ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Lixin Ding,Qian Guo,Ya’nan Ren,Pei Wang,Yongxiang Pan,Jin Ding,Feng Wang,Zhi Yang,Hua Zhu
Extracellular vesicles (EVs) act as carriers that transfer molecules between donor and recipient cells, thereby altering the phenotype and function of the latter. EVs derived from mesenchymal stem cells (MSCs) inherit the homing ability of their parent cells to tumor sites. We speculate that MSC-derived EVs labeled with the isotope zirconium-89 ([89Zr]Zr) will accumulate within tumors and have the potential for tumor location via positron emission tomography (PET) imaging. Here, as a proof of concept, we used [89Zr]Zr-labeled human umbilical cord MSC (hucMSC)-derived EVs to characterize the homing of EVs to tumor regions via PET imaging. The uptake of [89Zr]Zr-DFO-hucMSC-EVs by 4T1, H292, and FaDu cells increased in a time-dependent manner. [89Zr]Zr-DFO-hucMSC-EVs were rapidly cleared from the blood circulation, showing a 2-phase exponential decay with a biodistribution half-life of 0.46 h and an elimination-phase half-life of 11.87 h. At 24 h postinjection, [89Zr]Zr-DFO-hucMSC-EVs were mainly distributed in the liver (10.39 ± 0.52%ID/g) and, to a lesser extent, in the spleen (9.87 ± 0.87%ID/g). PET imaging in tumor-bearing mouse models revealed persistently high tumor accumulation. The projected effective dose for an adult human female was low and was 0.084 mSv/MBq. There was no obvious normal tissue toxicity following the administration of excessive radioactivity. In summary, these studies demonstrate the potential feasibility of using the [89Zr]Zr-DFO-hucMSC-EV tracer for noninvasive visualization of tumor lesions.
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高影响因子
FUEL
·
2025
·
IF 7.5
Liang Chu,Zhaokun Wang,Zhaohui Liu,Teng Zhao,Liyan Wang,Mu Yang,Ge Wang
Host-guest catalysts are promising for tailored applications but require innovative synthesis strategies. Herein, we report the first ambient aqueous-phase synthesis of bimetallic Ce/Zr MOF-801, followed by acid post-treatment. Utilizing defect engineering, Ce species are preferentially exposed within the robust Zr-MOF-801 substrate. This structural modification substantially enhances the host–guest catalyst’s oxidative desulfurization (ODS) performance. We systematically investigate synthesis parameters, spatiotemporal yield, and defect characterization, and refines catalytic conditions. Post-acid-treated Ce/Zr-MOF-801-H displays augmented external surface area (189 m 2 g −1 ), and exposed acidic sites while upholding the outstanding intrinsic stability of the Zr-MOF-801 substrate. Under optimal conditions (60 °C, 6 min), Ce/Zr-MOF-801-H completely eliminates dibenzothiophene (1000 ppm S), with a turnover frequency of 39.3 h −1 and catalytic activity of 53.2 mmol g −1 h −1 , far surpassing Zr-UiO-66-H. It maintains a desulfurization rate of 96.6% after five cycles. FTIR spectroscopy, quenching experiments, and ESR spectroscopy reveal that the exposed Ce sites serve dual roles: (1) activating the substrate by reducing the electron density of sulfur atoms and (2) facilitating H 2 O 2 into hydroxyl and superoxide radicals, driving ODS. This strategy not only advances industrial ODS applications but also sheds light on the synthesis of MOF-based host–guest catalysts.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Weibo Lu,Huangwei Ye,Yike Zhu,Yuhan Li,Huan Li,Qing Shen,Jian Chen
The non-destructive, real-time, and visual assessment of fish freshness is crucial for maintaining food quality and safeguarding public health. In this study, a pH-sensitive and colorimetric enhancement film was developed using a carboxymethyl cellulose/anthocyanin/metal-organic framework (CMC-BA-UIO). The concentration of UIO-66 in the film-forming solution significantly influences the mechanical properties and ammonia responsiveness of the indicator film, with the CMC-BA/2.5%UIO-66 variant exhibiting optimal performance. When utilized for real-time fish freshness monitoring at 4 °C, the CMC-BA/2.5%UIO-66 indicator film demonstrated a distinct color transition from purple to yellow, which exhibited a strong correlation with the rot index (TVB-N) of the fish. These findings indicate that the developed indicator film has potential applications in intelligent packaging for monitoring food shelf life, providing a visual alert to producers and consumers regarding food spoilage.
