Coatings
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2019
·Vol. 9
·期 3
·164
·
IF 2.33
Xiakeer Saitaer,Noor Sanbhal,Yansha Qiao,Yan Li,Jing Gao,Gaetan Brochu,Robert Guidoin,Awais Khatri,Lu Wang
Mesh infection is a major complication of hernia surgery after polypropylene (PP) mesh implantation. Modifying the PP mesh with antibacterial drugs is an effective way to reduce the chance of infection, but the hydrophobic characteristic of PP fibers has obstructed the drug adhesion. Therefore, to prepare antimicrobial PP mesh with a stable drug coating layer and to slow the drug release property during the hernia repair process has a great practical meaning. In this work, PP meshes were coated by bio-inspired polydopamine (PDA), which can load and release levofloxacin. PP meshes were activated with cold oxygen plasma and then plasma activated PP fibers were coated with PDA. The PDA coated meshes were further soaked in levofloxacin. The levofloxacin loaded PP meshes demonstrate excellent antimicrobial properties for 6 days and the drug release has lasted for at least 24 h. Moreover, a control PP mesh sample without plasma treatment was also prepared, after coating with PDA and loading levofloxacin. The antimicrobial property was sustained only for two days. The maximum inhibition zone of PDA coated meshes with and without plasma treatment was 12.5 and 9 mm, respectively. On all accounts, the modification strategy can facilely lead to long-term property of infection prevention.Keywords:polypropylene;hernia meshes;antibacterial;drug release;polydopamine
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2012
·
IF 3.832
Wei Sun,Xiuzheng Wang,Yuhua Wang,Xiaomei Ju,Li Xu,Guangjiu Li,Zhenfan Sun
In this paper a nanocomposite prepared by graphene (GR) and SnO 2 nanosheets was used to modify a N-hexylpyridinium hexafluorophosphate based carbon ionic liquid electrode. The presence of GR–SnO 2 nanocomposite on the electrode surface exhibited synergistic effects to improve the electrochemical performance of the modified electrode . Electrochemical behaviors of dopamine (DA) on the electrode were evaluated by cyclic voltammetry and differential pulse voltammetry . The results indicated that the GR–SnO 2 nanocomposite modified electrode displayed high electrocatalytic activity to the oxidation of DA with the increase of the redox peak currents and the decrease of the peak-to-peak separation. Under the selected conditions the oxidation peak current was proportional to the DA concentration in the range from 0.5 to 500.0 μmol/L with a detection limit of 0.13 μmol/L (S/N = 3). The modified electrode showed excellent selectivity and sensitivity even in the presence of high concentration of uric acid . The proposed method was applied to determine DA content in real samples with satisfactory results.
研究领域:
材料科学
·
分析化学
·
生物医学工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
·
IF 4.539
Lu Zhao,Jie Liu,Yunfeng Bai,Feng Feng,Xiaoming Yang
Herein, an innovative method to synthesize carbon dots (CDs) has been successfully established, and these CDs emitted the yellow fluorescence while epimedium served as the carbon source. To be specific, the CDs prepared here were equipped with the functional groups of -COOH, -NH 2 , -OH, C C and C O, providing the possibility of functioning as the fluorescent sensor . Importantly, introducing dopamine leaded to their fluorescence quenching of the as-prepared CDs, which was due to the electrostatic interaction between CDs and DA. Meanwhile, the proposed CDs achieved detecting DA with the linear range of 1.0 × 10 −7 to 1.0 × 10 −3 M at a detection limit of 8.7 × 10 −8 M. Moreover, the further addition of H 2 O 2 gradually resulted in the fluorescence recovering through destroying the electrostatic interaction as the concentration of H 2 O 2 varied from 10 −6 to 10 −2 M with the detection limit of 7.2 × 10 −7 M. Thereby, the CDs described here exhibited the potentiality of broadening the ways for assaying DA and H 2 O 2 .
