Catalysts
·
2026
·Vol. 16
·期 2
·185
·
IF 4.5
Jie Yang,Yongsheng Liu,Xiaowen Guo,Qi Yang,Yejun Guan
Gamma-valerolactone (GVL) can be used as a renewable solvent, flavoring agent, and precursor to produce liquid fuels and fine chemicals. GVL is mainly produced by the efficient hydrogenation of levulinic acid and its esters over a wide range of bifunctional catalysts under harsh conditions because high temperature is generally required for GVL formation. So far, the hydrogenation of levulinic acids/esters under mild conditions remains a great challenge. In this study, 2 wt.% Ru was loaded onto ZSM-5 zeolite (MFI) via a deposition–precipitation method and further wrapped by crystallization, forming a core–shell structure. Moreover, the wrapped Ru catalyst was coated with a petal-like layer of Mg3Si4O9(OH)4(MgSiO3) via a hydrothermal reaction in a Mg(NO3)2solution, thereby introducing alkalinity and achieving spatial separation of Mg and Ru. This dual-functional catalyst reduces the inhibitory effect of Mg on the Ru active center and enables efficient preparation of GVL from ethyl levulinate (EL) under mild conditions, achieving 100% EL conversion and 98% GVL selectivity in the aqueous phase at 80 °C in 2 h under 0.5 MPa of H2.
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FASEB JOURNAL
·
2026
·Vol. 40
·期 7
·e71690
·
IF 4.3
Wenqing Xu,Jinglve Zhang,Yutian Xiao,Tsz Lam Yau,Yuwei Luo,Yujun Shao,Ze Cheng,Chenchen Zuo,Junlong Tian,Shaorong Lei,Dingyu Wu
Infected traumatic wounds remain a formidable clinical challenge because existing bioadhesives provide only tissue adhesion and lack concurrent antimicrobial and regenerative capabilities. Here, we developed an injectable bioadhesive (CγR) that integrates an “antibacterial–adhesive–regenerative” (AAR) triad by precisely tuning the ratio of carboxymethyl chitosan (CMCS), autologous platelet-rich plasma (PRP), and γ-polyglutamic acid (γ-PGA). CγR exhibits > 99.9% bactericidal efficacy against Escherichia coli and Staphylococcus aureus , delivers instantaneous wet-tissue adhesion (> 3 kPa), and sustains a gradient release of PDGF, TGF-β, and VEGF. In a rat model of infected full-thickness wounds, a single application achieved sterile sealing and complete epithelialization within 6 days, increased collagen deposition by 1.5-fold, and markedly drove macrophage polarization toward the prohealing M2 phenotype. By condensing the conventional “suture–antibiotic–dressing” regimen into a one-step procedure, CγR offers a biosafe and readily scalable platform for managing contaminated complex wounds and holds promise for clinical translation. Graphical The injectable bioadhesive CγR integrates carboxymethyl chitosan (CMCS), platelet-rich plasma (PRP), and γ-polyglutamic acid (γ-PGA) to provide antimicrobial, adhesive, and regenerative effects. CγR bioadhesive exhibits sustained release of growth factors, promotes rapid wound closure, and accelerates tissue regeneration in infected wound models.
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高影响因子
CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Aoyu Li,Jun Yang,Yingying He,Changfeng Qu,Jinlai Miao
Acute wound healing still faces numerous challenges, such as excessive inflammatory response, prolonged hemostasis time, and insufficient tissue regeneration, which often lead to delayed wound healing and scar formation. To address these issues, this study developed a multifunctional “physical-ionic” dual-network hydrogel (PPF hydrogel). This hydrogel combines an elastic polyvinyl alcohol (PVA) scaffold with a rigid ionic network composed of γ-polyglutamic acid (γ-PGA) and fucoidan, cross-linked via Ca 2+ . The resulting hydrogel possesses a highly interconnected porous structure, exhibiting excellent mechanical strength and moderate tissue adhesion. In vitro and in vivo evaluations showed that the PPF hydrogel has good blood and cell compatibility, rapidly achieving hemostasis and promoting the proliferation and migration of L929 fibroblasts. In a mouse full-thickness skin resection model, the PPF significantly accelerated wound closure while reducing epidermal hyperplasia and promoting orderly collagen deposition. Mechanistically, the PPF effectively modulates the immune microenvironment by downregulating pro-inflammatory cytokines (TNF-α, IL-6) and upregulating anti-inflammatory factors (IL-10) and VEGF. This regulation promotes M2 macrophage polarization and angiogenesis, thereby accelerating the transition from the inflammatory phase to the remodeling phase. This dual-network hydrogel offers a promising therapeutic strategy for high-quality acute wound repair in regenerative medicine.
