AIP Advances
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2024
·Vol. 14
·期 8
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IF 1.4
Zheng Yu,Song Rujuan,Wei Shengjie,Dong Lei,Chen Yazhou
Long-term potentiation (LTP) in the Schaffer-CA1 region of the hippocampus is closely related to learning and memory. Magnetic stimulation, as an effective physical means of regulating synaptic plasticity, has received widespread attention. However, research on the mechanism of the effect of different frequencies of magnetic fields (MFs) on LTP is relatively scarce. This article focuses on Ca 2+ , Na + , K + , NMDA receptors, and AMPA receptors that play important roles in the process of MF regulation of LTP. A combined electrophysiological and pharmacological approach was used to identify Ca 2+ as a key factor in the modulation of LTP by MFs of different frequencies. Subsequently, further experiments revealed that low levels of intracellular Ca 2+ concentration ([Ca 2+ ] i ) intensified the inhibition of low-frequency MFs on LTP, while high levels of [Ca 2+ ] i enhanced the promotion effect of high-frequency MFs on LTP, indicating a positive correlation between [Ca 2+ ] i levels and MF regulation of LTP levels. The research results of this article may help explore the deeper relationship between different frequencies of MFs and synaptic plasticity, and they also have a certain reference value for magnetic stimulation therapy in the treatment of neurological diseases related to LTP injury or learning and memory deficits.
研究领域:
神经科学
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医学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Xiaotong Yu,Mengying Xia,Yuanhong Li,Geyun Chen,Chenhao Yu,Qianming Chen,Qiang Peng
Developing the delivery systems with high therapeutic efficacy and low side effects is of great interest and significance for anticancer therapy. Compared to the high cost in synthesizing new chemotherapeutic drugs, exploring the anticancer potentials of existing chemicals is more convenient and efficient. Sodium bicarbonate (BC), a simple inorganic salt, has shown its tumor inhibition capacity via regulating the acidity of tumor microenvironment. However, the effects of intracytoplasmic BC on tumor growth and the potentials of BC to serve as an anticancer agent are still unknown. Herein, we developed a BC-loaded cationic liposome system (BC-CLP) to deliver BC into the cytosol of cancer cells. The in vitro studies showed that the BC-CLP containing 1% BC (w/v) had a size of 112.9 nm and a zeta potential of 19.1 mV, which reduced the viability of the model cancer cells (human oral squamous cell carcinoma HSC-3 cells) to 13.7%. In contrast, the neutral BC-LP caused less than 50% viability reduction. We further found that BC-CLP released BC directly into cytoplasm via membrane fusion pathway rather than endocytosis, leading to the remarkable increase of cytosolic pH, which may contribute to the anticancer effect of BC-CLP. Our findings indicate that BC-CLP is a potential system for high-efficiency cancer therapy without causing drug-related side effects or resistance.
研究领域:
药剂学
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肿瘤学
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药物递送系统
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2024
·Vol. 48
·期 9
·4175-4183
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IF 2.7
Rong Wang,Jin Li,Jia-Jia Chen,Yu Guo,Yue Hu,Xiao-Qi Yu,Ji Zhang
Lipid nanoparticles (LNPs) are the most advanced non-viral platform for nucleic acid delivery, holding enormous potential applications in clinical therapy. However, some shortcomings remain, such as complex synthetic routes, low synthetic yield, and high cost. In this study, a series of lipid molecules with different cationic headgroups and hydrophobic tails were designed and prepared via Passerini reaction, which provided a convenient multi-component one-step synthetic process toward the lipid molecules with variable product structures for structure–activity relationship studies. The LNPs formed from these lipids could compress DNA efficiently and form stable lipoplexes with low cytotoxicity. The gene transfection efficiency was largely affected by the lipid structure including the cationic headgroup and hydrophobic tails. The lipids A3 with equal C14 length tails could induce the highest transfection efficiency, which was up to 25 times higher than Lipo 2000. Compared to the commercial transfection reagent, the efficiency of target LNPs was less negatively affected by serum. Mechanism studies by confocal microscopy and flow cytometry revealed that lipids with equal C14 length tails led to more efficient cellular uptake, which might contribute to their higher transfection efficiency. This study provides a new strategy for the construction of cationic lipid gene vectors for non-viral gene delivery by multi-component Passerini reaction.
