POLYMER SCIENCE SERIES B
·
2015
·Vol. 57
·期 5
·460-472
·
IF 0.577
Sa Zongpeng,Li Yapeng,Zhao Haochen,Hu Qi,Wei Jia,Wang Jingyuan
Through H-shaped macroinitiator glycol-chlorine((Cl) 2 -PEG-(Cl) 2 ) to initiate the ATRP reaction of 2-Hydroxyethyl Methacrylate (HEMA) we synthesized H-shaped copolymer (PHEMA) 2 - b -PEG- b -(PHEMA) 2 . After we modified the copolymer with histidine (His), the self-assembling and drug release behavior was studied. The morphology of the copolymer micelles and drug loaded micelles were examined by transmission electron microscope (TEM). Spherical micelles and core-shell structure with a diameter of 165 nm were obtained (at pH = 7.0). Due to the presence of imidazole-ring in histidine the copolymer show commendable pH-sensitivity, which made the copolymer potential application as drug carrier exhibiting good control-released property.
研究领域:
高分子化学
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药物递送系统
·
生物材料
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DOI
高影响因子
Pharmaceutics
·
2020
·Vol. 12
·期 2
·111
·
IF 4.421
Weinan Li,Jialin Sun,Xiaoyu Zhang,Li Jia,Mingxi Qiao,Xiuli Zhao,Haiyang Hu,Dawei Chen,Yanhong Wang
PEG-poly(β-amino ester) (PEG-PBAE), which is an effective pH-responsive copolymer, was mainly synthesized by Michael step polymerization. Thioridazine (Thz), which was reported to selectively eliminate cancer stem cells (CSCs), was loaded into PEG-PBAE micelles (PPM) prepared by self-assembly at low concentrations. The critical micelle concentrations (CMC) of PPM in water were 2.49 μg/mL. The pH-responsive PBAE segment was soluble due to protonated tertiary amine groups when the pH decreased below pH 6.8, but it was insoluble at pH 7.4. The Thz-loaded PEG-PBAE micelle (Thz/PPM) exhibited a spherical shape, and the drug loading was 15.5%. In vitro release of Thz/PPM showed that this pH-sensitivity triggered the rapid release of encapsulated Thz in a weakly acidic environment. The in vitro cytotoxicity and cellular uptake of various formulations at pH 7.4 and 5.5 were evaluated on the mammospheres (MS), which were sorted by MCF-7 human breast cancer cell lines and identified to be a CD44+/CD24−phenotype. The results of the cytotoxicity assay showed that blank micelles were nontoxic and Thz/PPM exhibited a similar anti-CSC effect on MS compared to Thz solution. Stronger fluorescence signal of Coumarin-6 (C6) was observed in MS treated by C6-loaded PPM (C6/PPM) at pH 5.5. The tumor inhibition rate and tumor weight of the free DOX and Thz/PPM groups were significantly different from those of the other groups, which free DOX and Thz/PPM effectively suppressed breast tumor growth in vivo. The above experimental results showed that Thz/PPM is an ideal and effective pH-responsive drug delivery carrier to a targeted therapy of CSCs.Keywords:poly(β-amino ester);polymeric micelles;pH-responsive;cancer stem cells;thioridazine
研究领域:
药学
·
肿瘤学
·
生物材料学
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DOI
PubMed
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Xin Wang,Xinyu Sun,Tong Bu,Qinzhi Wang,Hui Zhang,Pei Jia,Longwen Li,Li Wang
Because of increasing antibiotic resistance , careful construction of an efficient phototherm-nanozyme-hydrogel synergistic antibacterial platform is imperative for the treatment of bacteria-infected wounds. In this study, a carrageenan-based hydrogel embedded with polyethylene glycol dicarboxylic acid (COOH-PEG-COOH)-functionalized zirconium-ferrocene metal-organic frames nanosheets (PEG@Zr-Fc MOF hydrogel) was successfully constructed through COOH-PEG-COOH modification and physical assembly. The PEG@Zr-Fc MOF hydrogel could capture Gram-negative ( Escherichia coli ) and Gram-positive ( Staphylococcus aureus ) bacteria through reactive oxygen species (ROS) destruction and kill some bacteria by disintegration of H 2 O 2 into toxic hydroxyl radicals (•OH). Significantly, by introducing the photothermal performance of the PEG@Zr-Fc MOF hydrogel, the catalytic activity of the target material could be improved to achieve a synergistic sterilization effect. The wound infection model experiment confirmed that the PEG@Zr-Fc MOF hydrogel had powerful bactericidal activity and could achieve a rapid tissue repair effect. More importantly, the PEG@Zr-Fc MOF hydrogel had negligible biological toxicity and reduced the risk of inflammation. This study reveals that phototherm-nanozyme-hydrogel synergy holds great potential for bacterial wound infection therapy. Additionally, this is the first study to use two-dimensional MOF nanozymes in combination with hydrogel for antimicrobial therapy. Statement of significance Bacteria-infected wound is one of the serious threats to public health, and this topic has attracted tremendous attention worldwide in recent decades. Although numerous traditional therapeutic strategies that depend on antibiotics have been developed and applied for treating bacteria-infected wound disease, the effect of wound treatment is becoming increasingly unsatisfactory due to bacterial resistance. The present study provides a feasible method to treat bacterial wound infection by constructing a carrageenan-based hydrogel embedded with polyethylene glycol dicarboxylic acid (COOH-PEG-COOH) functionalized zirconium-ferrocene metal organic frame nanosheets (PEG@Zr-Fc MOF hydrogel). The experiments with the wound infection model confirmed that the PEG@Zr-Fc MOF hydrogel had powerful bactericidal activity and could achieve a rapid tissue repair. This strategy provides a promising avenue to further accelerate the development of antibacterial therapy in biomedical fields.
