POLYMER DEGRADATION AND STABILITY
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2019
·
IF 3.78
Wenzong Xu,Xiaoling Wang,Xiongjie Wu,Wu Li,Chuanming Cheng
Fire safety is very important in the application of epoxy resin (EP). To study the effect of fire safety, a new kind of double-modified graphene (F-RGO-CuMoO 4 ) was synthesized in this work. Firstly, GO was modified with 3-Triethoxysilylpropylamine (KH550) through the amidation reaction between the amino and carboxyl group to obtain organic functionalized graphene F-RGO. Subsequently, CuMoO 4 was introduced onto the surface of F-RGO by the electrostatic interaction . Then the prepared F-RGO-CuMoO 4 was added into EP to prepare an EP composite. The TEM test results of the EP/F-RGO-CuMoO 4 ultrathin section showed that F-RGO-CuMoO 4 was well dispersed in EP, indicating that the dispersion of graphene in EP was obviously improved after double modification. In addition, F-RGO-CuMoO 4 also effectively improved the fire safety of EP. Specifically, the total heat release (THR), peak heat release rate (PHRR), total smoke production (TSP) and smoke production rate (SPR) values of the EP/F-RGO-CuMoO 4 composite were reduced to 33.4 MJ/m 2 , 504 kW/m 2 , 24.5 m 2 and 0.27 m 2 /s, which were 43.7%, 59.9%, 62.3% and 66.7% lower than those of pure EP, respectively. The main fire safety mechanism of F-RGO-CuMoO 4 was explored according to the char residue analysis.
研究领域:
材料科学
·
火灾安全工程
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
·
2015
·Vol. 35
·期 11
·1415-1426
·
IF 2.982
Xu Wang,Ziqiang Tan,Yuanhu Pan,Awais Ihsan,Qianying Liu,Lingli Huang,Guyue Cheng,Dongmei Chen,Yanfei Tao,Zhenli Liu,Zonghui Yuan
Aditoprim (ADP), a new developed dihydrofolate reductase (DHFR) inhibitor, has great potential in clinical veterinary medicine because of its greater pharmacokinetic properties than structural analogs. Preclinical toxicology studies were performed to assess the safety of ADP including an acute oral toxicity test, a subchronic toxicity test and five mutagenicity tests. In the acute oral toxicity test, ADP was administered singly by oral gavage to Wistar rats and Kunming mice. The LD 50 calculated was 1400 mg kg –1 body weight (BW) day –1 in rats and 1130 mg kg –1 BW day –1 in mice. In a subchronic study, Wistar rats were administered ADP at dose levels of 0, 20, 100 and 1000 mg kg –1 diet for 90 days. Significant decreases were observed on body weight and food efficiency in the high-dose group. Treatment-related changes in clinical serum biochemistry were found in the medium- and high-dose groups. Significant increases in the relative weights of livers and kidneys in females and testis in males in the 1000 mg kg –1 diet, and significant decrease in relative weights of livers in males in the 100 mg kg –1 diet were noted. Histopathological observations revealed that the 1000 mg kg –1 ADP diet could induce lymphocytic infiltration and hepatocytic necrosis near the hepatic portal area. The genotoxicity of ADP was negative in tests, such as the bacterial reverse mutation assay, mice bone marrow erythrocyte micronucleus assay, in vitro chromosomal aberration test, in vitro cho/hgprt mammalian cell mutagenesis assay and mice testicle cells chromosome aberration. Based on the subchronic study, the no-observed-adverse-effect level for ADP was a 20 mg kg –1 diet, which is about 1.44-1.53 mg kg –1 BW day –1 in rats. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
药理学
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毒理学
·
兽医学
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 21
·3879
·
IF 5.719
Hongqiang Dong,Yuke He,Chen Fan,Zhongqiang Zhu,Chunrong Zhang,Xinju Liu,Kun Qian,Tao Tang
Based on high surface areas, adjustable porosity and microbicide activity, metal-organic frameworks (MOFs) HKUST-1 are widely used as drug release carriers for their slow degradation characteristics under slightly acidic conditions. In this work, porous HKUST-1 was reacted rapidly by cholinium salt (as the deprotonation agent and template) in an aqueous solution at room temperature. A novel antimicrobial system based on an imazalil encapsulated metal organic framework (imazalil IL-3@HKUST-1) was established. Imazalil IL-3@HKUST-1 could achieve synergism in inhibiting pathogenic fungi and bacteria. Moreover, six days after treatment, the slow and constant release of imazalil from imazalil IL@HKUST-1 exhibited better sustainability and microbicidal activity than imazalil. We believe that the method may provide a new strategy for related plant diseases caused by bacteria or fungi.Keywords:imazalil;ionic liquid;HKUST-1;antimicrobial activity;safety
研究领域:
植物病理学
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 19
·14801
·
IF 5.6
Hang Liu,Lin Wang,Chen Yao
