Advanced Optical Materials
·
2023
·Vol. 11
·期 15
·2203140
·
IF 9
Jing Yang,Ziyu Wang,Lu Liu,Le Wang,Zhen Chang,Jianxun Li,Kai Wang,Shengzhong (Frank) Liu
Organic lead halide perovskites are regarded as qualified candidates for the photoactive layers of semitransparent solar cells. The critical aspect of boosting the performance of semitransparent perovskite solar cells (PSCs) to a higher level lies in preparing perovskite films with both excellent photoelectric properties and high transmittance. Herein, it is realized that, through theoretical analysis, perovskite materials with bandgap of 2.00–2.30 eV are suitable for the preparation of semitransparent PSCs that can simultaneously achieve low thermal-energy loss, allow transmission of light for high photopic response, and provide acceptable transmittance for photovoltaic greenhouses. Then the study aims at improving the crystallinity and morphology of wide-bandgap perovskite films by using additive engineering. As such, PSCs with absorber bandgaps of 2.02, 2.16, and 2.32 eV deliver maximum power-conversion efficiencies of 12.08%, 9.17%, and 8.42%, respectively. Then the corresponding semitransparent PSCs are crafted with average transmittance of light detectable by the human eye of 9.41%, 23.26%, and 43.47%, respectively. Furthermore, the crop growth factors are predicted to be 21.25%, 29.48%, and 37.07%, respectively. This work gives full play to bandgap modulation in the fabrication of semitransparent PSCs, which will broaden the application of semitransparent solar cells in the field of building integrated photovoltaics.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Zhongjie Fei,Ping Liu,Chu Cheng,Rongbin Wei,Pengfeng Xiao,Youfa Zhang
Although numerous approaches were proposed for the nucleic acid (NA)-based SARS-CoV-2 detection, the nonideal NA desorption efficiency of conventional magnetic beads (MBs) limits their widespread application. In this study, we developed solvent-responsive MBs (called responsive MBs), which, in the presence of buffers, modulated the absorption and desorption capacities of NA by flipping the surface −COO–. Relative to other commercial MBs, responsive MBs exhibited similar absorption profiles and markedly enhanced desorption profiles. When applied for NA detection of complex samples, responsive MBs exhibited better performance of RNA detection than DNA, with obvious advantages in sensitivity. Specifically, the RNA and DNA desorption rates of commercial MBs were ∼85 and 82.5%, while those of responsive MBs were nearly 94 and 93.5%, respectively. Furthermore, responsive MBs exhibited remarkable extraction ability in a wide range of tissues and better performance of RNA extraction than DNA. When applied for SARS-CoV-2 detection, the responsive MBs along with the simulated digital RT-LAMP (a previously established apparatus) further improved detection efficiency, yielding a precise quantitative detection as low as 25 copies and an ultimate sensibility detection of 5 copies/mL. It was also successfully employed in numerous NA-based technologies such as polymerase chain reaction (PCR), sequencing, and so on.
