ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Xiaohui Kang,Lanpeng Zhang,Wei Jia,Liang Yang,Changlong Jiang
Methylglyoxal is considered a key indicator in evaluating wine flavor and quality, as well as an important marker for diabetic pathological syndromes. Rapid and accurate quantitative detection of methylglyoxal is essential in scenarios of wine production standards and human health monitoring. Herein, we report a visual method for detecting methylglyoxal via an NIR-excitable reversible ratiometric fluorescent hydrogel sensor, where NIR-excited upconversion nanoparticles serve as energy donors and eosin B acts as the energy acceptor, together forming an integrated ratiometric nanophotonic probe that ensures the accuracy of detection without being affected by various background fluorescence interference in different scenarios. The integrated optical probe is combined with a 3D network hydrogel to design a sensing patch that can be easily regenerated through simple treatment, exhibiting a distinct optical color response. Upon the addition of methylglyoxal, the G/R value of the sensing patch changes, enabling the real-time quantitative detection of methylglyoxal. Additionally, we combined the hydrogel sensing patch with a smartphone to create a portable sensing platform for the convenient visual detection of methylglyoxal. The probe and hydrogel sensing patch have detection limits for methylglyoxal as low as 59 and 75.4 nM, respectively. The portable sensing patch designed here provides an effective strategy for standardizing the wine production process and monitoring patient health.
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Qiuying Wang,Zhiwei Wang,Menghang Qi,Hang Zhao,Xin Xin,Anjali Verma,Theeranun Siritanon,Arthur P. Ramirez,M.A. Subramanian,Peng Jiang
The severe urban heat island effect emphasizes the heightened importance of reducing building energy consumption. Cool pigments with higher near-infrared reflectivity contribute to the overall coating performance of the building. In this work, a novel intense blue pigment with superior infrared reflectance based on Ni-doped Zn2SiO4 was successfully synthesized via the simple solid-state method. The crystal structure, oxidation states, and optical properties are analyzed. The oxidation state of Ni was confirmed to be +2 using magnetic analysis and XPS. The intense blue color exhibited by the solid solution is due to the 3T1(3F) → 3T1(3P) transition of Ni2+ at the tetrahedral sites. UV–vis–NIR spectra demonstrate that this pigment exhibits superior near-infrared reflectance compared to cobalt blue in the range of 900–1700 nm, indicating its potential application in the realm of building energy conservation.
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高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Jian Sun,Jintao Ye,Wenwei Tang,Bin Yu,Yong Gao,Shengli Wang,Haijuan Zhang
Surgical precision in tumor resection critically relies on real-time intraoperative imaging, yet conventional probes face limitations in specificity and spatiotemporal control. Here, we present a tumor microenvironment (TME)-activated near-infrared (NIR) fluorescent nanoprobe (DNS–DYE/PEG–NI) that integrates dual responsiveness to hypoxia and glutathione (GSH) for submillimeter-level surgical navigation. The system comprises a GSH-activatable NIR fluorophore (λex/em = 679/730 nm) quenched by 2,4-dinitrobenzenesulfonyl (DNS) moieties and hypoxia-sensitive amphiphilic PEG–NI micelles. Upon tumor accumulation via the enhanced permeability and retention (EPR) effect, a hypoxic TME triggers micelle disassembly through nitroimidazole (NI) reduction, releasing DNS–DYE. Subsequent GSH cleavage restores fluorescence via intramolecular charge transfer (ICT) recovery, achieving a 12.3-fold tumor-to-normal tissue signal ratio and >90% reduction in off-target activation compared to non-responsive controls. Systematic validation demonstrates: (1) dose-dependent fluorescence recovery (35-fold intensity increase at 10 mM GSH); (2) hypoxia-driven micelle destabilization (800% hydrodynamic diameter expansion); (3) sustained colloidal stability (12.9% size variation over 15 days); and (4) low cytotoxicity (cell viability >90% at 125 μg mL−1). In vivo studies reveal precise tumor delineation within 12 h post-injection, enabling real-time resection of submillimeter lesions. By coupling TME-specific activation with prolonged tumor retention, this dual-responsive nanoprobe advances fluorescence-guided surgery toward precision oncology, reducing positive margin rates from 70% to <5% in preclinical models.
