Science China-Life Sciences
·
2020
·Vol. 64
·期 3
·434-442
·
IF 4.611
Yu Guangshun,Feng Na,Zhao Dan,Wang Hao,Jin Yi,Liu Dandan,Li Zhenhua,Yang Xinjian,Ge Kun,Zhang Jinchao
Excessive reactive oxygen species (ROS) would attack living cells and cause a series of oxidative stress related diseases, such as liver damage. Hydroxyl radicals (·OH) are currently known as one of the most toxic and harmful free radicals to organisms. Therefore, studies involving hydroxyl radicals have become important research topics in the fields of biology, biochemistry, and biomedicine. In addition, imaging of analytes using upconversion nanoparticles (UCNPs) possesses significant advantages over that using general fluorescent dyes or nanoparticles due to its high spatial resolution, reduced photodamage, and deep tissue penetration properties. Herein, we designed a highly selective and sensitive hydroxyl radical nanoprobe based on the luminescence resonance energy transfer between upconversion nanoparticles and methylene blue (MB). The concentration of ·OH could be determined by the fluorescence recovery of the UCNPs due to the oxidative damage of MB. Using this nanoprobe, the ·OH in living cells or in liver tissues could be monitored with high sensitivity and selectivity.
研究领域:
生物化学
·
生物医学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 9
·6563-6575
·
IF 2.779
Li Jie,Xu Sai,Yu Yang,Liu Kaiying,Gao Yuefeng,Chen Baojiu
Multifunctional nanoparticles with marvelous temperature sensing and photothermal conversion are preferable in photothermal therapeutic applications. Herein, nanocomposites of NaYF 4 :Er 3+ /Yb 3+ @NaYF 4 :Nd 3+ /Yb 3+ core–shell upconversion nanoparticles (UCNPs) modified by polydopamine (PDA) were designed to achieve temperature sensing and efficiency of photothermal conversion. It has been found that under the irradiation of 808 nm laser, temperature sensing can be realized on the basis of the fluorescence intensity ratio of Er 3+ green light emission. In addition, the photothermal conversion ability of the UCNPs modified by PDA is greatly improved. Moreover, Nd 3+ as activator endows UNCPs excited by 808 nm, which can avoid overheating due to the absorption of the excitation band (980 nm) in water. Therefore, the multifunctional nanoparticles are expected to become an effective drug for cancer therapy in the future and this research will stimulate interest in designing multifunctional nanoparticles that are biocompatible, especially for in vivo tumor diagnosis.
研究领域:
生物医学工程
·
材料科学
·
纳米医学
✓ 已验证
DOI
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 31
·期 14
·145504
·
IF 3.551
Zixiao Zhao,Jiawei Shen,Min Wang
Numerous investigations have been devoted to visualizing latent fingerprints (LFPs) for personal identification in forensic investigation and age estimation. While simultaneous detection of chemicals in fingerprint residues has yet to be explored. Herein, fluorescent NaYF4:Yb/Tm up-conversion nanoparticles (UCNPs), which can emit blue fluorescence upon 980 nm near-infrared irradiation, have been employed in the imaging of LFPs with high contrast and high sensitivity. The furrows and ridges which provide detailed information of LFP have been displayed clearly by Tm-doped UCNPs. Meanwhile, the quantitation of nicotine residue in LFPs has been achieved based on the blue fluorescence absorbed by I2-nicotine complex, and the data was analyzed by MATLAB with modified OPTA algorithm. It was proved that the established strategy was specific, sensitive, reliable and practical toward nicotine residue in LFPs with a detection limit of 0.05 μg.
研究领域:
法医学
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材料科学
·
化学分析
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hongchao Geng,Rongfu Peng,Junning Wang,Yuting Dong,Yuzhang Yan,Jiahui Dong,Linlang Xu,Haiyan Kang,Xu Yan,Xia Zhang,Chaopeng Wang,Yanli Mao
The development of high-performance near-infrared (NIR) photocatalysts with long-term stability broaden the range of light absorption and improve the utilization rate of solar energy have not been explored sufficiently. Herein, a novel hybrid material of upconversion nanoparticle (NPs) CaF 2 : Yb, Er, Tm decorated with TiO 2 and Au NPs has been synthesized by a simple and robust solvothermal route for NIR light active photocatalysis. It has been found that effective energy transfer occurred from CaF 2 : Yb, Er, Tm to TiO 2 and Au NPs by a nonradiative luminescence resonance energy transfer process. The enhanced activity is attributed to the nanostructured architecture that favors the efficient charge transfer and the localized surface plasmon resonance effects of Au NPs. Thus, the heterojunction showed the synergetic effects of both upconversion and localized surface plasmon resonance features, which could broaden the absorption spectrum to the NIR. Our work demonstrates that CaF 2 :Yb,Er,Tm@TiO 2 -Au could be potential candidates for NIR active photocatalysts for environmental applications.