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CHEMICAL PAPERS
·
2023
·Vol. 77
·期 6
·2967-2976
·
IF 2.2
Ma Mingming,Liang Juanli
The voltammetric behavior of 2-aminoazotoluene (2-AMAT) is studied at pencil electrode (PEC) modified by electropolymerization of β-cyclodextrin (P-β-CD-PEC) in different supporting electrolyte at various pH values using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). At the scan rate of 0.1 V s −1 , 2-AMAT exhibits an irreversible oxidation peak at 0.67 V in phosphate buffer solution (PBS) with the pH value of 6.64. The electrochemical data suggest that the oxidation reaction of 2-AMAT at the surface of P−β−CD−PEC involves one electron and one proton. 2−AMAT has a significantly higher oxidation peak current on P−β−CD−PEC than pristine PEC, which is ascribed to the presence of cavities in polymer of β−CD on the surface of PEC. Under the optimized DPV conditions, the oxidation peak current is linear with 2-AMAT concentration in the range of 0.3 μM to 30.0 μM with a low limit of detection (LOD = 0.14 μM) and high sensitivity (1.45 μA /μM). The same 2-AMAT concentration was measured every two days in 20 days using the same P−β−CD−PEC. The results show that the relative standard deviation (RSD) of the peak current was 3.36%, indicating that the stability of P−β−CD−PEC is good. Five different bitches P−β−CD−PEC was used to determine the same 2-AMAT concentration and 4.29% RSD is obtained, which suggests that the reproducibility of this modified electrode is excellent. In addition to some metal ions, the structural substances such as 2,4-diaminotoluene and 4-chloroaniline do not interfere the determination of 2-AMAT, suggesting that P−β−CD−PEC has fine selectivity. Therefore, a new method for detecting 2-AMAT based on P−β−CD−PEC is developed. This method is successfully used to determine 2−AMAT in rose lotion cosmetics with satisfied results.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Shuxian Li,Yan Zhao,Fuqiang Hu,Yuechun Jiao,Jianming Zhao,Changyong Li
Ethoxy-substituted benzene has several stable conformations as the single bond in the ethoxy group is capable of internal rotation. Ethoxybenzonitrile may has more conformers due to different orientations of ethoxy with respect to the CN group. In this paper, the potential energy surface (PES) of 2-ethoxybenzonitrile in the ground state was calculated at the level of B3LYP/cc-pvdz, and five different molecular conformers were found on the PES. Only the most stable conformer I (trans) was observed in the supersonic molecular beam experiments. The resonance enhanced multiphoton ionization (REMPI) and mass analyzed threshold ionization (MATI) spectra of 2-ethoxybenzonitrile were measured and Franck-Condon simulations were performed, and the theoretical results are in good agreement with the experimental measurements. The similar molecular structures in S 0 , S 1 , and D 0 states imply the large Franck-Condon factors. The vibronic structures in S 1 and D 0 states were analyzed in detail and the vibronic features were assigned. The MATI spectra follow well the propensity rule Δν = 0, indicating that the molecular structures of the cationic and excited states are similar. Most of the observed vibrations are associated with the ring in-plane distortion. The band origin of the S 1 ←S 0 transition and the accurate adiabatic ionization energy of 2-ethoxybenzonitrile are determined for the first time to be 34 092 ± 2 and 69 796 ± 5 cm −1 , respectively.
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Drug Design Development and Therapy
·
2022
·
IF 4.319
Xin-Yu Liao,Yang Lei,Song-Feng Chen,Jing Cheng,Dan Zhao,Zhi-Feng Zhang,Xin Han,Ya Zhang,Hua-Bao Liao,Yang Zhuang,Juan Chen,Hai-Bing Zhou,Qi Wan,Ying-Ying Zou
Background: The authors have recently designed a new compound bisperoxovandium (pyridin-2-squaramide) [bpV(pis)] and verified that bpV(pis) confers neuroprotection through suppressing PTEN and activating ERK1/2, respectively. Intracerebral hemorrhage (ICH) is the second most common cause of stroke and has severe clinical outcome. In this study, we investigate the effect of bpV(pis) in ICH model both in vivo and in vitro.Materials and methods: The novel drug bpV(pis) was synthesized in the Faculty of Pharmacy, Wuhan University School of Medicine. An ICH model was generated on both SD rats and cells. bpV(pis) was injected into intracerebroventricular or culture media. Western blotting was applied to test the signal pathway. To determine the effect of bpV(pis) on PTEN inhibition and ERK1/2 activation, we measured the phosphorylation level of AKT (a direct downstream target of PTEN that negatively regulates AKT) and ERK1/2. FJC, MTT, and LDH were applied to measure the cell viability. Neurobehavioral tests were performed to measure the effect of bpV(pis).Results: The in vivo results showed that intracerebroventricular administration of bpV(pis) significantly alleviates hematoma, the damage of brain–blood barrier and brain edema. The in vitro results demonstrated that bpV(pis) treatment reduces ICH-induced neuronal injury. Western blotting results identified that bpV(pis) exerts a neuroprotective effect by significantly increasing the phosphorylation level of AKT and ERK1/2 after experimental ICH. Neurobehavioral tests indicate that bpV(pis) promotes functional recovery in ICH animals.Conclusion: This study provides first and direct evidence for a potential role of bpV(pis) in ICH therapy.
