TALANTA
·
2018
·
IF 4.244
Xi Su,Yi Xu,Huazhou Zhao,Shunbo Li,Li Chen
A microfluidic SERS chip integrated with blood separation and in-situ detection was designed and fabricated for the rapid detection of clinical blood samples. Each functional unit in the microfluidic SERS chip consist of separation-decantation cavity based on centrifugal separation principle, mixing channels and SERS detection chamber built with integrated nano-Au on Ag film microstructure. The serum creatinine was selected as a typical sample to demonstrate the capability of microfluidic SERS chip. It was found that the creatinine SERS characteristic peaks at 678 cm −1 can be effectively identified and the detection limit could be as low as 4.42 × 10 −3 μmol mL −1 in water. The blood samples were also tested in microfluidic SERS chip. The whole separation and test process could be completed within 2 min, which is a significant improvement in the field of creatinine detection. The whole blood of six cases clinical blood samples were also tested, and the results were consistent with the enzymatic results. The developed microfluidic SERS chip has advantages including reduction of the required quantity of blood sample, reusable and easy to operate. It is expected to provide a new method for rapid diagnostics .
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LANGMUIR
·
2014
·
IF 4.384
Pancras Ndokoye,Jun Ke,Jie Liu,Qidong Zhao,Xinyong Li
Gold nanostars coated with cysteine (Cys-AuNSs) were successfully synthesized and used in SERS-based copper ions (Cu2+) detection in aqueous media. The strong coordination ability of cysteine (Cys) with Cu2+ and the resulting Cys-AuNSs-Cu complex formation led to AuNSs aggregation and the drastic change in intensity and strength of COOH band spectra. The aggregation of AuNSs yielded distinct SERS signals, which exhibited remarkable sensitivity and selectivity for Cu2+ over other metal ions. Using this SERS-based sensing method, we have achieved a practical detection limit of 10 μM. Such AuNSs-based detection could provide promising alternative choices for future SERS-active AuNSs application.
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ELECTROCHIMICA ACTA
·
2015
·
IF 4.504
Li-Ping Mei,Wen-Jie Yin,Jiu-Ju Feng,Zhang-Ying Lv,Yu-Shuang Han,Ying Guo,Ai-Jun Wang
Hierarchical gold–platinum nanothorns (Au–Pt HTs) were prepared on a glassy carbon electrode (GCE) by one-step co-electrodeposition of HAuCl 4 and H 2 PtCl 6 with the assistance of N -methylimdazole as a growth-directing agent. This method was simple, facile and controllable, without any seed, template or surfactant. The experimental parameters including the dosage of the precursors and N -methylimdazole, electrodeposition potential and time were investigated in details. Furthermore, the as-prepared Au-Pt HTs displayed enhanced electrocatalytic activity and better stability toward ethylene glycol oxidation in alkaline media, compared with polycrystalline Au nanoparticles. Meanwhile, after self-assembly of 4-mercaptophenyl boronic acid (4-MBA), the functionalized Au–Pt HTs were explored for sensitive detection of glucose as highly Raman-active substrates.
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Nanoscale
·
2015
·Vol. 7
·期 18
·8405-8415
·
IF 7.394
Yahui Song,Tingting Miao,Peina Zhang,Cuixia Bi,Haibing Xia,Dayang Wang,Xutang Tao
We investigate the effect of gold (Au) seeds prepared in cetyltrimethylammonium chloride solution (CTAC-Au seeds) on the index facets of trisoctahedral gold nanocrystals (TOH Au NCs). We demonstrate that monodisperse {331}-faceted TOH Au NCs with controllable sizes (from 60 to 255 nm) can be successfully prepared in high yield by using 3.0 nm CTAC-Au seeds or as-prepared 70 nm TOH Au NCs as seeds. We find that the electrocatalytic performance on methanol oxidation and surface enhancement Raman spectroscopy (SERS) activity of {331}-faceted TOH Au NCs is size-dependent. In comparison with well-known nanoporous gold (0.088 mA cm−2), {331}-faceted TOH Au NCs with sizes of 110 nm exhibit fairly high catalytic activity (0.178 mA cm−2) on methanol oxidation (1.0 M) in alkaline media due to the presence of increasing density of atomic steps, ledges, and kinks on the NC surfaces. Their current density is reduced by less than 7% after 500 cycling tests. {331}-Faceted TOH Au NCs with sizes of 175 nm exhibit the highest SERS activity for 4-aminothiophenol (4-ATP) molecules. The enhancement factors of a1 modes of 4-ATP molecules can reach the order of 109 when the 4-ATP concentration is 3 × 10−6 M. Moreover, Raman signals (ag modes) of 4,4′-dimercaptoazobenzene (DMAB) molecules on TOH Au NCs are stronger than those on spherical Au NCs of comparable size due to the enhanced laser-induced transformation of 4-ATP molecules by high-index {331}-facets during SERS measurement. Furthermore, the SERS intensities of 4-methylbenzenethiol (4-MTP) molecules on TOH Au NCs are also higher than those on spherical Au NCs of comparable size due to sharp extremities.
