SEPARATION AND PURIFICATION TECHNOLOGY
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2020
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IF 5.774
Rongrong Qiang,ChenJie Wei,Ligang Lin,Xuesong Deng,Tiantian Zheng,Qi Wang,Yixin Gao,Yuzhong Zhang
Nowadays, the separation efficiency and stability of nanofiltration (NF) membrane are of widespread concern. Inspired by the biomineralization phenomenon and its unique structure with siliceous framework, a polyimide (PI) NF membrane decorated with “silica hard phase-polymer soft phase” 3D interwoven sponge bionic structure was fabricated via a simple and effective one-step phase inversion strategy. The obtained membranes demonstrated high pure water permeability of 65 L/(m 2 ·h) and rejections of Na 2 SO 4 (91.55%) and NaCl (30.21%) at 0.4 MPa, respectively. Moreover, siliceous sponge-like structures were determined by SEM analysis, with the degree of cross-linking after membrane pore regulated as high as 88.89%. The integrity and long-term stability of the membrane in different organic solvents, including methanol, cyclohexane, acetone, ethyl acetate, n -heptane, absolute ethanol and toluene were maintained for 72 h at 0.8 MPa. Furthermore, the PI/SiO 2 membrane with siliceous sponge biologically unique structure gives rise to a scope of bioinspired membranes and shows promising prospect for the treatment of solutions in extreme environments.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Xiangyu Meng,Junyi Yang,Shiming Xu,Chenchen Zhang,Baochun Ma,Yong Ding
Molybdenum based compounds, such as MoC x , MoSe 2 , MoS 2 MoP x , MoO x and their derivatives, have been considered as the alternative catalysts for platinum (Pt) whether in electrocatalytic or photocatalytic hydrogen evolution reaction (HER). This means molybdenum based compounds have great application potential in solving the energy crisis and environmental pollution. Herein, for the first time, the unexplored Mo 2 B x (x = 1 or 4) were investigated as the active components in a visible-light driven photocatalytic hydrogen production system. Experimental results demonstrate that they both exhibit excellent hydrogen evolution activities when combined with CdS or organic photosensitizers. Additionally, for the same kind of light-harvesting material, the photocatalytic HER activity of Mo 2 B 4 is obviously better than that of Mo 2 B. This clearly indicates the photocatalytic activities of them are affected by the content of electron deficient atom boron (B) in Mo 2 B x samples and exhibits a strong B dependence in photocatalytic HER. The reason for this B dependency is studied in detail by photo/electrochemical methods and optical characterizations in this work, where it is essentially caused by the difference in the electron transfer (ET) rates between light-harvesting material and Mo 2 B x samples and just manifested as B dependency. Additionally, the relation between photocatalysis and electrocatalysis in HER is discussed.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2020
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IF 3.99
Wenbo Liu,Chuanbin Fan,Ziao Zong,Nana Li,Kaixuan Ma,Bin Zhu,Xia Zhang,Yuhua Fan
Two novel Co(Ⅱ)-MOFs synthesized under solvothermal conditions, namely [Co 3 (L) 2 (bimb) 2 (H2O) 2 ] n ( OUC-1 ) and [Co 2 (L)(OH)(H 2 O) 2 ] n ( OUC-2 ) (bimb = 1,4-bis(lmidazol)butane, H 3 L = 3-(3,5-dicarboxylphenoxy)-5-carboxylpyridine), were used to remove Congo Red and Orange Ⅳ from aqueous environment, respectively. The influential parameters of the temperature and pH of solution, initial dye concentration, the structure and charge of dye on the adsorption performance were investigated. It is found that the dye with proper structure (i.e. organic groups favorable for adsorption, such as -NH 2 , -SO 3 H, etc, proper distance between the groups, linear structure and more benzene rings), richer negative charges, smaller molecular weight facilitates faster adsorbed. The intermittent operation experiments were adopted to make the adsorption isotherm and kinetics data of OUC-1 and OUC-2 accurately described by Langmuir isotherm and pseudo second-order kinetics. The intra-particle diffusion model indicates the adsorption process is controlled by the intra-particle diffusion and other adsorption stages. Two adsorbents release azo dyes easily through simple organic solutions and maintain high adsorption capacity after 8 cycles. Moreover, OUC-1 and OUC-2 also exhibit high adsorption performance in artificial seawater. The mechanism of selective adsorption involves pore filling, π-π stacking interaction, hydrogen bond and electrostatic interaction.