研究领域:
生物化学
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分子生物学
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药物递送系统
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Xiaofei Ma,Wenyi Wu,Qin Wang,Jinqiu Xu,Liangliang Cai
This study integrated a chiral selector with micelle pseudostationary phase to develop a novel chiral separation method in capillary electrophoresis. A new type of nanomicelles materials was prepared via amidation reaction using the carboxymethyl-β-cyclodextrin (CM-β-CD) as the hydrophilic group and long chain fatty amines as the hydrophobic group. This novel amide compound self-assembled into nanomicelles in a buffer solution, acting as both a chiral selector and pseudostationary phase. The separations of model drugs were notably improved when compared to the single CM-β-CD system and CM-β-CD/sodium dodecyl sulfate micellar electrokinetic capillary chromatograph system. This study optimized several separation parameters and comprehensively characterized the nanomicelles through several methods such as infrared spectroscopy, nuclear magnetic resonance spectroscopy, particle size determination, and transmission electron microscopy (TEM). Additionally, amlodipine was chosen as the model analyte to determine drug loading in both the single CM-β-CD system and the nanomicelles system using high performance liquid chromatography. The findings indicated that nanomicelles exhibited superior drug loading capacity. The particle size and TEM analysis visually confirmed the distribution of enantiomers in the hydrophobic core of nanomicelles. The proposed nanomicelles showed promise in chiral separation and this strategy opened up new pathways for the development of functional chiral materials.
研究领域:
分析化学
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药学
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2025
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IF 6.2
Cheng Chen,Haoyue Liu,Yutong Wang,Zhiwei Zhang,Yifan Jing,Lixia Jia,Yuanshu Xiao,Guohua Shan,Li Jiang
Carbon nanotubes, carbon nanospheres, long-chain alkyl amine, pentaerythritol-containing compound and branched amino polymer were mixed in ethanol medium without heat; by utilizing the in-situ growth of nanoscale low surface energy granules onto carbon matrix surface via the room-temperature reaction between acrylate-comprising reactant and amino substance, whereafter the hierarchical structural assembly was formed, the carbon nanotubes-based nonfluorinated superlyophobic paint was constructed in the one-pot spontaneous condition. Well-suited spraying technology was used for fixation of as-prepared superwetting paint on cotton textile to create fluoride-free hot-water-repellent cotton fabric coating, its contact angle and sliding angle were 155.0° and 2° tested by 95°C of water. Furthermore, the anti-fouling effect of such coated fabric to 95°C sewage and self-cleaning behavior, by dripping 95°C water onto coating product, were adequately established. Notably, universally applicable fabrication and large-scale formation of the hot-water-repellent coating were also realized, thereinto these coating surfaces of apocynum fabric, glass sheet, cardboard, plastic sheet, cork board and sponge, sprayed by the carbon nanotubes-based superwetting paint, had contact angles over 158° as well as 1° of sliding angles (tested water temperature, 95°C). Beyond that, the cellulose sheet coating, obtained using same strategy as mentioned above, could separate mixture of oil and hot water (55°C), meanwhile its oil-hot water separation flux and efficiency were 9370 L·m −2 ·h −1 and 99.7 %. It is believed that the self-developed carbon nanotubes-based nonfluorinated superwetting special paint product provides robust hot-water-repellent coating that is beneficial to the low-carbon development of hot liquid resistant surfaces with easy operability, environmental sustainability, and durable application.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Siwei Chen,Qingqing Chen,Baogang Wang,Hongsheng Lu
The application of carbon dots (CDs) as lubricant additives of nonpolar oils such as poly-α-olefins (PAOs) has been greatly hindered because most of CDs derived from the bottom-up method were water-soluble. In this work, the oil-soluble polymer brushes grafted CDs were synthesized by the surface-initiated atom transfer radical polymerization of bis-alkyl chain monomers. As expected, the polymer grafted CDs exhibited the excellent long-term dispersion stability in PAO owing to the principle of similar compatibility. As the lubricant additives of PAO4, the CDs showed the best friction-reducing and anti-wear properties when the polymerization time was 2 h. Adding 1 wt% of CDs could make the coefficient of friction and wear volume of PAO4 reduce by 64.1 % and 49.6 %, respectively. Moreover, both the tribological properties and anti-rust performance of CDs were superior to the commercially used ZDDP. The distinguished friction-reducing and anti-wear properties of CDs were attributed to the synergistic lubrication of carbon cores and polymer brushes. The rolling, repairing and polishing action of carbon cores, together with the tribo-reactions of polymer brushes, resulted in the formation of tough lubricating films on the rubbing surfaces, thereby tremendously alleviating the friction and wear of tribopair. The impressive anti-rust performance of CDs could be assigned to their strong adsorption ability on metallic surfaces. The above results are hopeful to provide useful information for the design and development of efficient multifunctional additives such as polymer-grafted metallic or inorganic nanomaterials.