研究领域:
生物医学工程
·
材料科学
·
微生物学
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DOI
PubMed
高影响因子
BIOMATERIALS
·
2012
·
IF 7.404
Meirong Huo,Aifeng Zou,Chengli Yao,Yong Zhang,Jianping Zhou,Jing Wang,Qinnv Zhu,Jing Li,Qiang Zhang
In this study, a ligand-PEG-lipid conjugate , octreotide-polyethene glycol-deoxycholic acid (OCT(Phe)-PEG-DOCA, or OPD) was successfully synthesized and used as a targeting molecule for N-deoxycholic acid-O, N-hydroxyethylation chitosan (DAHC) micelles for efficient cancer therapy. DAHC micelles exhibited good loading capacities for doxorubicin (DOX), a model anti-cancer drug, and the modification of OPD showed no significant effect on drug load while slightly increasing the particle size and partly shielding the positive charges on the surface of micelles. Accelerated release rate of DOX from micelles were also observed after OPD modification and the release profile exhibited pH-sensitive properties. Compared with DAHC-DOX micelles, OPD-DAHC-DOX micelles exhibited significantly stronger cytotoxicity to MCF-7 cells (SSTRs overexpression) but with hardly any difference from WI-38 cells (no SSTRs expression). The results of flow cytometry and confocal laser scanning microscopy further revealed that OPD-DAHC-DOX micelles could be selectively taken into tumor cells by SSTRs-mediated endocytosis . In vivo investigation of micelles on nude mice bearing MCF-7 cancer xenografts confirmed that OPD-DAHC micelles possessed much higher tumor-targeting capacity than the DAHC control and exhibited enhanced anti-tumor efficacy and decreased systemic toxicity. These results suggest that OPD-DAHC micelles might be a promising anti-cancer drug delivery carrier for targeted cancer therapy.
研究领域:
药剂学
·
肿瘤学
·
生物材料
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DOI
PubMed
高影响因子
POLYMER
·
2017
·
IF 3.684
Yuanyuan Tao,Hanying Zhao
Shell-sheddable polymeric assemblies are a type of self-assembled structures formed by amphiphilic block copolymers with cleavable linkages at the junction points. The shell-sheddable self-assemblies have been used as nanocarriers for drugs and inorganic nanoparticles . In this research, synthesis and self-assembly of amphiphilic tadpole-shaped block copolymer with disulfide bonds at the junction points were investigated. Dialkyne-terminated polystyrene (Da-PS) was synthesized by reversible addition-fragmentation chain transfer polymerization and thiol-disulfide exchange reaction. The tadpole-shaped block copolymer was synthesized by bimolecular coupling between azido-terminated PEG and Da-PS. Size exclusion chromatograph , FTIR, 1 H NMR and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass analysis results all indicated successful synthesis of the polymer. The tadpole-shaped block copolymer self-assembles into vesicles in aqueous solution. The disulfide bonds at the junction points can be cleaved by a reducing agent, resulting in aggregation of the assemblies.
