EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Yuxin Niu,Fuxiang Song,Rong Shan,Qianjuan Zhao,Zhuang Chen,Na Wang,Weibo Xie
The use of 3D printing technology has advanced the bone tissue engineering, and constructing large artificial bones for repairing large-scale bone defects is highly significant. This study aimed to construct large artificial bones in a precise and controllable manner, focusing on repairing critical-sized bone defects. The researchers used 3D printing technology to synthesize 3D PCL/β-TCP, and then evaluated its ability to promote MC3T3-E1 cell adhesion, proliferation, and new bone formation through a series of characterizations. The results confirmed that 3D PCL/β-TCP, presented as a lattice structure similar to natural bone, could be used to prepare personalized artificial bone blocks based on the actual range of bone defects. The researchers also experimented with dipping 3D PCL/β-TCP bone blocks in different proportions of β-TCP and found that PT2 showed better mechanical and hydrophilic properties. Further experiments showed that PT2 presented excellent biocompatibility and outstanding capacity to promote MC3T3-E1 cell proliferation and adhesion, and that 3D PCL/β-TCP bone blocks possessed good osteogenic activity. Finally, it was suggested that PT2 exhibited the property of promoting new bone formation. These findings provide experimental data support for the repair of critical-sized bone defects.
✓ 已验证
产品关联
DOI
高影响因子
ELECTROANALYSIS
·
2021
·Vol. 34
·期 2
·263-274
·
IF 3.223
Minling Ding,Qi Shu,Nan Zhang,Chaoren Yan,Huizhe Niu,Xiaoqian Li,Ping Guan,Xiaoling Hu
The amyloid-β peptide (1–42) (Aβ 42 ) can provide high diagnostic accuracy for the early diagnosis of Alzheimer's disease (AD). In this study, an immunosensor based on the peroxidase-like activity of heme-Aβ 42 was designed for Aβ 42 detection. The glassy carbon electrode (GCE) was electrodeposited Au particles (GCE/Au). The GCE/Au was modified using polythionine-methylene blue (PTH−MB), AuNPs, monoclonal antibody (anti-Aβ 42 ), and bovine serum albumin (BSA), successively. The GCE/Au/PTH−MB/AuNPs/anti-Aβ 42 /BSA could competitively recognize Aβ 42 and heme-Aβ 42 . The anchored heme-Aβ 42 showed strong electrocatalytic activity between H 2 O 2 and ferrocenemethanol. Under optimum conditions, we determined detection limits of 17.3 pM in PBS pH 7, 25.2 pM in serum, and 23.8 pM in saliva. The recovery ranged from 71.0 % to 117.8 %.
✓ 已验证
产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Zhisheng Zhou,Miao Zhu,Guowen Zhang,Xing Hu,Junhui Pan
5−Hydroxymethyl−2−furaldehyde (5-HMF) in dairy food products generated via Maillard reaction may bring health risks. Herein, the interaction of 5-HMF with β-casein (β-CN) and its influences on the structure and function of β-CN were investigated. 5-HMF was found to quench the inherent fluorescence of β-CN by a static mode and the binding constant was in the order of magnitude of 10 4 L mol −1 . Thermodynamic analysis indicated that hydrophobic forces played the major role in the interaction. The results of synchronous and three-dimensional fluorescence revealed that 5-HMF changed the microenvironment of tyrosine and tryptophan residues and interfered the stability of the polypeptide backbone structure in β-CN. Molecular docking revealed that 5-HMF bound to the hydrophobic cavity of β-CN mainly interacting with the amino acid residues Pro196, Val155, Leu163, Phe157 and Leu192. The binding of 5-HMF with β-CN caused partial unfolding of β-CN conformation, resulting in the increase in surface hydrophobicity and emulsifiability, and decrease in emulsification stability of β-CN, thereby reducing the solubility of β-CN. The study might facilitate the comprehensive understanding of 5-HMF affecting the structure and functional properties of β-CN.
