MONATSHEFTE FUR CHEMIE
·
2026
·
IF 2.2
Wang Yun,Zhang Qiang-qiang,Liu Zi-yin,Xie Zhuang-dong
The synthesis of 2-aryl-2,3-dihydroquinolin-4(1 H )-ones from aromatic aldehydes and and 1-(2-aminophenyl)ethanone catalyzed by l -proline in ionic liquids was achieved for the first time. High yields up to 88.7% were achieved. Mild reaction conditions, enhanced rates, improved yields, and reagents’ reactivity, which is different from that in standard organic solvents, are the remarkable features observed in ionic liquids. In addition, the reaction mechanism was studied using computational methods, and the results were consistent with experimental findings. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
VACUUM
·
2026
·
IF 4.3
Meng Li,Haiting Liu,Guoliang Liu,Jiani Dong,Jia Gao,Binbin Zhang,Xueyong Guo,Hua Fang,Xiong Cao
Molecular perovskite energetic material (H 2 dabco)[NH 4 (ClO 4 ) 3 ] (DAP-4) has attracted significant attention. However, its high thermal decomposition temperature hinders its application in propellants. To reduce its reaction energy barrier and modulate its decomposition and combustion performance, the catalytic effect of copper fluoride (CuF 2 ) on the thermal decomposition and combustion behavior of DAP-4 was systematically investigated in this work. DAP-4/CuF 2 composites with different CuF 2 contents (1 wt%, 3 wt%, and 5 wt%) were prepared by a mechanical mixing method. Their morphology, thermal behavior, reaction products and combustion mechanism were comprehensively characterized by SEM, XRD, DSC, TG, high-speed combustion photography, XPS and MS. The results indicated that the CuF 2 significantly reduced the thermal decomposition temperature of DAP-4 with a maximum decrease of 35.2 °C and the apparent activation energy decreased markedly, dropping from 370.40 kJ/mol for pure DAP-4 to approximately 155.82 kJ/mol for the DAP-4/5 wt%CuF 2 . Combustion experiments revealed that both the combustion pressure and pressurization rate were enhanced. A possibly reaction mechanism of energy release of DAP-4 with CuF 2 was proposed that CuF 2 accelerated the initial decomposition of DAP-4 through proton transfer reactions between ClO 4 − /F − and NH 4 + , leading to enhancing the reaction kinetics. This study provided a new pathway for the design and fabrication of DAP-4-based energetic materials in solid propellants.
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Yueli Liu,Zhijie Zheng,Jianeng Tao,Lizhi Wang,Wen Chen
Conventional ligand exchange strategies for FAPbI3 quantum dots (QDs) rely on polar solvents, which compromise colloidal stability and device performance. Herein, a ligand-mediated defect passivation strategy is proposed, in which 4-(trifluoromethyl)aniline (4-ATFB) is incorporated into the toluene-based solvent system during the purification of FAPbI3 QDs. The amino group of 4-ATFB coordinates with undercoordinated Pb2+ sites to passivate defects and optimize FA+ charge distribution, while outward-oriented trifluoromethyl group forms a barrier against moisture. The dual functionality stabilizes the lattice and suppresses defects during the purification process. Moreover, the carrier dynamics are significantly improved with 4-ATFB treatment, attributed to reduced defect density and suppressed trap-mediated losses, leading to enhanced radiative recombination. Consequently, the fabricated FAPbI3 QDs solar cells with 4-ATFB treatment exhibit a champion power conversion efficiency of 16.33%, representing a significant improvement over the control device (14.99%), together with exceptional operational stability that retains over 80% of the initial efficiency after 25 days of storage in an ambient atmosphere without encapsulation.
✓ 已验证
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2026
·Vol. 40
·期 33
·18043-18052
·
IF 6
Pang Bo,Pu Baian,Peng Hao,Xue Kang,Shi Chengxiang,Gao Ruijie,Ai Minhua,Huang Zhen-Feng,Zhang Xiangwen,Zou Ji-Jun,Pan Lun
Conventional
high-energy-density hydrocarbon fuels face an intrinsic
trade-off between increasing ring number and decreasing net heat of
combustion. To address this limitation, we propose a synthetic strategy
based on tandem [4 + 2]/[2 + 1] cycloaddition. Norbornadiene and methyl
dicyclopentadiene were employed as feedstocks to develop a coupled
synthetic approach that combines Diels–Alder [4 + 2] cycloaddition
for constructing a polycyclic framework with Simmons–Smith
[2 + 1] cyclopropanation for energy enhancement. By optimizing the
reaction parameters, the Diels–Alder and Simmons–Smith
reactions achieved optimal conversions of 77.89% and 90.96%, respectively,
with selectivities of 43.54% and 85.82%. The resulting fuel fraction
exhibits a high density of 1.060 g cm –3 , a volumetric
net heat of combustion of 44.85 MJ L –1 , and a freezing
point below −60 ° C. This study demonstrates an effective
strategy for simultaneously achieving high density, high volumetric
energy content, and excellent low-temperature performance, providing
useful guidance for the molecular design and synthesis of next-generation
high-energy-density fuels.