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PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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2020
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IF 4.361
Yanna Liu,Fenghua Xu,Shuang Liu,Gang Liu,Xiaohan Yang,Wenting Gao,Kai Fan,Henan Zhao,Jianmei Ma
Researchers have made considerable progress in elucidating psychological and exercise correlates of major depressive disorder (MDD). However, as the largest immune organ, far less is known about the role of gastrointestinal (GI) tract in the therapeutic mechanisms of exercise in MDD. In addition to the sites of the digestive tract that absorb nutrients, the GI tract also serves as a protective barrier against organisms. Inflammation and other consequences caused by disrupted GI barrier integrity are considered to be one of the mechanisms of depression, and the gut-brain axis (GBA) plays a critical role in this process. In this work, we observed the depression-like behaviors , intestinal barrier, central and peripheral inflammation, and related neurotransmitters through exercise intervention in the chronic unpredictable mild stress (CUMS) model, aiming to clarify the mechanisms of exercise to improve depression through GBA. Our results revealed that, following increased expressions of pro-inflammatory factors in intestine of CUMS mice, the levels of pro-inflammatory factors were all significantly raised in serum and brain simultaneously. Further, glial cells were activated in visceral nervous system and its related brain regions at the same time, accompanied by lower expression of occludin in CUMS mice. Importantly, our findings provide the first evidence that eight weeks of running exercise effectively inhibited neuro-immune interactions along gut-brain-axis and contributed obvious improvement of intestinal epithelial barrier (IEB). Finally, multivariate analysis putatively highlighted the role of exercise-induced IEB protection on depression treatment. We hope that our findings could warrant further study of therapeutic mechanisms of exercise in depression, specifically in disentangling the roles of intestinal function and IEB protection, and for developing more targeted clinical depression interventions.
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BIOMATERIALS
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2021
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IF 12.479
Yanzi Yan,Huiyi Liang,Xingliang Liu,Lixin Liu,Yongming Chen
Abnormal high level of cell free DNA (cfDNA) triggers chronic inflammation to exacerbate psoriasis symptoms. Scavenging cfDNA by topical cationic polymeric nanoparticles has been certified as an effective therapeutic strategy for treating psoriasis. However, cationic cfDNA scavengers have a great potential risk to organs after entering systemic circulation through skin barrier. For better transformation to clinical application, herein a series of poly(2-(dimethylamino)ethyl methacrylate) (PDMA) grafted hairy silica particles (cSPs) with tunable PDMA length and particle size are applied to scavenge cfDNA in dermis. We reveal that the structure of cSPs correlates with the permeation ability across stratum corneum, retention time in dermis, binding affinity to cfDNA, and toxicity tolerance, which in turn affect the therapeutic effect. Especially, the cSPs of 700 nm show more accumulation and longer retention in psoriatic lesions, leading to excellent treatment results. They also outperform the cSPs of 200 nm at a lower administration frequency. Thus, we address the issues of size, cationic content of cSPs to open a potential new avenue to topically treatment of psoriasis by targeting cfDNA in dermis.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Shumin Li,Fan Wu,Rongbin Lin,Jin Wang,Chunxia Li,Zhengquan Li,Jun Jiang,Yujie Xiong
Fe-based metal-organic frameworks (MOFs) have shown promising applications in photocatalysis, yet they are incapable of photocatalytic H 2 production due to their inappropriate conduction band (CB) position and large overpotential for H 2 evolution. Herein, we present a facile strategy enabling the photocatalytic H 2 production over Fe-based MOFs through dye sensitization. A combination of characterization techniques with theoretical simulation reveals that dye sensitization can effectively inject energetic electrons into Fe-MOFs and elevate their quasi-Fermi level under light irradiation, overcoming the surface overpotential for H 2 production from water. Furthermore, deposition of Pt nanoparticles on Fe-MOFs can lower the overpotential for H 2 evolution toward further enhanced photocatalytic activity. This work provides insights into MOF band structure engineering at electronic level, and proves a concept that harnesses MOF materials for targeted photocatalytic applications they are originally not fit for.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Hao Cheng,Zijun Jiang,Chenkai Sun,Zhen Wang,Guochen Han,Xin Chen,Tianyi Li,Zhechen Fan,Feng Zhang,Xiaoyu Yang,Lingyu Lv,Huaqing Zhang,Jianping Zhou,Yang Ding
The pro-metastatic potential of chemotherapy limits its therapeutic benefits against invasive cancer. Herein, a protein stabilized polymeric nanoparticle inspired relay drug delivery platform was developed to address post-chemotherapeutic metastasis. An ROS-responsive Phenylboronic acid (PBA)-Rich cationic polymer (RPP) bridges Doxorubicin (Dox) coordination and Snail-targeted siRNA (siSnail) compression, and natural apolipoprotein A-I (apoA-I) is attracted by surface electron-deficient PBA moieties for nanoparticle shaping, drug biostability, and tumour-penetration. The spatially-separated structure enables a timing-controlled relay drug delivery in tumour cells, where Dox gives a prior release phase by acidity, and RPP polymer is subsequently disintegrated by concentrated ROS for rapid siSnail liberation. In dual therapy, Dox pre-treatment upregulated pro-metastatic factors and aggravated metastasis, but subsequent liberation by siSnail silenced the central metastatic regulator of Epithelial-mesenchymal transition (EMT). The terminal nanoparticles exhibited advanced therapeutic efficacy, achieving primary tumour shrinkage (tumour weight inhibition, TWI of ~86.15%) and complete metastatic nodule elimination. This work promises to improve the clinical benefits of chemotherapy against invasive cancer.
