ANALYTICA CHIMICA ACTA
·
2018
·
IF 5.123
Yanan Zhao,Shiying Zou,Danqun Huo,Changjun Hou,Mei Yang,Junjie Li,Minghong Bian
Reliable and simple detection methods for chemotherapeutic agent contaminants, such as methotrexate , are required to minimize their possible toxic threat. However, detecting them remains a challenging in environmental and biological analysis. Here, we developed a fluorescent N, S co-doped carbon quantum dots (N, S co-doped CQDs) probe to detect methotrexate on the basis of the inner filter effect of fluorescence. Under optimized conditions, the fluorescent probe exhibits high sensitivity and specific selectivity with a linear detection range from 0.4 μg/mL to 41.3 μg/mL and a low detection limit of 12 ng/mL (S/N = 3). Further, this N, S co-doped CQDs fluorescent probe can be used to analyze extracellular fluids and wastewater samples satisfactorily, thereby showing a remarkable potential for broad applications in biological molecule determination and environmental analysis .
研究领域:
生物医学
·
环境科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Xin Wang,Yongli Liu,Qingxiang Zhou,Xueying Sheng,Yi Sun,Boyao Zhou,Jingyi Zhao,Jinghan Guo
2,4,6-Trinitrophenol (TNP) has absorbed much concerns because of its toxic effect and threat on the environment, which results from the fact that it is an important and universal reagent widely utilized for manufacturing many products. It is of great necessity to explore facile and efficient methods for monitoring TNP. In present study, carbon dots (CDs), a new carbonaceous nanomaterial with strong fluorescence, was applied to build a novel sensor for highly sensitive and selective detection of TNP. In the sensing procedure, the fluorescence intensity of as-prepared CDs was diminished with the presence of TNP due to inner filter effect (IFE) quenching mechanism. The sensitivity of the fluorescent sensor was very high with limit of detection down to 5.37 ng mL −1 . This fluorescent sensor was evaluated and excellent spiked recoveries were gained, which demonstrated that the developed sensor would be a robust tool for environmental applications.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Xiaohui Peng,Ya Wang,Qingying Wang,Jiaojiao Tang,Maosen Zhang,Xiupei Yang
In this work, sulfur quantum dots (TPA-SQDs) protected by terephthalic acid as a stabilizer were synthesized using a one-pot method. When excited at 310 nm, the synthesized TPA-SQDs solution emitted strong blue fluorescence at 428 nm, and the absolute quantum yield was as high as 85.99%. The proposed SQDs can be used as a fluorescent probe to specifically quench tartrazine (TZ), showing a good linear relationship (R 2 = 0.996) at TZ concentrations of 0.1–20 μM, with a detection limit of 39 nM. By analysing the fluorescence lifetime, UV–Vis absorption spectrum and zeta potential of the assay system, it can be speculated that the fluorescence quenching mechanism of TZ on TPA-SQDs is the inner filter effect (IFE). The proposed method was applied to the detection of TZ in vitamin water and orange juice, and the results were consistent with the determination results by high-performance liquid chromatography. The recoveries and relative standard deviations were 93.2–102.6% and 1.34–2.88%, respectively, which provided an alternative method for the determination of TZ in beverages or other food samples.
研究领域:
分析化学
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食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ANALYTICAL CHEMISTRY
·
2022
·Vol. 77
·期 9
·1141-1146
·
IF 1.237
Peng Fangfang,Zhou Xin,Cheng Wanmin,Ma Jimei,Jiang Hong
Abstract Carbon dots ( CDs ) with yellow-green fluorescence were synthesized by using m -aminophenol and ethylenediamine under mild conditions and applied as a sensor for detecting cysteine ( Cys ). Cys reacted with p -nitrophenyl acrylate via Michael addition and cyclization to form p -nitrophenol ( PNP ) which had the UV absorption maximum at 405 nm. PNP quenched the fluorescence of CDs at the excitation wavelength of 420 nm based on inner filter effect. The fluorescence intensity change of CDs was used as an output signal for Cys detection. The probe detected Cys over homocysteine and glutathione in a solution with high selectivity. The system was highly sensitive to Cys with low limit of detection of 0.8 μM and showed a good linear relationship in the range of 1–50 μM. This carbon dots probe has the potential to be applied in biological analysis.