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Nano Research
·
2014
·Vol. 7
·期 8
·1177-1187
·
IF 6.963
Huang Zhulin,Meng Guowen,Huang Qing,Chen Bin,Zhou Fei,Hu Xiaoye,Qian Yiwu,Tang Haibin,Han Fangming,Chu Zhaoqin
Surface-enhanced Raman spectroscopy (SERS) is a fast analytical technique for trace chemicals; however, it requires the active SERS-substrates to adsorb analytes, thus limiting target species to those with the desired affinity for substrates. Here we present networked polyacrylic acid sodium salt (PAAS) film entrapped Ag-nanocubes (denoted as Ag-nanocubes@PAAS) as an effective SERS-substrate for analytes with and without high affinity. Once the analyte aqueous solution is cast on the dry Ag-nanocubes@PAAS substrate, the bibulous PAAS becomes swollen forcing the Ag-nanocubes loose, while the analytes diffuse in the interstices among the Ag-nanocubes. When dried, the PAAS shrinks and pulls the Ag-nanocubes back to their previous aggregated state, while the PAAS network “detains” the analytes in the small gaps between the Ag-nanocubes for SERS detection. The strategy has been proven effective for not only singleanalytes but also multi-analytes without strong affinity for Ag, showing its potential in SERS-based simultaneous multi-analyte detection of both adsorbable and non-adsorbable pollutants in the environment.
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ANALYST
·
2016
·Vol. 141
·期 14
·4359-4365
·
IF 4.033
Hai-Xin Gu,Kai Hu,Da-Wei Li,Yi-Tao Long
A facile approach based on a bare gold nanoparticles (Au NPs) coupled film system as the surface-enhanced Raman scattering (SERS) substrate was developed for the effective detection of polycyclic aromatic hydrocarbons (PAHs). A smooth gold film (Au film) was self-assembled with a hydrophobic layer of an alkyl chain in order to capture the PAHs molecules from bulk solution to its surface. Next, the bare gold nanoparticles, about 60 nm in diameter without functional modification, were paved onto the PAHs-molecule-coated Au film. This was aimed at generating a plasmon coupling effect to illuminate a stronger electromagnetic field within the gaps between particles and film, exactly where the absorbed molecules were located. The effects of the Au film, alkyl chain, and Au NPs on the SERS response to PAHs were respectively investigated. Through utilizing this simple system, a reproducible and interference-free SERS detection was demonstrated. Furthermore, the excellent detection ability to sense a series of PAHs was achieved with low concentrations of 1.2 × 10−8 M, 2.0 × 10−8 M, 5.5 × 10−8 M, and 6.3 × 10−8 M for benzo[b]fluoranthene, fluoranthene, benzo[a]anthracene, and pyrene, respectively. This method, capable of sample preparation and SERS measurement on a portable carrier, would be an ideal candidate for practical applications under field conditions.
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PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
·
2017
·
IF 2.221
Ruoping Li,Jingliang Yang,Junhe Han,Junhui Liu,Mingju Huang
A Raman method employing silver nanoparticle (Ag NP) monolayer film as Surface-enhanced Raman Scattering (SERS) substrate was presented to rapidly detect melamine in milk. The Ag NPs with 80 nm diameter were modified by polyvinylpyrrolidone to improve their uniformity and chemical stability. The treatment procedure of liquid milk required only addition of acetic acid and centrifugation, and required time is less than 15 min. The Ag NP monolayer film significantly enhanced Raman signal from melamine and allowed experimentally reproducible determination of the melamine concentration. A good linear relationship (R 2 =0.994) between the concentration and Raman peak intensity of melamine at 681 cm −1 was obtained for melamine concentrations between 0.10 mg L −1 and 5.00 mg L −1 . This implies that this method can detect melamine concentrations below 1.0 mg L −1 , the concentration currently considered unsafe.
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Materials Research Express
·
2016
·Vol. 3
·期 6
·065018
·
IF 0.968
Pinhua Zhang,Guangliang Cui,Chuanhai Xiao,Mingzhe Zhang,Li Chen,Changmin Shi
We fabricated an Ag decorated Cu (Ag@Cu) nano/microstructure ordered array by facile template-free 2D electrodeposition combined with a galvanic reduction method for SERS applications. The Cu nano/microstructure ordered arrays were first synthesized by a 2D electrodeposition method, then Ag nanocubes were decorated on the arrays by galvanic reduction without any capping agent. The pollution-free surface and edge-to-face heterostructure of Ag nanocubes and Cu nano/microstructure arrays provide the powerful field-enhancements for SERS performance. The results verified that the Ag@Cu nano/microstructure ordered arrays have excellent activity for 4-Mercaptopyridine, and the sensitivity limit is as low as 10−8 M. Therefore, this facile route provides a useful platform for the fabrication of a SERS substrate based on nano/microstructure ordered arrays.
