INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2012
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IF 2.237
Shimin Kang,Xianglan Li,Juan Fan,Jie Chang
Hydrothermal carbonization of cellulose, lignin, d-xylose (substitute for hemicellulose), and wood meal (WM) was experimentally conducted between 225 and 265 °C, and the chemical and structural properties of the hydrochars were investigated. The hydrochar yield is between 45 and 60%, and the yield trend of the feedstock is lignin > WM > cellulose > d-xylose. The hydrochars seem stable below 300 °C, and aromatic structure is formed in all of these hydrochars. The C content, C recovery, energy recovery, ratio of C/O, and ratio of C/H in all of these hydrochars are among 63–75%, 80–87%, 78–89%, 2.3–4.1, and 12–15, respectively. The higher heating value (HHV) of the hydrochars is among 24–30 MJ/kg, with an increase of 45–91% compared with the corresponding feedstock. The carbonization mechanism is proposed, and furfural is found to be an important intermediate product during d-xylose hydrochar production, while lignin hydrothermal carbonization products are made of polyaromatic hydrochar and phenolic hydrochar. The formation of microspheres on the surface of cellulose and WM hydrochars is discussed, and transformation of the hemicellulose should be the reaction for WM microsphere production.
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Journal of Materials Chemistry B
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2024
·
IF 6.1
Fengyuan Liu,Jiashan Xia,Chun Tao,Changmei Chen,Xiangshu Cheng,Rongchun Yi,Lulu Wang,Yue Wang,Tao Deng
Chirality is a ubiquitous phenomenon in nature. The advent of nanomaterials has led to a gradual evolution of chiral studies from the molecular scale to the nanoscale. The emergence of carbon dots (CDs) has inaugurated a novel domain in the scientific and technological realms of carbon nanomaterials. In recent years, CDs have attracted increasing attention due to their luminescent properties, excellent biocompatibility and remarkable bioactivity. However, little attention has been paid to the chirality of the CDs and, in particular, the differences between CDs synthesized from racemic compounds and other chiral CDs, as well as the differences in the biological effects of chiral CDs, remain to be explored. Here, chiral CDs were synthesized from L-/D-/DL-arginine, and the differences in various aspects of chiral CDs were evaluated. We found that L-CDs without extreme differences in structure had brighter fluorescence and a more significant ability of NO generation and lipid droplet inhibition than the other two chiral CDs. Combined with its better drug loading and release ability, we validated its superior efficacy in tumor treatment. Therefore, this study provides a basis for further research on chiral carbon dots and their differences.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Yu Sun,Siyu Zuo,Ziye Li,Ping Li,Jianshe Hu
With mercury pollution causes serious threats to ecosystems and human health because of its extreme toxicity and bioaccumulation, the development of efficient removal technologies has become an urgent environmental priority. This study introduces a novel adsorbent thiazolo[5,4- d ]thiazole conjugated microporous polymer (TzTzCMP) for efficient Hg(II) removal from wastewater. TzTzCMP synthesized via condensation of dithiocarbamate and triformyl-phenol, exhibits a coral-like porous structure with a high specific surface area of 436.86 m 2 /g and sulfur-rich active sites containing 15.15 wt% sulfur, enabling exceptional Hg(II) adsorption. Experiments demonstrated rapid kinetics, reaching equilibrium within 10 min, and a maximum adsorption capacity of 1050 mg/g. The adsorption kinetics and isotherm data for Hg(II) on TzTzCMP are well described by the pseudo-second-order and Langmuir models, respectively, indicating that chemical interactions dominate the adsorption process. The material maintained >95 % efficiency over five regeneration cycles and showed good selectivity under coexisting ion interference, attributed to Hg(II) coordination with N/S atoms in TzTzCMP, as confirmed by X-ray Photoelectron Spectroscopy (XPS) analysis and density functional theory (DFT) calculations. Fixed-bed column tests achieved 99.99 % removal, reducing effluent concentration to 1 μg/L and meeting drinking water standards. Combining high adsorption capacity and removal rate, rapid adsorption efficiency, good stability and reusability, TzTzCMP presents a promising solution for industrial Hg(II)-contaminated wastewater treatment.
