JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·1-23
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IF 12.6
Fei Weidong,Xin Yu,Qian Wenqiang,Liu Mingqi,Zheng Caihong,Liu Yunxi,Chen Danfei,Zhou Ying,Xu Shanshan,Wu Xiaodong,Zhao Mengdan
Due to the insidious onset of ovarian cancer, the majority of patients are diagnosed at advanced stages, often presenting with extensive pelvic and abdominal metastasis. A significant proportion of these patients exhibit primary or acquired drug resistance, limiting improvements in the five-year survival rate. In this study, an analysis of patient-derived samples demonstrated a strong correlation between cholesterol levels and ovarian cancer progression. Membrane lipid therapy, a strategy that targets the composition, structure, and function of the cell membrane, has demonstrated notable potential in tumor therapy. Subsequently, a novel cholesterol oxidation-mediated membrane lipid therapy employing PLGA microspheres co-loaded with miriplatin (MiR) and cholesterol oxidase (COD) was proposed for drug-resistant advanced ovarian cancer therapy. The microspheres had a particle size of approximately 2.58 μm, with encapsulation efficiencies of 82.98 ± 0.09% for MiR and 32.83 ± 4.30% for COD. In vitro experiments demonstrated that COD-induced cholesterol oxidation modulated the membrane rigidity and fluidity of SKOV3-TR cells, thereby compromising membrane structural integrity and attenuating tumor cell migration. Additionally, the reactive oxygen species generated during cholesterol oxidation disrupted mitochondrial membrane potential and adenosine triphosphate production. The resulting energy deficiency and compromised membrane integrity reduced the expression and function of drug resistance-associated proteins, thereby enhancing chemosensitivity. Moreover, the combined effects of reactive oxygen species and MiR drove resistant cells towards apoptosis. In vivo studies demonstrated that the large-particle PLGA formulation effectively resided in the peritoneal cavity, resulting in superior therapeutic outcomes against drug-resistant metastatic ovarian tumor, as evidenced by fewer peritoneal metastatic nodules and diaphragmatic colonization sites, more extensive tumor tissue destruction, and prolonged survival. More importantly, PLGA encapsulation significantly decreased the toxic side effects associated with continuous platinum-based chemotherapy. Overall, cholesterol oxidation-mediated membrane lipid therapy represented a promising approach for treating advanced ovarian cancer. Graphical abstract
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Zeyi Guan,Liuyan Zhang,Yiqi Xie,Danting Wu,Binkai Yuan,Lichan Wu,Gengzhe Shen,Guibin Tan,Fujian Guo
Alkaline water electrolysis is recognized as an environmentally sustainable approach for generating high-energy-density clean hydrogen. However, its efficiency remains largely limited by the sluggish kinetics water dissociation in the hydrogen evolution reaction (HER), the challenge of activating water molecules, and the excessive consumption of OH − and high adsorption energy barriers of oxygenated intermediates during the oxygen evolution reaction (OER). In this work, A nanoneedle-structured Ru-NiCo₂O₄-Se electrocatalyst was developed, demonstrating excellent bifunctional electrocatalytic performance for both HER and OER. Through a combination of experimental characterizations and theoretical simulations, it had been revealed that the sharp-tip nanoneedle morphology generates intense local electric fields. These fields facilitate the enrichment of K + ions at the cathode, optimized the interfacial water structure, and substantially lower the energy barrier required for water dissociation. At the anode, the tip effect facilitated OH − accumulation, enhanced reactant mass transport, and accelerated OER kinetics. Moreover, metal–support interactions (MSI) between Ru nanoclusters and the support effectively modulate the adsorption behavior of H* and oxygenated intermediates, further boosting