MONATSHEFTE FUR CHEMIE
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2026
·
IF 2.2
Wang Yun,Zhang Qiang-qiang,Liu Zi-yin,Xie Zhuang-dong
The synthesis of 2-aryl-2,3-dihydroquinolin-4(1 H )-ones from aromatic aldehydes and and 1-(2-aminophenyl)ethanone catalyzed by l -proline in ionic liquids was achieved for the first time. High yields up to 88.7% were achieved. Mild reaction conditions, enhanced rates, improved yields, and reagents’ reactivity, which is different from that in standard organic solvents, are the remarkable features observed in ionic liquids. In addition, the reaction mechanism was studied using computational methods, and the results were consistent with experimental findings. Graphical abstract
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VACUUM
·
2026
·
IF 4.3
Meng Li,Haiting Liu,Guoliang Liu,Jiani Dong,Jia Gao,Binbin Zhang,Xueyong Guo,Hua Fang,Xiong Cao
Molecular perovskite energetic material (H 2 dabco)[NH 4 (ClO 4 ) 3 ] (DAP-4) has attracted significant attention. However, its high thermal decomposition temperature hinders its application in propellants. To reduce its reaction energy barrier and modulate its decomposition and combustion performance, the catalytic effect of copper fluoride (CuF 2 ) on the thermal decomposition and combustion behavior of DAP-4 was systematically investigated in this work. DAP-4/CuF 2 composites with different CuF 2 contents (1 wt%, 3 wt%, and 5 wt%) were prepared by a mechanical mixing method. Their morphology, thermal behavior, reaction products and combustion mechanism were comprehensively characterized by SEM, XRD, DSC, TG, high-speed combustion photography, XPS and MS. The results indicated that the CuF 2 significantly reduced the thermal decomposition temperature of DAP-4 with a maximum decrease of 35.2 °C and the apparent activation energy decreased markedly, dropping from 370.40 kJ/mol for pure DAP-4 to approximately 155.82 kJ/mol for the DAP-4/5 wt%CuF 2 . Combustion experiments revealed that both the combustion pressure and pressurization rate were enhanced. A possibly reaction mechanism of energy release of DAP-4 with CuF 2 was proposed that CuF 2 accelerated the initial decomposition of DAP-4 through proton transfer reactions between ClO 4 − /F − and NH 4 + , leading to enhancing the reaction kinetics. This study provided a new pathway for the design and fabrication of DAP-4-based energetic materials in solid propellants.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Yueli Liu,Zhijie Zheng,Jianeng Tao,Lizhi Wang,Wen Chen
Conventional ligand exchange strategies for FAPbI3 quantum dots (QDs) rely on polar solvents, which compromise colloidal stability and device performance. Herein, a ligand-mediated defect passivation strategy is proposed, in which 4-(trifluoromethyl)aniline (4-ATFB) is incorporated into the toluene-based solvent system during the purification of FAPbI3 QDs. The amino group of 4-ATFB coordinates with undercoordinated Pb2+ sites to passivate defects and optimize FA+ charge distribution, while outward-oriented trifluoromethyl group forms a barrier against moisture. The dual functionality stabilizes the lattice and suppresses defects during the purification process. Moreover, the carrier dynamics are significantly improved with 4-ATFB treatment, attributed to reduced defect density and suppressed trap-mediated losses, leading to enhanced radiative recombination. Consequently, the fabricated FAPbI3 QDs solar cells with 4-ATFB treatment exhibit a champion power conversion efficiency of 16.33%, representing a significant improvement over the control device (14.99%), together with exceptional operational stability that retains over 80% of the initial efficiency after 25 days of storage in an ambient atmosphere without encapsulation.