研究领域:
材料科学
·
光催化
·
纳米技术
·
环境科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Hua Yan,Chunfei Dai,Xingkun Luan,Hang Li,Chen Wang,Xiaona Li,Xuezhong Du
Multimodal tumor therapy based on “all-in-one” nanoplatforms enhances therapeutic efficacy, simplifies the construction process, and improves material utilization. Elemental selenium was successfully supported on upconversion nanoparticles (UCNPs) to constitute the near-infrared (NIR) light-responsive UCNP@Se heterostructures for the first time. Under 980 nm irradiation, the UCNP@Se heterostructures could not only produce holes and superoxide radicals •O2– but also catalyze the generation of hydroxyl radicals •OH by highly elevated levels of H2O2 in tumor cells to kill the tumor cells. In addition to the superior photocatalytic performance, elemental selenium itself also exhibited inherent inhibition activity against tumor cells. On the basis of the binding of anthracycline anticancer drugs such as doxorubicin (DOX) to the supported elemental selenium through Cu2+ bridging coordination, the UCNP@Se–Cu-DOX drug delivery system was constructed. The introduction of Cu2+ not only improved the efficient loading of DOX but also achieved the “AND” logic-controlled release of DOX under the combined stimuli of low pH and overexpressed glutathione (GSH) in tumor cells. Moreover, the loaded Cu2+ reacted with the overexpressed GSH to generate the active species CuII-GSSG upon NIR light irradiation, which further promoted tumor cell apoptosis. The NIR light-responsive UCNP@Se–Cu-DOX drug delivery system achieved the combination tumor therapy of selenium therapy, photocatalytic therapy, and logic-gated chemotherapy and has great potential applications in tumor therapy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Chunyan Zhang,Zhendong Fu,Feng Hong,Ge Pang,Tengri Dong,Yunxiao Zhang,Guixia Liu,Xiangting Dong,Jinxian Wang
Broad spectrum response photocatalyst is crucial for making full use of sunlight and widely used in efficient photocatalytic degradation of organic dyes. In this work, upconversion luminescence boosted broadband photocatalysts based on BiF 3 :Yb 3+ , Er 3+ nanoparticles (BFY) and the carbon nitride doped with various masses of barbituric acid (CNB x ) semiconductor materials (BFY/CNB x ) were successfully designed and produced for photocatalysis in UV–Vis–NIR region. Compared with pure g-C 3 N 4 , BFY/CNB 0.5 composites have better photocatalytic performance attributed to the utilization of broadband spectrum energy and effective charge separation. After 30 min illumination by visible light , photodegradation efficiency of RhB reaches about 99.4% by using BFY-2/CNB 0.5 . A plot of C/C 0 versus time indicates that the BFY-2/CNB 0.5 can degrade about 64.7% of RhB in 80 min by NIR irradiation. Under simulated solar light, the sample of BFY-2/CNB 0.5 reaches a maximum degradation efficiency of 98.0% within 15 min. The strengthened photocatalytic activity is due to the synergistic effect of CNB 0.5 and upconversion materials. The active species utilized in the degradation process were examined using capture experiments. After four continuous photocatalytic cycles, about 94.0% of RhB solution is degraded. The photocatalytic mechanism of the composite photocatalysts is also analyzed in detail. The results indicate that the prepared BFY/CNB 0.5 photocatalysts have good prospects in the field of environmental remediation.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
·
2020
·Vol. 646
·期 19
·1607-1610
·
IF 1.24
Cong Cao,Chang Hong,Yu Li,Guangshen Li,Guohua Jiang
Lanthanide doped upconversion luminescent nanoparticles (UCNPs) have drawn widely attention in biomedical research. The generally synthesized oleate capped UCNPs have no aqueous dispersibility so that surface modification is required to be water dispersible. Herein, we developed an easy-going but effective approach to prepare hydrophilic UCNPs based on oxidized alginate molecule (OAlg). After surface modification treatment, the OAlg modified UCNPs (UCNPs-OAlg) shows excellent dispersibility and longer stability in aqueous solution even after 180 days. After incubation with UCNPs-OAlg, the upconversion luminescent images of living Hela cells were clearly obtained. It indicated that oxidized alginate modified UCNPs can be candidate for excellent imaging probes in future.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 28