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Food Science and Human Wellness
·
2024
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IF 5.6
Lan Li,Shengye Yang,Xinyu Liang,Yameng Liu,Hualing Xu,Xiaozhen Guo,Cen Xie,Xiaojun Xu
Non-alcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide. Bupleurum is widely used in the treatment of non-alcoholic fatty liver, and saikosaponin D (SSD) is one of the main active components of Bupleurum. The purpose of this study was to investigate the efficacy of SSD in the treatment of NAFLD and to explore the mechanism of SSD in the improvement of NAFLD based on “gut-liver axis”. Our results showed that SSD dose-dependently alleviated high fat diet-induced weight gain in mice, improved insulin sensitivity, and also reduced liver lipid accumulation and injury-related biomarkers aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Further exploration found that SSD inhibited the mRNA expression levels of farnesoid X receptor ( Fxr ), small heterodimer partner ( Shp ), recombinant fibroblast growth factor 15 ( Fgf15 ) and apical sodium dependent bile acid transporter ( Asbt ) in the intestine, suggesting that SSD improved liver lipid metabolism by inhibiting intestinal FXR signaling. SSD can significantly reduce the gut microbiota associated with bile salt hydrolase (BSH) expression, such as Clostridium . Decreased BSH expression reduced the ratio of unconjugated to conjugated bile acids, thereby inhibiting the intestinal FXR. These data demonstrated that SSD ameliorated NAFLD potentially through the gut microbiota-bile acid-intestinal FXR pathway and suggested that SSD is a promising therapeutic agent for the treatment of NAFLD.
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Journal of the American Chemical Society
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2024
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IF 14.4
Liu Lin,Yunming Xu,Yiting Han,Ruikun Xu,Tongyue Wang,Zemin Sun,Zhenhua Yan
A deep understanding of the mechanism for the spin-magnetic effect on O–H cleavage is crucial for the development of new catalysts for water oxidation. Herein, we designed and synthesized the crystalline Fe-DABDT and Co-DABDT (DABDT = 2,5-diaminobenzene-1,4-dithiol) and optimized an effective magnetic moment to explore the role of the spin-magnetic effect in the regulation of water oxidation activity. It can be found that the OER activity of the catalyst is positively correlated with its effective magnetic moment. Under the external magnetic field, Fe-DABDT with more spin single electrons has a stronger spin-magnetic response to water oxidation than Fe/Co-DABDT and Co-DABDT. The increase in OER current of Fe-DABDT is nearly 2 times higher than that of Co-DABDT. Experimental and density functional theory studies show that magnetized Fe sites could realize nucleophilic reaction, accelerate the polarization of electron spin states, and promote the polar decomposition of O–H and the formation of the O–O bond. This study provides mechanistic insight into the spin-magnetic effect of oxygen evolution reaction and further understanding of the spin origin of catalytic activity, which is expected to improve the energy efficiency of hydrogen production.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Yunheng Wang,Hengle Wang,Tiantian She,Renjie Wang,Zhe Xu,Qiuyi Ji,Shaogui Yang,Limin Zhang,Huan He
Transition metals (TMs) are widely employed to improve poor intrinsic activity of biochar for peroxymonosulfate (PMS) activation towards water purification. However, the mechanistic effects of TMs on carbon substrates requires further understanding. Herein, we constructed TM-modified C-Ni and C-Ni-Co catalysts via simple pyrolysis of rice husk precursor, optimizing carbonaceous morphologic and electronic structures. The Co-Ni-Co (0.013 min −1 ) exhibited over 10 times higher performance than pristine biochar for iohexol (IOH) removal. Systemic spectroscopic and electrochemical measurements indicate that embedded Ni increases graphitization degree facilitating IOH adsorption by π-π conjugated attraction. And, the anchored Co enhances work function promoting electron extraction for selective generation of 1 O 2 . The interfacial d-p orbital hybridization increases the acidic degree on biochar for PMS adsorption, accelerating electron exchange for PMS activation. Our work attempts to study the complex interaction between carbon and metal sites by orbital hybridization to design efficient PMS activators for Fenton-like decontamination.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Wenting Wang,Zi Wang,Zhaojie Meng,Shuang Jiang,Zhi Liu,Hong-yan Zhu,Xin-dian Li,Jing tian Zhang,Wei Li