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高影响因子
Micromachines
·
2024
·Vol. 15
·期 1
·154
·
IF 3
Qingyun Li,Zihua Wang,Xuezhong Wang
The synthesis of multielement composite oxide nanomaterials containing Ce, Zr, Y, and Yb was investigated using a micro confined jet mixer reactor operated in continuous mode under supercritical water conditions. The obtained nanoparticles were characterized using ICP-AES, SEM-EDS, FTIR, Raman spectroscopy, XRD, and TEM. All samples exhibited a uniform particle shape and a narrow particle size distribution. An analysis of the d-spacing results using selected electron area diffraction (SAED) patterns confirmed the production of cubic-phase crystals. A BET test was employed to determine the specific surface area of the prepared nanoparticles. OSC and TPR techniques were utilized to characterize the oxygen storage capacity and reduction performance of the obtained samples, with an analysis conducted to determine how the different proportions of elements affected the performance of multielement mixed oxides. The ionic conductivity of multielement composite oxide was measured using alternating current impedance spectroscopy (EIS), and the impact of Y, Ce, and Yb on the electrolyte material’s ionic conductivity was analyzed.Keywords:confined jet mixer;multielement composite oxide;continuous hydrothermal flow synthesis;oxygen storage capacity;ionic conductivity
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
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IF 8.355
Qingfeng Yang,Hui Hong,Yongkang Luo
Discharged tetracycline (TC) seriously threatens human health and environmental safety. Herein, we developed a novel 3D flower-on-sheet structure of Zr-metal organic framework adsorbent with the assistant of N,S co-doped carbon dots as heterogeneous nucleation (UiO-67/NSC) for selective and effective removal of TC residue from contaminated water. Functional groups of UiO-67/NSC acts as a tentacle to identify TC molecules, and TC-adsorbed NSC can be separated easily by incorporating in UiO-67 structure. Hierarchical UiO-67/NSC exhibited excellent recognition performance with a wide sensitive range (0.08–20.0 mg/L) and low detection limit (0.063 mg/L) for TC. Particularly, vertically oriented 2D nanosheets in UiO-67/NSC alleviate the diffusion barrier and enhance mass transfer between adsorption sites and TC molecules, endowing it with an ability that can improve the TC adsorption capacity of parent UiO-67 to 427.35 mg/g. UiO-67/NSC with 0D structure has no significant toxic effect on human cells (HepG2 and Caco-2), which demonstrate the prepared hybrid structure is safety in practical application. Our data indicate the great potential of UiO-67/NSC as an innocuous, bifunctional, smart adsorbent for the effective detection and removal of TC residues, and we not only provide a rational design of advanced metal organic framework-based hierarchical adsorbents, but also shed light on an available method to toxic antibiotic residue recognition and water remediation.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Chunqi Yu,Yingqi Wang,Ke Wang,Shuai Zhang,Xiaopeng Hu,Yiwei Liu,Jiajia Xi
Chlorpyrifos (CPF) poses severe environmental and health risks, driving the need for on-site monitoring tools. This study presents a novel dual-recognition colorimetric sensor for ultrasensitive detection of CPF by coimmobilizing molecularly imprinted polymers (MIPs) and aptamers onto bimetallic Fe,Zr-MOF composites. The resulting Fe,Zr-MOF/Apt/MIP hybrid synergistically merges the structural robustness of MIPs with the conformational specificity of aptamers, while also functioning as both a nanocarrier and a peroxidase mimic. Notably, CPF binding sterically hinders substrate diffusion to catalytic sites, enabling quantitative detection via dose-dependent inhibition of TMB oxidation. The optimized sensor exhibits exceptional performance: a broad linear range (1–120 ng mL–1), ultralow detection limit (0.105 ng mL–1), and high specificity against interferents. When validated with complex matrices (apples, pears, and cabbage), it achieved satisfactory recoveries (91.0–110.0%). This work establishes a field-deployable strategy for on-site pesticide monitoring in food and environmental safety.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Baoshan He,Xiaoze Dong