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TETRAHEDRON
·
2022
·
IF 2.388
Li Rao,Hu-Cheng Shi,Yi Zou
A new fungal nonribosomal peptide-polyketide hybrid synthase , namely CogA, was discovered by genome mining from fungus Cordyceps gunnii . Its ability to synthesize 4-hydroxyl 2-pyrrolidinone alkaloid ( 1 ) via nonenzyme-catalyzed N-1-C-2 closure was confirmed by heterologous expression of it in Aspergillus nidulans . Further engineered biosynthesis of the fluoro-substituted 2-pyrrolidinone alkaloid analogues ( 4 and 5 ) has also been achieved in vivo .
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ACTA PHARMACOLOGICA SINICA
·
2022
·Vol. 44
·期 3
·499-512
·
IF 7.169
Xu Bing-tian,Li Meng-fan,Chen Ke-chun,Li Xing,Cai Ning-bo,Xu Jiang-ping,Wang Hai-tao
Cannabidiol (CBD) reportedly exerts protective effects against many psychiatric disorders and neurodegenerative diseases, but the mechanisms are poorly understood. In this study, we explored the molecular mechanism of CBD against cerebral ischemia. HT-22 cells or primary cortical neurons were subjected to oxygen-glucose deprivation insult followed by reoxygenation (OGD/R). In both HT-22 cells and primary cortical neurons, CBD pretreatment (0.1, 0.3, 1 μM) dose-dependently attenuated OGD/R-induced cell death and mitochondrial dysfunction, ameliorated OGD/R-induced endoplasmic reticulum (ER) stress, and increased the mitofusin-2 (MFN2) protein level in HT-22 cells and primary cortical neurons. Knockdown of MFN2 abolished the protective effects of CBD. CBD pretreatment also suppressed OGD/R-induced binding of Parkin to MFN2 and subsequent ubiquitination of MFN2. Overexpression of Parkin blocked the effects of CBD in reducing MFN2 ubiquitination and reduced cell viability, whereas overexpressing MFN2 abolished Parkin’s detrimental effects. In vivo experiments were conducted on male rats subjected to middle cerebral artery occlusion (MCAO) insult, and administration of CBD (2.5, 5 mg · kg −1 , i.p.) dose-dependently reduced the infarct volume and ER stress in the brains. Moreover, the level of MFN2 within the ischemic penumbra of rats was increased by CBD treatment, while the binding of Parkin to MFN2 and the ubiquitination of MFN2 was decreased. Finally, short hairpin RNA against MFN2 reversed CBD’s protective effects. Together, these results demonstrate that CBD protects brain neurons against cerebral ischemia by reducing MFN2 degradation via disrupting Parkin’s binding to MFN2, indicating that MFN2 is a potential target for the treatment of cerebral ischemia.
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International Journal of Smart and Nano Materials
·
2022
·
IF 4
Ping Zhang,Ziyi Xu,Zhiying Wu,Ping Xu,Canhui Yang
As the first version of synthetic hydrogel, poly(2-hydroxyethyl methacrylate) hydrogels have found broad applications. However, their poor mechanical performances have been long-standing hurdles for practical deployments. Herein, we report on strengthening the poly(2-hydroxyethyl methacrylate) hydrogels with biochar nanoparticles and hydrophobic aggregations, which are induced by solvent exchange and reinforced by freeze-thaw. Both the vast anchoring points on the multifunctional surfaces of the biochar nanoparticles and the aggregates formed between poly(2-hydroxyethyl methacrylate) chains engender strong and dissipative physical crosslinks. The resulting hydrogels exhibit marked mechanical properties, encompassing high stretchability ~7, high fracture toughness ~1360 J m−2, high elastic modulus ~180 kPa, low friction coefficient ~0.2, self-recovery, and non-swellability. Furthermore, we demonstrate the versatility of the proposed strategy by using water/ionic liquid binary solvent as the solvent system, Laponite as the nano-reinforcement, and dry-anneal as the hydrophobic aggregation enhancer to synthesize mechanically robust hydrogels. Poly(2-hydroxyethyl methacrylate) hydrogels of superior mechanical properties are expected to enable previously inaccessible applications in biomedicine and engineering.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Lin Wang,Feng Li,Sufang Wang,Jinsong Wu,Wenhui Zhang,Yan Zhang,Wentao Liu
The application of enzyme-inorganic hybrid nanoflowers in time-temperature indicators (TTIs) was studied for the first time. Lipase@Cu 3 (PO 4 ) 2 hybrid nanoflowers were prepared by the interaction between lipase and copper ions. Compared with free lipase, the activity of lipase in the nanoflowers was increased by 137%, and the storage stability was also improved significantly. Based on the enzymatic reaction between lipase and glycerol triacetate, six TTI prototypes with different concentrations of lipase@Cu 3 (PO 4 ) 2 hybrid nanoflowers were investigated. The color of the six TTIs changed from purple to yellow, and finally to green, and the activation energies were 46.86 kJ/mol, 51.17 kJ/mol, 54.99 kJ/mol, 60.00 kJ/mol, 62.17 kJ/mol, and 65.63 kJ/mol, respectively. The shelf life of TTIs can be determined by changing the ratio of lipase@Cu 3 (PO 4 ) 2 hybrid nanoflowers to glycerol triacetate, therefore the TTIs can be easily applied to real-time safety evaluation of many perishable foods.