The current study aimed to assess the effectiveness of pharmacological intervention with Platycodin D (PD), a critically active compound isolated from the roots of Platycodon grandiflorum, in mitigating cardiotoxicity in a murine model of type 2 diabetes-induced cardiac injury and in H9c2 cells in vitro. Following oral administration for 4 weeks, PD (2.5 mg/kg) significantly suppressed the elevation of fasting blood glucose (FBG) levels, improved dyslipidemia, and effectively inhibited the rise of the cardiac injury markers creatine kinase isoenzyme MB (CK-MB) and cardiac troponin T (cTnT). PD treatment could ameliorate energy metabolism disorders induced by impaired glucose uptake by activating AMPK protein expression in the DCM mouse model, thereby promoting the GLUT4 transporter and further activating autophagy-related proteins. Furthermore, in vitro experiments demonstrated that PD exerted a concentration-dependent increase in cell viability while also inhibiting palmitic acid and glucose (HG-PA)-stimulated H9c2 cytotoxicity and activating AMPK protein expression. Notably, the AMPK activator AICAR (1 mM) was observed to upregulate the expression of AMPK in H9c2 cells after high-glucose and -fat exposure. Meanwhile, we used AMPK inhibitor Compound C (20 μM) to investigate the effect of PD activation of AMPK on cells. In addition, the molecular docking approach was employed to dock PD with AMPK, revealing a binding energy of −8.2 kcal/mol and indicating a tight interaction between the components and the target. PD could reduce the expression of autophagy-related protein p62, reduce the accumulation of autophagy products, promote the flow of autophagy, and improve myocardial cell injury. In conclusion, it has been demonstrated that PD effectively inhibits cardiac injury-induced type 2 diabetes in mice and enhances energy metabolism in HG-PA-stimulated H9c2 cells by activating the AMPK signaling pathway. These findings collectively unveil the potential cardioprotective effects of PD via modulation of the AMPK signaling pathway.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Chu Juan,Liu Zhaoli,Yu Jie,Wang Heng-Guo,Cui Fengchao,Zhu Guangshan
Two-dimensional conjugated metal organic frameworks (2D c-MOFs) hold significant promise as electrode materials for alkali metal ion batteries while their electrochemical properties still lack reasonable and effective regulation. Here, two representative 2D c-MOFs (M-HHTQ/M-HHTP, M=Cu or Ni) as positive electrodes are used as models to explore the basic/microscopic principles of their complex storage mechanism in sodium ion batteries (SIBs). It is demonstrated that the energy storage mechanism of 2D c-MOFs is determined by the interaction between coordination covalent bonds and organic linkers. Theoretical calculations and experiment results have jointly demonstrated that the redox potential and theoretical capacity can be regulated based on the valence of M-O bond and the utilization of anions and cations, respectively. As a result, Cu-HHTQ achieves a high discharge voltage at 2.55 V (vs. Na + /Na), a higher stable specific capacity of 208 mAh g −1 at 0.05 A g −1 , and long cyclability with the capacity retention rate of 100% at 1 A g −1 after 2000 cycles.
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npj Computational Materials
·
2025
·Vol. 11
·期 1
·1-9
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IF 11.9
Yang Lan,Zhou Xiao,Ni Xudong,Huang Li,Zeng Lianduan,Wang Zhongyang,Song Jun,Fan Tongxiang
The optical static refractive index, a critical intrinsic property of materials, plays a vital role in advanced optoelectronic applications. Accurate prediction of this index is essential for the efficient design and optimization of materials with tailored optical properties. Here, we present a robust predictive model that accurately forecasts the optical static refractive indices of complex oxides across diverse crystal structures and compositions. By leveraging chemical bond theory, our model elucidates the influence of intrinsic physical properties, including chemical bonds and d-electron bands, on the refractive index. Through rigorous analysis of 41 complex oxide systems and 5 doped systems, we demonstrate that our predictions align closely with experimental data, showcasing the model’s high accuracy and broad applicability. This work not only accelerates the development of novel materials and spectral design but also provides profound physical insights for optimizing and customizing optical properties.