✓ 已验证
产品关联
DOI
高影响因子
POULTRY SCIENCE
·
2026
·Vol. 105
·期 11
·107437
·
IF 4.5
Zhanbang Ma,Fangfang Wang,Bing Wang,Zhihui Zuo,Zongxi Han,Huixin Li,Deying Ma
Vitamin D is increasingly recognized as an important regulator of innate and adaptive immunity, yet its antiviral role in chickens during fowl adenovirus serotype 4 (FAdV-4) infection remains unclear. In this study, we investigated the effects of oral vitamin D 3 supplementation on humoral immunity, tissue viral load, and immune-related gene expression in FAdV-4-infected chickens. Ninety 8-day-old specific pathogen-free chickens were randomly divided into two groups (n = 45/group) and fed a basal diet. The experimental group received oral vitamin D 3 dissolved in 0.1 mL soybean oil at a dose equivalent to 3000 IU/kg diet daily for 3 weeks, whereas the control group received soybean oil alone. After supplementation, all birds were challenged with FAdV-4. Vitamin D 3 supplementation significantly reduced tissue viral loads and increased serum antibody levels compared with the control group. At the transcriptional level, vitamin D 3 modulated key innate and adaptive immune markers, including Toll-like receptors (TLRs), avian β-defensins, and cytokines. It downregulated several TLRs and reduced the pro-inflammatory cytokines interleukin (IL)-6 and IL-8, while increasing the antiviral cytokines interferon-γ and IL-1β. Vitamin D 3 also increased vitamin D receptor expression, decreased inducible nitric oxide synthase, and reduced the apoptosis regulators B-cell lymphoma-2 (BCL-2) and Bcl2-associated X protein in selected tissues. In conclusion, vitamin D 3 supplementation enhanced antiviral defense against FAdV-4 infection, possibly by promoting humoral immunity and modulating innate immune and apoptosis-related responses. These findings provide new insight into the role of vitamin D 3 in limiting FAdV-4 infection and support its potential as a nutritional strategy for controlling viral diseases in poultry.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Zhongzhou Si,Haodong Chen,Shakoor Kashif,Ting Li,Fanghui Ma,Minghui Yang
Copper nanoclusters were synthesized based on 4-mercaptobenzoic acid (P-MBA) as template. • The addition of small molecule terephthalic acid (PTA) can enhance the fluorescence intensity. • The reaction between PTA and ascorbic acid can produce a blue fluorescent substance PTA-OH. • Acid phosphatase can catalyze the hydrolysis of l -ascorbic acid-2-phosphate to AA. • A ratiometric fluorescence assay for acid phosphatase was developed. Copper nanoclusters were synthesized based on 4-mercaptobenzoic acid (P-MBA) as template (P-MBA-CuNCs). Small molecule terephthalic acid (PTA) was then utilized to modify P-MBA-CuNCs and enhance the fluorescence intensity. Individual P-MBA-CuNCs were self-assembled into nanosheet aggregates in aqueous solution due to π-π stacking and hydrogen bonding interactions. These inter-cluster interactions accelerated the nonradiative process, resulting in quenching of the fluorescence. However, there is strong interaction between PTA and P-MBA, which blocks the inter-cluster interaction of CuNCs and enhances the fluorescence emission. In addition, the reaction between PTA and ascorbic acid (AA) can produce a blue fluorescent substance PTA-OH. Acid phosphatase (ACP) can catalyze the hydrolysis of l -ascorbic acid-2-phosphate (AAP) to AA. Therefore, a ratiometric fluorescence assay for ACP was constructed based on the CuNCs/PTA system with fluorescence intensity of CuNCs unchanged and fluorescence intensity of PTA-OH increased. The assay has linear response to ACP in the concentration range of 0.01–15 U/L, with detection limit as low as 0.003 U/L. The method was successfully applied to determination of the ACP in the human serum samples. Ratio fluorescence assay for acid phosphatase based on 4-mercaptobenzoic acid templated copper nanoclusters. Download: Download high-res image (111KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
iScience
·
2026
·Vol. 29
·期 10
·117739
·
IF 4.5
Lingxi Meng,Rongpu Liu,Siyi Wang,Junyi Wang,Ilya A. Vinnikov,Rong Yang,Xinyu Song,Hongming Zhang,Jiajia Wang,Wenjie Zhang