研究领域:
材料科学
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润滑工程
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表面化学
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DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
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2024
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IF 6.5
Xinyuan Wang,Xiaohua Jia,Hongyan Ren,Jin Yang,Haojie Song
Self-cleaning coatings need to have a certain degree of breathability to avoid peeling due to interfacial stress. In this study, a multifunctional superhydrophobic breathable DDA-PDA@BNNS/silicon resin coating is successfully designed by modifying sucrose-assisted exfoliation of boron nitride nanosheets (BNNS) with dodecylamine (DDA) and polydopamine (PDA). The coating shows a contact angle as high as 153.6° and a rolling angle as low as 4.8°, which can effectively avoid the adhesion of solid and liquid contaminants and extend the freezing time of ice up to six times. Meanwhile, the porous network structure of boron nitride nanosheets hardly changes the water vapor transmission rate of the substrate material . The DDA-PDA@BNNS/silicon resin breathable superhydrophobic coating is expected to achieve practical applications in long-lasting self-cleaning and antifouling.
研究领域:
材料科学
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表面工程
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
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2024
·
IF 4.4
Minzhi Chen,Chunlin Fan,Minghao Zhu,Nana Pan,Qi Quan,Xiaoyan Zhou
Wood-based phase change materials (WBPCM) have the potential to significantly reduce energy consumption in plywood structures, but the quest for a streamlined production strategy to facilitate their industrialization remains a formidable challenge. In this work, phase change plywood (PCP) was prepared by phase change adhesive (PCA), in which urea-formaldehyde resin (UF) served as the adhesive and different contents of paraffin wax (PW) as phase change materials (PCM). The use of PCA enabled the efficient and simplified production of wood-based composites with excellent energy-saving properties. By combination of the low thermal conductivity of wood with the energy storage capabilities of PCA, PCP demonstrated a high latent heat capacity of 67.53 J/g at 47.6 °C. 2D correlation Fourier transform infrared (2D FTIR) was carried out to analyze the phase transition mechanism. By adding PCA, the heat transfer time of PCP-3 from 40 to 55 °C was extended by 181%, compared with conventional plywood, which indicated an excellent energy-saving ability. Furthermore, finite element simulation was conducted to statistically simulate the thermal transition process of PCP. Our work presents a strategy for the design of phase change plywood with excellent energy-saving properties, while also enabling large-scale production.
研究领域:
材料科学
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能源工程
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Wanshun Deng,Rui Guo,Gang Wang,Zhixiang Zeng,Tianhui Ren,Shuaijun Pan
Hypothesis With varied affinities for distinct liquids, liquid/solid interfaces can exhibit different stability against external liquids. For liquid-infused Janus membranes with different surface chemistry, there may be significant osmotic pressure gradients across the membrane, facilitating liquid gating of various liquids in diverse systems. Such strategy may highly widen the application areas of liquid gating technology. Experiments Liquid-infused Janus membranes were prepared via the combination of hydroxyapatite (amphiphilic but more water-loving) on one side and 3-(dodecylamino) propane-1-sulfonic acid (amphiphilic but more oil-loving) on the other side and subsequent infusion of various liquids (water or oils). The gating property of them was studied for all the conditions and the application potential in various areas including medical and micro-reaction was also explored. Findings After being infused with certain liquids (i.e., water or oils), the obtained membranes displaying opposite affinity toward water and oils can universally gate immiscible liquids at a high rectification ratio in air and in liquids. The interfacial instability of liquid films on the reverse sides was found to be critical in the achievement of liquid gating. Moreover, such gating property is also applicable in the transportation of various soluble substances (ions and drugs) and facilitating the dislodgement of blood.