In this work, the feasibility of a novel sensitive electrochemistry aptasensor for the detection of patulin (PAT) using hierarchically porous metal organic [email protected] blue connection aptamer as signal tags was demonstrated. The substrate electrode of the aptasensor was prepared by electrodeposited gold nanoparticles (AuNPs) on chitosan-zinc oxide nano flower-modified electrode. Subsequently, the complementary single-stranded DNA was attached to the surface of the modified electrode by Au-S bond. Signal tags self-assemble on the surface of modified electrodes by aptamer-cDNA binding, while methylene blue as mediator for electrochemical detection. Thanks to the large specific surface area provided by zinc oxide nano flower, the electrode can load more signal tags and AuNPs to achieve signal amplification. In presence of PAT, Apt preferentially binds to PAT, causing dissociation of some Apt-cDNA and releasing some signal tags leading, resulting in decreased electrical signals. Under optimal conditions, the change in electrochemical signal was proportional to the logarithm of PAT concentration, from 5 × 10 −8 -5 × 10 -1 μg mL −1 , and the detection limit was estimated to be 1.46 × 10 -8 μg mL -1 . The aptasensor exhibited aceptable reproducibility, renewability, long-term stability and specificity. Moreover, aptasensor was reliable in determination of PAT in spiked apple juice samples.
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高影响因子
APPLIED CATALYSIS A-GENERAL
·
2024
·
IF 4.7
Xin-Hao Shen,Feng Liu,Qin-Qin Chen,Ying Gao,Xiao-Wen Wang,Xin Liu
The efficient degradation of emerging pollutants in water, represented by CBZ, is receiving increasing attention from all sectors of society. Although advanced oxidation reactions represented by Fenton reaction can efficiently degrade emerging pollutants, the problem of iron sludge that comes with it is hindering the further promotion of this technology. Herein, UiO-66(Zr)-2OH material was synthesized by hydrothermal method and loaded with Pd 0 NPs on the surface of the material by in situ reduction. The MOFs-H 2 -Accelerated Catalytic Fenton system was constructed by accelerating the regeneration of Fe(II) in the system by activating the [H] produced by H 2 introduced into the system at room temperature and pressure. Within 180 min, the removal of the target pollutant CZB could reach more than 99 % under the condition of only 25 µmol of Fe(II) and 25 mmol of H 2 O 2 .
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2022
·
IF 5.477
Yong Pan,Feng Liu,Yong Zhou,Chen Zhu,Haixia Pang,Baoming Xu
Background Phosphorus in wastewater is a major environmental concern. Very small phosphorus inputs in the environment can cause algal blooms that can deplete the dissolved oxygen and decrease the water quality, leading to eutrophication. Furthermore, some algal blooms produce toxins and bacterial growth that can cause human illness through exposure to contaminated water. Therefore, It is necessary to remove phosphorus before it is discharged to the environment. Methods adsorbent enhanced adsorptive ultrafiltration (UF) has recently emerged as an advanced ion recovery technology with membrane filtration function and adsorption function, and is very effective in removing cationic bisphosphate and anionic phosphate. Significant findings Herein, a novel defect-rich and covalently-crosslinked octanoic acid (OA)-UiO-66(Zr)-NH 2 /PVC adsorption ultrafiltration membrane are designed for removal of phosphate ions in water. The OA-UiO-66-NH 2 /PVC-33 membrane achieved the adsorption capacity (∼30 mgg −1 ) and higher removal efficiency (∼90%). The OA-UiO-66(Zr)-NH 2 /PVC ultrafiltration membrane exhibited a higher water flux of 266.9 L/(m 2 ·h·bar) compared to those of pristine PVC and UiO-66-NH 2 /PVC. Filtration and cyclic stability experiments reveal that OA-UiO-66(Zr)-NH 2 /PVC membrane can maintain a high retention capacity and exhibit excellent regeneration performance after 5 cycles.