研究领域:
材料科学
·
生物化学
·
分析化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Junming Zhang,Yingyi Ma,Yuhang Han,Kaizheng Xu,Shun Yao,Lei Shi,Min Zhu
Restacking or aggregation inhibition of MXene nanosheets is crucial to the maintenance of their excellent electrochemical performance during use. In this study, a positively charged surfactant is inserted into the MXene nanolayers through a simple self-assembly process based on electrostatic interaction, producing a MXene/surfactant complex with enlarged interlayer spacing. Then 3D MXene-based porous structure could be prepared by the facile and low-cost breath figure method, in which MXene/surfactant complex is used as a casting material, therefore the inhibition of restacking or aggregation and increase of surface area at multiscale are realized in one system at the same time. Benefiting from the high conductivity of MXene and increased surface area of 3D porous structure that can provide massive active sites and facilitate the electrolyte infiltration and ion or electron access, enhanced electrochemical performance, for instance, electrochemical sensing of dopamine (DA) is shown. A low detection limit of 36.8 nM with excellent anti-interference, reproducibility, repeatability and long-term stability is realized. Good accuracy for DA detection in real biological samples is also confirmed by determining DA concentration in complex human urine samples. More importantly, porous structure such as pore size, uniformity, order and porosity can be adjusted through tuning the fabrication conditions, thereby regulating its electrochemical properties. This work not only provides a high-performance electrode for electrochemical sensing, but also offers a simple and practical strategy for the construction of 3D porous MXene film that holds great potential in electromagnetic interference shielding, supercapacitors and batteries.
研究领域:
材料科学
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电化学
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生物医学工程
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产品关联
DOI
高影响因子
Polymers
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2022
·Vol. 14
·期 7
·1426
·
IF 4.967
Baoliang Wang,Lili Xing,Tieling Xing,Guoqiang Chen
In this study, a superhydrophobic fabric was synthesized by modifying the fiber’s surface with dopamine-containing hydroxyl functional groups. Furthermore, we introduced mercapto-based functional groups by the hydrolysis of mercaptopropylmethyldimethoxysilane (MPMDS) and finally grafted POSS and mercaptans using a thiol–ene click reaction. These processes generated a superhydrophobic fabric with a static contact and a sliding angle of 162° and 8°, respectively. The superhydrophobic fabric’s compact and regular micro-nano rough structure based on POSS and mercaptans provides stable fastness and durability, as well as high resistance to organic solvents, acid–base environments, mechanical abrasion, UV rays, and washing. Moreover, it can be used for self-cleaning and oil–water separation, and it has a wide range of applications in the coating industry.Keywords:dopamine;click chemistry;POSS;oil–water separation
研究领域:
材料科学
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纺织工程
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表面化学
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DOI
PubMed
高影响因子
NEUROSCIENCE LETTERS
·
2022
·
IF 3.197
Tianyi Yang,Guang Yue,Yu Ge,Yue Zhang,Peng Xu,Youmei Wang,Bo Li,Bin Di
Nitrous oxide (N 2 O) has a long history of abuse, but its abuse mechanism has not been clear yet. This research aimed at the possibility of mesolimbic dopaminergic system (MLDS) involved in the rewarding effect of N 2 O. In this work, the rewarding behavior of N 2 O in mice was evaluated using a typical gas-administered conditioned place preference (CPP) procedure. SCH 23390, a Dopamine D1 receptor (D1R) antagonist, and Haloperidol, a Dopamine D2 receptor (D2R) antagonist were administered during CPP to evaluate the role of dopamine receptors in the N 2 O-induced CPP. The accompanying changes in phosphorylation of extracellular signal-regulated kinase (ERK) in MLDS related brain regions, including the ventral tegmental area (VTA), caudate putamen (CPu), prefrontal cortex (PFC), and nucleus accumbens (NAc) were measured to assess the neural plasticity changes in the CPP mice by Western blot analysis. Results revealed that 60% N 2 O induced CPP in the gas-administered mice and promoted the ERK phosphorylation (p-ERK) in the NAc and CPu during the test session of the CPP test. Pretreatment of SCH 23390 (0.5 mg/kg) inhibited the acquisition of N 2 O-induced CPP and the enhanced p-ERK in NAc. It suggested that Dopamine D1 receptor may play an important role in the acquisition of N 2 O-induced CPP and the accompanied ERK activation in the NAc, which provide insight into the molecular mechanism in the rewarding properties of nitrous oxide.