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PubMed
高影响因子
ENERGY & FUELS
·
2026
·Vol. 40
·期 33
·18043-18052
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IF 6
Pang Bo,Pu Baian,Peng Hao,Xue Kang,Shi Chengxiang,Gao Ruijie,Ai Minhua,Huang Zhen-Feng,Zhang Xiangwen,Zou Ji-Jun,Pan Lun
Conventional
high-energy-density hydrocarbon fuels face an intrinsic
trade-off between increasing ring number and decreasing net heat of
combustion. To address this limitation, we propose a synthetic strategy
based on tandem [4 + 2]/[2 + 1] cycloaddition. Norbornadiene and methyl
dicyclopentadiene were employed as feedstocks to develop a coupled
synthetic approach that combines Diels–Alder [4 + 2] cycloaddition
for constructing a polycyclic framework with Simmons–Smith
[2 + 1] cyclopropanation for energy enhancement. By optimizing the
reaction parameters, the Diels–Alder and Simmons–Smith
reactions achieved optimal conversions of 77.89% and 90.96%, respectively,
with selectivities of 43.54% and 85.82%. The resulting fuel fraction
exhibits a high density of 1.060 g cm –3 , a volumetric
net heat of combustion of 44.85 MJ L –1 , and a freezing
point below −60 ° C. This study demonstrates an effective
strategy for simultaneously achieving high density, high volumetric
energy content, and excellent low-temperature performance, providing
useful guidance for the molecular design and synthesis of next-generation
high-energy-density fuels.
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NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Jiaoe Gong,Biao Zhang,Long He,Jingxuan Qiao,Shanliang Yuan,Qifei Bo
Hydrogen fluoride (HF), a highly corrosive and toxic industrial emission, poses severe environmental and health risks, necessitating the development of efficient solid adsorbents for its capture. In this study, a series of cross-linked 4-vinylpyridine (4-VP)/divinylbenzene (DVB) porous resins were synthesized via suspension polymerization, and their HF adsorption properties were systematically evaluated. By tuning the 4-VP/DVB ratio, the pore-forming agent dosage, and the polymerization temperature, the resins' surface area, pore structure, and nitrogen content were effectively controlled. Saturation adsorption experiments revealed that nitrogen content plays a dominant role in HF uptake, whereas the contribution of specific surface area is comparatively minor. The optimized resin, WPD-25-1-0.1, achieved a high saturated adsorption capacity of 853 mg g−1. Isotherm fitting demonstrated that HF adsorption follows the Freundlich model and is exothermic with heterogeneous surface characteristics. Thermodynamic analysis confirmed a strong synergistic adsorption mechanism, where pyridine nitrogen sites act as chemisorption centers and subsequently induce the formation of (HF)n hydrogen-bonded clusters. The resin also demonstrates excellent regenerability, maintaining over 97% capacity retention after five adsorption–desorption cycles using only N2 purging at 373 K. These results highlight the strong potential of 4-VP-based porous resins for industrial HF emission control and resource recovery.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Shiyi Zhang,Tongpeng Yue,Peixuan Jin,Xinyi Zhang,Qidong Huo,Wenxuan Li,Chen Tian,Hui Dong,Yinping Dong,Yu Zhao,Deguan Li
Radiation-induced intestinal injury (RIII) is a serious and common complication of radiotherapy, and there are currently no effective therapeutic strategies. This study investigates the protective role of 4-octyl itaconate (4-OI), a cell-permeable itaconate derivative, against RIII. In vitro , 4-OI pretreatment enhanced the viability of irradiated intestinal epithelial cells, reduced reactive oxygen species (ROS) accumulation, and alleviated DNA damage. In a murine model of total body irradiation, 4-OI administration mitigated intestinal structural disruption, promoted crypt stem cell regeneration, and suppressed epithelial apoptosis. Mechanistically, 4-OI exerted its cytoprotective effects by modulating the SLC7A11/GPX4 axis to inhibit ferroptosis and enhancing glutathione biosynthesis. Furthermore, 16S rRNA sequencing revealed that 4-OI treatment recalibrated radiation-induced gut microbiota dysbiosis, suggesting an additional microbiome-mediated protective pathway. To our knowledge, the results represent the first demonstration of 4-OI's protective effects in RIII pathogenesis, positioning it as a novel therapeutic candidate for clinical radioprotection through dual mechanism targeting.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
He Yaofeng,Shi Zhengyang,Liu Xiaokang,Zeeshan Muhammad,Zhang Guoqiang,Han Xiaoqiang,Ma Ting
To enhance the antifungal activity of 4-(diethylamino)salicylaldehyde
(DSA), 20 salicylaldehyde Schiff base compounds (L1–L20), including
nine novel derivatives, were synthesized and characterized by MS, 1 H NMR, and 13 C NMR. In vitro assays identified
compound L5 as the most active agent, with an EC 50 of 10.797
μg/mL (2-fold higher than DSA), and pot experiments confirmed
its efficacy against cotton damping-off disease. Mechanistic investigations
via electron microscopy, transcriptomics, physiological assays and
molecular docking suggest that L5 may target fatty acid synthase (FAS)
to interfere with fungal lipid biosynthesis, disrupt energy homeostasis,
and induce oxidative stress, which triggers synergistic membrane impairment
and oxidative damage and ultimately causes hyphal death. With a novel
target and a distinctive single-target, multieffect mode of action,
L5 is a promising candidate for new fungicide development.
