Gels
·
2022
·Vol. 8
·期 9
·570
·
IF 4.432
Qingrong Wu,Yu Fu,Wanying Yang,Shouxin Liu
Hydrogel is a good drug carrier, widely used in the sustained-release aspect of tumor drugs, which can achieve the continuous release of drugs to the tumor sites. In this study, diethylene glycol monomethyl ether methacrylate (MEO2MA) and poly (ethylene glycol) methyl ether methacrylate (OEGMA) are temperature-sensitive monomers. N-Methacryloyl-L-Histidine (Mist) is pH sensitive monomer and ligand for metal coordination bond. The temperature-sensitive monomers and pH sensitive monomer with stereocomplex of modified polylactic acid (HEMA-PLLA30/PDLA30) were mixed, under 2,2’-azobis (2-methylpropionitrile) (AIBN) as radical initiator, polymer was formed by free-radical polymerization. The polymer was then immersed in ZnSO4solution, the imidazole group of Mist monomer forms a tridentate metal coordination bond with Zn2+, temperature/pH double-responsive and physical double-crosslinked hydrogel was finally obtained. Comparing the hydrogen bond hydrogel, hydrogen bond and metal coordination bond double crosslinking hydrogel, metal coordination bond hydrogel, testing thermal stability, viscoelasticity, swelling, and morphology of three hydrogels. In addition, using UV-Visible spectroscopy (UV-Vis) to test the sustained release of the hydrophobic drug doxorubicin hydrochloride (DOX-HCl) in the human tumor environment (37 °C, pH = 5). We found that the temperature/pH double-responsive and physical double-crosslinked hydrogel had the most potential for the sustained drug release.
研究领域:
材料科学
·
药学
·
生物医学工程
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 15
·22560-22575
·
IF 0
Kong Yanli,Guo Meng,Lu Fan,Huang Aihua,Nie Yong,Ma Jiangya
Conventional inorganic coagulants (Al, Fe) and Al/Fe-based covalently bonded flocculants (CAFMs) had different hydrolysis species at different pHs, which subsequently led to differences in their binding sites and complexation ability with humic acid (HA). Studying the binding sites and interactions between CAFMs, AlCl 3 (Al), and FeCl 3 (Fe) hydrolysates and HA molecules is critical to understanding the coagulation mechanism. The results found that CAFM 0.6 , Al, and AlCl 3 combined FeCl 3 (Al/Fe) removed more than 90% of HA at pH 6, and CAFMs showed higher HA removal rate than that of Al, Fe, and Al/Fe under the same reaction conditions. The flocs of CAFMs contained abundant -NH 2 /OH as well as the large particle size, compact structure, and excellent settling performance. The hydrolyzed species of Al and Fe were predominantly Al b and Fe b at pH 6, but the hydrolyzed species of CAFMs were primarily (Al + Fe) c . Moreover, the hydrolyzed species of Al and Al/Fe were found to complex with HA functional groups such as -COOH, C = O, C-H/C–C, C = C, and C–OH to form ligand bonds, while the hydrolyzed species (Al + Fe) c of CAFMs could deeply interact with HA functional groups including C-O, -COOH, C = O, C-H/C–C, C = C, and C–OH by the adsorption and sweeping.
研究领域:
环境科学
·
水处理技术
·
胶体化学
·
无机化学
·
高分子科学
·
分析化学
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DOI
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Huizhen Wang,Pengfei Yang,Dongzheng Liu,Mengzhen Yu,Bowen Zhou,Yubing Zhang,Zhenyu Xiao,Weiping Xiao,Zexing Wu,Lei Wang
Developing efficient electrocatalysts for hydrogen evolution reaction (HER) in full pH range can promote the practical applications of hydrogen energy. In this work, nitrogen doped carbon nanosheets supported RuM (Mo, W, Cr) (RuM/NCN) are prepared through an ultrafast microwave approach. The carbon nanosheet structure coupled with the ultrasmall RuM nanoparticles can expose rich active sites to optimize the catalytic activity. Moreover, the strong metal-support interactions also favor to accelerate the reactions kinetics and improve stability. Thus, the developed RuMo/NCN (RuW/NCN) show excellent HER catalytic activities with overpotentials of 72 (75) mV, 82 (82) mV and 124 (1 1 9) mV to reach current density of 10 mA cm -2 in 1 M KOH, 0.5 M H 2 SO 4 and alkaline seawater , respectively, and also achieve excellent performance in 1 M PBS. This work provides a valid and novel avenue to design efficient electrocatalysts in renewable energy-related fields.