·17212-17221
·
IF 3.361
Haining Song,Yifei Zhou,Zexin Li,Haifeng Zhou,Fenglei Sun,Zhenlei Yuan,Peng Guo,Guangjun Zhou,Xiaoqiang Yu,Jifan Hu
Dual-function and multi-function sensors can use the same material or detection system to achieve the purpose of detection of two or more substances. Due to their high sensitivity and specificity, dual-function and multi-function sensors have potential applications in many fields. In this article, we designed a dual-function sensor to detect Sn(II) and ascorbic acid (AA) based on the inner filter effect (IFE) between NaYF4:Yb,Er@NaYF4@PAA (UCNPs@PAA) and Fe(II)–1,10-phenanthroline complex. Fe(II)–1,10-phenanthroline complex has strong absorption in most of the ultraviolet-visible light range (350 nm–600 nm), and this absorption band overlaps with the green emission peak of UCNPs@PAA at 540 nm; Fe(II)–1,10-phenanthroline complex can significantly quench the green light emission of UCNPs@PAA. When Sn(II) or AA is added to the UCNPs@PAA/Fe(III)/1,10-phenanthroline, they can reduce Fe(III) to Fe(II). Fe(II) can react with 1,10-phenanthroline to form an orange complex, thereby quenching the green light emission of UCNPs@PAA. And the quenching efficiency is related to the concentration of Sn(II) and AA; there is a linear relationship between quenching efficiency and the concentration of Sn(II) and AA, within a certain concentration range the detection limits of this dual-function sensor for Sn(II) and AA are 1.08 μM and 0.97 μM, respectively. In addition, the dual-function sensor can also detect Sn(II) and AA in tap and spring water.
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2019
·Vol. 30
·期 6
·1906137
·
IF 15.621
Qiuhong Min,Jing Lei,Xin Guo,Ting Wang,Qihua Yang,Dacheng Zhou,Xue Yu,Siu Fung Yu,Jianbei Qiu,Qiuqiang Zhan,Xuhui Xu
Lanthanide-doped upconversion nanoparticles (UCNPs) have significant applications for single-molecule probes and high-resolution display. However, one of their major hurdles is the weak luminescence, and this remains a grand challenge to achieve at the single-particle level. Here, 484-fold luminescence enhancement in LuF 3 :Yb 3+ , Er 3+ rhombic flake UCNPs is achieved, thanks to the Yb 3+ -mediated local photothermal effect, and their original morphology, size, and good dispersibility are well preserved. These data show that the surface atomic structure of UCNPs as well as transfer from amorphous to ordered crystal structure is modulated by making use of the local photothermal conversion that is generated by the directional absorption of 980 nm light by Yb 3+ ions. The confocal luminescence images obtained by super-resolution stimulated emission depletion also show the great enhancement of individual LuF 3 :Yb 3+ , Er 3+ nanoparticles; the high signal-to-noise ratio images indicate that the laser treatment technology opens the door for single particle imaging and practical application.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
Yana Liu,Cheng Zhang,Hui Liu,Yuebin Li,Zushun Xu,Ling Li,Andrew Whittaker
Rare-earth doped up-conversion nanoparticles (UCNPs) with high uniformity and dispersibility were synthesized by a facile solvothermal method. The conditions of synthesis for NaYF 4 :Yb/Tm were explored, and the NaYF 4 :Yb/Tm particles with the optimal size (about 300 nm) were obtained. Blue emission was observed with the excitation 980 nm near infrared (NIR) laser, indicating that the UCNPs can be potentially used for up-conversion luminescence (UCL) imaging. On basis of the optimal UCNPs, further coated by poly (ethylene glycol) (PEG) functionalized metal-organic frameworks (MOFs), a multifunctional platform UCNPs@MIL-PEG for cancer diagnosis and treatment was established. The core-shell structure was confirmed by TEM images. Doxorubicin (DOX) was selected as drug model and the drug loading of UCNPs@MIL-PEG was found to be 60%. Cytotoxicity indicated that UCNPs@MIL-PEG were highly biocompatible. The DOX release in different pH value revealed an excellent pH-triggered drug release. In addition, the UCNPs@MIL-PEG nanoparticles can be tracked by magnetic resonance imaging (MRI). A clear dose-dependent contrast enhancement in T 2 -weighted MR images indicated the potential act as T 2 MRI contrast agents. The UCNPs@MIL-PEG nanoparticles are expected to be simultaneously used for UCL/MR dual-mode imaging and pH-responsive drug release.