研究领域:
神经科学
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药理学
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行为科学
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产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
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2025
·
IF 7.9
Jiao Pan,Kejiang Li,Zhihao Wang,Chuan Li,Hongxin Shi,Minglong Yuan,Hongli Li,Dengbang Jiang
Implant-associated infections (IAIs) pose significant challenges to medical implants, especially in orthopedics, due to bacterial biofilm formation and increasing antibiotic resistance. Polylactic acid (PLA), a biodegradable material, is commonly used in implants but lacks inherent antibacterial properties. This study presents a novel multilayer antibacterial coating for PLA using dopamine (DA) self-polymerization and layer-by-layer (LBL) assembly. The PLA surface was first modified with polydopamine (pDA) coating. Antimicrobial peptides (AMP) were then covalently grafted onto the pDA-functionalized PLA surface through Michael addition and Schiff base reactions. Subsequently, a multilayered coating was constructed via electrostatic adsorption with hyaluronic acid (HA). The coating significantly enhanced the hydrophilicity of PLA and released AMP continuously for over 15 days, exhibiting > 99 % antibacterial efficacy against Staphylococcus aureus. Scanning electron microscopy (SEM) and biocompatibility assessments indicate that the coating exhibits both effective antibacterial properties by inhibiting bacterial adhesion and disrupting the integrity of the bacterial cell membrane, and demonstrates excellent biocompatibility. Besides, in the implant model of subcutaneous infection, the coating showed ability of better anti-infection and lower inflammatory response. The present study develops an antibacterial coating technology designed for biodegradable PLA implants, demonstrating significant potential to enhance the prevention and treatment of implant-associated infections.
研究领域:
生物材料
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表面工程
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感染控制
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组织工程
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产品关联
DOI
高影响因子
BIORESOURCE TECHNOLOGY
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2024
·
IF 9.7
Yongteng Zhao,Qingqing Li,Dan Chen,Min Yang,Feiyan Huang,Jiani Liu,Xuya Yu,Lei Yu
Dopamine (DA) has attracted attention because of its effects on Haematococcus lacustris biomass, astaxanthin production, and physiological responses. The alga treated with 25 μM DA combined with 1 g L –1 sodium chloride exhibited 7.63 %, 41.25 %, and 52.04 % increases in biomass (1.41 g L –1 ), astaxanthin content (32.37 mg/g), and astaxanthin productivity (3.51 mg L –1 d –1 ) respectively, compared with the salinity stress and high light. Exogenous DA treatment promoted lipid synthesis while reducing carbohydrate and protein contents. Moreover, carotenogenesis and lipogenesis-associated genes were upregulated under DA induction. Inhibition of reactive oxygen species and autophagy, along with mitogen-activated protein kinase activation, promoted astaxanthin accumulation under DA. Furthermore, DA application boosted astaxanthin biosynthesis by regulating the levels of respiratory metabolic intermediates, the γ-aminobutyric acid shunt, and important phytohormones. These findings present a potential and successful biotechnological approach for enhancing biomass and astaxanthin production in H. lacustris under stressful conditions.
研究领域:
藻类生物学
·
生物技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2020
·Vol. 18
·期 1
·1-13
·
IF 6.518
Wu Yiyong,Deng Peihong,Tian Yaling,Feng Jinxia,Xiao Jingyun,Li Junhua,Liu Jun,Li Guangli,He Quanguo
A method with high sensitivity, good accuracy and fast response is of ever increasing importance for the simultaneous detection of AA, DA and UA. In this paper, a simple and sensitive electrochemical sensor, which based on the polyvinylpyrrolidone (PVP)-graphene composite film modified glassy carbon electrode (PVP-GR/GCE), was presented for detecting ascorbic acid (AA), dopamine (DA) and uric acid (UA) simultaneously. The PVP-GR/GCE has excellent electrocatalytic activity for the oxidation of AA, DA and UA. The second-order derivative linear sweep voltammetry was used for the electrochemical measurements. The peak potential differences of DA-AA, DA-UA, and UA-AA (measured on the PVP-GR/GCE) were 212, 130 and 342 mV respectively. Besides, the over potential of AA, DA and UA reduced obviously, so did the peak current increase. Under the optimum conditions, the linear ranges of AA, DA and UA were 4.0 μM–1.0 mM, 0.02–100 μM, and 0.04–100 μM, respectively. The detection limits were 0.8 μM, 0.002 μM and 0.02 μM for AA, DA, and UA. The electrochemical sensor presented the advantages of high sensitivity and selectivity, excellent reproducibility and long-term stability. Furthermore, the sensor was successfully applied to the analysis of real samples.