研究领域:
材料科学
·
电化学
·
催化
·
能源材料
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DOI
高影响因子
DRUG DELIVERY
·
2018
·
IF 3.095
He-Lin Xu,Zi-Liang Fan,De-Li ZhuGe,Meng-Qi Tong,Bi-Xin Shen,Meng-Ting Lin,Qun-Yan Zhu,Bing-Hui Jin,Yasin Sohawon,Qing Yao,Ying-Zheng Zhao
Currently, combination drug therapy is one of the most effective approaches to glioma treatment. However, due to the inherent dissimilar pharmacokinetics of individual drugs and blood brain barriers, it was difficult for the concomitant drugs to simultaneously be delivered to glioma in an optimal dose ratio manner. Herein, a cationic micellar core (Cur-M) was first prepared from d-α-tocopherol-grafted-ε-polylysine polymer to encapsulate the hydrophobic curcumin, followed by dopamine-modified-poly-γ-glutamic acid polymer further deposited on its surface as a anion shell through pH-sensitive linkage to encapsulate the hydrophilic doxorubicin (DOX) hydrochloride. By controlling the combinational Cur/DOX molar ratio at 3:1, a pH-sensitive core–shell nanoparticle (PDCP-NP) was constructed to simultaneously target the cancer stem cells (CSCs) and the differentiated tumor cells. PDCP-NP exhibited a dynamic diameter of 160.8 nm and a zeta-potential of –30.5 mV, while its core–shell structure was further confirmed by XPS and TEM. The ratiometric delivery capability of PDCP-NP was confirmed by in vitro and in vivo studies, in comparison with the cocktail Cur/DOX solution. Meanwhile, the percentage of CSCs in tumors was significantly decreased from 4.16% to 0.95% after treatment with PDCP-NP. Overall, PDCP-NP may be a promising carrier for the combination therapy with drug candidates having dissimilar physicochemical properties.
研究领域:
药学
·
纳米技术
·
肿瘤学
·
神经科学
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DOI
PubMed
高影响因子
Environmental Science-Nano
·
2022
·Vol. 9
·期 9
·3629-3645
·
IF 9.473
Jiamei Li,Jia Wei,Mengdie Xu,Guoping Pan,Yifei Zhang,Luyi Xing,Yanan Li,Jun Li,Zijian Jiang
Metal sulfides have been found to be effective in removing organic pollutants from water in environmental catalysis. In this study, a porous graphitic biochar wrapped Co9S8 core–shell composite (Co9S8@N–O–BC) was designed for efficient activation of peroxymonosulfate (PMS) and degradation of sulfamethoxazole in an aqueous environment. Based on complementary characterizations and reactive oxygen species (ROS) quenching experiments, we proposed that boosted Co(II) regeneration by various existing S species along with formed N and O active sites in Co9S8@N–O–BC facilitated the cleavage of the O–O bond of PMS, thus resulting in a high-efficiency non-radical pathway. Consequently, Co9S8@N–O–BC/PMS achieved an outstanding degradation of sulfamethoxazole (100%) within 4 min in a wide pH range (3–11) and its turnover frequency (TOF) value was 11.96 min−1, up to 117 times higher than other reported catalysts as far as we know. The superior stability and wide applicability in sulfamethoxazole degradation with a series of inorganic ions, especially the production of very few harmless intermediates and the exceptional mineralization efficiency, also further demonstrated that the obtained catalyst possessed excellent potential for practical wastewater treatment.