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BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Kang Yang,Yongjun Hu,Ning Dong,Guichi Zhu,Tingfeng Zhu,Ningjing Jiang
The accurate and highly sensitive detection of prostate specific antigen (PSA) is particularly important, especially for obese men and patients. In this report, we present a novel aptamer-based surface-enhanced Raman scattering (SERS) sensor that employs magnetic nanoparticles (MNPs) core-Au nanoparticles (AuNPs) satellite assemblies to detect PSA. The high specific biorecognition between aptamer and PSA caused the dissolution of the core-satellite assemblies, thus the concentration of functionalized AuNPs (signal probes) existing in the supernatant was on the rise with the continual addition of PSA. The aptamer-modified MNPs were used as supporting materials and separation tools in the present sensor. With the assistance of magnet, the mixture was removed from the supernatant for the concentration effects. It was found that the corresponding SERS signals from the supernatant were in direct correlation to PSA concentrations over a wide range and the limit of detection (LOD) was as low as 5.0 pg/mL. Excellent recovery was also obtained to assess the feasibility of this method for human serum samples detection. All of these results show a promising application of this method. And this novel sensor can be used for the accurate and highly sensitive detection of PSA in clinic samples in the future.
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ACS Biomaterials Science & Engineering
·
2017
·
IF 3.234
Jie Feng,Limin Chen,Yuanzhi Xia,Jie Xing,Zihou Li,Qiuping Qian,Yan Wang,Aiguo Wu,Leyong Zeng,Yunlong Zhou
Gold nanobipyramids (Au NBPs) with two sharp tips present an extremely strong electric field enhancement, which endows them with more advantages in biomedical photonics than other gold nanostructures. The application of Au NBPs for diagnosis and therapy is now under intensive investigation. Here, we report Au NBPs for surface-enhanced Raman scattering (SERS) detection and photothermal therapy (PTT) of MCF-7 cancer cells both in vitro and in vivo via bioconjugation with Raman reporter 2-naphthalenethiol (2-NAP) and folic acid (FA). The results showed that bioconjugated Au NBPs not only could be used for the quantitative detection of the MCF-7 cells in the range of 5–500 cells/mL, but also lead to the enhanced Raman signal in MCF-7 tumor-bearing nude mice with high specificity. Moreover the bioconjugated Au NBPs exhibited excellent photothermal performance in both in vitro and in vivo therapies, in which the cell viability decreased to 6.44% and the relative volume of MCF-7 tumors treated with bioconjugated Au NBPs reduced to 0.037 under the irradiation of an 808 nm laser. Our results indicate that bioconjugated Au NBPs offer an excellent nanoplatform for PTT and SERS detection in the future.
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NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 22
·13968-13973
·
IF 3.269
Bing Zhang,Xuehua Yin,Deshuai Zhen,Wenhong Gu,Yingju Liu,Qingyun Cai
A metal–semiconductor heterojunction material was synthesized by electrodepositing Au nanoparticles onto the surface of WO3 nanoflowers that were grown on TiO2 nanotubes and applied, for the first time, to the surface-enhanced Raman scattering (SERS) detection of dyes. Owing to their nanoflower structure, a localized surface plasmon resonance was generated on the surface of the Au/WO3/TiO2 nanosheets, which brings about multiple enhanced three-dimensional electromagnetic fields. An enhanced factor of 3.6 × 106 was achieved. The spot-to-spot change in the SERS intensity was less than 15% and the SERS substrate could be preserved for at least 50 days. The analysis of dyes in real samples provided a recovery rate of 94.33–115.6%, indicating its potential applications in environmental analysis.
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PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2024
·Vol. 23
·期 12
·2211-2226
·
IF 2.7
Sun Chao,Liu Niansong,Wu Zhongxu,Wang Lizheng,Ding Jianjun
In response to the existing issues of cumbersome and time-consuming detection processes and limited application scope in current pesticide residue detection, this paper designed a novel flexible substrate for surface-enhanced Raman spectroscopy (SERS) by combining flower-like silver nanoparticles prepared by chemical reduction technology with a flexible sponge. The flexible substrate exhibits excellent SERS enhancement effects, with a minimum detection limit of 10 –12 mol/L for the probe molecule rhodamine 6G (R6G) and an average enhancement factor of 6.63 × 10 5 . For the commonly used pesticide thiram, the minimum detection limit is 0.1 mg/L, which is significantly lower than the maximum residue limits set by China and the USA for thiram. Further experiments confirmed the substrate's excellent uniformity and stability, and the use of finite difference time domain (FDTD) software revealed that the model combining flower-like silver nanoparticles with a sponge exhibited higher electromagnetic field intensity compared to the model without the sponge, resulting in abundant "hot spots". Additionally, the sparrow search algorithm (SSA) was used to optimize the backpropagation (BP) neural network for predicting the concentration of thiram pesticide. The experimental results indicated that the SSA–BP algorithm achieved a determination coefficient (R 2 ) of 0.99974 and root mean square error (RMSE) of 300.321, demonstrating good network performance and meeting the requirements of actual detection needs.
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