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DOI
PubMed
高影响因子
npj Precision Oncology
·
2025
·Vol. 9
·期 1
·1-21
·
IF 8
Li Xiaoli,Wang Jiashuo,Guo Jiaxing,Zhang Ming
Cisplatin resistance is a major challenge in laryngeal cancer treatment. Tumor necrosis factor-alpha-induced protein 2 (TNFAIP2) has been implicated in chemoresistance, though its role in laryngeal cancer remains unclear. We identified TNFAIP2 as a key gene associated with cisplatin resistance and developed a second near-infrared (NIR-II) light-responsive CRISPR-Cas9 nanosystem (APC@RBCs) to target it. In cisplatin-resistant Tu177/CDDP cells, light-activated knockout of TNFAIP2 significantly increased cisplatin sensitivity (IC50 reduced from 12.55 to 4.37 µg/mL). Mechanistic studies revealed that TNFAIP2 modulates cisplatin resistance via the NRF2 pathway, affecting oxidative stress response and epithelial-mesenchymal transition. TNFAIP2 deletion also suppressed cancer cell migration and invasion. Our results establish TNFAIP2 as a critical mediator of chemoresistance and demonstrate the potential of APC@RBCs as a precise, non-invasive gene therapy platform. This strategy offers a promising approach to overcoming cisplatin resistance and improving treatment outcomes in laryngeal cancer patients.
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PubMed
高影响因子
Small
·
2025
·
IF 12.1
Pengrui Wang,Chao Zhang,Lingkai Meng,Sixin Xu,Jieying Zhang,Hao Wang,Huai-Bin Liang,Wei-Kan Wang,Jian-Ren Liu,Xingjun Zhu
As the gold-standard neuroprotective intervention against cerebral ischemia-reperfusion injury, therapeutic hypothermia (TH) exhibits clinical efficacy while the current TH strategies are limited in application due to their non-specific cooling effect causing severe side effects. Developing targeted TH strategies still remains a problem. In this work, a near infrared emissive, ischemic targeted nanocomposite is demonstrated to achieve localized TH at the ischemic-reperfusion site. Rare earth doped nanoparticle as the core of the nanocomposite generates near infrared II luminescence for the guidance of delivery process. 2H,3H-decafluoropentane and ammonium nitrate loaded in the mesoporous silica layer of the nanocomposite serve as physical and chemical cooling agents for temperature reduction in the brain. Surface ligands modified with stroke-homing peptide and reactive oxygen species cleavable ketone moieties of the nanocomposite can target the inflammatory ischemic region and the promote cooling effects. By the intranasal administration of the nanocomposite in ischemic stroke mice model, infract area and pro-inflammatory factors levels of the brain are effectively reduced and the neurological functions are preserved. This work points to a concept of localized hypothermia method via nanomaterials, which may inspire the development of TH therapy for stroke in the future.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xinyue Cao,Yu Wang,Xiangyi Wu,Jinglin Wang,Haozhen Ren,Yuanjin Zhao
Chinese herb hydrogel has outstanding values in wound treatment. Tremendous effort is dedicated to developing functional and intelligent Chinese herb hydrogels for accelerating healing process. Herein, a novel multifunctional bilayer Chinese herb hydrogel patch for wound healing is presented. The patches are composed of a Ginsenoside compound K (GCK)-integrated chitosan inverse opal scaffold layer and a Bletilla striata polysaccharide (BP) hydrogel filler layer. As the photothermal conversion capacity of BP can trigger faster degradation of its hydrogel layer under near-infrared (NIR) light, the encapsulated BP can be controllably released to wound area and exhibit photothermal antibacterial and antioxidant effects. Besides, the inverse opal scaffold layer shows great mechanical property and moisturizing performance, and its released GCK can promote angiogenesis for long term therapeutic effects. Attractively, due to responsive structural color, the patch is endowed with self-reporting performance, which can real-time visually monitor the drug release degree. Taking advantages of these properties, the patches have been demonstrated to achieve satisfying therapeutic effects for in vivo wound treatment. Therefore, we believe that the proposed Chinese herb hydrogel patches are valuable as multifunctional patches for clinical treatment.