研究领域:
材料科学
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生物医学工程
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化学工程
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产品关联
DOI
PubMed
高影响因子
MINERALS ENGINEERING
·
2025
·
IF 5
Xuesong Jiang,Jifei Sun,Boyuan Ban,Ling Wang,Linhua Hu,Jian Chen
This study investigates the novel application of polyetheramine (PEA) as an eco-friendly collector for quartz-mica flotation separation under pH-neutral conditions, focusing on its flotation behavior, adsorption mechanisms, and separation efficacy compared to the conventional dodecylamine (DDA). The single mineral flotation demonstrated the superior selectivity of PEA, achieving an 87 % flotation recovery differential (93 % for quartz vs. 6 % for mica), significantly outperforming the 26 % differential of DDA. The mixed minerals (mass ratio: Quartz/Mica = 2/1) flotation shows that PEA can effectively separate the quartz and the mica. Composition analysis shows that the flotation product phase composition is consistent with the single mineral. The quartz content in the 2nd froth product reaches 95.88 % (78.86 % recovery). The mica content in the sink product reaches 71.19 % (91.09 % recovery). Adsorption test analysis indicates that PEA and DDA are mainly adsorbed on minerals by electrostatic adsorption through the ─NH 3 + group. DFT calculations show that the difference in PEA adsorption energy between the quartz and the mica surfaces is 1.52 eV (DDA is only 0.2 eV). Based on the above results we analyzed the adsorption and separation mechanisms. The findings establish PEA as a sustainable alternative to conventional pH-dependent collectors, eliminating acid/alkali consumption while maintaining high separation efficiency.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Yonggang Du,Yongfei Zhu,Jiayi Li,Yuxuan Li,Jianrui Xiao
Biodegradable and low-cost superhydrophobic absorption materials are still urgently required for the removal of organic compounds from sewage. In this study, sugarcane bagasse (SCB), an abundant and readily available byproduct from sugarcane industries, was used as substrate to fabricate the superhydrophobic adsorbent through a facile dip-coating technique. Firstly, β-FeOOH particles were in-situ grown on the SCB surface, which was further decorated with SiO 2 particles. Next, the modified SCB were coated with benzoxazine based on cardanol and dodecylamine (C D) followed by a thermal curing to obtain a superhydrophobic SCB (PC-D/β-FeOOH@SiO 2 /SCB) with a water contact angle (WCA) of 154°. PC-D/β-FeOOH@SiO 2 /SCB not only exhibited excellent oil absorption capacities in the range of 11.8 to 22.6 g/g for various organic solvents and oils, but also could successfully separate immiscible oil-water mixtures and emulsions with a separation efficiency of over 99.1 %. After 30 cycles of use, the absorption capacity of the modified SCB only displayed a slight decrease and its separation efficiencies for immiscible oil-water mixture, water-in-oil and oil-in-water emulsions are all more than 99.2 %, meanwhile, all these repeatedly used SCB still maintained a superhydrophobicity, demonstrating an outstanding reusability. Moreover, the WCA of PC-D/β-FeOOH@SiO 2 /SCB was still higher than 150 o after 48 h of immersion in HCl, NaOH and NaCl solutions, exhibiting a satisfactory chemical stability. Besides, the prepared SCB also possessed a high photocatalytic degradation activity to methylene blue. Therefore, this work not only provides a sustainable and cheap superhydrophobic absorbent for wastewater treatment, but also presents a route for the better utilization of SCB.
研究领域:
材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2024
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IF 4.4
Ying Bi,Liwu Zu,Zuoyuan Zhang,Lu Zhang,Binhui Zhao,Shanshan Cong,Tianyu Lan,Shaobo Dong,Yazhen Wang,Jiahang Xu
In accordance with the principle of green synthesis, two biobased benzoxazines with high-purity bifunctional groups, diethylstilbestrol-laurylamine (D-la) and diethylstilbestrol-furfurylamine (D-fa), were prepared by the solution method from laurylamine/furfurylamine, diethylstilbestrol, and polyformaldehyde. The synthesis process is simple, and the post-treatment is convenient. The structures of the synthesized monomers were characterized by Fourier transform infrared (FT-IR) spectroscopies, 1H NMR, and 13C NMR nuclear magnetic resonance. Monomer thermal polymerization and copolymerization were studied and monitored by differential scanning calorimetry (DSC) and FT-IR. DSC showed that D-la had a very wide processing window (132 °C), and the curing temperature gradually decreased between 249 and 255 °C with the increase in its content. The thermal stability of D-fa was studied by thermogravimetric analysis and dynamic thermomechanical analysis, and the test results showed that D-fa had a higher residual carbon content (51%) compared with D-la and its copolymer. As the D-fa content increased, the residual carbon content and thermal stability also increased. Therefore, these two biobased benzoxazines featured excellent processability and thermal stability. This work has important reference values for designing biobased benzoxazines with high performance.
研究领域:
材料科学
·
绿色化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）