Materials Science & Engineering C-Materials for Biological Applications
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2014
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IF 2.736
Jian-Tao Lin,Ying Zou,Chao Wang,Yue-Chun Zhong,Yi Zhao,Hui-Er Zhu,Guan-Hai Wang,Li-Ming Zhang,Xue-Bao Zheng
Cationic micellar nanoparticles for chemotherapeutic drugs and therapeutic gene co-delivery were prepared based on a poly-( N -ε-carbobenzyloxy- l -lysine) (PZLL) and dendritic polyamidoamine (PAMAM) block copolymer (PZLL-D3). PZLL-D3 was synthesized by a copper-catalyzed azide alkyne cyclization (click) reaction between α-alkyne-PZLL and azide focal point PAMAM dendrons. Its structure was characterized by 1 H NMR and FTIR, and its buffering capability was determined by acid–base titration. MTT, agarose gel electrophoresis and flow cytometry studies showed that PZLL-D3 revealed low in vitro cytotoxicity, strong pDNA condensation ability, protection of pDNA against deoxyribonuclease I degradation and high gene transfection efficiency in 293T and HeLa cells. In addition, the micellar nanoparticles delivered pDNA and anticancer drug doxorubicin (DOX) simultaneously and efficiently to tumor cells, and the DOX loaded nanoparticles showed sustained in vitro release at pH = 7.4 and 5.8.
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Shanshan Jin,Yongkang Chen,Fahui Li,Ping Yan,Guanhong Guo,Guangzhao Xu,Weiguo Song,Wenda Zhong
Currently, immunotherapy based on photothermal and the application of photodynamic therapy in anti-tumor treatment is showing great potential. Its uniqueness lies in the critical role of small molecule immunomodulators in promoting effective immune responses against tumors, and the use of laser-activated biophysical mechanisms to precisely trigger the swift demise of cancer cells, avoiding damage to surrounding normal tissues. However, the use of photodynamic therapy (PDT) alone is hampered by the tumors’ hypoxic environment, resulting in poor antitumor effects, while photothermal therapy (PTT) alone cannot arouse enough antigen presentation. It is of great significance to design photosensitizers (PSs) that possess both PDT and PTT effects. Herein, a series of PSs with both PDT and PTT efficacy are reported, ultimately selecting Cy7-Naph as the star molecule due to its best overall phototherapeutic effect. Upon reactive oxygen species (ROS) production and thermogenesis in tumor cells, Cy7-Naph induced significant apoptosis and eventually boosted the release of damage-associated molecular patterns (DAMPs) under near-infrared (NIR) light irradiation. By combining Cy7-Naph with the Toll-like receptor agonist Resiquimod (R848), a synergistic treatment for bilateral tumor-bearing mice is achieved. This combination promotes dendritic cell (DC) maturation and increases the infiltration of cytotoxic T lymphocytes (CTLs), leading to significant inhibition of both primary and distant tumors.
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DOI
PubMed
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
·
IF 7.7
Meng Tian,Baijing Li,Jianbo Sun
Triethylamine (TEA) finds extensive and critical applications across diverse domains including industrial manufacturing, pharmaceutical research and development, and agricultural cultivation. However, owing to its hazardous attributes such as toxicity and flammability, the detection of TEA has emerged as a pivotal step in safeguarding personal safety, mitigating environmental pollution, and elevating food safety standards. In the present study, Fe-doped cobalt-based metal-organic framework (MOF)-derived nanomaterials were successfully synthesized via a facile and efficient hydrothermal approach. Gas-sensing measurements reveal that the 5 at% Fe-doped Co 3 O 4 exhibits optimal performance, featuring an optimal operating temperature of 220°C and a response value sixfold that of the pure Co 3 O 4 sensor (21). Notably, the 5 at% Fe-doped Co 3 O 4 demonstrates rapid response and recovery time (32 s/34 s). Utilizing characterization techniques such as XPS and Fe-doped infrared spectroscopy for intermediate analysis, this work investigates the mechanism by which doping-induced charge transfer effects modulate the gas-sensing properties of the materials. Fe doping significantly enhances the gas-sensing activity, selectivity, and stability of cobalt-based MOF-derived materials by tailoring their local electronic structures. This discovery provides valuable theoretical underpinnings and experimental insights for the design of high-performance TEA gas sensors.
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THIN SOLID FILMS
·
2024
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IF 2
Xiaoyan Pan,Qingquan Zhang
This paper introduces a simple, robust and inexpensive method to create a thermal responsive coating for glass. The coating is a copolymer of N‑isopropylacrylamide (NIPAAm) and acrylamide (AAm), which can switch between clear and opaque states reversibly. The switching temperature can be adjusted from 32°C to 40°C by varying the percentage of acrylamide. The coating remains stable after switching 30 times and possesses switching function after six months storage at room temperature. These advanced properties enable the smart coating to be suitable for privacy and solar adaptive control.
