Cancer Medicine
·
2026
·Vol. 15
·期 8
·e72212
·
IF 3.5
Yanmin Zhang,Yaxi Shi,Wenlong Bai
Advanced epithelial ovarian cancer responds poorly to current treatments, creating an urgent need for novel therapeutic strategies. 1,25-dihydroxyvitamin D 3 (1,25D 3 ) exerts potent anti-proliferative effects on ovarian cancer cells in vitro, but the concentrations required for growth suppression in cell culture are not readily achievable in vivo, and higher doses induce hypercalcemia, which hinders its clinical translation. Sodium selenite (Na 2 SeO 3 ) has been identified as a chemopreventive agent that inhibits the growth of multiple cancer types. In this study, we demonstrated that combined treatment with Na 2 SeO 3 and 1,25D 3 exerts enhanced anti-proliferative efficacy against ovarian cancer cells both in vitro and in vivo. Specifically, 1,25D 3 upregulated the expression of vitamin D receptor (VDR) and Selenoprotein-P1 (SEPP1), and this effect was further enhanced by Na 2 SeO 3 co-treatment. Consistently, Na 2 SeO 3 augmented the suppressive effect of 1,25D 3 on ovarian cancer cell proliferation, demonstrating synergistic inhibitory activity. Notably, knockout (KO) of either VDR or SEPP1 abrogated this synergistic effect. Mechanistic investigations confirmed that SEPP1 is a direct target gene of VDR, and functional vitamin D response elements (VDREs) are present within its genomic locus. In vivo, low-dose 1,25D 3 (0.3 μg/kg) combined with Na 2 SeO 3 outperformed 1,25D 3 monotherapy, with no significant hypercalcemia, ascites formation, or metastasis observed throughout the treatment period. These findings indicate that Na 2 SeO 3 acts in combination with 1,25D 3 to induce SEPP1 expression, thereby enhancing the antitumor efficacy of low-dose 1,25D₃ against ovarian tumors. This study provides a promising strategy for the safe and effective application of 1,25D 3 in ovarian cancer therapy.
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Acta Biomaterialia
·
2026
·
IF 10.4
Hao Zhang,Yining Wang,Tian Deng,Jiahui Peng,Xiaxin Ye,Xing Zeng,Jingjing Zhu,Linzhe Huang,Xiaoming Zheng,Yun Li,Yang Kang
Sepsis is a serious syndrome characterized by acute dysfunction of multiple organs, and there is a notable lack of effective preventive strategies and interventions. As a natural anti-inflammatory and antioxidant feedback regulator in the body, itaconic acid can precisely and synergistically modulate anti-inflammatory and antioxidant effects through various mechanisms, providing a metabolic regulation strategy for inflammatory diseases and diseases related to oxidative damage. Previous studies primarily utilized small molecule derivatives of itaconate, such as dimethyl itaconate (DMI) and itaconate 4-octyl ester. However, their in vivo stability and tissue targeting capabilities are often suboptimal, significantly reducing their anti-inflammatory and antioxidant efficacy in disease treatment. Poly itaconic acid (pIA) was synthesized through a one-step polymerization method, and pIA NPs were prepared using nanoprecipitation, effectively addressing the current challenges associated with itaconic acid delivery. Through comprehensive in vitro and in vivo evaluations, the nanoparticles have demonstrated good biocompatibility in the inflammatory microenvironment and can specifically release, thereby enhancing its targeting at the sites of inflammation. In contrast to dimethyl itaconate, pIA NPs exhibited enhanced anti-inflammatory and antioxidant properties, which more effectively safeguard against multi-organ dysfunction caused by sepsis and increase the survival rate in mice. Mechanistic investigations demonstrated that these therapeutic benefits mainly occurred through the facilitation of