catalytic performance. The catalyst achieves overpotentials as low as −48 mV for HER and + 231 mV for OER at a current density of 10 mA·cm −2 , and delivers a high overall water splitting current of 100 mA·cm −2 at a cell voltage of only 1.7 V, along with remarkable long-term durability over hundreds of hours. This study presents an innovative strategy based on interfacial microenvironment engineering and electronic structure modulation, paving a fresh pathway for the development of cost-effective, high-performance, and long-lasting bifunctional electrocatalysts tailored for clean energy conversion.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Jin Liu,Yuyao Chen,Yue Shi,Bin Song,Jing Wang,Chong Zhang,Dan Zhang,Yuanyuan Feng
The development of hydrogen evolution reaction (HER) catalysts that combine high activity with high current density stability is an important step in promoting the scale-up preparation of green hydrogen in anion exchange membrane water electrolyzer (AEMWE). In this paper, we propose an asymmetrical “Nd−O–Ru” bridge active sites strategy in the rapid construction of rare earth metal oxides (M x O y , M = Nd, Ce) and ruthenium heterojunctions (M x O y @Ru/CNT, CNT stands for carbon nanotube) catalysts by a solvent-free microwave method. Experiments show that the catalyst exhibits excellent HER performance in alkaline media: driving 10 mA cm −2 and 1000 mA cm −2 only requires ultra-low overpotentials of 20 mV and 363 mV, and operates stably for 100 h at 1000 mA cm −2 . The combination of in situ Raman spectroscopy and theory calculations reveals that the p orbital of oxygen at the interface acts as an electronic bridge to mediate the coupling of the f orbital of Nd to the d orbital of Ru through “Nd−O–Ru” bridge enhancing the adsorption of water molecules while synergistically optimizing the free energy of hydrogen adsorption (ΔG H∗ ) and accelerating the kinetics of hydrolysis dissociation. Integrating this catalyst into the AEMWE yields current densities of 500 and 1000 mA cm −2 at voltages of 1.665 V and 1.806 V, respectively, thus offering a novel material design paradigm for industrial-scale water electrolysis. This study opens a new path for rational design of efficient energy conversion catalysts through orbital coupling engineering.
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ENERGY & FUELS
·
2025
·
IF 5.3
Wuyu Wang,Xuelai Zhao,Yanyan Cui,Xinghua Zhang,Lungang Chen,Qi Zhang,Longlong Ma
Jet fuels must simultaneously meet stringent requirements for energy density and freezing point to ensure safe operation under extreme flight conditions. The common technical route of biojet fuel is hydrodeoxidation after the platform molecule C–C coupling. The branched long-chain alkanes synthesized from biomass-derived C5–C6 esters and ketones platform molecules can meet the performance requirements of jet fuel, via the Claisen condensation as the C–C coupling step. The acetone-derived methyl isobutyl ketone (MIBK) and methyl pivalate were efficiently converted to C11 fuel precursor with branched chain structure over potassium tert-butoxide (t-BuOK) in N,N-dimethylformamide solution. MIBK was fully converted at room temperature for 7 h, with a 95% yield of C11 oxygenated compounds. Under the same conditions, a series of C10–12 oxygenated compounds with a yield around 80% could be synthesized from methyl pivalate and other ketones. In addition, the oxygenated compounds generated alongside the Claisen condensation reaction could serve as jet fuel precursors, thereby ensuring high atomic economy of ketones. After hydrodeoxygenation, these oxygenated precursors are transformed into isomeric alkanes with freezing points below −100 °C, meeting and even surpassing aviation fuel standards. Importantly, the mild conditions, high selectivity, and compatibility with a wide range of ketone feedstocks indicate the route’s strong industrial application potential for large-scale production of ultralow freezing biojet fuel for extreme aviation environments.