研究领域:
材料科学
·
光学
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Plant Methods
·
2019
·Vol. 15
·期 1
·1-13
·
IF 3.17
Song Yadi,Chen Shang,Wang Xiujuan,Zhang Rui,Tu Lichan,Hu Tianyuan,Liu Xihong,Zhang Yifeng,Huang Luqi,Gao Wei
Background Tripterygium wilfordii Hook. f. ( T. wilfordii ) is an important medicinal plant with anti-inflammatory, immunosuppressive and anti-tumor activities. The main bioactive ingredients are diterpenoids and triterpenoids, such as triptolide, triptophenolide and celastrol. However, the production of terpenoids from original plants, hairy roots and dedifferentiated cells (DDCs) are not satisfactory for clinical applications. To find a new way to further improve the production of terpenoids, we established a new culture system of cambial meristematic cells (CMCs) with stem cell-like properties, which had strong vigor and high efficiency to produce large amounts of terpenoids of T. wilfordii . Results CMCs of T. wilfordii were isolated and cultured for the first time. CMCs were characterized consistent with stem cell identities based on their physiological and molecular analysis, including morphology of CMCs, hypersensitivity to zeocin, thin cell wall and orthogonal partial least square-discriminant analysis, combination of transcriptional data analysis. After induction with methyl jasmonate (MJ), the maximal production of triptolide, celastrol and triptophenolide in CMCs was 312%, 400% and 327% higher than that of control group, respectively. As for medium, MJ-induced CMCs secreted 231% triptolide and 130% triptophenolide at the maximum level into medium higher than that of control group. Maximal celastrol production of induced CMCs medium was 48% lower than that of control group. Long-term induction significantly enhanced the production of terpenoids both in cells and medium. The reason for increasing the yield of terpenoids was that expression levels of 1 - deoxy - d - xylulose - 5 - phosphate synthase ( DXS ), 1 - deoxy - d - xylulose - 5 - phosphate reductoisomerase ( DXR ) and hydroxymethylglutaryl - CoA synthase ( HMGS ) were upregulated in CMCs after induction. Conclusions For the first time, CMCs of T. wilfordii were isolated, cultured, characterized and applied. Considering the significant enrichment of terpenoids in CMCs of T. wilfordii , CMCs could provide an efficient and controllable platform for sustainable production of terpenoids, which can be a better choice than DDCs.
研究领域:
植物生物技术
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植物化学
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药用植物
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 4
·1-9
·
IF 5.705
Song Jinyi,Yang Chengcheng,Ma Jiao,Han Qian,Ran Peiyao,Fu Yingzi
An electrochemical chiral multilayer nanocomposite was prepared by modifying a glassy carbon electrode (GCE) via opposite-charge adsorption of amino-modified β-cyclodextrin (NH 2 -β-CD), gold-platinum core-shell microspheres (Au@Pts), polyethyleneimine (PEI), and multi-walled carbon nanotubes (MWCNTs). The modified GCE was applied to the enantioselective voltammetric determination of tryprophan (Trp). The Au@Pts enable an effective immobilization of the chiral selector (NH 2 -β-CD) and enhance the electrochemical performance. Scanning electron microscopy, transmission electron microscopy, UV-vis spectroscopy, FTIR and electrochemical methods were used to characterize the nanocomposite. Trp enantiomers were then determined by differential pulse voltammetry (DPV) (with a peak potential of +0.7 V vs. Ag/AgCl). The recognition efficiency was expressed by an increase in peak height by about 32% for DPV determinations of L-Trp compared to D-Trp in case of a 5 mM Trp solution of pH 7.0. Response was linear in the 10 μM to 5.0 mM concentration range, and the limits of detection were 4.3 μM and 5.6 μM with electrochemical sensitivity of 43.5 μA·μM −1 ·cm −2 and 34.6 μA·μM −1 ·cm −2 for L-Trp and D-Trp, respectively (at S/ N = 3).
Schematic of an electrochemical chiral multilayer nanocomposite composed of multi-walled carbon nanotubes (MWCNTs), polyethyleneimine (PEI), gold-platinum core-shell microspheres (Au@Pt) and amino-modified β-cyclodextrin (NH 2 -β-CD). It was prepared by modifying a glassy carbon electrode (GCE) for enantioselective voltammetric determination of tryptophan (Trp) enantiomers.
研究领域:
分析化学
·
生物化学
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2017
·
IF 1.174
Lei Guo,Yangdong Hu,Lianying Wu,Chen Liang,Weitao Zhang
To achieve green hydrolysis technology of hemicellulose through repeated using hydrolysate, the hydrolysis of hemicellulose in corncob was studied. The influence of repeated use of corncob hydrolysate on concentrations of d -xylose and l -arabinose was investigated. The loss rates of d -xylose in the prepared d -xylose solutions both with and without corncob, and repeated using corncob hydrolysate under identical acidity condition were discussed. The result shows that d -xylose concentration and l -arabinose concentration are all gradually increasing with the growing time of repeated use of corncob hydrolysate. After the fifth repetition, the concentrations of d -xylose and l -arabinose are 196.7 g·L − 1 and 22.0 g·L − 1 , respectively. Substance inhibiting the degradation of d -xylose is generated during repeated use of corncob hydrolysate, and the production is further proved by the change of d -xylose concentration and the loss rate of d -xylose over heating time.
研究领域:
生物技术
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化学工程
·
可持续化学
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危险品化学品经营许可证（带存储）