研究领域:
药学
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生物医学工程
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材料科学
·
伤口护理
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Biao-Qi Chen,Yu-Hong Shi,Yang Zhang,Da-Gui Zhang,Xiao-Chang Lu,Qin-Xi Xu,Yu-Jing Pan,Ranjith Kumar Kankala,Shi-Bin Wang,Ai-Zheng Chen
Triple-negative breast cancer (TNBC) is a highly aggressive subtype lacking specific molecular targets, rendering conventional therapies ineffective. Key obstacles in treatment include elevated intracellular glutathione (GSH), poor drug penetration, and an immunosuppressive tumor microenvironment. Herein, a four-in-one Janus-type near-infrared (NIR)-driven nanomotor is employed, composed of copper selenide (Cu 2-x Se) asymmetrically coated with disulfide-bridged periodic mesoporous organosilica (PMO) and loaded with doxorubicin (DOX), termed C&P-DOX. Upon NIR irradiation, Cu 2-x Se generates localized hyperthermia, propelling the nanomotor into deep tumor regions due to their asymmetrical structure. After internalization, high GSH triggers disulfide cleavage, promoting GSH depletion, disrupting redox homeostasis, and achieving controlled DOX release. The uniform distribution and effective release of DOX throughout the tumor enhance cytotoxic effects, inducing significant tumor cell apoptosis. In addition, the synergistic mild photothermal therapy and chemotherapy induce immunogenic cell death, releasing damage-associated molecular patterns and tumor-associated antigens that promote dendritic cell maturation and T-cell activation. This process transforms the tumor immunosuppressive microenvironment into an immunogenic environment, enhancing cytotoxic T lymphocyte infiltration and synergizing with PD-L1 antibody therapy to amplify immune responses. The four-pronged C&P-DOX nanomotor effectively penetrates deep tumors, depletes GSH, combines tumor treatment, and enhances immunotherapy outcomes, integrating active synergistic chemo-photothermal-immune therapy for improved TNBC treatment.
研究领域:
纳米医学
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肿瘤学
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药学
·
免疫治疗
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材料科学
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生物医学工程
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Guannan Zhang,Ying Lu,Jianbo Song,Di Huang,Meiwen An,Weiyi Chen,Peide Han,Xiaohong Yao,Xiangyu Zhang
After resection of bone tumour, the risk of cancer recurrence and numerous bone defects continues to threaten the health of patients. To overcome the challenge, we developed a novel multifunctional scaffold material consisting mainly of nano-hydroxyapatite particles ( n -HA), MXene nanosheets and g-C 3 N 4 to prevent tumour recurrence and promote bone formation. N -HA has the potential to restrict the growth of osteosarcoma cells, and the combination of MXene and g-C 3 N 4 enables the scaffolds to produce photodynamic and photothermal effects simultaneously under near infrared (NIR) irradiation. Surprisingly, n -HA can further enhance the synergistic anti-tumour function of photodynamic and photothermal, and the scaffolds can eradicate osteosarcoma cells in only 10 min at a mild temperature of 45 ℃. Moreover, the scaffold exhibit exceptional cytocompatibility and possesses the capacity to induce osteogenic differentiation of bone marrow mesenchymal stem cells. Therefore, this multifunctional scaffold can not only inhibits the proliferation of bone tumour cells and rapidly eradicate bone tumour through NIR irradiation, but also enhances osteogenic activity. This promising measure can be used to treat tissue damage after bone tumour resection.
研究领域:
生物医学工程
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材料科学
·
癌症治疗
·
组织工程
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PubMed
高影响因子
ACS Nano
·
2017
·
IF 13.942
Xujiang Yu,Ang Li,Chengzhi Zhao,Kai Yang,Xiaoyuan Chen,Wanwan Li
Multifunctional nanomaterials with integrated diagnostic and therapeutic functions, combination therapy to enhance treatment efficacy, as well as low toxicity have drawn tremendous attentions. Herein, we report a multifunctional theranostic agent based on peptide (LyP-1)-labeled ultrasmall semimetal nanoparticles of bismuth (Bi-LyP-1 NPs). Ultrasmall Bi NPs (3.6 nm) were facilely synthesized using oleylamine as the reducing agent and exhibited a higher tumor accumulation after being conjugated with the tumor-homing peptide LyP-1. The abilities to absorb both ionizing radiation and the second near-infrared (NIR-II) window laser radiation ensured that Bi-LyP-1 NPs are capable of dual-modal computed tomography/photoacoustic imaging and efficient synergistic NIR-II photothermal/radiotherapy of tumors. Moreover, Bi-LyP-1 NPs could be rapidly cleared from mice through both renal and fecal clearance and almost completely cleared after 30 days. Such multifunctional nanoparticles as efficient cancer theranostic agents, coupled with fast clearance and low toxicity, shed light on the future use of semimetal nanoparticles for biomedicine.