研究领域:
分析化学
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生物传感
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医学检测
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产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2023
·
IF 3.6
Yongfeng Liu,Xiuwen Shao,Zhaoju Gao,Xiaolin Zhu,Zhangcheng Pan,Yupeng Ying,Jinpeng Yang,Wei Pei,Jia Wang
Sulfur quantum dots (SQDs), as a novel metal-free fluorescent material, are getting increasingly tremendous attention in metal ion detection, especially for Fe 3+ , due to the merits of antimicrobial potential, low toxicity, and exciting optoelectronic properties. However, sensing mechanism of SQD based fluorescent probe for Fe 3+ is not clear yet, and high sensitivity and large detection range remain a challenge. Here, we report the synthesis of hydrophilic SQDs as a fluorescent nanoprobe for Fe 3+ via a fluorescent turn-off mode. We systematically studied the quenching mechanism by ultraviolet–visible absorption spectra , steady-state and time-resolved photoluminescent spectra, and temperature-dependent quenching constants. Results unclearly evidenced the quenching behavior to both inner filter effect and static quenching. Furthermore, the nanoprobe presents a large detection range from 2.5 to 700 μM and a limit of detection low to 53.6 nM, both of which are the record performance to our knowledge. At last, it shows high selectivity toward Fe 3+ and presents no ionic strength effect in the range of investigation, which enables surprising results for Fe 3+ detection in deionized water with interference ion and real water samples.
研究领域:
分析化学
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纳米材料科学
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环境科学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Ting Zhou,Luyao Zang,Junjie Sun,Xia Zhang,Zijie Qu,Xia Liu,Guodong Zhang,Xiufeng Wang,Fang Wang,Zhiqing Zhang
Considering the severe hazard to health posed by nitrophenol (NP) isomers, especially 4-NP, reliable and selective detection strategies are urgently challenged. In this study, a fluorescence platform based on glutathione-stabilized gold/silver nanoclusters (GSH-Au/Ag NCs) and zeolite imidazolate framework material (ZIF-8) was developed for 4-NP detection. The synergistic effect of gold and silver makes the bimetallic nanoclusters (GSH-Au/Ag NCs) much better in optical properties than gold nanoclusters. Subsequently, GSH-Au/Ag NCs with aggregation-induced emission (AIE) effect was encapsulated into ZIF-8 to obtain GSH-Au/Ag NCs@ZIF-8 nanocomposite. Compared with GSH-Au NCs, the fluorescence signal was efficiently further improved nearly 7 times through the confinement effect of ZIF-8, and the fluorescence lifetime was increased from 1.2 μs to 6.9 μs. The addition of 4-NP effectively quenched the fluorescence emission peak of GSH-Au/Ag NCs@ZIF-8 at 600 nm, and the assay exhibited highly sensitivity to 4-NP with the detection limit of 1.11 μM from 2.0 μM to 35 μM. Especially, results showed that 4-NP could be easily discriminated from nitrophenol isomers (3-NP and 2-NP). The mechanism research demonstrated that the absorption curve of GSH-Au/Ag NCs@ZIF-8 + 4-NP overlapped greatly with the fluorescence excitation spectrum of GSH-Au/Ag NCs@ZIF-8, and the fluorescence lifetime of GSH-Au/Ag NCs@ZIF-8 did not change when 4-NP was present or not. Therefore, the mechanism of GSH-Au/Ag NCs@ZIF-8 for 4-NP detection was mainly attributed to the inner filter effect (IFE). Furthermore, the developed detection assay was applied to water sample with satisfactory recovery results, demonstrating its high potential in monitoring 4-NP in environment.