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Nature Sustainability
·
2024
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IF 25.7
Gao Zhiwen,Wang Yu,Yuan Lei,Shi Xinrui,Shang Yihao,Jiang Jingang,Zhang Min,Fang Shuhui,Zhang Wei,Liu Yue
Co-upcycling of mixed plastics offers a viable approach to reusing carbon resources in plastic wastes and realizing circular economy. However, the presence of polyvinyl chloride (PVC) often complicates the co-upcycling processes, because chlorine (Cl) released from PVC can deactivate catalysts and enter final products. Moreover, existing plastic upcycling processes usually require harsh reaction conditions. Here we present a strategy enabling efficient co-upcycling of PVC and polypropylene (PP) at mild conditions. We use chlorine-resistant ionic liquids butylpyridinium chloride-aluminium chloride to dechlorinate PVC and simultaneously depolymerize the PP–PVC mixture into Cl-free liquid hydrocarbons, with the co-production of hydrogen chloride (HCl) as byproduct. This conversion approach operates at room temperature without the use of external hydrogen or noble metal catalysts. The Cl-free liquid hydrocarbon yield is up to 97.4 wt% of C and H in the feed PP–PVC mixture. This work can incentivize further technical development in plastic upcycling and improve the sustainability of plastic waste management.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2024
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IF 3.7
Huijun Shang,Hengli Li,Weijun Li,Feng Pan,Zhan Du
In this paper, the effects of reaction parameters on the deep-reduction and carbonization process of WO 2 -Co to WC-Co were studied. The results indicate that oxygen loss rate of WO 2 is positively correlated with temperature and methane partial pressure. The partial pressure of methane has no significant effect on the formation rate of WC. The carbon content and particle size of the product increase with the increase of CH 4 partial pressure. By synergistically regulating the reaction temperature to 950 °C, methane partial pressure to 1.25%, and reaction time to 60 min, ultrafine WC-Co powder without η phase can be obtained. The particle size of the composite powder is 128 nm, with total carbon content of 6.16%, free carbon content of 0.4%, and residual oxygen content of 0.05%, respectively. The growth rate relationship of tungsten carbide is as follows:
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INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
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2025
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IF 4.6
Xiao-Hui Yang,Guo-Hua Zhang
Fully dense and fine-grained W 2 B 5 ceramics were successfully fabricated by spark plasma sintering at 1375 °C using metallic cobalt as additive. Co reacted with W 2 B 5 to form binary (CoB) and ternary phases (W 3 CoB 3 ) during sintering process. Experimental results showed that the relative density of W 2 B 5 ceramic increased from 96.7 % (for pure W 2 B 5 ceramic sintered at 1800 °C) to 99.0 % with 10 wt% Co addition and 99.5 % with 20 wt% Co addition (sintered at 1375 °C), respectively. Due to the lower sintering temperature, the grain size of W 2 B 5 in W 2 B 5 -10Co decreased from 5.3 ± 0.2 μm to 3.2 ± 0.1 μm relative to pure W 2 B 5 . However, in the case of 20 wt% Co addition, W 2 B 5 grains grew anisotropically, forming elongated strips with a length of 4.2 ± 0.3 μm and a width of 1.1 ± 0.2 μm. The W 2 B 5 -10Co composite exhibited superior mechanical properties with the Vickers hardness of 19.7 ± 0.3 GPa (30 Kg), fracture toughness of 8.7 ± 0.4 MPa·m 1/2 and flexural strength of 783.2 ± 22 MPa. Compared to pure W 2 B 5 ceramics, the hardness remained almost unchanged, while the fracture toughness and flexural strength were significantly improved by 61.8 % and 49.8 %, respectively. These improvements benefitted from the combination of high densification degree, fine-grained strengthening and in-situ CoB phase formation improving interfacial adhesion via semi-coherent interfaces. However, excessive addition of Co (20 wt%) induced stress concentration via brittle CoB coalescence, outweighing the densification benefit and drastically reducing hardness and flexural strength.
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JOURNAL OF POLYMER RESEARCH
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2025
·Vol. 32
·期 6
·1-9
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IF 2.8
Tian Erlin,Qin Xiaofan,Yan Fufeng,Chen Jing,Dai Haiyang,Xue Renzhong,Zhang Tingting,Li Tao
In this study, five co-polyimide (co-PI) films were synthesized through copolymerization using 6FDA and PMDA as dianhydride monomers paired with ODA diamine. By systematically varying the 6FDA/PMDA molar ratio, we successfully regulated the microstructural characteristics of co-PI films, particularly their free volume and molecular chain rigidity. The structure–property relationships were comprehensively investigated using positron annihilation lifetime spectroscopy (PALS), with special emphasis on thermal, dielectric, and mechanical performance. Notably, the glass transition temperature (Tg) exhibited a progressive decrease from 384.9 ℃ for PI-1 to 307.8 ℃ for PI-5. This thermal behavior is related to the increase of free volume and the decrease of molecular chain rigidity caused by higher 6FDA content. Correspondingly, the dielectric constant ( k ) at 10 4 Hz decreased from 3.55 to 2.46 across the series, demonstrating that enhanced free volume effectively reduces dielectric polarization. However, this microstructural modification came at the expense of mechanical integrity, as evidenced by the descending tensile strength trend with increasing 6FDA proportion. These findings demonstrate an effective strategy for developing high-performance polyimide films combining low dielectric constant with balanced thermal and mechanical properties.
