FOOD CHEMISTRY
·
2026
·
IF 10.4
Lv Ya-Nan,Wang Ping-Ping,Fu Xiong,Chen Chun
Optimized emulsion gels were stabilized by crosslinker-free thiolated pectin. • Enhanced interfacial adsorption was verified by quartz crystal microbalance. • Curcumin encapsulation was enhanced by thiolated pectin-based emulsion gels. • Colon targeted and sustained release under in vitro simulated digestion was achieved. In this study, thiolated pectin with tunable modification degrees was successfully synthesized. Structural confirmation was achieved and the thiol group content was determined to range from 321.25 to 565.47 μmol/g. Thiolated pectin effectively stabilized gel-like emulsions with storage modulus (981.6–2027.2 Pa) remarkably higher than that of unmodified ones (46.4 Pa). Microscopic analysis revealed a honeycomb-like network that tightened with higher thiolation levels. Quartz crystal microbalance with dissipation demonstrated improved interfacial adsorption and the formation of a cohesive film via disulfide bond. The curcumin encapsulation was significantly improved to 89.87% by thiolated pectin, and curcumin retention was approximately doubled relative to unmodified pectin. Furthermore, the curcumin release was significantly inhibited in the simulated gastric and small intestinal phases, while its cumulative release during the simulated colonic phase reached up to 71.75%. This work proposed an exogenous crosslinker-free strategy for the encapsulation of lipophilic bioactives, which exhibited considerable potential for colon-targeted delivery. Download: Download high-res image (138KB) Download: Download full-size image
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BIOPHYSICAL CHEMISTRY
·
2022
·
IF 3.628
Xuejiao Gao,Sujuan Wang,Jiawei Dong,Jie Li,Yuangong Zhang,Yuxia Wu,Xinwu Ba
Curcumin has attracted more attention because of its inhibition efficacy on protein amyloid fibrillation. However, the inhibition mechanism was still ambiguous and the clinical application of curcumin was greatly limited because of its poor stability at physiological conditions for the presence of β-diketone moiety. In this paper, a new mono-ketone-containing curcumin analogue (MDHC) was designed and synthesized to realize the possible inhibition mechanism and unveil the important role of β-diketone moiety of curcumin in the inhibition process of amyloid fibrillation using hen egg white lysozyme (HEWL) as model protein. Although all experiment results (ThT, CR, ANS and TEM) showed that the inhibitory capacity of curcumin was better than MDHC, MDHC still could show obvious inhibition effect. Molecular docking showed that both curcumin and MDHC could bind with HEWL by hydrogen bond of phenloic hydroxyl and the binding energy of MDHC was higher than that of curcumin. All the findings inferred that β-diketone group was one of great important groups in the inhibition process of HEWL amyloid fibrillation, which provided more room to construct novel inhibition reagents.
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Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 8
·1836-1846
·
IF 7.779
Ze-Yu Liu,Xiao-Yue Tang,Chuan-Qing Huang,Jin Zhang,Wen-Qian Huang,Yong Ye
Antibacterial upconversion nanoparticles (UCNP)-based photodynamic-chemical combined therapy (UCNP-aPCCT) provides an ideal method to solve the problem of antibiotic-resistant bacteria in deep-tissue infections. Saponin is a kind of natural product exhibiting promising antibacterial activity. Curcumin is also a natural product that could be used as photosensitizer for antibacterial photodynamic therapy (aPDT). Herein, we have designed the dual-layer silica-coated upconversion nanoparticles combined with UCNP-photodynamic therapy (PDT) and chemotherapy using curcumin as a photosensitizer and the Camellia sapogenin derivative (CSD) as an antibacterial agent. It turned out that the prepared UCNP@mSiO2(Cur)@DmSiO2(CSD)@PVP nanoparticles displayed high antibacterial activity against Escherichia coli and Staphylococcus aureus under near-infrared (NIR) irradiation at 808 nm. Its antibacterial activity is stronger than that of the simple sum of saponin and curcumin aPDT, indicating the existence of a synergetic photodynamic-chemical effect. The current nanoparticle drug system may have potential applications for deep-tissue anti-infection treatment.