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
Mengjie Zhang,Zixuan Chen,Haixin Qin,Xiaoyan Yang,Wei Cao,Shufeng Liu
Abtract Heme binds to amyloid β -peptide (A β ) in the brain of Alzheimer΄s disease (AD) patients, thus forming heme-A β complexes and leading the characteristic pathological features of AD. The heme-A β complexes reduce O 2 by 2e − to obtain co-reactant H 2 O 2 . In this work, two-dimensional graphite-like carbon nitride (g-C 3 N 4 ) was hybridized with heme via π-π interaction to construct an electrochemiluminescence (ECL) biosensor for detection of A β peptides. The capture aptamer was firstly immobilized on the gold electrode, and then incubated with target A β peptides and g-C 3 N 4 -heme. The g-C 3 N 4 -heme-A β composite was subsequently anchored on the electrode and showed a signal-on, label-free ECL emission based on dual co-reactants enhancement attributed to in-situ generated H 2 O 2 and original K 2 S 2 O 8 in PBS buffer. Under the optimum experimental conditions, the ECL biosensor has a sensitive response to A β peptides with a linear range of 10 fM-0.1 μM and a detection limit of 3.25 fM. Considering prominent specificity, reproducibility, and stability, the proposed biosensor was used to assess recovery of A β peptides in human serum and the result was satisfactory. We believe that the established method would offer a useful analytical means for quantifying A β peptides in a biological matrix.
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 5
·1127-1134
·
IF 1.915
Ning An,Lijuan Wang,Jingjing Zhao,Lili Lv,Ning Wang,Huaizhong Guo
An interesting study on chiral nonaqueous capillary electrophoresis (NACE) was developed in this paper. Two new chiral selectors, a lactobionic acid–boric acid complex and a D-(+)-xylose–boric acid complex were respectively in situ synthesized in nonaqueous background electrolytes (BGEs) containing methanol and triethylamine. They were found to be applicable for the enantioseparation of fourteen amino alcohols including eight β-blockers and six β-agonists by NACE. In order to achieve good enantioseparation, the effects of chiral selector concentration, BGE composition, capillary temperature, and applied voltage were systematically investigated. Under the optimized conditions, most of the tested amino alcohols achieved good chiral resolution. The effects of the molecular structures of chiral selectors and analytes on enantioseparation were discussed in terms of molecular interactions. The method was proved to be suitable for routine analysis of propranolol enantiomers, since it provided satisfactory results during linearity, precision, and accuracy (recovery) studies using the lactobionic acid–boric acid complex as the chiral selector. Good linearity was obtained in the range of 1.0–100.0 μg mL−1 for each propranolol enantiomer and the recoveries for them ranged from 96.4% to 105.9% with the relative standard deviation (RSD) less than 6.4%. This chiral NACE method was applied for the determination of propranolol enantiomers from tablets and the average contents were 101.3% for (R)-propranolol and 98.5% for (S)-propranolol (n = 5).
研究领域:
分析化学
·
药物分析
·
手性分离
·
电泳技术
·
药物代谢
·
分子识别
·
药剂学
✓ 已验证
DOI
高影响因子
Frontiers in Bioscience-Landmark
·
2020
·Vol. 25
·期 3
·549-563
·
IF 2.747
Jun Shi,Qiuwei Zhu,Jianbo Wu,Ping Zhu
Gastric cancer (GC) is the most common cancer with a poor prognosis and the third leading cause of cancer death in the world, for which no effective therapeutic target exists. We tested the hypothesis that FAM46C might be involved in regulation of proliferation and apoptosis in GC. FAM46C was down-regulated and its expression negatively correlated with the expression of β-catenin that drives proliferation and apoptosis. Overexpression of FAM46C inhibited cell proliferation, induced G1 phase arrest and promoted apoptosis. Activation of Wnt/β-catenin signaling pathway in GC cell lines quenched the effect of FAM46C overexpression. On the other hand, FAM46C silencing attenuated DKK1-mediated inhibition of G1 phase, cessation of proliferation and induction apoptosis. Together, these data show that FAM46C shows tumor suppressor properties and such effects are mediated, at least in part, by Wnt/β-catenin in GC.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
Royal Society Open Science
·
2019
·Vol. 6
·期 3
·
IF 2.515
Shijie Shen,Wenwu Zhong,Zongpeng Wang,Zhiping Lin,Shangshen Feng
A series of β-FeSe nanorods composited g-C3N4 were prepared. The structure, morphology, chemical state, photocatalytic activity, electrochemical impedance and photoluminescence of β-FeSe/g-C3N4 composites were well characterized. It is found that the decolourization rate of 3 wt% β-FeSe/g-C3N4 composites reaches 4.4 times than that of g-C3N4. The improved photocatalytic properties could be ascribed to the reduced recombination of photogenerated electrons and holes, which is derived from the excellent ability of β-FeSe to capture and transfer electrons. This work provides an alternative co-catalyst for decolourizing organic matter.