nuclear factor erythroid 2-related factor 2 nuclear translocation and the reprogramming of macrophages by pIA NPs. Furthermore, the preparation process of the nanoparticles are simple and cost-effective, providing a foundation for the clinical translational application of itaconic acid. Statement of significance This work innovatively developed a simple, safe esterase-responsive polymer delivery system for itaconic acid, solving defects of complex preparation, poor stability and targeting of conventional systems. It advanced sepsis therapy and macrophage metabolic regulation research. For journal readers, it links nanomedicine, immunometabolism and sepsis treatment, providing valuable insights for researchers in inflammatory diseases and drug delivery. Download: Download high-res image (236KB) Download: Download full-size image
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POLYMER COMPOSITES
·
2025
·
IF 4.7
Boyin Yang,Zilong Jiang,Yang Yang,Bo Jiang,Hong Gao,Yingshuang Shang,Haibo Zhang
Interface thermal resistance is the key factor in influencing the thermal conductivity of filler-reinforced composites. Building a covalent-bond bridge between the resin and filler effectively reduces the interface thermal resistance by creating thermal transmission pathways. A covalent-bonded poly (ether-ether-ketone)/boron nitride (PEEK/BN) composite (i-PEEK/BNNS-FOH) was prepared by functionalizing BN and incorporating it into the in situ polymerization process. With an addition of 30 wt% functionalized BN, the thermal conductivity of i-PEEK/BNNS-FOH reached 1.79 W m −1 K −1 , an increase of 12% over ungrafted PEEK/BN. Foygel's model calculations proved that the modification of BN reduced interface thermal resistance by 48%. Additionally, the improved interface contributed to better mechanical properties, reaching a tensile strength of 97 MPa with a 10 wt% filler addition. This covalent-bond bridging strategy highlights modified BN fillers for high-temperature applications and an efficient method for the preparation of thermally conductive special engineering plastics.
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CHIRALITY
·
2025
·Vol. 37
·期 7
·e70043
·
IF 3
Min Wei,Yinxin Yang,Ruoxi Huang,Linxu Dong,Haikuan Yuan,Lijuan Zhang,Jie Lu
In this work, a novel pair of chiral ionic liquids (CILs) based on cis- and trans-myrtanol was designed, synthesized, and applied in the enantioselective liquid–liquid extraction (LLE) of DL-3-phenyllactic acid (DL-3-PLA). DL-3-PLA, a naturally occurring broad-spectrum antimicrobial compound, exhibits distinct biological activities in its enantiomeric forms, making its separation of significant interest for pharmaceutical and food applications. The CILs were synthesized starting from (1S)-(−)-β-pinene via oxidative hydroboration, followed by subsequent functional group modifications, and were fully characterized using 1 H NMR, FTIR, DSC, and TGA. Optimization of the LLE parameters (0.10-M CILs in n-octanol, 0.10-M DL-3-PLA in water, pH 6.8, 298.15 K) yielded a single-stage enantiomeric excess ( ee ) of 15.68%. Using five consecutive extractions with the trans-CILs isomer, a cumulative ee of 95.18% was achieved. Quantum mechanical calculations, including electrostatic potential analysis, IGMH isosurface mapping, and binding energy evaluations, revealed that both the cis- and trans-CILs isomers exhibited strong chiral recognition toward D-3-PLA, with the trans-CILs isomer showing superior recognition performance compared to the cis-CILs isomer. These results underscore the potential of the designed CILs as effective chiral selectors for the DL-3-PLA separation and provide a promising strategy for practical applications in enantioselective separations.
