Materials Today Bio
·
2026
·
IF 10.2
Chen Chen,Na Zhang,Fructueux Modeste Amona,Xiaolei Han,Qi Tang,Lanxin Geng,Guangfu Liao,Jie Zhang,Tushuai Li
Chronic wounds infected with multidrug-resistant bacteria pose a significant challenge to global health, as traditional monotherapies often fail to eradicate pathogens and restore the damaged wound microenvironment. Engineering innovative nanocomposites that integrate synergistic therapeutics and controlled release is a pivotal strategy for advanced wound management. Here, we developed a novel multi-drug metal-organic framework (MOF) nanocomposite, BBR + FA@UiO, by covalently grafting ferulic acid (FA) onto UiO-66-NH 2 and physically loading berberine (BBR). Drawing from "Jun–Chen–Zuo–[ Shi ]" hierarchy of Traditional Chinese Medicine (TCM), this design used the MOF as a robust porous carrier “[ Shi ]” for the antibacterial drug "Jun" (BBR) and antioxidant drug "Chen/Zuo" (FA). BBR + FA@UiO exhibits potent, synergistic antibacterial and antibiofilm activity against critical clinical pathogens like MRSA and Pseudomonas aeruginosa, through a pH/ROS-responsive release mechanism in the infected site. Functionally, BBR + FA@UiO activates the Nrf2/Keap1 pathway in macrophages, thereby mitigating oxidative stress and enhancing mitochondrial function. Consequently, proliferation and migration of Human Umbilical Vein Endothelial Cells (HUVECs) are restored through promoting angiogenesis. In vivo, BBR + FA@UiO significantly accelerates healing by eradicating bacteria, enhancing collagen deposition, and improving vascularization, driven by the coordinated activation of the Nrf2/HO-1 antioxidant axis and pro-regenerative Wnt/β-catenin and TGF-β signaling pathways. Demonstrating excellent biocompatibility and no systemic toxicity, this work establishes BBR + FA@UiO as a new therapeutic approach that merges TCM with advanced MOFs for comprehensive wound care.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Yuhang Yuan,Wenting Cai,Jiaxin Xu,Jianhua Cheng,Ke-Si Du
Copper-based MOF (Cu-PABA) was selected to immobilize laccase (Lac) at optimum pH because of its favorable acid resistance. Cu-PABA@Lac biocomposites were synthesized in situ by the one-step method under moderate conditions (water environment and normal temperature and pressure). Cu-PABA@Lac had great potential to maintain stability due to the protection of the Cu-PABA shell and reasonable conformational changes. In addition, Cu-PABA@Lac could be used repeatedly by centrifugation, as confirmed in the degradation experiment of bisphenol A (BPA). Because of the synergistic effect of copper ions between laccase and Cu-PABA, the K m value decreased (from 0.0024 to 0.0014 mM); therefore, the affinity between laccase and guaiacol was enhanced. In conclusion, the system provides a choice for immobilized acid-resistant enzymes and a solution for environmental BPA degradation.
研究领域:
环境科学
·
生物技术
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ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Minghu Zhao,Zhen Huang,Shixing Wang,Libo Zhang,Yang Zhou
Mercury ions can cause a series of hazards to humans and the environment, even in trace amounts. Here, we designed a novel adsorbent (Cys-UiO-66) by functionalizing NH2-UiO-66 with l-cysteine for selective removal of Hg(II) from solution. The Cys-UiO-66 was characterized by different instruments. The adsorption property of Cys-UiO-66 was evaluated by batch methods. The maximum adsorption capacity was 350.14 mg/g at pH 5.0. Furthermore, the adsorption isotherm and kinetics models were in accord with the Langmuir and pseudo-second-order models, respectively, evidencing that the adsorption behavior was dominated by monolayer chemisorption. The Cys-UiO-66 had better affinity for Hg(II) than other coexisting ions in wastewater and could be regenerated for at least five cycles. The results prove that Cys-UiO-66 is a talented and efficient sorbent for mercury ions.