Engineered ultrashort peptides, serving as an alternative to natural antimicrobial peptides, offer benefits of simple and modifiable structures, as well as ease of assembly. Achieving excellent antibacterial performance and favorable biocompatibility through structural optimization remains essential for further applications. In this study, we assembled lipoic acid (LA)–modified tripeptide RWR (LA–RWR) with β–cyclodextrin (β–CD) to form nano–inclusion complexes. The free cationic tripeptide region in the nano–inclusion complex provided high antibacterial activity, while β–CD enhanced its biocompatibility. Compared with peptides (LA–RWR, LA–RWR–phenethylamine) alone, inclusion complexes exhibited lower minimum inhibitory concentrations/minimum bactericidal concentrations (MICs/MBCs) against typical Gram–negative/Gram–positive bacteria and fungi, along with improved planktonic killing kinetics and antibiofilm efficiency. The antibacterial mechanism of the nano–inclusion complexes was confirmed through depolarization experiments, outer membrane permeability experiments, and confocal laser scanning microscopy observations. Furthermore, biological evaluations indicated that the hemolysis rate of the inclusion complexes decreased to half or even lower at high concentrations, and cell viability was superior to that of the non–included peptides. Preliminary in vivo studies suggested that the inclusion complexes, optimized for antibacterial activity and biosafety, could be used as promising antibacterial agents for potential applications.Keywords:antimicrobial peptide;β–cyclodextrin;inclusion complexes;antibacterial activity;biosafety
研究领域:
微生物学
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药学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2016
·
IF 6.333
Qingfu Wang,Yong Yu,Jun Ma,Ning Zhang,Jianjun Zhang,Zhihong Liu,Guanglei Cui
A flame retardant and thermally dimensional stable membrane with high permeability and electrolyte wettability can overcome the safety issues of lithium ion batteries (LIBs) at elevated temperatures. In this work, a multifunctional thermoset nonwoven membrane composed of melamine formaldehyde resin (MFR) nano-fibers was prepared by a electro-spinning method. The resultant porous nonwoven membrane possesses superior permeability, electrolyte wettability and thermally dimensional stability. Using the electrospun MFR membrane, the LiFePO 4 /Li battery exhibits high safety and stable cycling performance at the elevated temperature of 120 °C. Most importantly, the MFR membrane contains lone pair electron in the nitrogen element, which can chelate with Mn 2+ ions and suppress their transfer across the separator. Therefore, the LiMn 2 O 4 /graphite cells with the electrospun MFR multifunctional membranes reveal an improved cycle performance even at high temperature. This work demonstrated that electrospun MFR is a promising candidate material for high-safety separator of LIBs with stable cycling performance at elevated temperatures.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
International Journal of Nanomedicine
·
2019
·
IF 4.471
Zhenmiao Qin,Feng Chen,Demei Chen,Yong Wang,Yinfeng Tan,Junfeng Ban
Background Triamcinolone acetonide (TAA) is an effective and the most commonly used corticosteroid hormone for the treatment of hypertrophic scars (HSs). However, the clinically used dosage has poor tissue permeability and injection safety. By contrast, lipid nanoparticles (LNPs) have the advantage of high affinity for the skin.Materials and methods This article describes the preparation of TAA-LNPs using poly(lactic-co-glycolic acid) as a carrier material, which have good biocompatibility and biodegradability. Based on a systematic investigation of its physicochemical properties, a rabbit ear HSs model was established to evaluate the percutaneous permeability of TAA-LNPs in scar tissue in vitro as well as to assess its curative effect and skin irritation.Results The results showed that the TAA-LNPs formed uniform and round particles under fluoroscopy and had a complex structure in which a nanoparticle core was surrounded by multiple vesicles. The particles were 232.2±8.2 nm in size, and the complimentary potential was -42.16 mV. The encapsulation efficiency was 85.24%, which is greater than that of other common liposomes and nanoparticles. A test of in vitro scar tissue permeability showed that penetration into scar tissue was twofold and 40-fold higher for TAA-LNPs than for common liposome and commercial suspensions, respectively. The concentration of the absorbed drug effectively inhibited fibroblast proliferation, achieved a therapeutic effect in HSs, and did not stimulate intact or damaged skin.Conclusion The preparation of TAA into LNPs for transdermal administration can enhance transdermal permeation performance and the safety of this drug, which is beneficial for the treatment of HSs.