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POLYMER COMPOSITES
·
2025
·
IF 4.7
Yang Zheng,Guanghong Du,Yi Sun,Jiachen Wang,Wei Liu,Guanghui Cui,Zhanpeng Wu
Carbon fiber-reinforced polymer composites are commonly used in ablative materials, but achieving a balance between thermal insulation, mechanical strength, and anti-ablation performance is challenging. This study presents a series of polyphosphazenes with trichloroethoxy substituents, which enhance the mechanical and thermal properties of the synthesized polyphosphazenes. The effects of different types and amounts of fiberized carbon fillers, including carbon fibers, carbon fiber powder, and carbon nanofibers, on the poly[(2,2,2-trichloroethoxy)/(aryloxy)] phosphazene composites were investigated. The composite reinforced with 10 phr (parts per hundred rubber) of fiberized carbon fillers showed a 49.1% reduction in linear ablation rate and 31.4% in charring ablation rate, compared with the baseline. The mechanical properties of the composite and charred layer improved by 57.5% and 215%, respectively. This is due to the fact that the carbon filler facilitates the formation of dense charred layers with low porosity and high graphitization, which prevent heat and flame penetration. The fiberized carbon-reinforced polyphosphazene composites exhibit excellent ablation resistance and mechanical performance, making them ideal for high-performance thermal insulation in extreme conditions.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2025
·
IF 2.2
Meng Zhang,Congyao Wang,Ruiqi Zhao,Jiabo Yuan
Background Asthma is a chronic disease characterized by airway remodeling, which results in a progressive decline in lung function. Senkyunolide A is one of the effective components of ligusticum chuanxiong Hort, it shows protective effects on many human diseases. However, the role of Senkyunolide A in asthma remains unclear. Results In our study, we established an asthma mouse model by ovalbumin (OVA) sensitization and challenge, and Senkyunolide A (20 mg/kg and 40 mg/kg) was given by intraperitoneal injection. For in vitro study, lung epithelial BEAS-2B cells were treated with TGF-β1 to induce epithelial mesenchymal transformation. Our study showed that Senkyunolide A (40 mg/kg) alleviated airway injury, inflammatory infiltration and airway remodeling induced by OVA in asthma mice. Meanwhile, Senkyunolide A (40 μM) recovered the high level of cell migration and profibrotic factors expression induced by TGF-β1. Mechanistically, Senkyunolide A abolished the effect of OVA or TGF-β1 on Smad2/3 phosphorylation at site Ser 465/467 /Ser 423/425 in mice or BEAS-2B cells and inhibited the activation of NLRP3 inflammasome induced by OVA. Conclusions In total, our study indicated that Senkyunolide A alleviated airway damage and airway remodeling in asthmatic mice and regulated the progress of asthma by inhibiting the TGF-β/Smad2/3 signaling pathway and NLRP3 activation.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Jiaxin Qu,Xiaoqing Dang,Li Cao,He Wang,Huachun Zheng,Shuo Ji
The irreversible “heel formation” during cyclic adsorption/vacuum-thermal regeneration of volatile organic compounds (VOCs) on activated carbon reduces adsorption capacity and service life. However, the chemical composition of pore accumulations, their formation mechanisms, and correlations with carbon microstructure remain unclear, limiting VOCs resource recovery and pollution control. In this study, the effect of heel formation on activated carbon adsorbents and the mechanism of heel formation were investigated by repeated cyclic adsorption/vacuum thermal regeneration experiments using xylene as a model pollutant. The results showed that strong chemisorption between xylene and activated carbon adsorbents generated heel buildup (4.26%–5.46%), which caused hindered complete regeneration (retaining 83.8%–90.1% of the capacity in 10 cycles). The decrease in micropore volume (16.4%–39%) of the four activated carbon adsorbents indicated that the heel preferentially accumulated in the micropore. Furthermore, Boehm titration demonstrated a strong correlation between heel buildup and acidic surface oxygen functional groups (SOFGs) for activated carbon, suggesting their primary role in inducing pore accumulation. Thermogravimetric analysis (DTA) and in situ diffuse reflectance infrared Fourier transform spectroscopy (In situ DRIFTs) further clarified that there was a strong chemisorption of acidic SOFGs between the interface of xylene and the adsorbent, leading to the blockage of the pore structure and the occupation of the interfacial adsorption active sites. This study provides critical insights for designing highly efficient and stable adsorbents, advancing VOCs resource recovery and pollution control.