研究领域:
分析化学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Yuan Yan,Jia Hui Liu,Rong Sheng Li,Yuan Fang Li,Cheng Zhi Huang,Shu Jun Zhen
The traditional synthesis methods of carbon dots (CDs) have some disadvantages of complicated operation and a large amount of energy consumption. To address these limitations, we synthesized yellow-green luminescent CDs at room temperature according to the principle of amine-aldehyde condensation in this work. This reaction is simple, economical, energy saving and is extremely consistent with the concept of green synthesis and sustainable development . In addition, studies have found that tetracycline hydrochloride (TC) can quench the fluorescence of the as-prepared CDs through Inner filter effect (IFE). The changes of the fluorescence intensity also have a good linear relationship with the concentration of TC in the range of 10.0–400.0 μM, and the detection limit is 6.0 μM. This method has been successfully used to determine the tetracycline content of tetracycline tablets. Finally, the interaction mechanism between TC and CDs was analyzed and discussed.
研究领域:
分析化学
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环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2012
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IF 3.655
Minwei Zhang,Xianyi Cao,Hongkun Li,Fengrui Guan,Jiajia Guo,Fei Shen,Yeli Luo,Chunyan Sun,Ligong Zhang
A simple, rapid and sensitive fluorescent assay for determination of melamine has been developed based on inner filter effect (IFE) of gold nanoparticles (AuNPs) on the fluorescence of CdTe quantum dots (QDs). When thioglycolic acid-capped CdTe QDs was mixed with citrate-stabilized AuNPs , the fluorescence of CdTe QDs was significantly quenched via the IFE of AuNPs. With the presence of melamine, melamine could induce the aggregation and corresponding absorbance change of AuNPs, which then resulted in the recovery of IFE-decreased emission of CdTe QDs. Under the optimum conditions, the detection limit for melamine in raw milk was 0.02 mg L −1 . The application of this method in samples of melamine-spiked raw milk suggested a recovery between 103% and 104%. Therefore, the obvious merits provided by the present assay, such as simplicity, rapidity, low cost, and high sensitivity, would make it promising for on-site screening of melamine adulterant in raw milk.
研究领域:
食品科学
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
·
2019
·Vol. 30
·期 5
·988-996
·
IF 1.335
Wang Cheng-ya,Shang Shanzhai,Zheng Xudong,Lei Ping,Han Jingmei,Yuan Linda,Li Zhiqiang,Wang Ru,Gong Weimin,Tang Jianguo,Yang Yaling
In this paper, Cu-doped carbon quantum dots (Cu-CQDs) were prepared by carrying out thermolysis of Na2[Cu(EDTA)] and hydroxylamine hydrochloride at 300 ºC for 2 h. The as-prepared Cu-CQDs were characterized by UV-Vis, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). The Cu-CQDs exhibited good fluorescence property, high stability, excitation-dependent emission behavior and a quantum yield of 9.8%. More significantly, the synthesized Cu-CQDs were developed for sensing rutin (RT) based on the fluorescence quenching of the prepared Cu-CQDs. A good linear relationship between the fluorescence quenching of Cu-CQDs and different concentrations of RT was obtained in the range of 0.1-15 µg mL-1 with a correlation coefficient of 0.9959. The detection limit was as low as 0.05 µg mL-1 (signal-to-noise ratio, S/N = 3). The possible mechanism of fluorescence quenching was explored, which was proved to be inner filter effect. Importantly, the proposed method was successfully applied in the detection of RT tablet samples and with satisfactory results, showing the practical applications.