研究领域:
药剂学
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生物医学工程
·
皮肤科学
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DOI
高影响因子
APPLIED CLAY SCIENCE
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2023
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IF 5.6
Menghan Yu,Haiyan Wu,Yuhang Meng,Menghan Qu,Huaming Yang
Given the global proliferation of pathogenic microorganisms , there exists a pressing imperative to cultivate efficacious nanomaterials possessing antimicrobial attributes, thereby impeding the transmission of infectious diseases. Clay-based nanoparticles , due to their inherent properties, serve as optimal candidates for the creation of innovative antimicrobial agents, particularly for coating materials . In this study, ZnO nanoparticles were synthesized on talc surfaces and doped with Ag + , yielding an effective antimicrobial composite (Ag-ZnO/talc). The primary aim was to comprehensively evaluate the antimicrobial effectiveness, material compatibility, and biosafety of Ag-ZnO/talc, as well as its potential applications in antibacterial coatings . The finding underscored the remarkable antibacterial properties of Ag-ZnO/talc composites, chiefly through the generation of reactive oxygen species , leading to impairment of the bacterial membrane and leakage of nucleic acid content. A biosafety evaluation indicated minimal cytotoxicity, a low hemolysis rate, and negligible skin tissue reactions, thereby suggesting its suitability for human application. Furthermore, the incorporation of the antimicrobial agent Ag-ZnO/talc did not significantly alter the physicochemical characteristics of the coating, while maintaining an enduring antimicrobial effect for a duration of two months. These findings establish the potential of clay-based antimicrobials for effective and safe application in coatings, facilitating the development of antimicrobial coatings in diverse industrial and public health environments.
研究领域:
纳米材料科学
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微生物学
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毒理学
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材料科学与工程
✓ 已验证
DOI
高影响因子
Nano-Micro Letters
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2023
·Vol. 15
·期 1
·1-12
·
IF 26.6
Li Jingjing,Liu Zhexuan,Han Shaohua,Zhou Peng,Lu Bingan,Zhou Jianda,Zeng Zhiyuan,Chen Zhizhao,Zhou Jiang
Animal models are applied to evaluate the biosecurity and biocompatibility of the zinc-ion batteries with the electrolytes of different zinc salts.
Leakage scene simulations and histological analysis are employed in investigating the tissue response after battery implantations, in which ZnSO 4 exhibits higher biosecurity.
Sn hetero nucleus is introduced to stabilize the zinc anode, which not only facilitates the planar zinc deposition, but also contributes to higher hydrogen evolution overpotential.
研究领域:
生物医学工程
·
材料科学
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DOI
高影响因子
ADVANCED MATERIALS
·
2024
·Vol. 36
·期 27
·2402401
·
IF 27.4
Xinyu Rui,Rui Hua,Dongsheng Ren,Feng Qiu,Yu Wu,Yue Qiu,Yuqiong Mao,Yi Guo,Gaolong Zhu,Xiang Liu,Yike Gao,Chang Zhao,Xuning Feng,Languang Lu,Minggao Ouyang
Quasi-solid-state batteries (QSSBs) are gaining widespread attention as a promising solution to improve battery safety performance. However, the safety improvement and the underlying mechanisms of QSSBs remain elusive. Herein, a novel strategy combining high-safety ethylene carbonate-free liquid electrolyte and in situ polymerization technique is proposed to prepare practical QSSBs. The Ah-level QSSBs with LiNi 0.83 Co 0.11 Mn 0.06 O 2 cathode and graphite–silicon anode demonstrate significantly improved safety features without sacrificing electrochemical performance. As evidenced by accelerating rate calorimetry tests, the QSSBs exhibit increased self-heating temperature and onset temperature ( T 2 ), and decreased temperature rise rate during thermal runaway (TR). The T 2 has a maximum increase of 48.4 °C compared to the conventional liquid batteries. Moreover, the QSSBs do not undergo TR until 180 °C (even 200 °C) during the hot-box tests, presenting significant improvement compared to the liquid batteries that run into TR at 130 °C. Systematic investigations show that the in situ formed polymer skeleton effectively mitigates the exothermic reactions between lithium salts and lithiated anode, retards the oxygen release from cathode, and inhibits crosstalk reactions between cathode and anode at elevated temperatures. The findings offer an innovative solution for practical high-safety QSSBs and open up a new sight for building safer high-energy-density batteries.