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RARE METALS
·
2024
·
IF 9.6
He Jin-Di,Wang Han-Du,Zhang Xu-Ming,Huang Li,Li Yun,Xia Lu,Pi Chao-Ran,Li Jian-Ping,Zheng Yang,Gao Biao,Huo Kai-Fu
The development of cost-effective, highly efficient and stable catalysts is critical to promote the industrial alkaline hydrogen evolution reaction (HER). However, single-component catalysts often cannot handle the multiple kinetic steps during hydrogen production. To address this challenge, a heterogeneous catalyst comprising metal Co, CoO and carbon-doped Mo 2 N (Co–CoO–C/Mo 2 N/CC) was synthesized by heat treatment of carbon cloth-supported CoMoO 4 microrods in a mixed reduction atmosphere. The resulting catalyst has rich interfaces, exhibiting excellent initial HER activity with an overpotential of 27 mV at 10 mA·cm −2 and a Tafel slope of 37 mV·dec −1 . Further studies show that the activity and stability of the catalyst can be tailored by the dynamic surface reconfiguration and doping effects. The carbon doping and high crystallinity in Mo 2 N help to reduce the dissolution of Mo and the surface metal Co is preferentially converted into stable Co(OH) 2 , thus stabilizing the structure of the catalyst and coordinating various reaction kinetics. In an electrolyzer comprising a heterogeneous Co–CoO–C/Mo 2 N cathode and NiFe layered double hydroxides (LDH) anode, only 1.58 V is required to achieve a current density of 50 mA·cm −2 , outperforming Pt/RuO catalysts. After continuous electrolysis for 100 h, the potential increases by merely 19 mV from the initial 1.58 V, indicating excellent stability. This study presents a novel strategy for developing highly active and stable heterogeneous catalysts, offering insights into the dynamic evolution of catalyst structures and laying the groundwork for designing efficient and stable composite catalysts for energy conversion applications. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Yirong Wang,Xuan Yu,Zhonghong Xia,Xuanrong Li,Ya Gao,Jing Zhang,Wuliang Feng,Xingli Zou,Yufeng Zhao
The high overpotential and sluggish kinetics of oxygen evolution reaction (OER) severely hinder the widespread application of electrochemical water splitting, especially at industrial-level current densities. Herein, we report a novel heterostructural Ni-based metal organic framework (MOF)-Ni 2 P in-situ grown on iron foam (NiMOF-Ni 2 P/IF), which shows remarkable OER activity and stability. We demonstrate that the work function difference between NiMOF and Ni 2 P leads to the strong electron coupling effect by promoting electron transfer at the interface and results in a discernible upward shift of the d-band center of Ni sites for favorable OH − adsorption. The as-fabricated NiMOF-Ni 2 P/IF exhibits an ultralow overpotential of 330 mV and a small cell voltage of 1.796 V to drive NiMOF-Ni 2 P/IF‖Pt/C system at 1000 mA cm −2 in 1 M KOH, outperforming the majority of state-of-the-art non-noble-metal-based electrocatalysts. Furthermore, the catalyst shows remarkable performance even under harsh industrial conditions of 40, 60, and 80 °C in 6 M KOH. In addition, NiMOF-Ni 2 P/IF holds great promise with remarkable stability of 200 h and 600 cycles in simulated seawater and secondary zinc-air batteries (ZABs), respectively. This work offers a rational design strategy for low cost, high activity, and long durability OER electrocatalyst based on in-depth comprehension of the electronic coupling effect.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Lixia Wang,Jia Huang,Xinran Hu,Zhiyang Huang,Mingcheng Gao,Di Yao,Tayirjan Taylor Isimjan,Xiulin Yang