Apoptosis at bone defects drives an anti-osteogenic oxidative stress environment • IL-4 drives a pro-reparative macrophage phenotype and upregulates the Arg1 pathway • Exogenous Arg fuels efferocytosis and secretion of pro-regenerative factors • Co-delivery of IL-4 and Arg via injectable hydrogel accelerates bone regeneration Summary Host bone microenvironment is a critical factor for successful bone regeneration during implantation. In this work, we identified a spatiotemporal mismatch at drilling-induced injury sites where initial apoptosis outpaces macrophage recruitment, leading to apoptotic cell accumulation and oxidative stress that impairs osteogenic differentiation. To mitigate this phenomenon, we developed a synergistic strategy co-delivering interleukin 4 (IL-4) and arginine (Arg) to reprogram the microenvironment. Mechanistically, IL-4 recruits and polarizes macrophages toward a pro-reparative M2 phenotype, while Arg fuels the arginase-1 metabolic pathway to sustain continual efferocytosis and secretion of pro-regenerative cytokines. In a mouse bone injury model, transcriptomic and histological analyses confirmed that this strategy accelerates apoptotic clearance and establishes an M2-dominant environment, significantly enhancing early bone regeneration. Altogether, this work proposes a novel therapeutic paradigm targeting macrophage efferocytosis to resolve early microenvironmental imbalances, providing a promising therapeutic approach to promote bone defect healing and offering novel insights into optimizing host microenvironments for osseointegration following implantation. Download: Download high-res image (245KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2026
·
IF 3.3
Min Zhao,Zhengwei Ding,Saima Perveen,Lulu Qin,Zaicheng Nie,Tao Yu,Mingming Mao,Yuanyuan Cheng,Junyu Wang,Pengfei Li
The cyclohexane skeleton is ubiquitous in small-molecule drugs and bioactive natural products. However, there remains a lack of synthetic methods for polysubstituted cyclohexanes that simultaneously satisfy the requirements of readily available starting materials, high atom economy, and low-cost catalysts, which to a certain extent limits the application of this type of skeleton in the field of drug research and development. Herein, we report the first example of a boron radical-catalyzed intermolecular (4 + 2) cycloaddition reaction between cyclobutanes and alkenes, a strategy that provides an efficient and general method for the synthesis of polysubstituted cyclohexanes. This reaction exhibits broad substrate scope, being compatible with monosubstituted, 1,1-disubstituted, and trisubstituted alkenes and can selectively construct tri-, tetra-, and pentasubstituted cyclohexane derivatives in moderate-to-excellent yields.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Siyuan Chen,Lihao Gu,Chenglong Ye,Xinyi Zhao,Xingxing Zhang,Jianming Xu,Dan Luo,Xi Wang,Jia Luo,Jun Deng,Wei Liu
Hyperpigmentation remains a significant dermatological challenge. Although 4-butylresorcinol (4-BR), undecylenoyl phenylalanine (UPA), and stearyl glycyrrhetinate (SG) exhibit complementary mechanisms targeting these pathways, their therapeutic potential is limited by poor solubility, instability, and insufficient skin permeation. To overcome these barriers, a nanostructured emulsion system co-encapsulating 4-BR, UPA, and SG (BUS-NEs) was developed via high-pressure homogenization. The optimized BUS-NEs displayed a mean particle size of 55.01 nm, encapsulation efficiencies exceeding 90%, good stability, and a sustained release profile. Compared with Free-BUS, BUS-NEs significantly improved cellular uptake and skin permeation while maintaining excellent biocompatibility. Mechanistic studies revealed that BUS-NEs exerted superior anti-melanogenic effects by potently inhibiting intracellular tyrosinase activity, reducing melanin production, and downregulating key genes in the α-MSH-stimulated signaling pathway. Furthermore, BUS-NEs displayed robust antioxidant and anti-inflammatory activities, effectively scavenging ROS and suppressing the secretion of pro-inflammatory cytokines. These multifunctional benefits were validated in advanced models: BUS-NEs significantly reduced melanin deposition and improved skin brightness in UVB-irradiated 3D reconstructed human skin, and demonstrated pronouncedc depigmentation and antioxidant protection in vivo using zebrafish models. In conclusion, the BUS-NEs platform successfully overcomes the delivery limitations of 4-BR, UPA, and SG, enabling their complementary, multi-target action for effective hyperpigmentation management, representing a promising nanotechnological strategy for advanced dermocosmetic applications. Download: Download high-res image (304KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