研究领域:
环境催化
·
水处理
·
材料科学
·
化学工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Ning Zuo,Jinchao He,Chengbo Yin,Qingxiang Guo,Shan Tan,Tianhui Lu,Liping Huang,Dexin Fang
Adsorption isotherms serve as the cornerstone for evaluating adsorbent performance and elucidating interfacial mechanisms. For pollutants with proton-binding capacity, such as phosphate (P), the adsorption process itself often induces significant pH shifts, making the accurate determination of such pH-dependent isotherms crucial yet challenging. The conventional method for its determination – maintaining a constant pH through in-situ intermittent manual adjustments – suffers from a critical lack of standardized protocols, undermining the reproducibility and inter-laboratory comparability of published data. This study introduces and validates a predictive framework that constructs accurate P adsorption isotherms at specific equilibrium pH (pH eq ) values using a matrix of simple, reproducible initial pH (pH ini ) control experiments. Layered double hydroxide (LDH), a material with pH-responsive surface chemistry, was used as a model adsorbent to validate the framework. A robust relationship was established between the pH eq and the equilibrium P adsorption amount ( q e ). This experimentally derived pH eq - q e map allowed for the accurate construction of Langmuir isotherms across target pH eq values (5 to 10) via interpolation. The predicted values for q e and equilibrium concentration ( c e ) showed excellent agreement with experimental data, with relative root mean squared errors (RRMSE) of only 3.72% and 4.42%, respectively. Multi-stage pH adjustment experiments further confirmed the framework's robustness, showing less than 2.5% deviation from predicted values. By addressing the standardization issue in pH-dependent adsorption studies, this predictive framework establishes a more reliable foundation for systematic adsorbent comparison, mechanistic investigation, and rational design of adsorption-based water treatment technologies.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yanfang Li,Kang Xu,Huilin Hu,Lixia Jia,Yizhong Zhang,Ciren Zhuoga,Pengli Yang,Xin Tan,Wanqian Guo,Weichang Hao,Tao Yu,Jinhua Ye
Constructing atomic-level cation vacancies is an effective strategy to modulate the electronic properties of host materials, thus promoting charge transfer and redox reaction kinetics. Herein, ultrathin Bi 24 O 31 Br 10 nanosheets with cationic vacancy was synthesized via an inventive precipitation strategy by adding appropriate arginine. The difunctional arginine can changes the pH of the synthetic system and selectively deprive Bi atoms on the surface to form Bi vacancies through strong affinity between functional groups and cations. The abundant Bi vacancy decrease the Gibbs free energy change and provide channels to promote bulk adsorption of Cr(VI), thus effectively reduces the carrier migration distance during in situ bulk photocatalytic reduction of Cr(VI) and induces the formation of new impurity states to improve the utilization of visible light. Bi vacancy mitigates strong excitonic effects confined by significantly reducing exciton binding energies, thus effectively promote the separation of photo-generated charges and suppress reorganization of photon-generated carrier. Benefiting from these merits, these exclusive V Bi -Bi 24 O 31 Br 10 ultra-thin nanosheets exhibit superior reduction performance for Cr(VI), and the removal rate was more than 90% at universal pH (2–10). This work provides a new idea for the construction of cation vacancies and a feasible method for the removal of Cr(VI) under alkaline conditions.
研究领域:
材料科学
·
环境科学
·
化学
·
纳米技术
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DOI
高影响因子
RSC Advances
·
2019
·Vol. 10
·期 1
·21-28
·
IF 3.049
Yongqian Li,Yunlong Mao,Chi Xiao,Xiaoli Xu,Xueyong Li
pH is a critical parameter used to specify the acidity or alkalinity of an aqueous solution in chemistry, food processing, and medical care. In this study, a conductimetric-type micro pH sensor has been achieved using PANI membrane fabricated on a flexible substrate film aiming to monitor wound healing. The sensor is based on the incorporation of a polyaniline (PANI) membrane, interdigital electrode, and polyimide (PI) substrate. PANI was doped with dodecyl benzene sulfonic acid (DBSA) to obtain good conductivity. The electrodes were patterned on the PI film by etching. The contact area between the PANI and interdigital electrodes improves the responsiveness of the pH sensor. A sensitivity of 58.57 mV per pH over the entire pH range from 5.45 to 8.62 was obtained experimentally, along with a superior repeatability of 8% FS (full scale) and a temperature drift of 6.8% FS. This micro flexible pH sensor aims to monitor the pH value of wound healing, which also facilitates the realization of online monitoring of the pH for telemedicine, food safety, and home health care.
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Miao Deng,Rong Guo,Shuya Zang,Jingdong Rao,Mengmeng Li,Xian Tang,Chunyu Xia,Man Li,Zhirong Zhang,Qin He
Natural killer (NK) cell-based immunotherapy presents a promising antitumor strategy and holds potential for combination with chemotherapy. However, the suppressed NK cell activity and poor tumor retention of therapeutics hinder the efficacy. To activate NK cell-based immuno–chemotherapy and enhance the tumor retention, we proposed a pH-responsive self-aggregated nanoparticle for the codelivery of chemotherapeutic doxorubicin (DOX) and the transforming growth factor-β (TGF-β)/Smad3 signaling pathway inhibitor SIS3. Polycaprolactone-poly(ethylene glycol) (PCL-PEG2000) micelles modified with dibenzylcyclooctyne (DBCO) or azido (N3) and coated with acid-cleavable PEG5000 were established. This nanoplatform, namely, M-DN@DOX/SIS3, could remain well dispersed in the neutral systemic circulation, while quickly respond to the acidic tumor microenvironment and intracellular lysosomes, triggering copper-free click reaction-mediated aggregation, leading to the increased tumor accumulation and reduced cellular efflux. In addition, the combination of DOX with SIS3 facilitated by the aggregation strategy resulted in potent inhibition of melanoma tumor growth and significantly increased NK cells, NK cell cytokines, and antitumor T cells in the tumor. Taken together, our study offered a new concept of applying copper-free click chemistry to achieve nanoparticle aggregation and enhance tumor retention, as well as a promising new combined tumor treatment approach of chemotherapy and immunotherapy.