研究领域:
材料科学
·
光催化
·
纳米材料
·
环境化学
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Xiuqin Dong,Weilin Wang,Guochao Yang,Lingtao Wang
The hierarchical porosity of zeolite is a key factor affecting its catalytic activity and stability for bulky molecules involved reactions. However, it is still challenging to introduce mesoporosity into heteroatom-incorporated zeolites in a facile manner while maintaining the catalytic activity. In this work, a strategy for mesoporosity development in incorporated zeolites based on two templates (TEAOH and surfactants) under hydrothermal conditions was proposed, and hierarchical Zr-incorporated β zeolite was successfully prepared and used to catalyze the ETB reaction. In this process, OH– etches the zeolite framework while TEA+ preserves the microporous structure and the surfactant as the mesoporogen. The mesopore size (2.1–3.2 nm) can be tailored by changing the alkyl chain length (C10–C16) of the surfactant. During the treatment, the chemical environment of Zr in Zr-β zeolite did not change and the amount of Lewis acid was increased, showing that the mesoporosity could improve the accessibility of active sites. The hierarchical Zr-β zeolite showed better catalytic performance than the parent Zr-β zeolite in the ethanol–acetaldehyde to butadiene reaction, the conversion of ethanol and acetaldehyde can reach 63.7%, and the selectivity of butadiene can reach 76.6%. The stability of hierarchical Zr-β zeolite is significantly higher than that of microporous Zr-β zeolite, whose conversion can be maintained at 35.0% and selectivity at 70.9% at TOS = 24 h. The mesoporosity can increase the capability of coke which mitigates the deactivation.
研究领域:
催化化学
·
材料科学
·
多孔材料
·
工业催化
·
化学工程
·
分子筛
·
反应工程
✓ 已验证
DOI
高影响因子
Reaction Chemistry & Engineering
·
2026
·
IF 3.1
Tianyuan Xiao,Xinyue Dong,Yong Li,Xiaoya Ding,Guangming Yin
Non-stoichiometric bismuth oxyhalides represent a category of semiconductor photocatalysts with extensive application potential. Herein, Bi2O3, Bi12O17Cl2, and Bi12O17Cl2/β-Bi2O3 microsphere materials were prepared through the calcination. The photocatalytic degradation performance of Bi12O17Cl2/β-Bi2O3 composite microspheres on methylene blue (MB) simulated wastewater under visible light was investigated. The results indicate that the photocatalytic degradation efficiency of MB can reach up to 91.50% in a 10 mg/L solution by Bi12O17Cl2/β-Bi2O3 composite microspheres. The photocatalytic mechanism of Bi12O17Cl2/β-Bi2O3 was explored using free radical trapping experiments, UV-vis DRS, and Nyquist curve analysis, revealing that the material forms a type II heterostructure. This work presents a novel perspective on the design of advanced coupledsemiconductor materials for the degradation of organic pollutants.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING & TECHNOLOGY
·
2020
·Vol. 43
·期 11
·2259-2265
·
IF 1.543
Juan Xu,Ping Zhu,Xiangyi Liu,Ying Hou,Xiaoqin Yang,Shaoyun Shan,Yong Ma,Duo Pan,Binbin Dong,Zhanhu Guo
High-density fuel was prepared by catalytic dimerization and subsequent hydrogenation. Different amounts of phosphotungstic acid (H 3 PW 12 O 40 , HPW) were loaded on mesoporous silica (SBA-15) by a simple impregnation method to prepare HPW/SBA-15 catalysts. The prepared catalysts were mesoporous. Characterizations indicated that the dispersion and the specific surface area depend on the HPW amount. The obtained dimers from catalytic dimerization of β -pinene underwent isomerization and then dimerized to form the heterogeneous products. At the optimum load of HPW, the HPW/SBA-15 catalyst displayed the highest catalytic activity and the increased yield of dimer for a 3-h reaction. After the subsequent hydrogenation reaction, the obtained hydrogenated dimer products displayed a density and a volume calorific value comparable to those of commercial JP-10.