研究领域:
材料科学
·
能源技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xue-Xue Zhang,Xing Zhang,Chi Zhang,Xu Zhao,Zhi-Jian Yang,Qi-Long Yan
It is challenging to balance the energy and sensitivity for the development of energetic materials (EMs). In this paper, the HMX crystals with improved energy density but lower sensitivity have been prepared by intercalation of triaminoguanidine-glyoxal crosslinked graphene oxide (GO-TAGP). The morphologies and structure of intercalated HMX crystals depend largely on the content of GO-TAGP. Notably, the presence of a higher percentage of GO-TAGP leads to a transition of HMX crystal structure to the γ-form. It has been shown that with the constraint of GO-TAGP, HMX crystals show a significant enhancement in energy content. With intercalated 3.7 wt% of GO-TAGP, the density of modified HMX increased to 1.93 g·cm −3 with higher heat of explosion (5421 J·g −1 ) and higher heat of formation (140.6 kJ·mol −1 ) than that of neat HMX (1.89 g·cm −3 , 5242J·g −1 and 75.8kJ·mol −1 ). Importantly, remarkably improved thermal stability of modified HMX have been achieved, disclosing an excluded polymorphic transition via DSC and the variable-temperature powder XRD technique. In specific, the modified HMX with intercalated 1.0 wt% GO-TAGP exhibits superior safety performance with the impact energy increased to 26.5 J, even 780 % higher than pristine HMX (3 J). The detonation performance of as-modified HMX was tested, achieving an enhanced detonation velocity of 9254 m·s −1 , whereas that of raw HMX is only 9010 m·s −1 . This approach could offer an efficient strategy to enhance the energy content of HMX with significantly improved thermal stability and safety performance.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 11
·3168-3177
·
IF 6.1
Qi Zhang,Ruibing Lv,Ying Wang,Zhenghang Luo,Pengyang Pan,Tingwei Wang,Quancheng Liu
Laser-sensitive primary explosives (LSPEs) have long been a focus of attention as the material foundation for safer and more efficient laser-initiation technology. However, LSPEs often have poor safety due to their structural characteristics, which greatly limits the development and application of laser initiating technology. In this work, we introduced the concept of multidentate chelates into LSPEs and innovatively propose the concept of energetic quadridentate chelates. To achieve this highly creative idea, we synthesized an energetic flexible chelating ligand, namely, 1,2-bis(3-nitroamino-1,2,4-triazol-5-yl)ethane (BNATE), and prepared a novel metal quadridentate chelate, namely, [Cu(BNATE)·2H2O] (1), by chelating it with Cu2+. Through a series of tests, including X-ray single-crystal diffraction analysis, thermogravimetric analysis, and differential scanning calorimetry (TG-DSC), and evaluation of the safety and detonation performance, it was proven that this compound adhered to the high stability characteristics of the chelate, and its safety and detonation performance were superior to previous LSPEs. Moreover, through laser-initiation experiments, it was determined that the compound had excellent photosensitivity and a lower laser-initiation threshold. To explain the reason why the chelate structure is specifically sensitive to a laser, diffuse reflection ultraviolet and TD-DFT simulations were conducted, which not only demonstrated experimentally that chelation had a good enhancement effect on the laser photosensitivity but also confirmed the mode of electron transfer in the quadridentate chelate structure.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Yuzhen Wang,Xiao Yang,Ziwei Yang,Hangbin Xia,Xiaoqin Si,Jiahui Hao,Dongxue Yan,Huili Li,Ke Peng,Jie Sun,Changcan Shi,Huaqiong Li,Wenzhong Li
The development of a natural, additive-free, absorbable sponge with procoagulant activity for noncompressible hemostasis remains a challenging task. In this study, we extracted high molecular weight keratin (HK) from human hair and transformed it into a hemostatic sponge with a well-interconnected pore structure using a foaming technique, freeze-drying, and oxidation cross-linking. By controlling the cross-linking degree, the resulting sponge demonstrated excellent liquid absorption ability, shape recovery characteristics, and robust mechanical properties. The HK10 sponge exhibited rapid liquid absorption, expanding up to 600% within 5 s. Moreover, the HK sponge showed superior platelet activation and blood cell adhesion capabilities. In SD rat liver defect models, the sponges demonstrated excellent hemostatic performance by sealing the wound and expediting coagulation, reducing the hemostatic time from 825 to 297 s. Furthermore, HK sponges have excellent biosafety, positioning them as a promising absorbable sponge with the potential for the treatment of noncompressible hemostasis.
研究领域:
生物医学工程
·
材料科学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）