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Human Cell
·
2025
·Vol. 38
·期 6
·1-17
·
IF 3.1
Li Qingsheng,Liu Yuxi,Zhang Lin,Zheng Yi,Feng Xiaofan,Wang Yanjie
The occurrence of tumor metastasis is associated with the phenotype of tumor-associated macrophages (TAMs). Within the tumor microenvironment, TAMs undergo metabolic reprogramming. Aerobic glycolysis contributes to TAM polarization into an M2-like phenotype. Cedrol is a component extracted from herbal medicines. Anti-cancer activities of cedrol have been reported, however, its effect on the metabolic reprogramming and pro-metastatic ability of TAMs remains unclear. Here, we found that cedrol reduced THP-1-derived macrophage polarization into M2-like phenotypes. Cedrol impaired the promoting effects of TAMs on the migration and invasion of lung cancer cells. Tumor metastasis in C57BL/6 mice was reduced following cedrol treatment, accompanied by decreases in M2-like TAMs in the lung tissues. Cedrol treatment decreased glucose consumption and lactate production and downregulated glycolysis-associated gene expression. A glycolytic inhibitor (2-DG) was utilized to confirm that suppression of glycolysis in TAMs limited the metastasis of lung cancer cells. MYC was identified as a downregulated gene in cedrol-treated TAMs based on the mRNA sequencing analysis. MYC overexpression could reverse the effects of cedrol on TAMs. Cedrol treatment reduced MYC expression at least partly via the PI3K-Akt pathway. These findings suggest that cedrol exerts anti-tumor effects by inhibiting TAM polarization into an M2-like phenotype by modulating MYC-mediated aerobic glycolysis, indicating cedrol as a potential drug for lung cancer treatment.
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Foods
·
2025
·Vol. 14
·期 12
·2116
·
IF 5.1
Xianghui Yan,Ting Peng,Zheling Zeng,Pengbo Wang,Yifang Gao,Xuefang Wen,Jiaheng Xia,Deming Gong,Ping Yu
Medium chain triglycerides (MCTs) are regarded as an important ingredient for functional foods and nutraceuticals.Cinnamomum camphoraseed kernel oil (CCSKO) contains more than 95% medium chain fatty acids (MCFAs), which is a significantly higher level than palm kernel oil (62%) and coconut oil (55%). However, the safety assessment of CCSKO, as the only natural MCT oil rich in capric acid and lauric acid found so far in the world, has not been fully verified. The study aimed to investigate the 90-day sub-chronic oral toxicity and teratogenicity of CCSKO. In the sub-chronic oral toxicity study, no clinically significant adverse events occurred in male or female Sprague–Dawley (SD) rats with CCSKO daily administration for 13 weeks. Moreover, there were no dose–response relationships between CCSKO and body-weight gain, food intake and food utilization in male or female SD rats. No significant differences (p> 0.05) were found in the hematological properties or organ weights between the male and female SD rats. In the teratogenicity test, no toxicological signs were observed in either Wister pregnant rats or fetuses. The no-observed-adverse-effect level of CCSKO was determined to be more than 4 mL/kg body weight. These results suggested that CCSKO may be an excellent edible oil with high oral safety.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ciyang Zhang,Tianxiang Hang,Ziwen Shi,Ming Yang,Keren Lu,Haiyan Jing,Mingzhu Xia,Qingli Hao,Xifeng Xia,Wu Lei
Corrosion is one of the major problems affecting the durability and structural integrity of metallic materials, and the addition of various functional factors to epoxy coatings to impart multifunctional properties has been widely used. However, systems that physically mix multiple functional ingredients to achieve a multifunctional coating can lead to inter-ingredient competition, destabilizing the overall properties. This work developed a smart corrosion inhibition system based on ZIF8 encapsulated 1-Aminostyrene derivative (ZIF8@L1) to address these challenges. When corrosion occurs, the change in pH at the corrosion site disrupts the ZIF8 structure, releasing L1, which forms a protective film on the iron surface, effectively slowing down steel corrosion. As corrosion progresses, L1 coordinates with Fe 3+ , resulting in the cleavage of