Mxene nanosheets and a polymerizable deep eutectic solvent (PDES) composed of vinyl pyrrolidone (VP), itaconic acid (IA), and N-isopropyl acrylamide (NIPAM) is developed. The resulting MXene-based eutectogel microneedle (MF-MXene@MN) combines photothermal responsiveness, antioxidant activity, and temperature-triggered drug release for photothermal conversion and reactive oxygen species (ROS) scavenging. The gradient-height design inspired by crocodile teeth enhances tissue adhesion, while DLP 3D printing enables personalized wound dressing geometries with <50 µm resolution. In vitro and in vivo studies demonstrated a 94.88% wound closure rate within 10 days, 3.2-fold increased angiogenesis, 68% reduced bacterial viability ( S. aureus : 32.59%; E. coli : 48.17% under NIR), and pH-/temperature-responsive mangiferin release (88.3% cumulative release via 5 NIR cycles). These synergistic functions promote wound healing, offering superior antibacterial ability, tissue regeneration promotion, and drug release control compared to traditional wound dressings and microneedle systems. This multifunctional platform integrates bioinspired design, stimuli-responsive materials, and additive manufacturing, providing a transformative solution for precision wound management.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Taihe Han,Shuai Mu,Qin Huang,Jiaxing Sun,Xin Lv,Yanxia Zhang,Xiaoyan Liu,Wei Guo,Haixia Zhang
The development of high fluorescence quantum yield molecular fluorophores for second-order near-infrared (NIR-II) imaging is highly desirable but remains challenging due to the lack of reliable design guidelines. We report a method to construct “J-aggregates” by combining the inhibition of twisted intramolecular charge transfer (TICT) and electron-withdrawing strategies. Introducing electron-withdrawing substituents at the middle position of the classic boron dipyrromethene (BODIPY) backbone promotes J-type slip stacking, enhancing NIR-II fluorescence through increased electrostatic repulsion and intermolecular hydrogen bonding. The 3,5-aryl position is modified with sulfone and quaternary piperazine groups. The negative inductive effect (–I effect) from strong electron-withdrawing action increases the ionization potential (IP) of the amino group, inhibiting the TICT process and improving the quantum yield to 9.03 % and 16.9 %, respectively. Notably, the fluorescence quantum yield of NBDP-SO 2 increased to 18.2 % after self-assembly with F127, successfully applied in bioimaging. This study provides a new method for constructing high fluorescence quantum yield NIR-II emission by manipulating molecular stacking and establishing the relationship between molecular structure, intermolecular interactions, and fluorescence properties.
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Inorganics
·
2025
·Vol. 13
·期 5
·153
·
IF 3
Qianhong Zheng,Genying Zeng,Chenxing Liao,Huoming Huang,Weixiong You,Xinyu Ye,Liaolin Zhang
Bi-doped glasses and fibers have been widely applied in solid-state and fiber lasers. However, the mechanism underlying near-infrared (NIR) luminescence remains unclear, and Bi-related luminescence centers (BLCs) are prone to alteration during fiber fabrication, making it challenging to achieve high-performance Bi-doped glass fibers. In this work, Bi-, Bi-Al-, and Bi-Ge-doped silica glasses were investigated to elucidate the origin of NIR luminescence. Two broad NIR fluorescence bands were observed in silica glasses, originating from distinct BLCs. The longer-wavelength fluorescence band at 1423 nm, demonstrating sensitivity to Bi doping concentration and homogeneity, is attributed to Bi clusters (aggregates of Bi+ions), whereas the shorter-wavelength emission, independent of Bi concentration, originates from isolated Bi+ions. A vacuum-assisted melting-in-tube method with a single-step heating process was employed to fabricate Bi-doped silica-based glasses and fibers. The fluorescence bands of the fibers remained consistent with those of the precursor glasses, indicating no new BLCs were formed during fiber fabrication. The modulation of fluorescence bands was primarily governed by Bi cluster formation. Suppressing Bi clustering through co-doping with Al/Ge or optimizing fabrication conditions offers an effective route to tailor the fluorescence properties of Bi-doped glasses and fibers.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Jinqiao Li,Xuefeng Chu,Wenfu Yan,Gang Liu
