JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Huange Zhen,Mengyuan Wu,Zhijie Yuan,Zhibo Qi,Yingshuang Meng,Xihong Zu,Dan Liu,Gaohong He,Xiaobin Jiang
Nanofiltration (NF) is a promising technique to achieve sustainable and efficient separation of antibiotics with high industrial value. In this work, carboxymethyl- β -cyclodextrin (CM- β -CD) modified nanofiltration membrane was fabricated through interfacial polymerization (IP) for high concentration cephalexin solution separation, which is a classic antibiotic pharmaceutical wastewater. In principle, CM- β -CD can slow down the diffusion of amine monomers via electrostatic attraction, steric effect, hydrogen bonding and adsorption of the piperazine (PIP) monomer onto the hydrophilic surface, which renders amine monomer the high local concentration. The fabricated NF membranes possessed a larger proportion of dense primary layer on the surface. In addition, the accumulation of CM- β -CD between the substrate membrane and polyamide (PA) layer played the role as a barrier with specific cavity structure and bulk carboxylate to enhance the rejection of cephalexin. The cavity structure and stacking gap of CM-β-CD simultaneously rendered the membrane interlayer highly permeable. The optimal CM- β -CD modified membrane exhibited high rejection of cephalexin (94.7%) and water permeability of 122.4 L m −2 h −1 MPa −1 when the concentration of cephalexin was 3473.9 ppm (10 mmol/L). This work furnished an available way to prepare a novel nanofiltration membrane with efficient separation performance for relevant pharmaceutical production wastewater.
研究领域:
环境科学
·
材料科学
·
制药工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2015
·
IF 3.368
Manlin Wang,Peng Liu,Yu Wang,Dongmei Zhou,Chen Ma,Dongju Zhang,Jinhua Zhan
The effective recognition and enrichment of trace polychlorinated biphenyls (PCBs) in the environment are currently challenging issues due to human health concerns. In this paper, a surface absorptive layer coating superparamagnetic Fe 3 O 4 nanoparticles for PCBs enrichment were prepared. This protocol involved the synthesis of Fe 3 O 4 particles through a solvothermal reaction and the covering of a silica layer bonded β-cyclodextrin (β-CD) over Fe 3 O 4 via a sol–gel process to construct core–shell Fe 3 O 4 @β-CD composites. β-CD was linked covalently to Fe 3 O 4 nanoparticles to generate the binding sites, enhancing the stability of Fe 3 O 4 nanoparticles in water. Meanwhile, superparamagnetic Fe 3 O 4 core could be rapidly separated from matrix to simplify time-consuming washing extraction. The adsorption capacity of Fe 3 O 4 @β-CD composites to PCB28 and PCB52 in aqueous solutions was investigated. To estimate the theoretical binding site number of Fe 3 O 4 @β-CD, the obtained binding data were replotted according to Scatchard equation. The host–guest interaction between β-CD and PCBs were further examined with density functional theory (DFT) calculations. It provides theoretical evidence of β-CD as host molecule has a higher binding amount towards PCB-28 than PCB-52 on the basis of their optimized geometries and calculated complexation energies. The nanomaterial reported herein is an ideal candidate for various applications, including the recognition and removal of environmentally deleterious substances.