研究领域:
催化化学
·
燃料化学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Biochemistry and Biophysics Reports
·
2021
·
IF 0
Xiaomin Zhang,Yidan Chen,Ju Yao,Yingxin Zhang,Mengying Li,Bo Yu,Kaifeng Wang
Temozolomide (TMZ) is a widely used chemotherapeutic agent for malignant glioma. β-Elemene has been reported to have the ability of passing through the blood-brain barrier and reverse multidrug resistance. In the present study, transport of drugs through the in vitro blood-brain barrier (BBB) model also suggested that β-elemene can assist in TMZ transport to the brain. Plasma and brain pharmacokinetics demonstrated that when β-elemene is used in combination with TMZ, the metabolic rate of TMZ in plasma is slowed, and mean residence time (MRT) in brain is prolonged. The brain tissue distribution at 1 h indicated that the combination of TMZ and β-elemene promotes the distribution of β-elemene in the brain but slightly reduces the distribution of TMZ in the brain. Furthermore the antitumor effect and toxicity in vivo were also investigated. The combination of β-elemene and TMZ was well tolerated and significantly inhibited tumor growth in glioma xenografts. In summary, the present study indicates a synergistic antitumor effect of β-elemene and TMZ in glioma.
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2021
·Vol. 102
·期 1
·109-116
·
IF 1.633
Ma Mingfang,He Zirui,Zhou Shumin,Liu Xuyan,Zhao Min,Wang Xinyan,Liu Huan,Hao Aiyou
Abstract Even through gels based on the polymer modified with β-cyclodextrin have been researched widely, there are only few studies focus on gels based on β-cyclodextrin directly. In this study, we report a novel smart responsive β-cyclodextrin/graphene oxide hybrid gel. Graphene oxide can be loaded into the network of β-cyclodextrin gel successfully by co-assembly method, which can be supported by transmission electron microscope and scanning electron microscope. Hydrogen bonding is the main driving force in gel formation from fourier transform infrared spectroscopy and X-ray diffraction analysis. More interesting is that β-cyclodextrin/graphene oxide hybrid gel can respond to multiple stimuli sensitively. The change of temperature can induce the formation and deformation of gel reversibly. Besides, gel will collapse with the addition of different metal ions including Na + , K + , Zn 2+ , Ba 2+ and Fe 3+ . Hence, this composite gel is a smart responsive material, may have great potential applications in intelligent material fields. Graphic Abstract
In this study, we report a
novel smart responsive β-cyclodextrin/graphene oxide hybrid gel. Graphene oxide
can be loaded into the network of β-cyclodextrin gel successfully by
co-assembly method, which can be supported by transmission electron microscope
and scanning electron microscope. Hydrogen bonding is the main driving force in
gel formation from fourier transform infrared spectroscopy and X-ray
diffraction analysis. More interesting is that β-cyclodextrin/graphene oxide
hybrid gel can respond to multiple stimuli sensitively. The change of
temperature can induce the formation and deformation of gel reversibly.
Besides, gel will collapse with the addition of different metal ions including
Na + , K + , Zn 2+ , Ba 2+ and Fe 3+ .
Hence, this composite gel is a smart responsive material, may have great
potential applications in intelligent material fields.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）