Low-energy photon conversion is crucial for the efficient utilization of solar energy. To this end, a synergistic chemical structure modification method is practiced to enhance the wide-spectrum photocatalytic activity of g-C 3 N 4 (BPDCN). By altering the calcination time, we achieve an advanced small size morphology state, which significantly improves the photocarrier transport properties of g-C 3 N 4 . Furthermore, the copolymerization reaction, regulated by varying calcination temperatures, synchronously completes the doping of pyridine and the introduction of N-deficient structure in BPDCN. The modified conjugated framework of BPDCN exhibits broad spectral response capability extending up to the near-infrared region. Additionally, the construction of conjugated carbon region enhances the O 2 adsorption property of BPDCN, expanding the advanced oxidation applications in oxytetracycline degradation. The rich-defect structure of BPDCN further boosts the efficient utilization of photogenerated carriers. Consequently, the optimized BPDCN demonstrates an outstanding photocatalytic H 2 evolution (PHE) activity of 4238.1 μmol g⁻¹ h⁻¹ , approximately 63 times higher than that of pristine UCN. BPDCN also shows the significant low-energy photon utilization ability with a measurable PHE activity of 15.7 μmol g⁻¹ h⁻¹ under NIR irradiation. This work highlights the importance of chemical structure design in organic photocatalyst development.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Guannan Zhang,Ying Lu,Jianbo Song,Di Huang,Meiwen An,Weiyi Chen,Peide Han,Xiaohong Yao,Xiangyu Zhang
After resection of bone tumour, the risk of cancer recurrence and numerous bone defects continues to threaten the health of patients. To overcome the challenge, we developed a novel multifunctional scaffold material consisting mainly of nano-hydroxyapatite particles ( n -HA), MXene nanosheets and g-C 3 N 4 to prevent tumour recurrence and promote bone formation. N -HA has the potential to restrict the growth of osteosarcoma cells, and the combination of MXene and g-C 3 N 4 enables the scaffolds to produce photodynamic and photothermal effects simultaneously under near infrared (NIR) irradiation. Surprisingly, n -HA can further enhance the synergistic anti-tumour function of photodynamic and photothermal, and the scaffolds can eradicate osteosarcoma cells in only 10 min at a mild temperature of 45 ℃. Moreover, the scaffold exhibit exceptional cytocompatibility and possesses the capacity to induce osteogenic differentiation of bone marrow mesenchymal stem cells. Therefore, this multifunctional scaffold can not only inhibits the proliferation of bone tumour cells and rapidly eradicate bone tumour through NIR irradiation, but also enhances osteogenic activity. This promising measure can be used to treat tissue damage after bone tumour resection.
研究领域:
生物医学工程
·
材料科学
·
癌症治疗
·
组织工程
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ACS Nano
·
2017
·
IF 13.942
Xujiang Yu,Ang Li,Chengzhi Zhao,Kai Yang,Xiaoyuan Chen,Wanwan Li
Multifunctional nanomaterials with integrated diagnostic and therapeutic functions, combination therapy to enhance treatment efficacy, as well as low toxicity have drawn tremendous attentions. Herein, we report a multifunctional theranostic agent based on peptide (LyP-1)-labeled ultrasmall semimetal nanoparticles of bismuth (Bi-LyP-1 NPs). Ultrasmall Bi NPs (3.6 nm) were facilely synthesized using oleylamine as the reducing agent and exhibited a higher tumor accumulation after being conjugated with the tumor-homing peptide LyP-1. The abilities to absorb both ionizing radiation and the second near-infrared (NIR-II) window laser radiation ensured that Bi-LyP-1 NPs are capable of dual-modal computed tomography/photoacoustic imaging and efficient synergistic NIR-II photothermal/radiotherapy of tumors. Moreover, Bi-LyP-1 NPs could be rapidly cleared from mice through both renal and fecal clearance and almost completely cleared after 30 days. Such multifunctional nanoparticles as efficient cancer theranostic agents, coupled with fast clearance and low toxicity, shed light on the future use of semimetal nanoparticles for biomedicine.