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高影响因子
ACS Nano
·
2025
·
IF 16
Yu Lou,Haoran Wang,Zhicong Zhou,Miao Zeng,Zhongliang Yan,Xueying Yang,Pengfei Fu,Arui Huang,Dong Li,Tom Wu,Yang Bai,Hui-Ming Cheng
Pure-red perovskite light-emitting diodes (PeLEDs) are critical for next-generation displays, while existing systems based on mixed Br/I compositions, quasi-2D phases, or colloidal 0D quantum dots are still facing challenges in fulfilling the requirements of the Recommendation BT.2020 (Rec. 2020) red standard. CsPbI3 nanoplatelets (NPLs) whose bandgap depends on thickness-size are a promising candidate for pure-red light-emitting emitters, but their practical use as LEDs has been hampered by the metastability of the emissive CsPbI3 cubic phase. Here, we report the synthesis of stabilized γ-CsPbI3 NPLs with a tailored surface coordination by incorporating a trace amount of dimethyl sulfoxide (DMSO) and N,N’-dimethylpropyleneurea (DMPU) into the precursor. These ligands selectively coordinate with undercoordinated Pb2+ sites in [PbI6]4– octahedra through Lewis acid–base interactions, redistributing the electron density at Pb centers and inducing lattice distortion by the Pb–I–Pb bond angle torsion, thereby stabilizing the γ-phase. The complementary effect of the polarities and the coordination capacities of DMSO/DMPU guide anisotropic growth along the [100] direction, enabling atomic-precision control of the NPL thickness (4 monolayers) to tailor the quantum-confined pure-red emission. The resultant pure-red PeLEDs achieve Commission Internationale de l’Eclairage (CIE) coordinates of (0.708, 0.292), 100% compliance with the Rec. 2020 specification, as well as an external quantum efficiency (EQE) of over 12% and a superior operational lifetime with a half-lifetime (T50) of 360 min, representing the highest reported values for CsPbI3 NPL-based PeLEDs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jing Yang,Zhu Liang,Hui Zhao,Jingping Huang,Ying Song,Jingyu Zhu,Yishu Yan,Yuntao Zhu
IFN-γ has been shown to exert potent anti-fibrotic effects in early stages of liver fibrosis, but the drug development has been impeded by systemic toxicity arising from off-target receptor activation. To overcome this therapeutic challenge, a nanodelivery platform (~200 nm) through covalent conjugation of sulfated hyaluronan (S-HA) with branched polyethyleneimine (PEI) was developed. Upon loading with IFN-γ, the nanoplatform achieved significantly enhanced hepatic accumulation effect. The resulting S-HA-PEI-IFN-γ formulation significantly attenuated M1 type macrophage polarization and associated pro-inflammatory cytokine release induced by free IFN-γ treatment, the key contributors to systemic adverse effects. Mechanistically, the nanoparticle of S-HA-PEI within the formulation exhibited synergistic effect with IFN-γ to suppress hepatic stellate cell (HSC) activation by blocking TGF-β/Smads signaling pathway. In a CCl 4 -induced murine liver fibrosis model, S-HA-PEI-IFN-γ administration achieved remarkable reduction in collagen deposition as compared to free IFN-γ treatment, accompanied by concurrent downregulation of Collagen-I (Col I) and α-smooth muscle actin (α-SMA) expression. By integrating targeted delivery, toxicity mitigation and synergistic anti-fibrotic effect, the S-HA-PEI-IFN-γ nano-therapeutic represents a promising transformative strategy for combating liver fibrosis.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Wanchun Lin,Yingchun Liu,Jiayuan Yang,Bo-Mei Liu,Wei Liu,Maoping Lyu,Jesse Zhu,Hui Zhang
Recent public health issues and the rise of antimicrobial resistance have driven the demand for durable, self-activating antimicrobial surfaces. Traditional metal oxide coatings often suffer from uncontrolled ion release and limited antibacterial mechanisms, which hinder their long-term effectiveness. In this work, a mechanically robust, friction-activated hydrophobic antibacterial coating is developed by integrating γ-Bi 2 O 3 , polydimethylsiloxane (PDMS), and nanoscale hydrophobic SiO 2 . PDMS imparts low surface energy, while SiO 2 reinforces mechanical stability; substrate adhesion is further enhanced via plasma treatment followed by KH570 silane grafting. Microscale tetrahedral γ-Bi 2 O 3 (∼6 μm) with nanoscale tips (∼200 nm) enables a synergistic antibacterial effect through controlled Bi + release and mechanical membrane disruption, while maintaining low cytotoxicity. Upon friction activation, the P 1 B 2 S 0.04 coating exhibited an increase in water contact angle from 113.1 ± 1.7 ° to 145.9 ± 3.7 ° after 1000 abrasion cycles. The antibacterial rates against E. coli reached 99.94 %, 99.67 %, and 99.87 %, and S. aureus values were 97.77 %, 99.08 %, and 99.29 % after 300, 600, and 900 cycles, respectively. Cytotoxicity tests confirmed good biocompatibility, with cell viability exceeding 80 %. These results indicate that the coating maintains sustained antibacterial performance after repeated abrasion, showing strong potential for applications on medical and public surfaces.