研究领域:
环境化学
·
材料科学
·
吸附技术
·
重金属去除
·
水处理
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6
Qing’ai Chen,Yuwei Zhou,Guobin Huang,Chenchen Lin,Xucong Lin
Background Shellfish toxin residues (e.g., okadaic acid, OA) in seafood are a global concern, and the development of precise, sensitive portable test kits is therefore necessary. Magnetic nanoparticle-aptasensors (MNAS) are attractive for specific recognition and sensitive assay, yet direct epitaxial aptamer immobilization on Fe 3 O 4 causes thin, scattered coatings, leading to limited probe capacity and non-specific adsorption. Fabricating high-efficiency MNAS with dense, ordered aptamer arrays for precise detection thus remains a challenging yet promising goal. Results We propose a high-performance magnetic nanoparticle-aptasensor (MNAS) mediated by UiO-66-NH 2 MOFs prepared with a secondary growth strategy (denoted as UiO/UiO-MOFs), in which AuNPs were uniformly anchored on MOF and facilitated the orientation-ordered nucleic acid aptamers enabling specific test of trace OA. The UiO/UiO-MOFs served as a scaffold with ordered amino group arrays, facilitating the construction of a homogeneous AuNPs interface and thus the tethering of high-density aptamers (up to 12.5 μmol/kg). This sensing platform synergistically integrated the advantages of ordered UiO/UiO-MOF self-assembly, robust AuNPs bridging, and the spherically ordered configuration of dense aptamers, thereby achieving efficient target OA recognition with minimal non-specific cross-reactivity. Coupled with laser-induced fluorescence (LIF) detection, the sensor exhibited excellent specificity, ultra-high sensitivity (limit of detection, LOD = 30 pg/mL), and outstanding stability. Notably, the sensor was successfully applied for the accurate on-site detection of OA residues in real mussel and clam samples, with satisfactory recovery rates ranging from 83.0±3.3% to 107.7±1.3%. Significance This study posed an affordable yet powerful strategy capable of simultaneously realizing efficient UiO/UiO-MOFs surface mediation surface mediation and high capacity of spherical orientation-ordered aptamers. It expands the toolkit for epitaxial aptamer immobilization on MNAS, facilitates the ordered anchoring of aptamers, and thus enables the construction of advanced MNAS tailored for shellfish toxin detection.
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Materials Today Communications
·
2026
·
IF 4.9
Qinhui Ren,Li Hu,Fuhua Wei,Wei Shang,Min Li,Zhao Liang
The Zn/Mn-MOFs/GO composites were synthesized via a solvothermal method, and their structural characteristics were investigated using XRD, SEM, and FT-IR techniques for the adsorption study of Minocycline and Orange IV. The experimental results show that when the concentration of the minocycline solution is 30 ppm and 150 mg of GO/Zn/Mn - MOF composites is added, the maximum removal rate can reach 94.4%. When the concentration of the Orange IV solution is 30 ppm and 150 mg of GO/Zn/Mn - MOF composites is added, the maximum removal rate can reach 99.7% within 30 min. The influence of pH on the adsorption performance of these composites for Minocycline and Orange IV was thoroughly examined. The adsorption effect is better under acidic conditions. In summary, the Zn/Mn-MOFs/GO composite demonstrates excellent capability in removing Minocycline and Orange IV, offering significant implications for the management of organic pollutants.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Yunhong Pi,Quanming Chen,Qin Xu,Yating Han,Weilong Wang,Xiaolan Cai,Zhuowen Huang,Tiejun Wang
Microwave-enabled coordination reconstruction creates Ni–O–Sn–N motif in MOFs. • Ni sites and Sn relay nodes promote a short-range N→Sn→O→Ni LMCT pathway. • The electron-relay architecture enhances charge transfer and suppresses recombination. • Ni-Sn/e-NH 2 -UiO-66 delivers 293.6 mmolg cat −1 h −1 H 2 production with < 1% CO. • Operando studies and DFT support a formate-mediated photothermal reforming pathway. Engineering efficient ligand-to-metal charge transfer (LMCT) pathways in metal-organic frameworks (MOFs) is critical for enhancing photothermal redox catalysis but remains challenging due to limited electronic coupling between photosensitive ligands and catalytic metal centers. Here, we report a microwave-enabled coordination reconstruction strategy to construct cascaded LMCT pathways within NH 2 -UiO-66 for efficient photothermal methanol-to-hydrogen conversion. By sequentially anchoring high-density Ni sites and incorporating Sn species as electronic relay nodes, a directional N→Sn→O→Ni charge-transfer network is proposed inside the MOF scaffold. Microwave irradiation not only promotes structural polarization but also drives the formation of a strongly coupled heteroatomic coordination environment, enabling shortened electron migration distance and accelerated interfacial charge transport. The optimized Ni-Sn/e-NH 2 -UiO-66 catalyst exhibits a H 2 production