研究领域:
材料科学
·
药物递送系统
·
高分子化学
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DOI
高影响因子
Wood Material Science & Engineering
·
2026
·
IF 1.9
Chen Chen,Yuhan Liu,Weiqi Leng,Wanzhao Li,Jiangtao Shi
Dimensional stabilized treated wood can preserve its natural properties and be used in some humid environments. It is necessary to develop an effective treatment method. This study reported a technique that gets refined internally and externally for improving wood dimensional stability. Herein, polyethylene glycol (PEG) impregnation was the ‘internal’ factor and propyltrimethoxysilane (PTMS) vapor deposition was the ‘external’ factor. Both were jointly applied to treat Liriodendron tulipifera wood. FTIR, XPS and XRD were used to analyze the chemical changes and indicated new bonds formed among PEG, PTMS and wood. Micromorphology of modified wood was observed by SEM. Weight percent gain after PEG and PTMS coating was about 77%. The water contact angle of combined modified wood was greater than 135°. Reduction of pores in modified wood is another reason for hydrophobicity. The additive effect of PEG and PTMS significantly reduced the water absorption of modified Liriodendron tulipifera wood, with the PTMS coating potentially mitigating the leaching of PEG, markedly reducing the dimensional changes of the wood. This demonstrates the wide applicability, durability, and dimensional stability of PEG/PTMS-modified wood.
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DOI
高影响因子
NANOTECHNOLOGY
·
2017
·Vol. 28
·期 8
·085603
·
IF 3.44
Xiaoqing Yi,Dan Zhao,Quan Zhang,Jiaqi Xu,Gongdao Yuan,Renxi Zhuo,Feng Li
Herein, we prepared folate-targeting core crosslinked polymeric micelles (CCL/FA) containing multiple disulfide bonds located at the interface and core of the micelles to co-deliver doxorubicin (DOX) and the P-glycoprotein (P-gp) inhibitor tariquidar (TQR) for reversing drug resistance. The stability and redox-responsive behavior of the CCL/FA micelles was evaluated through the changes in morphology, molecular weight and hydrodynamic size. On the one hand, the micelles possessed good stability, which led to the suppression of drug release from the CCL micelles in the physiological environment. On the other hand, under reductive conditions, the CCL micelles collapsed rapidly and accelerated drug release markedly. In vitro cytotoxicity measurements, combined with confocal laser scanning microscopy (CLSM) and flow cytometry, confirmed that the dual-drug-loaded micelles exhibited obviously higher cytotoxicity to MCF-7/ADR-resistant cells than free DOX · HCl, single-drug loaded CCL micelles and nontargeted CCL micelles. The results imply that co-delivering DOX and TQR by CCL/FA micelles may be a promising way of overcoming multidrug resistance in tumor treatments.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2019
·
IF 5.439
Bingmeng Li,Dan Shu,Ruifang Wang,Lanlan Zhai,Yuye Chai,Yunjun Lan,Hongwei Cao,Chao Zou
Inspired by the common preparation method of mesoporous silica where polyethylene glycol (PEG) was used as template to obtain porous silica , PEG/silica (PEG@SiO 2 ) composite as shape-stabilized phase change material for energy storage was well prepared. In this paper, PEG was used as phase change material (PCM) to store and release thermal energy and SiO 2 acted as the supporting matrix. Various techniques were employed to characterize the structural and thermal properties of PEG@SiO 2 . The results indicate that PEG was encapsulated in SiO 2 shell with physical interactions. The phase change enthalpy of PEG@SiO 2 is 164.9 J/g in the melting process and 160.1 J/g in the solidifying process with the mass fraction of 97 wt%. It is a considerably exciting result as the value is so close to pristine PEG’s (178.6 J/g). PEG@SiO 2 exhibited excellent thermal reliability based on the results of undergoing the heating-cooling cycle 100 times. Also, PEG@SiO 2 had a good thermal stability within its working temperature range. This study provides a general approach for increasing the loading of PCMs in porous materials and thus the energy storage capability.
研究领域:
材料科学
·
能源工程
✓ 已验证
DOI
高影响因子
FUEL
·
2026
·
IF 7.8
Kande Liu,Sitan Wang,Ranran Tao,Ziying Ju,Lishan Zheng,Naiwang Liu,Fahai Cao,Xuan Meng,Li Shi
As a vital chemical intermediate, o-cresol is integral to many high-value manufacturing processes. Its synthesis via the methylation of phenol using methanol represents a green and atom-efficient route. Despite exhibiting promising ortho -selectivity, conventional α-Fe 2 O 3 catalyst are often limited by insufficient activity under mild conditions, restricting their practical utility. To address the limited catalytic efficiency of conventional α-Fe 2 O 3 in low-temperature o-cresol synthesis, a nano α-Fe 2 O 3 catalyst was fabricated using a polyethylene glycol (PEG) assisted precipitation method. The catalyst was comprehensively characterized using XRD, N 2 physisorption, TEM, NH 3 -TPD, XPS and EPR. These analyses elucidated the role of PEG in the catalyst synthesis, demonstrating that the PEG-assisted method significantly enhances specific surface area, acidity and oxygen vacancies, thereby collectively improving catalytic performance. Compared to α-Fe 2 O 3 , the novel catalyst achieved a significantly higher phenol conversion of 15.8 % versus 8.5 % under 340 °C and 3 h −1 . Furthermore, the amount of PEG added in the assisted precipitation process was optimized and the mechanism of the phenol methylation reaction over 2.5PEG/α-Fe 2 O 3 was clarified. The results provide a basis for designing efficient catalysts, thereby facilitating their industrial application in o-cresol production.