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ACS Sustainable Chemistry & Engineering
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2019
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IF 6.97
Yankun Li,Zihao Wei,Ye Zhang,Zhifen Guo,Dashu Chen,Peiyun Jia,Peng Chen,Hongzhu Xing
A dual-emitting dye@MOF composite has been synthesized by incorporating a fluorescent dye eosin Y (EY) within a UiO-type zirconium-based metal–organic framework (Zr-MOF) through a synthetic encapsulation method. The Zr-MOF prevents the aggregation of EY molecules and keeps EY molecules stably included after synthesis. As expected, an energy transfer from Zr-MOF to EY molecules occurred because of the good overlap between the emission of Zr-MOF and the absorption of EY. As a result, the obtained EY@Zr-MOF composite features a weak blue emission at 446 nm and a strong yellow emission at 553 nm. By using the relative height of the two emission peaks replacing absolute peak height as detecting signals, EY@Zr-MOF composite acts as a self-calibrating luminescent sensor for selectively detecting Fe3+, Cr2O72–, and 2-nitrophenol. Furthermore, the observed fluorescence responses of the composite toward analyte are highly stable and reversible after recycling experiments. To the best of our knowledge, this is the first example of a dye@MOF-implicated self-calibrating sensor for Fe3+, Cr2O72–, and 2-nitrophenol detection.
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ACS Catalysis
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2019
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IF 12.221
Xingxing Li,Yu Pan,Hong Yi,Jingcheng Hu,Dali Yang,Fengzhi Lv,Wendian Li,Jinping Zhou,Xiaojun Wu,Aiwen Lei,Lina Zhang
Improving the selectivity and retaining the efficiency of catalysts are essential for industrial processes and remain a great challenge. Herein, we developed a facile route to synthesize Pd nanocubes (NCs) using Eosin Y as the photosensitizer under visible light. Subsequently, Pd NCs were uniformly loaded on N-doped carbon nanofibrous microspheres (NCMs) from carbonated chitin microspheres. This Pd NCs@NCM exhibited high reactivity and selectivity in alkyne semihydrogenation. For example, the hydrogenations of phenylacetylene to styrene and of 3-phenyl-2-propyn-1-ol to (Z)-cinnamyl alcohol were 12.9 and 18.3 times faster with Pd NCs@NCM than with Lindlar catalyst. According to the Mott–Schottky effect, loading of Pd NCs on N-doped carbon constructed a rectifying contact and decreased the electron density of Pd NCs. Density functional theory (DFT) calculations suggested that the high concentration of holes doped in Pd NCs weakened the interaction of alkenes on the Pd (100) facet and prevented further hydrogenation for a long time; this period of durable time is very helpful in chemical manufacturing. Thus, Pd NCs@NCM maintained both high reactivity and selectivity in comparison with surface-modified catalysts. This work provides an alternative strategy to design Mott–Schottky catalysts for selective hydrogenation reactions.