研究领域:
环境科学
·
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Guojuan Zhang,Yujie Han,Zhiguang Liu,Lifang Fan,Yujing Guo
A triple-amplified and ratiometric electrochemical aptasensor for CA125 was designed based on hemin–graphene/SH-β-cyclodextrin@PdPt nanoflower (H-Gr/SH-β-CD@PdPtNF) composites and an exonuclease I (Exo I)-assisted strategy. In the nanocomposite, hemin acts as an internal reference signal owing to the reversible heminox/heminred pair. PdPtNFs can significantly improve the electron transfer rate. SH-β-CD can efficiently enrich quercetin probes through host–guest recognition and increase the second indicator signal. In the presence of CA125, due to the specific binding between the aptamer and CA125, the conformational change of dsDNA (designed by the CA125 aptamer and its complementary DNA) results in the release of quercetin embedded in dsDNA. Subsequently, the free quercetin and DNA fragments are enriched on the H-Gr/SH-β-CD@PdPtNF-modified electrode. Thus, an enhanced oxidation peak from quercetin (IQ) and a reduced peak from hemin (Ihemin) can indicate the same biological identification event. In addition, the recycling amplification of CA125 by Exo I can effectively assist the increase of the quercetin signal. The value of IQ/Ihemin is linear with the concentration of CA125 in the range from 6.0 × 10–4 to 1.0 × 103 ng/mL, and the limit of detection is 1.4 × 10–4 ng/mL. The recovery of CA125 in human blood serum samples was from 99.2 to 104.4%. The proposed sensor is sensitive and reliable, which provides an avenue for the development of triple amplification and ratiometric signal strategies for detecting tumor markers in clinical diagnostics.
研究领域:
生物医学工程
·
临床诊断
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2017
·
IF 3.684
Jia-Min Li,Chuan-Shan Hu,Jian-Ming Shao,Hui-Juan Li,Peng-Yun Li,Xi-Chuan Li,Wei-Dong He
Ternary hydrogels composed of poly[acrylamide- co -2-(dimethylamino)ethyl methacrylate] [P(AM- co -DMAEMA)], poly(vinyl alcohol) (PVA) and β -cyclodextrin ( β -CD) were fabricated based on the multiple physical interactions such as inclusion complexation, hydrogen bonding and polymer crystallinity , and exhibited high storage modulus . To illustrate the individual role of each physical interaction, symmetrical investigation has been performed. P(AM- co -DMAEMA)s with two compositions , prepared by radical polymerization at −20 °C below the freezing point of reaction medium of water, were served as the inclusion guest for the inclusion host of β -CD. The inclusion complex between dimethylaminoethyl group of DMAEMA and β -CD was identified through 2D NOESY NMR spectroscopy . Hydrogen bonding between each pairs of hydrogel components was confirmed with FTIR analysis and contributed the second form of crosslinkage. Under freezing polymerization and further freezing-thawing treatment, PVA component tended to crystallize to serve as the third type of physical crosslinkage, which was recognized with X-ray diffraction. Rheological and thermo-gravimetrical analysis was used to inspect the modulus and thermal stability of the hydrogels, respectively. Three hydrogels of P(AM- co -DMAEMA)/PVA-g- β -CD, P(AM- co -DMAEMA)/PVA/ β -CD and P(AM- co -DMAEMA)/PVA were synthesized under the same condition to make the comparison. The whole results disclosed the strong dependence of hydrogel properties on the hydrogel components, reflecting the synergistic effects of different physical crosslinkages for the formation of those physical hydrogels.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
WOOD SCIENCE AND TECHNOLOGY
·
2013
·Vol. 48
·期 1
·195-206
·
IF 1.884
Wang Ting,Si Hongyan,Li Bin
Poplar wood flour, a low-cost and abundantly available material, was modified by grafting β - cyclodextrin in the presence of citric acid, aiming to expand the application of wood flour. The product was characterized by Fourier transform infrared spectroscopy and the technique of the phenolphthalein probe. By the technique of inverse gas chromatography and the method of Hamieh, the values of surface free energy and nonpolar part of the free energy were obtained. The results demonstrate that the dispersive component of the surface free energy of the products will increase with temperature increases, and the product presents a Lewis basic character with K
b / K
a = 3.67. Based on the structure of the product, the basicity comes from two parts. One is the rich electronic environment of the β - CD inner cavity, and the other is the formation of ester bonds through crosslinking between β - CD and wood flour by CA.