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DOI
高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 153
·期 3
·732-739
·
IF 2.936
Li Jianying,Liu Rong,Ye Qian,Cai Mingzhong
[RuCl 2 ( p -cymene)] 2 in a mixture of poly(ethylene glycol) (PEG-400) and water is shown to be a highly efficient catalyst for the annulation of N -methoxybenzamides with alkynes. The reaction proceeded smoothly at 60 ºC with MesCO 2 K as a cocatalytic additive under external oxidant-free conditions, delivering a variety of substituted isoquinolones in mostly good to excellent yields. The isolation of the crude products can be easily performed by extraction with diethyl ether and more importantly, [RuCl 2 ( p -cymene)] 2 /PEG-400/H 2 O system could be facilely recycled and reused more than six times without any apparent loss of catalytic efficiency. Graphical Abstract
Ruthenium-catalyzed annulation of N -methoxybenzamides with alkynes leading to isoquinolones by using [RuCl 2 (p-cymene)] 2 /PEG-400/H 2 O as a highly efficient and recyclable catalytic system is described.
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xin-zheng Jin,Zhen-yu Yang,Chen-hui Huang,Jing-hui Yang,Yong Wang
Recently, the miniaturization of microelectronics has proposed a more urgent demand for the multi-functionalization of packaging materials. Here, a PEDOT:PSS/MXene/PEG composite, which is prepared by vertical directional freezing and vacuum infiltrating, integrates the function of heat management & EMI shielding into single packaging material. The melting & cooling enthalpy (237.6 & 236.1 J g −1 ) and the phase transition temperature of composite are enhanced synchronously for the first time. The zigzag modification of polyethylene glycol (PEG) crystal is induced by poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). The rest of crystal with (7/2) helix conformation packs preferentially along the (1 2 0) plane. The stability of the melting composite is enhanced. The PEG leakage is less than 0.66 %, and over 80 % dimension is maintained under the pressure of 1.88 kPa. The composite shows excellent photo-thermal (η = 94.9 %) and electro-thermal (t η = 7.86) conversion performances. The EMI shielding mechanism is reflection-dominated and the total EMI shielding effectiveness (SE T ) of composite is 29.8 dB at the framework content as low as 1.22 wt%, which is the relatively low filler content and the highest enthalpy efficiency among the reported composites with the equivalent SE T . The HF-band shielding capability of composite is verified by the Tesla kit. The assembled heterogeneous asynchrony photo-thermal-electric conversion system identifies its potential application on photo-thermal converters and heat buff. The HF-band & X-band (Sub-6G) EM waves shielding and heat management in microelectronics can be achieved simultaneously by applying this composite.
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Jing Wang,Yapin Liu,Tao Liu,Xingmin Xu,Yunxia Hu
PSf- b -PEG block copolymers with different PEG contents were synthesized to fabricate the highly perm-selective and anti-fouling ultrafiltration (UF) membranes. PEG homopolymer was also blended into the polysulfone casting solutions to fabricate the control (PSf/PEG blend) membranes. The membrane pore structure , surface properties and separation performances of PSf- b -PEG block copolymer membranes and PSf/PEG blend membranes were investigated to identify the role of PEG block for the pore formation. Our results find that the higher PEG content in the PSf- b -PEG block copolymer and in the PSf/PEG blend system was favorable to form more pores and thinner top skin layer with the slightly larger pore size and the higher MWCO of the fabricated membranes. But under the same content, PEG in the block copolymer could help to generate more pores but with similar pore size than PEG in the blend system during the phase-inversion process, which is because of the micro-phase separation of PSf block and PEG block. The fabricated PSf- b -PEG21 (PSf- b -PEG having 21 wt% PEG) membrane had a high water permeation coefficient of 980.0 ± 33.0 LMH/bar and a high BSA rejection above 98%, succeeding the current perm-selectivity upper-bound of the reported polymeric UF membranes. Antifouling experiments confirmed that the PSf- b -PEG21 membrane exhibited a slow and less flux decline during the fouling stage, but a fast and high flux recovery after the backwash cleaning. Our work provides some insights on the relationship of PSf- b -PEG block copolymer composition and membrane structure-separation properties.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）