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iScience
·
2026
·Vol. 29
·期 10
·117739
·
IF 4.5
Lingxi Meng,Rongpu Liu,Siyi Wang,Junyi Wang,Ilya A. Vinnikov,Rong Yang,Xinyu Song,Hongming Zhang,Jiajia Wang,Wenjie Zhang
Apoptosis at bone defects drives an anti-osteogenic oxidative stress environment • IL-4 drives a pro-reparative macrophage phenotype and upregulates the Arg1 pathway • Exogenous Arg fuels efferocytosis and secretion of pro-regenerative factors • Co-delivery of IL-4 and Arg via injectable hydrogel accelerates bone regeneration Summary Host bone microenvironment is a critical factor for successful bone regeneration during implantation. In this work, we identified a spatiotemporal mismatch at drilling-induced injury sites where initial apoptosis outpaces macrophage recruitment, leading to apoptotic cell accumulation and oxidative stress that impairs osteogenic differentiation. To mitigate this phenomenon, we developed a synergistic strategy co-delivering interleukin 4 (IL-4) and arginine (Arg) to reprogram the microenvironment. Mechanistically, IL-4 recruits and polarizes macrophages toward a pro-reparative M2 phenotype, while Arg fuels the arginase-1 metabolic pathway to sustain continual efferocytosis and secretion of pro-regenerative cytokines. In a mouse bone injury model, transcriptomic and histological analyses confirmed that this strategy accelerates apoptotic clearance and establishes an M2-dominant environment, significantly enhancing early bone regeneration. Altogether, this work proposes a novel therapeutic paradigm targeting macrophage efferocytosis to resolve early microenvironmental imbalances, providing a promising therapeutic approach to promote bone defect healing and offering novel insights into optimizing host microenvironments for osseointegration following implantation. Download: Download high-res image (245KB) Download: Download full-size image
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Siyuan Chen,Lihao Gu,Chenglong Ye,Xinyi Zhao,Xingxing Zhang,Jianming Xu,Dan Luo,Xi Wang,Jia Luo,Jun Deng,Wei Liu
Hyperpigmentation remains a significant dermatological challenge. Although 4-butylresorcinol (4-BR), undecylenoyl phenylalanine (UPA), and stearyl glycyrrhetinate (SG) exhibit complementary mechanisms targeting these pathways, their therapeutic potential is limited by poor solubility, instability, and insufficient skin permeation. To overcome these barriers, a nanostructured emulsion system co-encapsulating 4-BR, UPA, and SG (BUS-NEs) was developed via high-pressure homogenization. The optimized BUS-NEs displayed a mean particle size of 55.01 nm, encapsulation efficiencies exceeding 90%, good stability, and a sustained release profile. Compared with Free-BUS, BUS-NEs significantly improved cellular uptake and skin permeation while maintaining excellent biocompatibility. Mechanistic studies revealed that BUS-NEs exerted superior anti-melanogenic effects by potently inhibiting intracellular tyrosinase activity, reducing melanin production, and downregulating key genes in the α-MSH-stimulated signaling pathway. Furthermore, BUS-NEs displayed robust antioxidant and anti-inflammatory activities, effectively scavenging ROS and suppressing the secretion of pro-inflammatory cytokines. These multifunctional benefits were validated in advanced models: BUS-NEs significantly reduced melanin deposition and improved skin brightness in UVB-irradiated 3D reconstructed human skin, and demonstrated pronouncedc depigmentation and antioxidant protection in vivo using zebrafish models. In conclusion, the BUS-NEs platform successfully overcomes the delivery limitations of 4-BR, UPA, and SG, enabling their complementary, multi-target action for effective hyperpigmentation management, representing a promising nanotechnological strategy for advanced dermocosmetic applications. Download: Download high-res image (304KB) Download: Download full-size image
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Journal of the American Chemical Society
·
2026
·
IF 16.6
Jie Zhang,Tingting Ye,Guo Chen,Deyuan Yao,Xin Zhang,Chuanguo Zhang,Jing Zhao,Pei Wang,Junfeng Ding,Zhi Zeng,Xianlong Wang
Realizing compounds entirely composed of aromatic hexazine N6 rings with high stability is a long-term challenge. Existing high-pressure synthesized compounds contain a maximum of 5.36% N atoms, forming aromatic [N6]4– rings. We predict that all N atoms contribute to aromatic [N6]4– rings in K4N6, which become stable at 60 GPa and can stably exist up to 600 K at 0 GPa. Furthermore, K and KN3 are suggested as precursors for the synthesis of K4N6. Following this approach, based on the diamond anvil cell, K4N6 with 100% nitrogen atoms forming aromatic hexazine [N6]4– rings is synthesized at 45 GPa after laser heating and identified by synchrotron X-ray diffraction and Raman spectroscopy. Our results bring us closer to achieving aromatic N6 rings at ambient condition.