研究领域:
生物医学工程
·
癌症治疗
·
纳米技术
·
诊断成像
·
放射治疗
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高影响因子
Nanoscale
·
2020
·Vol. 12
·期 21
·11562-11572
·
IF 6.895
Ziliang Zheng,Qi Chen,Rong Dai,Zhuo Jia,Chenhua Yang,Xiaoyang Peng,Ruiping Zhang
Nanosystems responsive to a tumor microenvironment (TME) have recently attracted great attention due to their potential in precision cancer theranostics. However, theranostic nanosystems with a TME-activated consecutive cascade for the accurate diagnosis and treatment of cancer have rarely been exploited. Herein, an activatable theranostic nanosystem (Bi2S3-Ag2S-DATS@BSA-N3 NYs) is designed and constructed on the basis of a one-pot biomineralization method and surface functional modification to improve second near-infrared (NIR-II) fluorescence/photoacoustic (PA) imaging-guided photothermal therapy (PTT)/gas therapy (GT). Based on enhanced penetration and retention (EPR) effect-mediated tumor accumulation, the tumor-overexpressed glutathione (GSH) can accelerate hydrogen sulfide (H2S) generation from the nanoparticles by reacting with the encapsulated diallyl trisulfide (DATS). Meanwhile, the in situ released H2S can be used not only for gas therapy, but also to start the reduction of –N3(−) to –NH2(+), thereby enhancing the tumor-specific aggregation of NYs. As a result, the activatable nanosystems with excellent tumor accumulation and biodistribution could achieve an accurate NIR-II/PA dual-modality imaging for guiding the synergistic anticancer efficacy (PTT/GT). Thus, this work provides a promising TME-mediated continuously responsive strategy for efficient anticancer therapy.
研究领域:
生物医学工程
·
癌症治疗
·
纳米医学
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高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xueyuan Guo,Ling Li,Wenhua Jia,Chen Zhang,Wei Ren,Chenghui Liu,Yanli Tang
Phototherapies such as photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted great attention in the field of cancer treatment. However, the individual PDT or PTT makes it difficult to achieve optimal antitumor effects compared to the PDT/PTT combined therapy. Also, the effect of PDT is usually limited by the penetration depth of the UV–vis light source. Herein, we designed and synthesized novel composite nanoparticles UCNPs-CPs, which are constructed from two conjugated polymers and upconversion nanoparticles β-NaYF4:Yb,Tm (UCNPs) via a coordination reaction. By virtue of the excellent spectral overlap between absorption of conjugated polymers and emission of UCNPs, the UCNPs can absorb NIR light and effectively excite conjugated polymers by energy transfer to produce massive reactive oxygen species under 980 nm excitation and heat energy under 808 nm laser irradiation, achieving photodynamic/photothermal synergistic therapy. The in vitro cellular investigation proves that the dual modal phototherapy exhibits enhanced antitumor ability compared to single PDT or PTT. Furthermore, UCNPs-CPs inhibit tumor growth 100% in a 4T1 breast tumor mice model with both NIR laser irradiation, indicating that UCNPs-CPs is an excellent platform for synergistic PDT/PTT treatment. Thus, this study provides a promising strategy for NIR-triggered dual modal phototherapy.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Wenwu Zhou,Jianyong Ye,Sheng Zhuo,Danxia Yu,Ping Fang,Rong Peng,Yue Liu,Weifan Chen
The pigments with high near-infrared (NIR) reflectance hold great promise toward both fundamental types of researches and applications for the realization of comfortable indoor-temperature by mitigating urban heat island effect. However, the facile yet simple method for the NIR reflective pigments with bright color and non-toxic feature remains a huge challenge, limiting their practical application. Herein, we proposed a mild and universal method of solution combustion for constructing the non-toxic and NIR reflective yellow-green pigments of Al-doped Y 3 Fe 5 O 12 . The Y 3 Fe 4 AlO 12 pigment presented a high NIR reflectance of 87.66%, and an outstanding acid/alkali resistance. Moreover, the pigment had an impressive color performance (L* = 78.72, a* = − 4.05, b* = 40.04). Besides, the practical near-infrared reflection performance revealed that the transient surface temperature of the Y 3 Fe 4 AlO 12 pigment was 7.6 °C lower than that of the pigment with similar color on the market. This research supplied high NIR reflecting pigments of Y 3 Fe 5−x Al x O 12 as promising coatings for roofs and exterior walls of buildings, acting as a favorable solution for urban heat island effect.