研究领域:
分析化学
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 27
·50642
·
IF 3.125
Zhimei Wei,Shouyu Zhang,Xiaojun Wang,Shengru Long,Jie Yang
Cr (VI) is a highly toxic pollutant to humans, to achieve high adsorption capacity, easy recovery, and good reusability, polyethersulfone/polydopamine (PES/PDA) ultrafine fibers were prepared successfully. A series of preparing effect factors were investigated systematically and the optimum one is 8.5 pH value at room temperature and 2 g/L dopamine concentration. And then they were used as an adsorbent for the removal of Cr (VI) ions from wastewater. The effect factors pH, the adsorbent dosage, and time were discussed on Cr (VI) adsorption process and the Cr (VI) adsorption behavior was investigated. It is found that the maximum Cr (VI) adsorption capacity is 115.2 ± 4.8 mg/g at pH = 3 using 0.06 g PES/PDA with 80 mins. The Cr (VI) adsorption process followed the pseudo-second-order model (r 2 ≥ 0.99) and adsorption isotherms were fitted to the Langmuir model (R 2 ≥ 0.999). Furthermore, the Cr (VI) adsorption mechanism was supposed according to the X-ray photoelectron spectroscopic results. Finally, PES/PDA ultrafine fibers were considered to be a promising adsorbent with good stability (decomposing temperature, 356°C), high adsorption efficiency (112.1 ± 2.5 mg/g), and good reusability (three times) on the coexistence of anions and the actual industry wastewater environment.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INSTRUMENTATION SCIENCE & TECHNOLOGY
·
2017
·
IF 0.874
Shuyan Niu,Yajie Fang,Kun Zhang,Juan Sun,Jun Wan
A facile and sensitive fluorescent strategy for the determination of dopamine is reported using 2, 3-diaminophenazine. Dopamine caused autooxidation in the presence of oxygen with catalysis by Mn2+ and formed 2, 3-dihydro-1H-indole-5,6-dione. 2, 3-Diaminophenazine provided relatively strong fluorescence. 2, 3-Diaminophenazine in aqueous solution caused fluorescence quenching when the aminochrome condensed with 2, 3-diaminophenazine to allow the determination of dopamine. Under the optimized conditions, the linear dynamic range for dopamine was from 2.0 × 10−6 mol · L−1 to 6.1 × 10−5 mol · L−1 with a detection limit of 1.76 × 10−6 mol · L−1.
研究领域:
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Hualan Zhou,Yuan Wu,Yongxiang Su,Feng Wang,Shuai Yuan
The silicon-based materials show high capacities. However, the poor intrinsic conductivity and severe volume change during the process of lithiation and delithiation restrict the application. In this work, the nanoscale silicon (Si) with silver-polydopamine (Ag/PDA) hybrid coating was designed and successfully prepared by a simple one-pot liquid-phase redox reaction method. The electrochemical properties of the anode materials for lithium ion batteries were characterized, and the mechanism for the excellent cycling performance were investigated by cyclic voltammetry (CV), Electrochemical impedance spectra (EIS), scanning electron microscopy (SEM) and the operando visual observation during lithiation/delithiation process. According to the results, the presence of PDA and Ag is advantageous to enhance the electronic conductivity in the charge-discharge process. The Si/Ag/PDA ternary composite electrode exhibits high capacity and more stable cycling characteristics than Si and Si/PDA electrodes especially at large current densities, which remains 1168.8 mAh g −1 and after 100 cycles at 2 A g −1 .
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）