研究领域:
高分子化学
·
木材科学
·
表面科学
·
材料化学
·
分析化学
✓ 已验证
DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Shao-Lu Li,Dandan Cheng,Niamat Ullah,Youcai Chen,XinMeng Wang,Mengfan Wang,Qiyu Duan,Genghao Gong,Yunxia Hu
Graphene oxide (GO) membrane is considered as one of the preferred choice for textile wastewater treatment thanks to its unique 2D interlayer channel features. However, GO laminar stacking is inclined to water-induced structure instability, and the narrow interlayer spacing limit mass transport efficiency, hampering its effectiveness in water treatment applications. Herein, a layer-by-layer stacked microcomposite membrane based on GO and highly microporous β-cyclodextrin based nanosheets (β-CDNS) served as intercalator was developed. The distinctive layered structure was further stabilized by covalent cross-linking with glutaraldehyde (GA). The microporous β-CDNS offered additional nanochannels that facilitated the rapid penetration of water molecules, while the abundant -OH groups provided sites for chemical cross-linking, enhancing membrane stability. The optimal GO/β-CDNS1 membrane exhibited a superior water permeance of up to 83.5 LMH/bar, with >99 % rejection for dyes such as Congo red (CR), methyl blue (MB), and chrome black T (CBT), 95.5 % for acid fuchsin (AF). Meanwhile, the GO/β-CDNS1 membrane demonstrated ultra-low (<5 %) retention for inorganic salts (MgSO 4 , MgCl 2 and NaCl), with a separation factor as high as 194 for MB/NaCl mixtures. Therefore, employing functional interlayer nano-additives to well regulate the GO interlayer structure offers a promising guideline for developing high-performance GO-based membranes.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 11
·862
·
IF 4.3
Na Xia,Qian Zhou,Yanquan Liu,Dan Gao,Siming Zhu,Zuoshan Feng
Neohesperidin (NH), a bioactive flavanone glycoside, exhibits multifaceted pharmacological properties including antioxidant and anti-inflammatory activities. However, its clinical application is severely constrained by inherent physicochemical limitations such as poor aqueous solubility and instability under physiological conditions. To address these challenges, this study developed a dual-carrier nano-liposomal system through the synergistic integration of phospholipid complexation and hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion technologies. Two formulations—NH-PC (phospholipid complex) and NH-PC-CD (phospholipid/HP-β-CD hybrid)—were fabricated via ultrasonication-assisted ethanol precipitation. Comprehensive characterization using FTIR and PXRD confirmed the amorphous dispersion of NH within lipid bilayers, with complete elimination of crystalline diffraction peaks, indicative of molecular-level interactions between NH’s hydroxyl groups and phospholipid polar moieties. The engineered nanosystems demonstrated remarkable solubility enhancement, achieving 321.77 μg/mL (NH-PC) and 318.75 μg/mL (NH-PC-CD), representing 2.01- and 1.99-fold increases over free NH. Encapsulation efficiencies exceeded 95% for both formulations, with sustained release profiles revealing 60.81% (NH-PC) and 80.78% (NH-PC-CD) cumulative release over 72 h, governed predominantly by non-Fickian diffusion kinetics. In vitro gastrointestinal simulations highlighted superior bioaccessibility for NH-PC-CD (66.35%) compared to NH-PC (58.52%) and free NH (20.85%), attributed to enhanced stability against enzymatic degradation. Storage stability assessments further validated the robustness of HP-β-CD-modified liposomes, with NH-PC-CD maintaining consistent particle size (<3% variation) and encapsulation efficiency (>92%) over 30 days. Antioxidant evaluations demonstrated concentration-dependent DPPH radical scavenging, wherein nanoencapsulation significantly amplified NH’s activity compared to its free form. This study establishes a paradigm for dual-functional nanocarriers, offering a scalable strategy to optimize the delivery of hydrophobic nutraceuticals while addressing critical challenges in bioavailability and physiological stability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2019
·Vol. 11
·期 10
·1716
·
IF 3.164
Feng Guo,Guiying Li,Songmei Ma,Hengquan Zhou,Xinyi Chen