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高影响因子
ADVANCED MATERIALS
·
2026
·
IF 29.1
Zhihao Sun,Lin Liu,Junwei Zhang,Yuhang Liu,Yifeng Wang,Ying Wan,Fanxing Bu,Bao Zhang,Wanhai Zhou,Dongyuan Zhao,Dongliang Chao
Unlike neutral aqueous batteries with cationic Zn 2+ as the charge carrier, alkaline batteries with anionic [Zn(OH) 4 ] 2‒ and OH ‒ are actually commercially feasible and thermodynamically stable thanks to their ability to suppress hydrogen evolution. Whereas commercial separators in alkaline batteries, without ion regulation capability, fail to suppress severe dendrite and passivation of anionic [Zn(OH) 4 ] 2‒ and accelerate ion transport of anionic OH ‒ . Herein, we tailor the coordination structures of alkali-stable cationic complexes in polymer separators (CCPS) to construct anionic OH ‒ selective transfer channels. Synchrotron spectroscopic characterizations and theoretical calculations reveal that the low-coordination cationic complexes expose more positive charge density, electrostatically attracting more negative charge from [Zn(OH) 4 ] 2‒ . In situ electrochemical digital holography technology and time-of-flight secondary ion mass spectrometry analyses further confirm the homogeneous [Zn(OH) 4 ] 2‒ distribution at the CCPS-electrode interface, oriented Zn deposition, and impeded passivation. As a result, CCPS enables alkaline Zn||Cu cells to operate over 5500 cycles at 1 mA cm ‒2 with a high coulombic efficiency of 99.99%. Alkaline Ni–Zn batteries exhibit ultrastable cycling over 1000 cycles at 6 C and maintain 86.17% of their maximum capacity at 10 C. Our work may provide practical and effective separator strategies to accelerate the commercialization of alkaline batteries.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Yan Wu,Min Fang,Ting Su,Li Zhang,Xuefeng Mao,Rui Ding,Wenzhong Yang,Hui Xu
The development of functional hydrogel composites for environmental remediation represents a prominent research direction in sustainable materials science. In this investigation, a hierarchical (GO- g -P4VP/CdSe)@PAA hydrogel was fabricated through a multi-step synthesis protocol. Graphene oxide-grafted poly(4-vinylpyridine)/cadmium selenide (GO- g -P4VP/CdSe) nanocomposite was initially synthesized via facile hydrothermal crystallization, followed by integration into a polyacrylic acid (PAA) matrix through solution-phase crosslinking. The photocatalytic performance evaluation demonstrated that the composite hydrogel exhibited remarkable visible-light-driven catalytic activity. This enhanced degradation efficiency is attributed to the synergistic effects between the P4VP-mediated charge transfer pathways and the GO/CdSe heterojunction structure, which effectively suppresses photogenerated carrier recombination. The three-dimensional (3D) porous hydrogel architecture further promotes reactive oxygen species generation through improved pollutant adsorption-concentration effects and multiple light-refraction events, underscoring its potential for water treatment applications.
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