研究领域:
生物医学工程
·
纳米医学
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2018
·
IF 4.484
Tao Wang,Haifeng Zhou,Zhichao Yu,Guangjun Zhou,Juan Zhou,Dapeng Huang,Leilei Sun,Peng Gao,Yuzhen Sun,Jifan Hu
NaGdF4: A (A = Eu, Tb)@NaGdF4: Yb, Tm@NaGdF4: Yb, Nd core–shell–shell is designed to achieve 808 nm excited upconversion emission tuning. On the basis of the above core–shell–shell nanostructure, intense upconversion emission has been realized for activators without long-lived intermediate states (Eu3+, Tb3+) through Gd3+-mediated energy migration under 808 nm irradiation, enriching the emission colors. The spatial separation, where sensitizer (Nd3+), accumulator (Tm3+), and activator (Eu3+, Tb3+) are doped into separated layers, effectively suppresses nonradiative decays so that the doping concentration of Nd3+ can reach to 40%, vastly enhancing the luminescence intensity. Notably, when Gd3+ ions are replaced by Nd3+ or inert Y3+ in NaGdF4: Yb, Nd outer shell, without Gd3+-mediated energy migration, the deleterious energy transfer from Tm3+ in the interlayer to surface quenchers is suppressed, and thus, more active energy is trapped by activators, which induces the further change of upconversion emission color. Furthermore, the multicolor upconversion tuning can also be realized via Tb3+-mediated energy migration. 808 nm excited multicolor upconversion tuning, overcoming low tissue penetration and overheating effect under 980 nm excitation, improves the feasibility of upconversion nanoparticles in multicolor imaging and multiplexed detection areas.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2020
·
IF 5.115
Yanchun Wei,Sen Liu,Changjiang Pan,Zhongmei Yang,Ying Liu,Jianfang Yong,Li Quan
Background Photothermal therapy with accurate and real-time temperature detection is desired in clinic. Upconversion nanocrystals (UCNs) are candidate materials for simultaneous temperature detection and photothermal agents carrying. However, the weak luminescence and multiple laser excitations of UCNs limit their application in thermal therapy.Materials and Methods NaYF4:Yb3+,Er3+,Nd3+, PL-PEG-NH2, IR-806 and folic acid are selected as structural components. A nanoprobe (NP) integrated with efficient photothermal conversion and sensitive temperature detection capabilities is synthesized for precise photothermal therapy. The probes are based on near-infrared upconversion nanocrystals doped with Yb, Er and Nd ions, which can be excited by 808 nm light. IR-806 dye molecules are modified on the surface as molecular antennas to strongly absorb near-infrared photons for energy transfer and conversion.Results The results show that under an 808 nm laser irradiation upconversion luminescence of the nanocrystals is enhanced based on both the Nd ion absorption and the FRET energy transfer of IR-806. The luminescence ratio at 520 and 545 nm is calculated to accurately monitor the temperature of the nanoparticles. The temperature of the nanoprobes increases significantly through energy conversion of the molecular antennas. The nanoparticles are found successfully distributed to tumor cells and tumor tissue due to the modification of the biocompatible molecules on the surface. Tumor cells can be killed efficiently based on the photothermal effect of the NPs. Under the laser irradiation, temperature at mouse tumor site increases significantly, tissue necrosis and tumor cell death can be observed.Conclusion Precision photothermal therapy can thus be achieved by highly efficient near-infrared light absorption and accurate temperature monitoring, making it promising for tumor treatment, as well as the biological microzone temperature detection.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）