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MATERIALS CHEMISTRY AND PHYSICS
·
2022
·
IF 4.778
Zhijia Zhang,Huifeng Mei,Qiang Wang,Rui Li,Guojun Wang,Hao Wei,Xiao Ouyang
Unlike the organisms in nature, the synthetic materials are difficult to repair the damage via self-regulation. Even the self-healing materials generally require the external stimuli (e.g., temperature, pressure, light, etc ) to repair themselves. In this paper, self-healing polyurethane elastomer was designed and prepared based on 2-ureido-4[1 H ]-pyrimidinone compound by the simple physical blending method. The tensile strength and the elongation at break of the self-healing polyurethane elastomer were 0.65 MPa and 623.1%, respectively. The healing performance was measured by cut-off experiment, showing that the fracture of the self-healing polyurethane elastomer was healed at room temperature without external stimuli and kept excellent mechanic properties. The healing efficiencies of the tensile strength and the elongation at break were achieved to 87.7% (0.57 MPa) and 71.7% (446.7%) after healing at room temperature with 30 h, respectively. When the temperature was up to 80 °C, the healing time curtailed at 1 h. And the tensile strength and the elongation at break were recovered to 0.59 MPa and 532.1%, respectively. These promising results provide a strategy that allows increasing the life cycle of materials, adapting them to a circular economy model, thus reducing the generation of waste.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2021
·
IF 3.171
Tiefeng Wang,Jinxiang Dong
The coal (syngas)-to-ethylene glycol (CTEG), is contaminated with the naughty impurity 2-Methoxyethanol (ME) generated during the hydrogenation stage, which affect the quality of EG for fiber-grade polyester production. Distillation, is the employed separation process in industrial, which makes production complicated because of the heat sensitivity of the impurities system. Melt crystallization has been regarded as an effective technology to obtain high-purity organic compounds based on the melting points difference, which could avoid the problems by heating. In this work, we have explored the feasibility of the static melt crystallization on the separation of EG/ME in a jacketed crystallization tube. The experimental parameters were investigated, which covers crystallization and sweating stage in each step. The results showed that the purity of EG could reach ≥99.8% from the binary system studied via the quaternary separation process.
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Frontiers in Microbiology
·
2020
·
IF 4.236
Cui Haoran,Zhang Leiliang
The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is one of seven human coronaviruses. G-quadruplexes are intrinsic obstacles to genome replication. Whether G-quadruplexes are present in human coronaviruses is unknown. In the current study, we have predicted that all seven human coronaviruses harbor G-quadruplex sequences. Conserved G-quadruplex sequences in SARS-CoV and SARS-CoV-2 were analyzed and verified by circular dichroism (CD) spectroscopy and Thioflavin T fluorescence assay. Similar to SARS-CoV, SARS-CoV-2 encodes an nsP3 protein, which is predicted to associate with G-quadruplexes. Targeting G-quadruplex sequences in the SARS-CoV-2 genome by G-quadruplex ligands could be a new way to conquer COVID-19.
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