A temperature, glutathione (GSH), and H2O2multi-responsive composite nanocarrier (MSN-SS-Fc@β-CD-PNIPAM) based on β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star polymer capped ferrocene modified mesoporous silica nanoparticles (MSN-SS-Fc) was successfully prepared. The surface of the mesoporous silica was first modified by ferrocene (Fc) via a disulfide bond (–SS–) to form an oxidizing and reducing site and then complexed with a β-CD-PNIPAM star shaped polymer through host–guest interactions as a nano-valve to provide temperature responsive characteristics. The structure and properties of the complex nanoparticles were studied by FTIR, TGA, EDS, Zeta potential, and elemental analysis. Doxorubicin (DOX) and Naproxen (NAP), as model drugs, were loaded into nanocarriers to assess drug loading and release behaviour. The release of drugs from nanocarriers was enhanced with an increase of the GSH, H2O2concentration, or temperatures of the solution. The kinetics of the release process were studied using different models. This nanocarrier presents successful multi-stimuli responsive drug delivery in optimal stimuli and provides potential applications for clinical treatment.Keywords:disulfide bond;ferrocene;multi-responsive;nanocarrier;MSNs
研究领域:
材料科学
·
药物递送
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2016
·
IF 2.848
Jia-liang Lv,Shang-ru Zhai,Yuan Fan,Zhi-min Lei,Qing-da An
There is an interesting but challenging task to develop a facile and cost-effective procedure for the making of multifunctional bio-adsorbents for environmental applications. Herein, low-temperature solution-carbonized rice husk (RH-c), β-cyclodextrins (β-CD) and Fe 3 O 4 were synergically combined to prepare a new kind of multifunctional bioadsorbent, i.e . RH-c/Fe 3 O 4 /CD, and applied for the adsorption of methylene blue (MB) from aqueous solution. The structure, morphology and magnetic properties were characterized by powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), 13 C nuclear magnetic resonance spectra (NMR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM) techniques. Initial concentration of MB, contact time, pH effect, adsorption mechanisms and recycling test were also thoroughly investigated. The adsorption equilibrium data was best fitted by Langmuir isotherm model and the adsorption kinetics followed pseudo-second-order models for all samples. The maximum capacity predicted by the Langmuir model is 359.8 and 438.6 mg/g for RH-c/Fe 3 O 4 /CD and RH-c/CD2, respectively. The adsorption test suggested that resulting multifunctional RH-c/Fe 3 O 4 /CD is a promising bioadsorbent for dye molecules removal from aqueous system.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Shengmei Tai,Zhijuan Qian,Hongxin Ren,Alberta Osei Barimah,Chifang Peng,Xinlin Wei
A colorimetric assay based on an enzyme-inhibition strategy is promising for the on-site detection of pesticide residues . However, very few works of pesticide detection were reported based on the inhibition toward nanozymes although nanozymes have demonstrated many advantages in sensing various targets. Herein, a facile colorimetric detection for Glyp was developed based on β [email protected] enzyme mimics. The β [email protected] with high peroxidase-like activity was synthesized using random DNA double strands as template and β -CD as surface ligand. β [email protected] could catalyze the H 2 O 2 -3,3′,5,5′-tetramethylbenzidine (TMB) system. The oxidation product OxTMB with a blue color and presented a large absorption signal at 652 nm. However, Glyp could destroy the synergic effect between redox doublet (Cu 2+ /Cu + ) on the β [email protected] A-CuNCs surface, resulting in the inhibition of the peroxidase-like activity. Colorimetric detection for Glyp could be established by detecting the changes of absorption signal at 652 nm. The linear range was 0.02–2 μ g/mL and the detection limit was 0.85 ng/mL (3δ/s). The method was applied in measuring Glyp spiked in lake water and various food samples. This method had rapidness, high sensitivity, and selectivity advantages, indicating the high application potential in monitoring Glyp residue in food.