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POLYMER
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2021
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IF 4.43
Jidong Dai,Min Liang,Zhigang Zhang,Katrien V. Bernaerts,Tianzhu Zhang
Poly (lactide- co -glycolide) (PLGA) has emerged as an important material in tissue engineering. However, lactic acid (LA) produced during PLGA degradation is prone to inflammation, which is a shortcoming that must be avoided. To this end, a method for preparing crystalline PLGA is described here by using cross-linking nucleation. The pentaerythritol (PET), L-lactide and glycolide were first used to prepare the four-armed PLGA (4arm-PLGA) via the ring-opening polymerization (ROP) method. Such symmetrical four-armed PLGA was then grafted and crosslinked with N’N-methylenebisacrylamide (MBAM) simultaneously, and finally obtained the crystalline 4arm-PLGA (C4-PLGA-M). The C4-PLGA-M has controllable crystallinity , which could effectively control the degradation rate of PLGA. The C4-PLGA-M were characterized by POM and WAXS , and the accelerated degradation tests of C4-PLGA-M showed a sixfold increase at most in the degradation time compared to alone four-armed PLGA. The results of cell culture confirmed that the reduction of LA from hydrolysis process could be beneficial to the cell growth. Such crystalline C4-PLGA-M is expected to have ideal performance in tissue engineering.
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高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2018
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IF 3.129
Hao-Xiang Gao,Zhi-Long Yu,Qiang He,Shan-Hu Tang,Wei-Cai Zeng
A potentially functional yogurt co-fermentation with Gnaphalium affine was prepared and its quality and antioxidant properties were investigated. According to the classic procedure, a novel yogurt was successfully prepared with Gnaphalium affine extract (EGA). During the storage period, the pH value and titratable acidity of yogurt showed no obvious changes compared with control. However, the texture properties of yogurt, such as firmness, adhesiveness, cohesiveness and springiness, could be effectively improved. Moreover, the yogurt possessed the lower syneresis susceptibility and higher viability of Lactobacillus bulgaricus and Streptococcus thermophilus than the control. Furthermore, the yogurt showed remarkable antioxidant potential to scavenge 2, 2′-azinobis-3-ethylbenzthiazoline-6-sulphonate (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide and hydroxyl radicals. Meanwhile, the yogurt could enhance the activities of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and it could also lead to a significant decrease of malondialdehyde (MDA) level in animal serums. The current results suggest that the yogurt co-fermentation with EGA possesses high quality properties and remarkable antioxidant potential, and thus has the great potential to be used as a novel functional food product in food industry.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Zhao Wang,Wenyue Zhao,Ze Li,Yazhou Peng,Chang Gao,Lei Shi,Wenjing Hua,Weidong Fei,Yu Zhao
The search for multiferroic materials with ferroelectric and ferromagnetic properties at room temperature continues to be driven by the prospect of new devices. In this paper, Ba 2+ -Ti 4+ co-doped Y 1- x (Ba 0.5 Ti 0.5 ) x FeO 3 were prepared by a traditional solid-state reaction method. The ferroelectricity and ferromagnetism of the co-doped ceramics have been enhanced simultaneously with the maximum polarization of 0.48 μC/cm 2 and the maximum magnetization of 3.25 emu/g, the switched charge density (0.26 μC/cm 2 ) measured by PUND tests indicating the intrinsic and switchable remanent polarization. The increase of Fe 2+ content (increased to 28 % with the increase of doping content) caused by Ba 2+ -Ti 4+ co-doping destroys the antiferromagnetic ground state, and the doping strategy enlarges the tilt angle of oxygen octahedron from 144.93° to 148.63°. The magnetic domain switches caused by the external electric field were directly observed by magnetic force microscopy, indicating the modulation of magnetic domain by polarization at room temperature. This work may provide useful information for the structural design and performance improvement of multiferroic materials.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Jianwen Ge,Yu Cui,Li Liu,Rui Li,Fandi Meng,Fuhui Wang
Rational design on the well wrapped core-shell microstructure of Co@ SiO x C composites was successfully conducted through reduction process of cobalt, efficient condensation reaction of KH-550 silane coupling agent as well as high temperature calcination . The SiO x C shell possessed 3D cross-linked network structure consisting of dielectric carbon and silicon composition for optimal electromagnetic matching. The microstructure, morphology, elements distribution, electromagnetic property and microwave absorption performance were fully characterized, respectively. This SiO x C shell effectively inhibited the agglomeration of cobalt particles, and regulated the complex electromagnetic parameters by decreasing permittivity and introducing polarization relaxation, all of which determined the efficient reflection loss with RL min value of −60.3 dB at 16.2 GHz and matching thickness of only 2.05 mm. Meanwhile, the effective absorption band is up to 7.1 GHz at 2.3 mm. By optimizing of core-shell structure and material components, the high-absorption performance was obtained through impedance matching, multi-interfacial polarizations, dipole (or defects) polarization and magnetic loss. Therefore, the Co@ SiO x C composites present a facile and promising route toward the design of large-scale-preparation and excellent microwave absorbing materials.
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