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Journal of Functional Foods
·
2022
·
IF 5.223
Hongxia Gao,Ce Cheng,Suqiong Fang,David Julian McClements,Li Ma,Xing Chen,Liqiang Zou,Ruihong Liang,Wei Liu
Curcumin was encapsulated within dairy milk products (skim, low-fat and whole) using a pH-driven method. The curcumin was incorporated into all milk products at a high encapsulation efficiency (>85%) and was shown to be in an amorphous state. Ultracentrifugation analysis showed that the curcumin was mainly associated with the milk fat globules in the whole and low-fat milk but with the casein micelles or whey proteins in the skimmed milk. The chemical stability of curcumin during storage and heat treatment was higher for the whole milk. Encapsulation of curcumin within milk using the pH-driven method led to a higher in vitro bioaccessibility (after simulated gastrointestinal digestion) and in vivo antioxidant activity (after oral administration to rats) than simply mixing powdered curcumin with milk. This study may lead to the production of nutraceutical-enriched dairy products that could be used as functional foods to improve human health and wellbeing.
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Pharmaceuticals
·
2022
·Vol. 15
·期 3
·275
·
IF 5.215
Long Chen,Xin Fu,Mei Lin,Xingmao Jiang
Methods of large-scale controllable production of uniform monodispersed spherical nanoparticles have been one of the research directions of scientists in recent years. In this paper, we report an azeotropic distillation-induced evaporation self-assembly method as a universal method, and monodispersed hydrophobic ordered mesoporous silica nanospheres (MHSs) were successfully synthesized by this method, using triethoxymethylsilane (MTES) as the silica precursor and hexadecyl trimethyl ammonium bromide (CTAB) as the template. SEM and TEM images showed good monodispersity, sphericity, and uniform diameter. Meanwhile, SAXS and N2adsorption–desorption measurements demonstrated a highly ordered lamellar mesostructure with a large pore volume. The model drug, curcumin was successfully encapsulated in MHSs for drug delivery testing, and their adsorption capacity was 3.45 mg g−1, which greatly improved the stability of curcumin. The release time when net release rate of curcumin reached 50% was extended to 6 days.Keywords:drug delivery;curcumin;azeotropic distillation;self-assembly;hydrophobic;mesoporous silica nanospheres
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Food Hydrocolloids for Health
·
2022
·
IF 0
Zihan Cai,Chaoyi Shen,Zian Deng,Di Wu,Kunsong Chen
In this work, the multilayer film with polycaprolactone as the outer layers and the curcumin-loaded gelatin film as the inner layer were fabricated by sequential solution blow spinning (SBS). The hydrophobic outer layers improved the water contact resistance and protected the inner layer from being dissolved by water. The interactions of hydrogen bonds between the outer and inner layers enhanced the thermal stability. The hydrophobicity and mechanical properties of the gelatin film were also improved by the sandwich structure. The multilayer film exhibited good slow-release ability, releasing curcumin continuously for 312 h. Meanwhile, the multilayer film was as effective as the single-layer gelatin loaded with curcumin against Escherichia coli and Staphylococcus aureus . The results of this study indicate that multilayer nanofilm fabricated by SBS have promising applications for the encapsulation and controlled release of antibacterial substances.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 26
·e52421
·
IF 3.057
Yuanzuo Zou,Fen Wang,Angran Li,Jie-Xin Wang,Dan Wang,Jian-Feng Chen
Practical application of versatile nanomaterials to food engineering is desirable. In this study, highly encapsulated curcumin-loaded shellac (Cur@Lac) nanoparticles are efficiently prepared via a rotating packed bed (RPB). In this modified co-precipitation process, the morphology of Cur@Lac nanoparticles is systematically investigated under experimental parameters involving the high-gravity level, the volume of antisolvent and the concentration of shellac. By virtue of the highly structured polymeric ester matrices of shellac and adequate supersaturation brought from RPB on a microscale, the obtained Cur@Lac nanoparticles with uniform size exhibit high encapsulation efficiency of over 96%. After 2 months of storage at room temperature, the aqueous Cur@Lac nanodispersions exhibit long-term stability with no agglomeration or sedimentation, and the final retention rate of curcumin was over 85%. Colored drinks of fruit syrup (pH = 4.0), fruit soda (pH = 6.0), and soda water (pH = 8.3) are prepared by using the Cur@Lac as the colorant, which possessed orange-yellow color. The nanocomposites of alkali-sensitive indicators based on cellulose paper and gelatin film demonstrated in the work show promising application value for sensing of alkaline solution and gas of perishable food.