Current Analytical Chemistry
·
2024
·Vol. 22
·期 1
·84-91
·
IF 1.7
Si Chen,Yiming Nie,Qing Liu,Fang Chen
Background4-n-butylresorcinol (4nBR) was widely used in the treatment of chloasma and skin whitening cosmetics. As a decolorizing agent, it can effectively control the activity of tyrosinase. Market regulatory authorities require truthful labeling of ingredients in cosmetics. Therefore, the quantitative determination of 4nBR is of great practical significance.HypothesisAt present, the main detection method of 4nBR reported in the literature is HPLC. Compared with the HPLC method, optical methods offer several advantages, including low cost, and simplicity, which make them suitable for on-field detection applications. A convenient spectrophotometric method was established for 4nBR detection.MethodsFe3+ can oxidize the common colorless chromogenic substrate 3,3',5,5'-tetramethylbenzidine (TMB) to blue oxTMB. Based on the fact that 4-n-butyl resorcinol (4nBR) can reduce oxTMB, a convenient and rapid spectrophotometric method for the determination of 4nBR was proposed.ResultsUnder the optimum conditions, the absorbance at 652 nm has a good linear relationship with the concentration of 4nBR in the range of 1.2 - 16 μM. The linear equation for the detection of 4nBR was ΔA = 0.0546 c (μM) - 0.0026 (r2=0.9962), and the detection limit was 0.33 μM. The accuracy of this method is comparable to that of HPLC.ConclusionThis method has good selectivity for 4nBR and good anti-interference ability for common additives in cosmetics. The proposed method can be applied to the determination of 4nBR in thereal samples.
✓ 已验证
DOI
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Shiyi Zhang,Tongpeng Yue,Peixuan Jin,Xinyi Zhang,Qidong Huo,Wenxuan Li,Chen Tian,Hui Dong,Yinping Dong,Yu Zhao,Deguan Li
Radiation-induced intestinal injury (RIII) is a serious and common complication of radiotherapy, and there are currently no effective therapeutic strategies. This study investigates the protective role of 4-octyl itaconate (4-OI), a cell-permeable itaconate derivative, against RIII. In vitro , 4-OI pretreatment enhanced the viability of irradiated intestinal epithelial cells, reduced reactive oxygen species (ROS) accumulation, and alleviated DNA damage. In a murine model of total body irradiation, 4-OI administration mitigated intestinal structural disruption, promoted crypt stem cell regeneration, and suppressed epithelial apoptosis. Mechanistically, 4-OI exerted its cytoprotective effects by modulating the SLC7A11/GPX4 axis to inhibit ferroptosis and enhancing glutathione biosynthesis. Furthermore, 16S rRNA sequencing revealed that 4-OI treatment recalibrated radiation-induced gut microbiota dysbiosis, suggesting an additional microbiome-mediated protective pathway. To our knowledge, the results represent the first demonstration of 4-OI's protective effects in RIII pathogenesis, positioning it as a novel therapeutic candidate for clinical radioprotection through dual mechanism targeting.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Yan Wu,Min Fang,Ting Su,Li Zhang,Xuefeng Mao,Rui Ding,Wenzhong Yang,Hui Xu
The development of functional hydrogel composites for environmental remediation represents a prominent research direction in sustainable materials science. In this investigation, a hierarchical (GO- g -P4VP/CdSe)@PAA hydrogel was fabricated through a multi-step synthesis protocol. Graphene oxide-grafted poly(4-vinylpyridine)/cadmium selenide (GO- g -P4VP/CdSe) nanocomposite was initially synthesized via facile hydrothermal crystallization, followed by integration into a polyacrylic acid (PAA) matrix through solution-phase crosslinking. The photocatalytic performance evaluation demonstrated that the composite hydrogel exhibited remarkable visible-light-driven catalytic activity. This enhanced degradation efficiency is attributed to the synergistic effects between the P4VP-mediated charge transfer pathways and the GO/CdSe heterojunction structure, which effectively suppresses photogenerated carrier recombination. The three-dimensional (3D) porous hydrogel architecture further promotes reactive oxygen species generation through improved pollutant adsorption-concentration effects and multiple light-refraction events, underscoring its potential for water treatment applications.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）