研究领域:
分析化学
·
环境科学
·
食品安全
·
农业化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 2
·662
·
IF 4.6
Xiaoyan Ran,Ping Guo,Caifang Liu,Yulan Zhu,Cheng Liu,Bangjin Wang,Junhui Zhang,Shengming Xie,Liming Yuan
The chiral covalent-organic framework (CCOF) is a new kind of chiral porous material, which has been broadly applied in many fields owing to its high porosity, regular pores, and structural adjustability. However, conventional CCOF particles have the characteristics of irregular morphology and inhomogeneous particle size distribution, which lead to difficulties in fabricating chromatographic columns and high column backpressure when the pure CCOFs particles are directly used as the HPLC stationary phases. Herein, we used an in situ growth strategy to prepare core–shell composite by immobilizing MDI-β-CD-modified COF on the surface of SiO2-NH2. The synthesized MDI-β-CD-modified COF@SiO2was utilized as a novel chiral stationary phase (CSP) to explore its enantiomeric-separation performance in HPLC. The separation of racemates and positional isomers on MDI-β-CD-modified COF@SiO2-packed column (column A) utilizing n-hexane/isopropanol as the mobile phase was investigated. The results demonstrated that column A displayed remarkable separation ability for racemic compounds and positional isomers with good reproducibility and stability. By comparing the MDI-β-CD-modified COF@SiO2-packed column (column A) with commercial Chiralpak AD-H column and the previously reported β-CD-COF@SiO2-packed column (column B), the chiral recognition ability of column A can be complementary to that of Chiralpak AD-H column and column B. The relative standard deviations (RSDs) of the retention time and peak area for the separation of 1,2-bis(4-fluorophenyl)-2-hydroxyethanone were 0.28% and 0.79%, respectively. Hence, the synthesis of CCOFs@SiO2core–shell composites as the CSPs for chromatographic separation has significant research potential and application prospects.Keywords:chiral covalent-organic frameworks;core–shell composites;high-performance liquid chromatography;chiral separation
研究领域:
化学
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS
·
2016
·Vol. 16
·期 8
·1241
·
IF 2.033
Jing Liu,Haoyuan Cai,Chaoyang Chen,Guangsong Yang,Cheng-Fu Yang
In this study, the hybrid Au–Ag hexagonal lattice of triangular and square lattice of quadrate periodic nanoparticle arrays (PNAs) were designed to investigate their extinction spectra of the localized surface plasmon resonances (LSPRs). First, their simulating extinction spectra were calculated by discrete dipole approximation (DDA) numerical method by changing the media refractive index. Simulation results showed that as the media refractive index was changed from 1.0 to 1.2, the maximum peak intensity of LSPRs spectra had no apparent change and the wavelength to reveal the maximum peak intensity of LSPRs spectra was shifted lower value. Polystyrene (PS) nanospheres with two differently arranged structures were used as the templates to deposit the hybrid Au–Ag hexagonal lattice of triangular and square lattice of quadrate periodic PNAs by evaporation method. The hybrid Au–Ag hexagonal lattice of triangular and square lattice of quadrate PNAs were grown on single crystal silicon (c-Si) substrates, and their measured extinction spectra were compared with the calculated results. Finally, the fabricated hexagonal lattices of triangular PNAs were investigated as a sensor of polychlorinated biphenyl solution (PCB-77) by observing the wavelength to reveal the maximum extinction efficiency (λmax). We show that the adhesion of β-cyclodextrins (SH-β-CD) on the hybrid Au–Ag hexagonal lattice of triangular PNAs could be used to increase the variation ofλmax. We also demonstrate that the adhesion of SH-β-CD increases the sensitivity and detection effect of PCB-77 in hexagonal lattice of triangular PNAs.Keywords:hybrid Au–Ag periodic nanoparticle arrays;discrete dipole approximation (DDA);sensor;β-cyclodextrins (SH-β-CD);polychlorinated biphenyl
研究领域:
纳米技术
·
分析化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）