研究领域:
材料科学
·
环境科学
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2025
·
IF 6.3
Qianyi Li,Yuxuan Zheng,Jingyao Zhang,Zhiyong Xiong,Haibo Jin,Yuefeng Su,Caihong Feng,Ning Li,Chengzhi Wang,Jingbo Li
Cesium tungsten bronze (Cs x WO 3 ) is of significant interest due to its unique spectral selectivity, which is utilized in transparent thermal insulation coatings. However, the low-cost batch preparation of Cs x WO 3 nanopowders remains a challenge. In this study, we performed an Sb doping modification of Cs x WO 3 . It was observed that Sb doping makes Cs x WO 3 more prone to breakage, facilitating the preparation of nanoparticle Cs x WO 3 through a simple solid-state reaction followed by mechanical milling. A 7 % Sb doping results in a small average particle size of 108 nm using moderate ball milling. Meanwhile, appropriate Sb doping enhances the transparent thermal insulation properties of Cs x WO 3 . A 3 % Sb doping raises the integrated visible light transmittance ( T lum , 380–780 nm) of Cs x WO 3 from 61.7 % to 65.40 %, and improves the near-infrared shielding efficiency ( Ψ NIR , 780–2500 nm) from 61.20 % to 65.92 %, increasing by approximately 4 % and 5 %, respectively. The reasons for these property improvements are discussed based on experiments concerning bandgap ( E g ) and oxygen vacancy concentrations induced by Sb doping. This study indicates that Sb doping of 1–3 at% can produce Cs x WO 3 nanopowders with better performance in a low-cost method, which is of great significance for advancing the production and practical application of nano-sized tungsten bronze powder in energy-saving coatings.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Wenlu Pan,Qun Zeng,Kai Li,Wei Lü
Tuning the luminescence properties of efficient near-infrared (NIR) phosphors is critical to expanding their applications in NIR spectroscopy. In this paper, a series of novel Cr 3+ -doped LaZnAl 11 O 19 (LZAO: Cr 3+ ) phosphors are synthesized via a high-temperature solid-phase method. These phosphors exhibit NIR emission in the range of 650–900 nm, with the LZAO: 0.10Cr 3+ achieves an excellent internal quantum efficiency (IQE) of 89.9 %. Notably, it demonstrates excellent thermal stability, maintaining 97.2 % of the initial photoluminescence intensity at 513 K. Through co-doping with Nd 3+ , the NIR emission broadens across the 650–1100 nm range, and leads to a substantial enhancement in Nd 3+ emission intensity due to efficient Cr 3+ →Nd 3+ energy transfer. Remarkably, the optimum LZAO: Cr 3+ , Nd 3+ phosphor exhibits a high IQE (82 %) and an outstanding anti-thermal quenching behavior (118.0 % @ 513 K), with the underlying mechanism of its thermal stability further elucidated through defect level model. In addition, the synthesized phosphors show great promise for multifunctional applications in NIR phosphor-converted light emitting diodes, plant growth lighting, non-destructive testing, luminescence thermometry and solar cells.
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