rate of 293.6 mmolg Cat −1 h −1 , 13 times higher than that of the thermocatalytic counterpart, with an apparent quantum efficiency of 56.7% at 380 nm. Benefiting from synergistic photothermal activation and enhanced LMCT efficiency, methanol reforming is initiated at a low temperature of 120 °C with suppressed CO formation. This work highlights microwave-assisted LMCT cascade engineering as a versatile strategy for programming directional charge-transfer pathways in MOF-based photothermal catalytic systems. Download: Download high-res image (260KB) Download: Download full-size image Microwave irradiation is employed as a coordination-engineering tool rather than a conventional heating source, enabling the formation of a heteroatomic Ni–O–Sn–N coordination motif through stepwise installation of high-density Ni single sites and Sn relay nodes in etched NH 2 -UiO-66 framework. The resulting resulting electronically coupled architecture promotes a short-range N→Sn→O→Ni electron-relay pathway, facilitating ligand-to-metal charge transfer and electronic utilization for efficient photothermal methanol reforming.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Fang Zheng,Lidong Guo,Rundao Chen,Feng Zhou,Zhiguo Zhang,Qiwei Yang,Yiwen Yang,Qilong Ren,Zongbi Bao
The separation of hexane isomer mixtures into their individual components is one of the most important while challenging industrial process to produce high-octane gasoline. Herein robust M(pz)[Ni(CN) 4 ], termed MpzNi (M = Co, Ni, pz = pyrazine) that can realize efficient separation of ternary mixtures into the pure, individual components. As optimal pore channels with double-accessible open metal sites providing the adsorbate-dependent affinity differences for molecular exclusion behavior via temperature programming, CopzNi reached optimum performance with not only exceptional selectivity of linear/monobranched alkanes and monobranched/dibranched alkanes, but also notably higher adsorption capacity than those of the previously reported adsorbents. Breakthrough experiments with equimolar ternary C6 alkane isomers and binary branched mixtures confirmed CopzNi can highly capture n -hexane and 2-methylpentane from their mixtures. The excellent separation efficiency, lower-energy regeneration, scalability, recyclability as well as high stability render the CopzNi a benchmark candidate for implementation in the current separation processes.
研究领域:
化学工程
·
材料科学
·
分离技术
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Small
·
2025
·
IF 12.1
Xu Wang,Shanghua Xing,Mingqian Tan
Separation of easily degradable bioactive compound of astaxanthin (AXT) from nature source with low content and several interfering carotenoid analogues is particularly challenge. Here, four mesoporous metal-organic frameworks (meso-MOFs) is reported with different pore chemistry and pore geometry of cage-type and channel-type feature for AXT adsorption and separation. The maximal adsorption capacities of AXT by cage-type PCN-777 and MIL-101-NH 2 are higher than channel-type PCN-222 and NU-1000, and their adsorption capacities (40–469.4 mg g −1 ) outperform previous benchmark and commercial materials (2.5–26.2 mg g −1 ). Particularly, NU-1000 achieved the optimal balance between high adsorption capacity (111.3 mg g −1 ), rapid adsorption kinetic (≈0.5 h), excellent AXT adsorption selectivity over other carotenoid as well as efficient release (86%) for AXT. In addition to the optimal pore geometry, its superior separation performance is driven by multi-sites electrostatic attraction coupling with van der Waals interactions, demonstrated by electrostatic surface potential analysis, density-functional theory calculations and spectroscopy analysis. The practical AXT separation potential from shrimp shell waste is validated by fixed-bed column sorption experiments with nearly 3 times enhancement in purity over initial crude extract. This work provides a new perspective for the development of advanced porous materials for sustainable production of bioactive compounds from nature source.
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CRYSTENGCOMM
·
2016
·Vol. 18
·期 39
·7614-7619
·
IF 3.849
Somboon Chaemchuem,Zhou Kui,Francis Verpoort
Lithium incorporation in metal–organic frameworks during solvothermal synthesis demonstrates a significant modification of the structure chemistry and surface properties of MOFs towards the adsorption selectivity of gas mixtures (CO2 and CH4) at ambient conditions. Variation of the lithium loading (xLi-MOF-5) led to tunability of the interpenetration resulting in materials with substantial differences in their properties. The behavior of xLi-MOF-5 was evaluated via phase identification based on XRD, functional group coordination using FTIR and adsorption measurements applying N2, CO2 and CH4 gas adsorption/desorption analysis. These efforts give rise to a new strategy to tailor MOFs for high efficiency CO2 adsorption and separation.