研究领域:
癌症研究
·
纳米技术
·
免疫疗法
·
化疗
·
药学
✓ 已验证
DOI
PubMed
高影响因子
Arabian Journal of Chemistry
·
2020
·Vol. 13
·期 6
·5900-5910
·
IF 4.762
Fengxia Zhang,Wenyao Dong,Yongshan Ma,Tianyi Jiang,Bing Liu,Xuemei Li,Yuanyuan Shao,Junsen Wu
The pH detection in the alkaline range is particularly important in many fields such as leather processing, waste water treatment, paper industry, and metal mining and finishing. Compared with traditional analysis methods such as colorimetric sensors and electrochemical sensors, the fluorescence and colorimetric probes for pH measurements have attracted much more attention due to their advantages of high sensitivity, excellent selectivity, noninvasiveness, low cost, fast response time, the possibility of continuously measurement, etc. However, there are few fluorescent probes fiting for alkaline pH monitoring. Acturally, the design and synthesis of them were more significant for new probes producing. In this study, the design, synthesis, and practical application of two novel fluorescent pH probes for alkaline pH assay were discussed. Both of the two probes were derived from perylene tetra-(alkoxycarbonyl). The red or blue shift of the absorption/fluorescence spectrum was caused by the introduction of electron donor amino or oxygen ring in the bay region. Due to electronic separation of the OH group from the electron-withdrawing core, the probes have high pKa values and cover the pH range from 8 to 12. They exist in either fluorescent acid form or non-fluorescent basic form. It was investigated that the amino substituent at bay region had a higher pKa value than O-heterocyclic annulated perylene, which showed that the adjustable pKa value could be achieved by the modification of electron withdrawing groups. The probes would have a wide use for testing strips measurements and monitoring pH changes in concrete.
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DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Xiao Long Xiong,Yun Peng Ma,Hui Liu,Cheng Zhi Huang,Jun Zhou
The determination of pH values is crucial in various fields, such as analytical chemistry, medical diagnostics, and biochemical research. pH test strips, renowned for their convenience and cost-effectiveness, are commonly utilized for pH qualitative estimation. Recently, quantitative methods for determining pH values using pH test strips have been developed. However, these methods can be prone to errors due to environmental factors, such as lighting conditions, which affect the imaging quality of the pH test strips. To address these challenges, we developed an innovative approach that combines machine learning techniques with pH test strips for the quantitative determination of pH values. Our method involves extracting artificial features from the pH test strip images and combining them across multiple dimensions for comprehensive analysis. To ensure optimal feature selection, we developed a feature selection strategy based on SHAP importance. This strategy helps in identifying the most relevant features that contribute to accurate pH prediction. Furthermore, we integrated multiple machine learning algorithms, employing a robust stacking fusion strategy to establish a highly reliable pH value prediction model. Our proposed method automates the determination of pH values through pH test strips, effectively overcoming the limitations associated with environmental lighting interference. Experimental results demonstrate that this method is convenient, effective, and highly reliable for the determination of pH values.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2022
·
IF 4.598
Yaosheng Liu,Yongxing Diao,Guangxing Hu,Yuyan Zhao,Yan Shi,Hongda Wang,Zhuang Li
Metal-based pH sensor has wide applications in industrial monitoring, soil environment, marine safety, and other fields. In this study, we proposed to renew the antimony-based sensor by physical polishing and electrochemical cathode reduction. Compared with before polishing, the pH response sensitivity after polishing increased from 0.034 V/pH to 0.042 V/pH, electrochemical cathode reduction renewed the pH response sensitivity improved from 0.018 V/pH to 0.032 V/pH (10 min) and 0.043 V/pH (30 min). The reasons for the deterioration of the pH response performance of the antimony-based sensor were analyzed by SEM, EDS, and XRD, and the renewable mechanisms of the sensor were proposed. The renewable effect of electrochemical cathode reduction on the degradation of sensor accuracy was evaluated for long-term monitoring. It is expected to realize remote online renewal of sensors under on-site unattended conditions, to reduce operation and maintenance costs of the sensor. These results provide solutions for the repeated regeneration of metal-based pH sensors which were degraded in performance and have significance for promoting the development and wide applications of renewable pH sensors.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）