The pursuit of efficient and economically viable catalysts for liquid/solid-state zinc-air batteries (ZABs) is of paramount importance yet presents formidable challenge. Herein, we synthesized a vacancy-rich cobalt/manganese oxide catalyst (Co/MnO@NC) stabilized on a nitrogen-doped mesoporous carbon (NC) nanosphere matrix by leveraging hydrothermal and high-temperature pyrolysis strategy. The optimized Co/MnO@NC demonstrates fast reaction kinetics and large limiting current densities comparable to commercial Pt/C in alkaline electrolyte for oxygen reduction reaction (ORR). Moreover, the Co/MnO@NC serves as an incredible cathode material for both liquid and flexible solid-state ZABs, delivering impressive peak power densities of 217.7 and 63.3 mW cm −2 and robust long-term stability (459 h), outperforming the state-of-the-art Pt/C and majority of the currently reported catalysts. Research indicates that the superior performance of the Co/MnO@NC catalyst primarily stems from the synergy between the heightened electrical conductivity of metallic Co and the regulatory capacity of MnO on adsorbed oxygen intermediates. In addition, the abundance of vacancies regulates the electronic configuration, and superhydrophilicity facilitates efficient electrolyte diffusion, thereby effectively ensuring optimal contact between the active site and reactants. Besides, the coexisting NC layer avoids the shedding of active sites, resulting in high stability. This work provides a viable approach for designing and advancing high-performance liquid/solid-state ZABs, highlighting the great potential of energy storage technology.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Huamei Tong,Xinyu Zheng,Mengyue Qi,Di Li,Jianjun Zhu,Deli Jiang
Constructing bifunctional non-precious metal electrocatalysts with advanced industrial value and excellent electrocatalytic performance to achieve efficient overall water splitting is important but difficult. Herein, a heterogeneous electrocatalyst comprising of CoMo alloys anchored Fe 2 O 3 nanosheets was prepared by hydrothermal and electrodeposition methods. The strongly coupled interfaces between the CoMo alloys and Fe 2 O 3 nanosheets promote charge redistribution, which could improve electron transfer efficiency and accelerate reaction kinetics, potentially optimizing reactant adsorption energy. Further density functional theory (DFT) calculations reveal that the construction of CoMo/Fe 2 O 3 /NF heterostructured catalyst facilitates to promote interfacial charge redistribution and enhance charge transfer capacity, thus boosting the catalytic performance. Benefiting from this, the optimal CoMo/Fe 2 O 3 /NF heterostructure demonstrates a minimal overpotential of 71 mV at 10 mA cm −2 for the HER and 266 mV at 50 mA cm −2 for the OER. Remarkably, the catalyst served as a bifunctional electrode for water splitting, resulting in a cell voltage down to 1.5 V at a current density of 10 mA cm −2 . This research provides an effective way for the construction of non-precious iron oxides-based bifunctional electrocatalysts using alloy/metal oxide interfacial engineering strategy.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Yang Liu,Hailong Feng,Weiyi Li,Xueping Wang,Guoxiang Huang,Longxia Wang,Xingqiu Li,Yuxing Xie,Chenglu Liang
Catalysts in-situ reconstructed from transition metal sulfides for oxygen evolution reaction (OER) have been regarded as potential alternatives for the noble metal catalysts . Intriguingly, it was found that the self-optimized SO 4 2− @Cu doped Co(OH) 2 catalyst was reconstructed from bimetallic sulfide of CuCo 2 S 4 . During the OER process, the copper was partially leached and meantime doped into the in-situ generated Co(OH) 2 with SO 4 2− adsorption, while only oxides were discovered in counterparts of mono-metal sulfides. As a result, the SO 4 2− @Cu doped Co(OH) 2 catalyst exhibited superior OER performances, with low overpotentials of 211/272 mV to achieve the current densities of 10/100 mA cm −2 , exceeding the counterparts reconstructed from mono-metal sulfides. Experimental and theoretical results suggested that the in situ generated Cu doped Co(OH) 2 possessed thin and loosely layered structure with expanded lattice spacing (lattice spacing expanded from 0.28 nm to 0.46 nm) due to the SO 4 2− adsorption, making the intermediates more accessible to the active centers. In addition, the catalyst surface changed from hydrophobicity to super hydrophilicity , which greatly accelerated the mass transfer. This work indicated that the in-situ reconstruction process was greatly influenced by the interactions between metal sites and sulfide species, directly influencing the OER performances of the reconstructed catalysts.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Huimin Mao,Xinyue Qu,Hongsheng Ma,Jingqi Chi,Zhenyu Xiao,Yongming Chai,Zexing Wu,Xiaobin Liu,Lei Wang