研究领域:
材料科学
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化学工程
·
环境科学
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物理化学
·
纳米技术
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Mengyi Huang,Zhenxin Liang,Jinling Huang,Yuehong Wen,Qi-Long Zhu,Xintao Wu
Metal–organic frameworks (MOFs) have been extensively studied in host–guest chemistry by means of ultrahigh porosities, tunable channels, and component diversities. As the host matrix, MOFs exhibit immense potential in the preparation of single-phase white light-emitting (SPWLE) materials. Nonetheless, it is a great challenge that the size of the introduced guest molecules is limited by MOF pores, which affects the WLE optimization. In this work, two-dimensional (2D) MOFs are first utilized as the host matrices to simultaneously encapsulate red–green–blue fluorescent dyes for SPWLE. Various dyes@2D MOF composites with high-quality WLE performances and ultrathin nanosheet morphologies are directly assembled from 2D MOF precursors and dyes in high yields. Owing to the flexible interlamellar space of 2D MOFs, different types and sizes of guests can be easily introduced, which greatly expands the range of available MOF hosts and guests, making the WLE much more tunable. The strategy of employing 2D MOFs as the host matrices to introduce multicomponent dyes for SPWLE nanosheets resolves the restriction of MOF pores on the guest molecule size and opens a new avenue to rationally design and prepare SPWLE nanosheets that are highly solution-processable.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Dandan Huang,Hairong Li,Weining Liu,Yawen Chen,Wenjie Wang,Xi Tan,Mingyang Zhao,Qionglin Cheng,Ming Yi,Genliang Han,Guohan Liu
Acetone is used in a variety of fields for being highly volatile chemicals that may have detrimental effects on both industrial security and human health. With a view to testing the leak and concentration of acetone, we have successfully developed TiO 2 /Fe 2 O 3 -X (TF-X) sensors via a carboxyl group-shared coordination route. Here, Ti 3 C 2 T x MXene and Fe salt provide chelation sites enabling coordination with carboxyl groups to fabricate two kinds of MOFs (MIL-125(Ti)/MIL-53(Fe)) followed by calcination . The tightly coupled heterogeneous interface between TiO 2 and Fe 2 O 3 promotes carrier transfer and elicits sharp resistance variation thereby raising the sensitivity towards acetone. Meantime, the porous TF-X heterostructures generate numerous oxygen vacancies and surface functional groups to be conducive to the gas flow and surface reaction. Accordingly, the optimal TF-400 heterostructure endows the extraordinary sensitivity ( R = 446.8) to 100 ppm acetone at 268 ℃, much higher than that of the pristine TiO 2 and Fe 2 O 3 . Rapid response (15 s) and recovery (7 s) time are implemented, as well as remarkable selectivity and stability. Moreover, the enhanced mechanism of TF-400 heterostructure is presented and studied. It is anticipated to open up a new avenue for the design and synthesis of high-sensitivity acetone sensors.
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VACUUM
·
2023
·
IF 4
Jian Zhang,Chang Xu,Jing Li,Huanjun Lu,Shaohui Zhang,Chao Wang
In this paper, the Cu-/Ni-based one-dimensional (1D) conductive metal-organic frameworks (c-MOFs) nanorods (Cu 3 (HHTP) 2 /Ni 3 (HHTP) 2 ) have been synthesized successfully through a one-pot hydrothermal method . The effect of reaction time, MOFs compositions and ratio of solvent on the performance of Cu 3 (HHTP) 2 -/Ni 3 (HHTP) 2 - based resistive temperature sensors was studied by sensing platforms. Compared with Ni 3 (HHTP) 2 -based sensor, Cu 3 (HHTP) 2 -based sensor, which was assembled under DMF volume of 0.5 mL and reaction time of 12 h (Cu7), provided the optimal performance, for example, relative variation of resistance (RVR) near-linearly decreased by 85.9% from 20 °C to 80 °C, and the temperature coefficient of resistance (TCR) reached up −0.0157 °C -1 . Moreover, the resistance value of the Cu 3 (HHTP) 2 -based sensor is 0.106 kΩ, which exhibited a minimum resistance under different temperatures. These results demonstrate that the use of Ni 3 (HHTP) 2 -based 1D c-MOFs for fabrication of temperature sensor provides good conductivity and high thermo-responsive sensitivity. Hence, this study provided an excellent example for the simple preparation and practical application of 1D c-MOFs-based near-linear temperature sensor.
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