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高影响因子
Acta Metallurgica Sinica-English Letters
·
2021
·Vol. 35
·期 3
·411-424
·
IF 2.755
Xu Rong,Li Ruidi,Yuan Tiechui,Zhu Hongbin,Li Ping
In order to refine the microstructure and improve the performance of direct energy deposited (DED) additively manufactured Al–Mg–Sc–Zr alloy, TiC-modified Al–Mg–Sc–Zr composites were prepared by DED and the effect of TiC content on the microstructure and performance was studied. In the absence of TiC particle, the microstructure of Al–Mg–Sc–Zr alloy prepared by DED consisted of fine grains with average size of 8.36 μm, and well-dispersed nano-Al 3 (Sc,Zr) particles inside the grains and Mg 2 Si phase along the grain boundaries. With the addition of 1 wt% TiC, the microstructure of TiC/Al–Mg–Sc–Zr prepared by DED became finer apparently compared with that without TiC; while the further increase of TiC content to 3 wt%, the microstructure of TiC/Al–Mg–Sc–Zr prepared by DED became coarser with appearance of a new kind of needle-like (Ti,Zr) 5 Si 3 phase. Also, the addition of TiC decreased the porosity of Al–Mg–Sc–Zr prepared by DED. Simultaneously, after the addition of TiC, the tensile strength increased from 283.25 MPa to 344.98–361.51 MPa, and the elongation increased from 3.61% to 9.58–14.10%. The potential mechanism of the microstructure evolution and strength improvement was discussed. This research will provide new insights into the available metal matrix composites by laser additive manufacturing (LAM).
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Huadong Fu,Rui Chen,Yong Xie,Zheng Wei,Yan Qin,Zhixiong Huang
Element-hybrid phenolic aerogel composites are often utilized as lightweight thermal protection materials for aerospace craft. Zr-phenolic (Zr-PR) aerogels have been extensively studied due to their exceptional high-temperature resistance. However, the phase transformation of ZrO2, the pyrolysis product of Zr-PR, caused the volume changes and internal stresses, greatly limiting the application of Zr-PR. In this work, a small amount of nano-Y2O3 particles was directly doped into the Zr-PR aerogel composites to form the nanoscale mosaic structure. This aerogel composite exhibited properties of low density (0.51 g/cm3) and low thermal conductivity (<0.151 W/(m K)); moreover, it showed a significant improvement in oxidative ablation resistance with a 33% reduction in the linear ablation rate. The research indicated that the doping of nano-Y2O3 effectively addressed the adverse effects associated with ZrO2 phase transformation by in situ rapidly forming (<60s) the dense yttria-stabilized zirconia (YSZ) thermal barrier layer on the ablation surface, which significantly delayed the thermal-oxidative ablation of the composites. Additionally, the pyrolytic carbon (PyC) on the ablation surface can form abundant multilayered graphene structures due to the catalytic graphitization effect produced by the solid-solution reaction of YSZ, which further enhanced the oxidation resistance. This work provides a simple and efficient approach to improve the ablation performance of Zr-PR aerogel composites, broadening their application in extreme thermal environments.
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高影响因子
TALANTA
·
2025
·
IF 6.1
Yuling Gao,Hui Xiao,Zhengang Han,Shuying Li,Shengya Zhang,Yaqi Zhao,Lei Zhang,Jing Chen,Xiaoquan Lu
In light of the critical necessity for precise detection of mercaptan in gasoline, due to its potential to induce metal corrosion and catalyst poisoning, this study investigates a novel methodology that employs resonance energy transfer (RET) between upconversion nanoparticles (UCNPs) and zirconium-based porphyrinic metal-organic frameworks (MOFs) to develop a highly sensitive and selective electrochemiluminescence (ECL) sensor. The NaYF 4 : Yb 3+ , Er 3+ @NaYF 4 @MOFs nanocomposite has been thoroughly characterized and exhibits enhanced ECL emission. This enhancement is attributed to the efficient RET between the UV-vis absorption of the Zr-based porphyrinic MOFs and the upconversion luminescence emission of the UCNPs. Upon interaction with mercaptan, the ECL signal experiences a significant decrease due to the interaction between mercaptan and Zr-based porphyrinic MOFs, leading to the quenching of the ECL signal. This phenomenon facilitates the sensitive detection of mercaptan within a linear range of 0.5 mg/L to 200 mg/L, with a low detection limit of 0.054 mg/L. The sensor demonstrates high selectivity and excellent stability, making it a promising tool for the quality control and environmental monitoring of mercaptan in gasoline.
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