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MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2022
·Vol. 478
·期 2
·241-247
·
IF 3.842
Zhou Quan,Cai Xu,Huang Ying,Zhou Youliang
Curcumin (CUR) is an extract of Curcuma longa Linn., which has various pharmacological activities. The instability, low water solubility and bioavailability of CUR greatly limit its clinical application. This work prepared Pluronic F127-liposome-encapsulated curcumin (CUR-LIP-F127) and explored its functional role in wound healing. Liposome-encapsulated curcumin (CUR-LIP) and CUR-LIP-F127 were prepared. Human keratinocyte cell line (HaCaT) was treated with CUR, Pluronic F127-liposome (LIP-F127) and CUR-LIP-F127, or combined with ML385 (Nrf2 inhibitor). The expression of mRNAs and proteins was detected by quantitative real-time PCR and western blotting. MTT and wound healing assays were performed to detect cell viability and migration. CUR, LIP-F127 and CUR-LIP-F127 all had no influence on cell viability of HaCaT cells. CUR-LIP-F127 treatment significantly accelerated cell migration and enhanced the expression of nuclear factor erythroid-related factor 2 (Nrf2) and kelch-like erythroid cell-derived protein 1 (Keap1) in HaCaT cells with respect to CUR or LIP-F127 treatment. ML385 treatment impaired CUR-LIP-F127-mediated promotion of migration and up-regulation of Nrf2 and Keap1 in HaCaT cells. This work demonstrated that CUR-LIP-F127 activated Nrf2/Keap1 signaling pathway to promote migration of HaCaT cells, suggesting that CUR-LIP-F127 may contribute to wound healing.
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Foods
·
2022
·Vol. 11
·期 11
·1625
·
IF 5.561
Xin Xu,Zhiyi Zhang,Junlong Zhu,Dan Wang,Guoyan Liu,Li Liang,Jixian Zhang,Xiaofang Liu,Youdong Li,Jiaoyan Ren,Qianchun Deng,Chaoting Wen
This study aimed to design a Pickering emulsion (PE) stabilized by whey protein isolate nanofibers (WPINs) prepared with subcritical water (SW) to encapsulate and prevent curcumin (Cur) degradation. Cur-loaded WPINs–SW stabilized PE (WPINs–SW–PE) and hydrothermally prepared WPINs stabilized PE (WPINs–H–PE) were characterized using the particle size, zeta potential, Congo Red, CD, and TEM. The results indicated that WPINs–SW–PE and WPINs–H–PE showed regular spherical shapes with average lengths of 26.88 ± 1.11 μm and 175.99 ± 2.31 μm, and zeta potential values were −38.00 ± 1.00 mV and −34.60 ± 2.03 mV, respectively. The encapsulation efficiencies of WPINs–SW–PE and WPINs–H–PE for Cur were 96.72 ± 1.05% and 94.07 ± 2.35%. The bio-accessibility of Cur of WPINs–SW–PE and WPINs–H–PE were 57.52 ± 1.24% and 21.94 ± 2.09%. In addition, WPINs–SW–PE had a better loading effect and antioxidant activities compared with WPINs–H–PE. SW could be a potential processing method to prepare a PE, laying the foundation for the subsequent production of functional foods.Keywords:subcritical water;whey protein isolate nanofibers;high internal phase Pickering emulsion;curcumin deliver system;bioavailability
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2022
·
IF 5.589
Chengzhi Gao,Lanfang Zhang,Minhao Xu,Yi Luo,Ben Wang,Meiyan Kuang,Xingyou Liu,Meng Sun,Yue Guo,Lesheng Teng,Chenhui Wang,Yan Zhang,Jing Xie