研究领域:
分析化学
·
材料科学
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DOI
高影响因子
ANALYST
·
2020
·Vol. 145
·期 19
·6254-6261
·
IF 3.978
Guoyan Zhang,Meihao Xiang,Rong-Mei Kong,Fengli Qu
Determination of glutathione (GSH) is closely related to the clinical diagnosis of many diseases. Thus, a fluorescent and colorimetric dual-readout strategy for the sensitive determination of glutathione was proposed. The mesoporous silica nanoparticle–gold nanocluster (MSN–AuNC) nanocomposites with significantly enhanced emission and effectively improved photostability characteristics were used as fluorescent probes. Based on the inner filter effect (IFE), the fluorescence of MSN–AuNCs at 570 nm can be effectively quenched by oxidized 3,3′,5,5′-tetramethylbenzidine (oxTMB) with absorption in the wavelength ranges of 330–470 nm and 500–750 nm. However, the addition of GSH could cause the reduction of blue oxTMB to colorless TMB, resulting in the inhibition of IFE and the recovery of the fluorescence of MSN–AuNCs. Therefore, using oxTMB as both quencher and color indicator, a dual-readout oxTMB/MSN–AuNC sensing system for the sensitive determination of GSH was constructed. As signal amplification is caused by the fluorescence enhancement of MSN–AuNCs, the detection limits as low as 0.12 μM and 0.34 μM can be obtained for fluorescent and colorimetric assay, respectively. This method may not only offer a new idea for the sensitive and effective determination of GSH, but also broaden the applications of AuNCs in fluorescent and colorimetric dual-readout bioanalysis.
研究领域:
生物分析化学
·
医学诊断
✓ 已验证
DOI
PubMed
高影响因子
ANALYST
·
2019
·Vol. 144
·期 13
·4006-4012
·
IF 4.019
Haoyu Chen,Li Wu,Yuqi Wan,Lulu Huang,Ningxing Li,Jinyang Chen,Guosong Lai
In this work, a kind of environment-friendly and water-dispersible silicon nanodot (SiND) was rapidly synthesized by using the mild reagents (3-aminopropyl)triethoxysilane (APTES) and glucose. It was found that the fluorescence of the as-prepared SiNDs can be quenched obviously by permanganate due to the inner filter effect. Inspired by this finding, a novel fluorescent sensor for sensitive detection of hydrogen peroxide (H2O2) was developed through the oxidation–reduction reaction between permanganate and H2O2. The detection limit of H2O2 is down to 2.8 nM. Since H2O2 is an important molecule and involved in various studies, this sensor could be applied in various H2O2-related biological analyses. As a proof-of-application demonstration, a sensitive biosensor for glucose detection was constructed through the catalytic oxidation of glucose to generate H2O2. The as-constructed sensor showed good linear response to glucose over the range from 0.16 to 16 μM with a detection limit of 0.11 μM. Moreover, the biosensor can be readily extended to other sensors for different targets, which indicates the broad applications of the proposed sensing strategy in biomedical analysis.
研究领域:
生物化学
·
分析化学
·
生物医学工程
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Yuxin He,Hanting Wang,Yuting Yan,Xinhui Jiang,Hecun Zou,Zhengwei Zhang
Gefitinib, a highly significant antitumor drug, is now commonly employed in clinical settings as a first-line treatment for patients with advanced or metastatic non-small cell lung cancer, colon cancer, and breast cancer. Herein, a convenient, rapid, and accurate fluorescence method based on nitrogen-doped carbon dots (NCDs) was designed for ultrasensitive detection of gefitinib. The NCDs were easily synthesized through one-pot hydrothermal process using p -phenylenediamine and D-glutamic acid as the precursors. The sensing strategy relied on the fluorescence of NCDs at 345 nm, which was selectively reduced by gefitinib based on the inner filter effect (IFE). With a broad linear range of 0.025–30 μg/mL and a low limit of detection of 5.5 ng/mL, the probe was successfully applied to the detection of gefitinib in human serum samples, demonstrating strong practicality, affordability, and high accuracy. The proposed sensor is simple in design, fast in detection and cost-effective, and exhibits promising application in drug real-time analysis.
研究领域:
分析化学
·
药物分析
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）