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Nanomaterials
·
2018
·Vol. 8
·期 11
·877
·
IF 3.504
Guangyu Lei,Jingwen Ma,Zhen Li,Xiaobin Fan,Wenchao Peng,Guoliang Zhang,Fengbao Zhang,Yang Li
In this paper, a facile route has been developed to prepare magnetic trimetallic Au-Ag-γ-Fe2O3/rGO nanocomposites. The impact of the preparation method (the intensity of reductant) on the catalytic performance was investigated. The nanocomposites were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The prepared nanocomposites show fine catalytic activity towards the reduction reaction of 4-nitrophenol (4-NP). The nanocomposites also have superparamagnetism at room temperature, which can be easily separated from the reaction systems by applying an external magnetic field.
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高影响因子
ACS Applied Electronic Materials
·
2024
·
IF 4.3
Zihan Zhou,Silin Han,Yunwen Wu,Tao Hang,Huiqin Ling,Jie Guo,Su Wang,Ming Li
The SiO2 layers, as the dielectric in the multistack storage cells of 3D NAND, are detrimentally dissolved by phosphoric acid (PA) during the selective Si3N4 etching. The thinning of SiO2 layers leads to the failure of subsequent processes; thus, an etching inhibitor for SiO2 is crucial for 3D NAND fabrication. However, most inhibitors are currently limited to neutral or alkaline solutions. In this work, the γ-ureidopropyltriethoxysilane (UPTES), compatible with a hot-concentrated PA solution, was applied to the wet-etching process for the first time and exhibited an inhibitory effect on SiO2 etching by retarding the etch rate over 60% without affecting the Si3N4 etching. The saturation adsorption of UPTES on the SiO2 substrate is confirmed to occur around the critical concentration, according to the Langmuir–Freundlich adsorption isotherm. The adsorption behavior of UPTES exhibits a reliance on its concentration. Around the critical concentration, the UPTES molecules chemisorb on the SiO2 surface by Si–O–Si covalent bonds to form ordered UPTES-siloxane layers, avoiding contact between SiO2 and the etchant; whereas oversaturated UPTES polymers physisorb not only on SiO2 but also on Si3N4, impeding the Si3N4 etching. This work contributes to a step forward in the effective wet-etching process in high-density 3D NAND fabrication.
研究领域:
半导体制造
·
材料科学
·
微电子学
·
表面化学
·
湿法刻蚀技术
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高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Xinying Ma,Huiping Lv,Meifeng Chen,Hua Liu,Shouqing Xue,Qi Zhu,Xueliang Wang
Propyl gallate (PG), a common anti-oxidant used in food, has garnered extensive attention due to its possible harm to human health. Herein, a highly sensitive sensor for determination of PG in foodstuffs was fabricated by electropolymerizing γ-aminobutyric acid (GABA) and electrodepositing gold (Au) on a glassy carbon electrode (GCE). Scanning electron microscopic (SEM) images showed that the poly GABA formed a layer of uniform membrane, and the deposited Au was needle-like nanoclusters (AuNC). The electrochemical experiments showed that, under the optimal conditions, the modified electrode can be used for determination of PG in a wide concentration range from 0.06 to 3.6 μmol/L, with a correlation coefficient (R) of 0.9990 and a detection limit of 0.001 μmol/L (S/N = 3). The applicability of the sensor was verified by detecting PG in food samples, such as instant noodles, biscuits and edible oils, with excellent specificity and good recoveries (94.0–100.6 %), indicating that the sensor has application prospects in food safety control.