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ENVIRONMENTAL POLLUTION
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2019
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IF 5.714
Rong Shen,Yichang Yu,Rong Lan,Ran Yu,Ze Yuan,Zhining Xia
As a new type of pollutant, fluoroquinolones (FQs) antibiotics are ubiquitous in environment and have some threat to human health and ecological environment. Their ecological toxicity to the environment urgently need to be assessed. Therefore, we firstly explored the toxic effects and possible mechanism of cardiovascular toxicity induced by gatifloxacin (GTFX) and ciprofloxacin (CPFX) using zebrafish model. After 24 h exposure, the zebrafish treated with GTFX showed pericardial edema which was further investigated by histopathological examination, while CPFX exposure did not induce morphological abnormalities. However, both of them induced cardiac dysfunction, such as decreased heart rate and cardiac output which was showed a positive correlation with the concentration. To better understand the possible molecular mechanisms underlying cardiovascular toxicity in zebrafish, we investigated the transcriptional level of genes related to calcium signaling pathway and cardiac muscle contraction . The results indicated that the expression of ATPase ( atp2a1l ) and cardiac troponin C ( tnnc1a ) genes were significantly inhibited, the expression of calcium channel ( cacna1ab ) gene showed slight promoted trend after CPFX exposure. For zebrafish treated with GTFX, the expression of atp2a1l genes was also significantly inhibited, while the expression of tnnc1a genes was slightly inhibited and cacna1ab genes expression had no obvious effect. The present study firstly revealed that GTFX exposure can induce morphological and functional abnormalities on the cardiovascular system of zebrafish. Though CPFX exposure did not induce morphological abnormalities, the function of cardiovascular system was still damaged. Mechanistically, this toxicity might result from the pressure of down-regulation of genes associated with calcium signaling pathway and cardiac muscle contraction. The results of this study can provide a valuable theoretical basis for the establishment of FQs environmental quality standards in water environment, environmental drug regulation and risk management.
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RSC Advances
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2018
·Vol. 8
·期 24
·13417-13422
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IF 2.936
Yipeng Huang,Guihua Ruan,Yuji Ruan,Wenjuan Zhang,Xianxian Li,Fuyou Du,Cunjie Hu,Jianping Li
Hypercrosslinked porous polymer hybridized graphene oxide with polymeric high internal phase emulsions (polyHIPEs/GO) were designed as versatile composites for water treatment. Morphologies, chemical composition and thermal stability of the composites were characterized by SEM, FTIR, XPS, XRD and TGA. Tunable adsorption properties and enhanced visible-light photocatalysis towards organic dyes were achieved by the manipulation of functional groups and the inclusion of Ag3PO4, respectively. The adsorption capacity of polyHIPEs/GO towards cationic methyl blue (MB) and rhodamine B (RB) is 1250.3 and 1054.1 μg g−1, respectively. Aminated polyHIPEs/GO (polyHIPEs(NH2)/GO) possesses an adsorption capacity of 1967.3 μg g−1 to anionic eosin Y (EY). The tandem columns of polyHIPEs(NH2)/GO and polyHIPEs/GO can successively and selectively remove the cationic and anionic dyes in a mixed dye solution. Furthermore, enhanced photodegradation ability was obtained after GO reduction and Ag3PO4 addition on polyHIPEs(NH2)/GO. Results show that 3.5 × 10−5 M of MB, RB and EY can be completely photodegraded by 20 mg of the novel photocatalyst within 20, 40 and 35 min, respectively. This work demonstrates that polyHIPEs/GO exhibits tunable properties for multiply progressive applications in water treatment and catalysis.
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Nature Communications
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2018
·Vol. 9
·期 1
·1-14
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IF 12.353
Liang Huiyi,Peng Bo,Dong Cong,Liu Lixin,Mao Jiaji,Wei Song,Wang Xinlu,Xu Hanshi,Shen Jun,Mao Hai-Quan,Gao Xiaohu,Leong Kam W.,Chen Yongming
Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that ~40 nm cationic nanoparticles (cNP) can scavenge cfDNA derived from RA patients and inhibit the activation of primary synovial fluid monocytes and fibroblast-like synoviocytes. Using clinical scoring, micro-CT images, MRI, and histology, we show that intravenous injection of cNP into a CpG-induced mouse model or collagen-induced arthritis rat model can relieve RA symptoms including ankle and tissue swelling, and bone and cartilage damage. This culminates in the manifestation of partial mobility recovery of the treated rats in a rotational cage test. Mechanistic studies on intracellular trafficking and biodistribution of cNP, as well as measurement of cytokine expression in the joints and cfDNA levels in systemic circulation and inflamed joints also correlate with therapeutic outcomes. This work suggests a new direction of nanomedicine in treating inflammatory diseases.
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