the C-N bond within the Schiff base and the disappearance of the intramolecular charge transfer (ICT) process, leading to fluorescence enhancement, thus enabling real-time visualization of the corrosion area. Experiments have shown that the decomposition products of L1 also have a certain corrosion inhibition effect on iron. To further elucidate the corrosion inhibition mechanism, this study provides an in-depth analysis of the corrosion inhibition effects of the organic small molecules discussed in this paper utilizing various characterization tools and first-principles computational methods. This work proposes an intelligent system that integrates corrosion inhibition, self-healing, and fluorescence tracing, providing a novel perspective for multifunctional intelligent coatings and opening up new pathways for multifunctional composite coatings, which are suitable for a wide range of applications.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Xu Zhang,Hui Wang,Xiangyu Wang,Ning Wang,Xuehua Wu
The liquid organic hydrogen carriers (LOHCs) system has attracted much attention because of its promising characteristics. In this paper, 4-methylindole (4-MID), was selected and studied in hydrogenation and dehydrogenation processes as a potential liquid organic hydrogen carrier (LOHC) because of its theoretical hydrogen storage density of 5.76 wt%, a melting point of 5 °C and a boiling point of 267 °C. Full hydrogenation of 4-MID was carried out over a 5 wt% Ru/Al 2 O 3 catalyst in the range of 160–200 °C at 7 MPa. The results showed that the hydrogenation reaction rate was positively correlated with the temperature, and the apparent activation energy was 67.3 kJ/mol. The structure of the hydrogenation intermediates was calculated to determine a reasonable reaction pathway by means of Material Studio calculations. The full hydrogenation product, was dehydrogenated over a 5 wt% Pd/Al 2 O 3 catalyst in the range of 150–180 °C at 101 kPa. The fully dehydrogenation was accomplished at 150 °C for 70 min. The cycling performance of 4-MID was investigated and it was found that after three cycles, its hydrogenation and dehydrogenation performance was good.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Jinsong Che,Yi Zhang,Shida Li,Xiujuan Li
The antioxidant and anti-inflammatory properties of Xianju wheat paste (XJWP), a traditional condiment originating from Hubei Province, China, were evaluated for the first time. XJWP is an essential appetizer and condiment for local residents. It is also utilized for its anti-inflammatory properties in treating minor wounds in daily life, which suggests that it possesses bioactive properties, notably anti-inflammatory effects. In this study, five extracts of XJWP were obtained using different polar solvents, and all of them exhibited antioxidant activity through DPPH, •OH, ABTS free radical scavenging tests and ferric reducing antioxidant power. Subsequently, a lipopolysaccharide-induced RAW264.7 cell model was established to evaluate their anti-inflammatory effects. All of the XJWP extracts significantly inhibited NO secretion in the cells ( p < 0.05), and ethyl acetate extract (XJ-EA) exhibited the most potent effect characterized by an EC 50 value of 61.92 μg/mL. At a concentration of 40 μg/mL, XJ-EA suppressed the overproduction of TNF-α, IL-6, and IL-1β to normal levels. The in vivo anti-inflammatory activity of XJ-EA was evaluated using a mouse model of ear edema induced by xylene exposure. The result revealed that high-dose XJ-EA reduced the ear edema rate in mice by 56 %, mitigated oxidative damage, inhibited the activity of COX-2 and iNOS, decreased the levels of prostaglandin E2 and NO, and achieved significant anti-inflammatory effects ( p < 0.05). Qualitative analysis identified 21 potential anti-inflammatory components in XJ-EA, and molecular docking studies showed favorable interactions with iNOS and COX-2. These findings provide a theoretical foundation for the development of XJWP as a functional condiment, and even as a natural antioxidant and anti-inflammatory drug resource to improve public health and increase the economic value of this product.
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危险品化学品经营许可证（带存储）