研究领域:
食品安全
·
电分析化学
·
纳米材料
·
传感器与生物传感器
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高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2017
·Vol. 75
·期 6
·1466-1473
·
IF 1.197
Li Shifeng,Qi Fang,Xiao Min,Fan Hongtao,Shen Yanming,Du Kaige,Zhang Zhigang,Li Wenxiu
Mg-Al layered double hydroxides (LDHs) adsorbent was synthesized in situ on γ -Al 2 O 3 for the removal of Cr(VI) from aqueous solution. The material was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electronic microscopy and thermogravimetry and differential thermal analysis. Compared to the LDHs powder, the calcined LDHs sorbent prepared in situ on γ -Al 2 O 3 had higher specific surface area and was easy to recover and reuse. The adsorptive capacity for removing Cr(VI) from aqueous solution was resulting from the memory effect of LDHs based on the XRD results. Both the pseudo-second-order kinetic model and the Langmuir model fit the experimental data well. Furthermore, the adsorbent exhibits excellent sorption–regeneration performances.
研究领域:
环境科学
·
材料化学
·
水处理
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高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2026
·
IF 8.4
Zewei Liu,Liping Zhang,Mingqian Cheng,Ling Chen,Wei Fang,Qihong Cen,Chao Chen,Bin Li
CF 4 , is a highly potent greenhouse gas emitted by the electrolytic aluminum industry, with a global warming potential 7390 times that of CO 2 . Its urgently necessary to effectively control and decompose it. Alumina industry is the upstream of electrolytic aluminum industry, from which the red mud (RM) generated should be recycled. In this study, the decomposition performance of CF 4 was improved by loading γ-Al 2 O 3 on hydrochloric acid-treated RM. Under optimal conditions (reaction temperature of 650 °C, WHSV of 1500 h −1 , and material dosage of 1 g), the decomposition efficiency of Al 1 HRM 2 for CF 4 reached 85 %. Compared with the unmodified acid-treated RM (HRM), the conversion rate and stability were significantly improved. The results of NH 3 -TPD, Py-IR and XPS indicated that acid treatment and addition of γ-Al 2 O 3 significantly increased the Lewis acid site and medium-strong acid site of Al 1 HRM 2 . During the reaction, CF 4 adsorbs and dissociates at the strongest Lewis acid site (Al Ⅲ ), forming an intermediate (CF 2 O) and CO 2 to achieve the decomposition of CF 4 . In comparison with existing decomposition techniques, the method proposed here avoids the generation of corrosive HF, while also promoting the development of a greener aluminum industry and the formation of high-value fluorides.
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高影响因子
INTERNATIONAL DENTAL JOURNAL
·
2026
·Vol. 76
·期 3
·109505
·
IF 5.2
Jiawen Liu,Yidan Xu,Zhiyuan Lin,Suqing Tu,Chen Chen,Haifeng Xie
Introduction and aims This study investigated the synergistic effect of combining 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) and γ-methacryloxypropyl trimethoxysilane (γ-MPTS) in one primer on bonding to lithium disilicate ceramics. Methods A 5% ethanol solution with 10-MDP and γ-MPTS (1:1 by volume) was prepared. The mixed solutions after 24 hours, 72 hours, 7 days, and 6 months storage were characterized by Fourier transform infrared spectroscopy (FTIR). Ultraviolet-visible (UV-Vis) spectrophotometric titration monitored the intermolecular interactions and their dynamics within 30 minutes of mixing. 84 IPS e.max CAD specimens were etched with 5% HF acid and assigned to four surface pretreatment groups: control, 10-MDP, γ-MPTS, and 10-MDP+γ-MPTS. After applying RelyX Ultimate resin cement, 1-mm composite resin cylinders were bonded and light-polymerized. The bonded assemblies were then stored in water for 24 hours or aged via 6 months storage plus 5000 thermocycles before micro-shear bond strength testing. The data were analysed using multivariate analysis of variance ( P < .05). Six machine learning models including Logistic Regression, Decision Tree, Random Forest, Extra Trees, Gradient Boosting, and Extreme Gradient Boosting were employed to evaluate the feature importance influencing bond strength. Results FTIR and UV-Vis analyses indicated that 10-MDP promoted the hydrolysis and siloxane condensation of γ-MPTS, forming a stable organic-inorganic hybrid network. The combined group showed the highest initial (24.22 MPa) and aged (16.07 MPa) bond strength, with more cohesive failures. Machine learning confirmed the combined primer as the most critical factor. Conclusions The coexistence of 10-MDP and γ-MPTS in a single solvent environment provides a synergistic effect, significantly enhancing both the bonding strength and durability of glass-based ceramics. Clinical Relevance A combined 10-MDP/γ-MPTS primer stabilizes the adhesive interface and increases the durability of ceramic restorations for better long-term success.
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危险品化学品经营许可证（带存储）