研究领域:
生物医学工程
·
癌症治疗
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纳米技术
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诊断成像
·
放射治疗
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Dayu Huang,Yuhang Zhang,Xingru Chen,Ziyong Cheng,Hongzhou Lian
The development of efficient and stable near—infrared (NIR) emitters using solution—processable materials remains a key challenge for flexible optoelectronics. This study addresses this need by constructing a novel ternary heterostructure through a room—temperature, sulfur—anion mediated transformation of CsPbCl 3 : Mn 2+ nanocrystals. Unlike conventional binary systems, this architecture enables a unidirectional energy cascade: from the CsPbCl 3 host to Mn 2+ emitters, and subsequently to the in—situ formed PbS domain, resulting in enhanced NIR emission. Systematic investigation reveals that optimal incorporation of C 6 H 18 SSi 2 is critical for modulating the heterointerface, which in turn opens a highly efficient energy transfer pathway. The resulting nanocomposite exhibits exceptional stability, retaining 95 % of its photoluminescence after six months under ambient conditions. Furthermore, the successful fabrication of flexible films with uniform electroluminescence underscores the practical potential of this heterostructure for next—generation optoelectronic devices.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
钙钛矿纳米晶
·
能量转移
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高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xueyuan Guo,Ling Li,Wenhua Jia,Chen Zhang,Wei Ren,Chenghui Liu,Yanli Tang
Phototherapies such as photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted great attention in the field of cancer treatment. However, the individual PDT or PTT makes it difficult to achieve optimal antitumor effects compared to the PDT/PTT combined therapy. Also, the effect of PDT is usually limited by the penetration depth of the UV–vis light source. Herein, we designed and synthesized novel composite nanoparticles UCNPs-CPs, which are constructed from two conjugated polymers and upconversion nanoparticles β-NaYF4:Yb,Tm (UCNPs) via a coordination reaction. By virtue of the excellent spectral overlap between absorption of conjugated polymers and emission of UCNPs, the UCNPs can absorb NIR light and effectively excite conjugated polymers by energy transfer to produce massive reactive oxygen species under 980 nm excitation and heat energy under 808 nm laser irradiation, achieving photodynamic/photothermal synergistic therapy. The in vitro cellular investigation proves that the dual modal phototherapy exhibits enhanced antitumor ability compared to single PDT or PTT. Furthermore, UCNPs-CPs inhibit tumor growth 100% in a 4T1 breast tumor mice model with both NIR laser irradiation, indicating that UCNPs-CPs is an excellent platform for synergistic PDT/PTT treatment. Thus, this study provides a promising strategy for NIR-triggered dual modal phototherapy.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Wenwu Zhou,Jianyong Ye,Sheng Zhuo,Danxia Yu,Ping Fang,Rong Peng,Yue Liu,Weifan Chen
The pigments with high near-infrared (NIR) reflectance hold great promise toward both fundamental types of researches and applications for the realization of comfortable indoor-temperature by mitigating urban heat island effect. However, the facile yet simple method for the NIR reflective pigments with bright color and non-toxic feature remains a huge challenge, limiting their practical application. Herein, we proposed a mild and universal method of solution combustion for constructing the non-toxic and NIR reflective yellow-green pigments of Al-doped Y 3 Fe 5 O 12 . The Y 3 Fe 4 AlO 12 pigment presented a high NIR reflectance of 87.66%, and an outstanding acid/alkali resistance. Moreover, the pigment had an impressive color performance (L* = 78.72, a* = − 4.05, b* = 40.04). Besides, the practical near-infrared reflection performance revealed that the transient surface temperature of the Y 3 Fe 4 AlO 12 pigment was 7.6 °C lower than that of the pigment with similar color on the market. This research supplied high NIR reflecting pigments of Y 3 Fe 5−x Al x O 12 as promising coatings for roofs and exterior walls of buildings, acting as a favorable solution for urban heat island effect.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）