Seawater electrolysis is undoubtedly a more sustainable alternative to pure water electrolysis at present. However, it is hindered by the relatively slow kinetics of the oxygen evolution reaction and the detrimental effects of chloride ions in seawater that require resolution. In this study, we developed a straightforward synthesis method and successfully prepared FeNiCoMnCr high-entropy oxide (HEO). The strong coupling among multiple 3d orbitals of the transition metals allows for significant regulation of the catalyst’s electronic structure, enabling oxidation and reduction processes at the active site to spontaneously approach an equilibrium state. Additionally, Lewis acid Cr 6+ selectively adsorbs OH − , further enhancing both activity and stability of the catalyst in alkaline seawater. This research provides valuable insights into utilizing HEOs for seawater electrolysis and elucidates the roles of metals within HEOs.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Zhenzhong Liu,Suyue Luo,Xinran Yin,Shuo Zhang,Minghui Guo
The present work effectively achieved the production of a self-supporting electrode with high efficiency. The process involves incorporating nickel and molybdenum carbide (Mo 2 C) phases within the channels of wood through high-temperature calcination at the nanoscale. The obtained carbonized wood (CW) possesses low tortuosity and three-dimensional vertical channels, providing an excellent substrate for the preparation of Ni-Mo 2 C/N-CW electrodes. Mo 2 C is well known for its considerable potential as a non-precious metal electrocatalyst with enhanced catalytic activity. The successful doping of nickel and nitrogen into molybdenum carbide not only promotes the formation of β-Mo 2 C, but also improves the electron transfer rate and mass diffusion pathway. Consequently, the Ni-Mo 2 C/N-CW electrode exhibits excellent performance in the hydrogen and oxygen evolution reactions (HER and OER, respectively). Only voltages of 89 and 253 mV are required to achieve a current density of 10 mA cm −2 , respectively. When the Ni-Mo 2 C/N-CW catalyst is used as both cathode and anode during hydrolysis, current densities of 10 and 100 mA cm −2 can be achieved with excellent durability and stability at voltages of 1.56 and 1.72 V, respectively. The distinctive porous structure of the wood substrate is of crucial importance for promoting the adsorption and dissociation of water molecules, enhancing the catalytic performance. In addition, the present material exhibits advantageous characteristics, including a high specific surface area and a significant number of adsorption sites, making it a very promising candidate for applications involving the adsorption of dyes, such as rhodamine B (RhB).
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Lingzhe Meng,Shuwen Niu,Zhengyu Wei,Xue Qin,Faheem Naseem,Wei Wei
Iron phthalocyanine (FePc) with tetracoordinated Fe-N 4 site shows promising activity for catalyzing the oxygen reduction reaction (ORR) in alkaline media. However, the consecutive proton-coupled electron transfer (PCET) steps with water as the proton donor and low electronic conductivity of FePc raise the kinetic barriers for device application. Herein, a significant effect of polyoxometalates (POMs) on the ORR kinetics of Fe-N 4 sites via surface coordination of FePc is revealed. POM clusters modulate the interactive steric/electronic environment of Fe-N 4 , leading to a low barrier for H 2 O cleavage to produce protons along with a high electron transfer rate, thereby accelerating the PCET steps of FePc. With precisely controlled electron charge of POM clusters, the influence and mechanism of heteropoly blue in promoting PCET steps of FePc relative to heteropoly acid are elucidated, and noticeably enhanced ORR activity and reaction current are achieved. These findings highlight the potential of POMs as ligands to optimize dynamics of Fe-N 4 atomic sites toward efficient alkaline ORR.
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