A co-delivery system of SN38 (7-ethyl-10-hydroxyl camptothecin) prodrug and CUR (curcumin) was designed for the treatment of lung cancer by pulmonary delivery. SN38 was linked to cell-penetrating peptide (CPP) TAT via a polyethylene glycol (PEG) linker to form the SN38 prodrug (TAT-PEG-SN38). Liposomes co-loaded with amphiphilic TAT-PEG-SN38 and curcumin (Lip-TAT-PEG-SN38/CUR) were successfully prepared by a microfluidic method for the treatment of lung cancer via pulmonary delivery. Lip-TAT-PEG-SN38/CUR showed nanometer-sized sphericity and a particle size of 171.21 nm. Besides, Lip-TAT-PEG-SN38/CUR exhibited enhanced antiproliferative effect, increased cell apoptosis induction and improved cell cycle arrest compared to the single agents in vitro. The combination induced significant tumor inhibition in a BALB/c mouse lung cancer model. These results indicated that our SN38 prodrug and curcumin co-delivery system was a promising candidate for lung cancer treatment.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Ying Zhang,Hongjun Yan,Rixiang Su,Peiyuan Li,Fangzhou Wen,Yingbin Lv,Jinyun Cai,Wei Su
Photodynamic therapy is a promising alternative to antibiotics in the treatment of bacterial infection, which has the advantages of less side effects, no drug resistance and accurate treatment. However, most photosensitizers (PSs) have some disadvantages, such as poor water solubility, serious self-quenching, poor stability and so on. Therefore, solving the limitations of traditional photosensitizers has become a hot issue in photodynamic therapy. On this basis, the lysozyme (Lys)-gold nanocluster (AuNCs)-curcumin (Cur) conjugate was used as a new type of water-soluble photosensitizer and combined with the bacterial surface through electrostatic interaction to form a bacterial surface enriched in PSs. At the same time, real-time bacterial imaging can be achieved by using the fluorescence properties of Lys-AuNCs-Cur. Under 405 nm light and dark conditions, the inactivation effect of Lys-AuNCs-Cur on Staphylococcus aureus and Escherichia coli was higher than that of free Cur. Moreover, Lys-AuNCs-Cur can also produce enough ROS to kill methicillin-resistant Staphylococcus aureus . The excellent antibacterial properties of nanoparticles may be attributed to the synergism of antibacterial protein lysozyme and AuNCs-Cur nanocomplexes and the increase of 1 O 2 production. The results of scanning electron microscope and fluorescence microscopic imaging showed that the cell membrane of E. coli and S. aureus was seriously damaged, and facilitated penetration of Lys-AuNCs-Cur nanocomplexes into the bacteria through the damaged cell membrane, and improve the photoinactivation efficiency of bacteria. More importantly, nanoparticles exhibited almost negligible dark cytotoxicity. The coupling of Cur and gold nanoclusters can significantly improve the stability of free curcumin molecules and the ability to generate ROS. Therefore, this work is of great significance for the development of new antimicrobial agents against bacterial infection.
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FOOD CONTROL
·
2022
·
IF 6.652
Tao Zhang,Wenshuo Zhang,Yajun Deng,Yifu Chu,Yuye Zhong,Guannan Wang,Yabo Xiong,Xinghai Liu,Lingyun Chen,Houbin Li
Introducing natural products to obtain ultraviolet (UV) shielding materials for inhibiting the photo-oxidation of oily foods is environmentally friendly food technology. Instead of traditional physical mixing, curcumin was introduced into castor oil-based waterborne polyurethane as a chain extender and compounded with gelatin for bioactive composite films. With the increase of curcumin-based waterborne polyurethane (CWP), the film with 10 wt% CWP achieved nearly complete ultraviolet shielding. The swelling index and water solubility were reduced by 800% and 12.93%, respectively. The tensile strength and elongation at break increased by 183% and 114%, respectively. In addition, CWP enhanced the antioxidant activity of curcumin in water system by 52.10% and reduced the oxidation degree of soybean oil by 62.03–87.84%. This work provides a new idea for compounding natural active small molecules with polymers.
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