BIOMEDICINE & PHARMACOTHERAPY
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2018
·
IF 3.457
Miao Yan,Zhu-feng Wu,Dan Tang,Feng Wang,Yi-wen Xiao,Ping Xu,Bi-kui Zhang,Yi-ping Liu,Da-xiong Xiang,Hoan Linh Banh
Voriconazole (VRC) and proton pump inhibitors (PPIs) have similar metabolic pathways. The objectives of the study are to evaluate the impact of PPIs on the pharmacokinetics of VRC. Human liver microsomes model was applied to assess the inhibitory effects of PPIs on the metabolism of VRC in vitro. A retrospective study was also carried out to explore the relationship between the plasma VRC trough concentrations and PPIs uses. Patients were divided into six groups: control (n = 166), lansoprazole (LAN, n = 38), esomeprazole (ESO, n = 19), omeprazole (OME, n = 45), pantoprazole (PAN, n = 43), and ilaprazole (ILA, n = 38) groups. All five PPIs showed concentration-dependent inhibitory effects on the VRC metabolism in human liver microsomes, among which LAN, OME and ESO were three of the most potent inhibitors. Consistently, co-administered with LAN, OME and ESO significantly increased the plasma VRC trough levels ( p < 0.05), whereas there was no significant association between VRC concentrations and PAN or ILA use. Interestingly, patients in the PPIs groups were more likely to reach the therapeutic VRC range of 1–5.5 μg/mL in steady state when compared with control patients (75–81% VS 69%). In conclusion, although all PPIs showed inhibitory effects on the VRC metabolism in vitro, only LAN, OME and ESO significantly increased VRC plasma concentrations. This study should be helpful for choice of the type of PPIs for patients administered with VRC.
研究领域:
临床药理学
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药物代谢
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医学研究
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产品关联
DOI
PubMed
高影响因子
AQUACULTURE
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2025
·
IF 3.9
Keda Ying,Xinru Ren,Meiru Tong,Siyu Ye,Yuhong Shi,Qianjin Zhou,Jiong Chen
Multidrug-resistant (MDR) pathogens are a significant threat to aquaculture due to their resistance to most conventional drugs. AcrAB-TolC is a known MDR efflux pump that increases antibiotic resistance. Inhibiting such pumps is a promising strategy in drug discovery. In this study, phytocompounds derived from Commelina communis (Asiatic dayflower) have been identified as candidate inhibitors for AcrB of Aeromonas hydrophila through virtual screening, encompassing molecular docking and molecular dynamics (MD) simulation. Consequently, five phytocompounds from the Asiatic dayflower met the criteria as suggested by the TCMSP database. Among them, flavocommelin, luteolin, and delphin_qt, exhibiting values higher than or equal to the control PAβN, emerged as candidate inhibitors of AcrB protein according to molecular docking analysis. Luteolin, which adhered to Lipinski's rule of five, was stable in binding to AcrB in a 50 ns molecular dynamics simulation. Luteolin also attenuated the reduction in Nile Red fluorescence in a dose-dependent manner, indicating the actual inhibition of the AcrAB-TolC efflux pump of the MDR A. hydrophila Y-1. The checkerboard synergy analysis revealed that luteolin exerted a positive impact on the six tested antibiotics, with fractional inhibitory concentration (FIC) indexes ranging from 0.125 to 0.375. Luteolin and florfenicol were recognized for having the best synergistic activity. When Ctenopharyngodon idella (grass carp) and Plecoglossus altivelis (ayu) were infected by A. hydrophila Y-1, the combination of luteolin and florfenicol markedly enhanced the survival rate and declined the bacterial load, as compared to either luteolin or florfenicol alone. Thus, luteolin is an effective efflux pump inhibitor for AcrAB-TolC of A. hydrophila , enhancing antibiotic sensitivity and exhibiting synergistic effects with antibiotics.
研究领域:
微生物学
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药理学
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分子生物学
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产品关联
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Xinghao Hu,Fengrui Zhang,Runmin Liu,Jinchang Jiang,Xianfu Bao,Yiming Liang
Previous electrochemically powered yarn muscles cannot be usefully operated between extreme negative and extreme positive potentials, since generated stresses during anion injection and cation injection partially cancel because they are in the same direction. We here report an ionomer-infiltrated hybrid carbon nanotube (CNT) yarn muscle that shows unipolar stress behavior in the sense that stress generation between extreme potentials is additive, resulting in an enhanced stress generation. Moreover, the stress generated by this muscle unexpectedly increases with the potential scan rate, which contradicts the fact that scan-rate-induced stress decreases for neat CNT muscles. It is revealed by the electro-osmotic pump effect that the effective ion size injected into the muscle increases with an increase in the scan rate. We demonstrate an electrochemically powered gel-elastomer-yarn muscle adhesive that generates and delivers muscle-contraction-mimicking stimulation to a target tissue.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of the American Chemical Society
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2018
·
IF 14.357
Zhen Zhang,Pei Li,Xiang-Yu Kong,Ganhua Xie,Yongchao Qian,Ziqi Wang,Ye Tian,Liping Wen,Lei Jiang
The creation of an artificial solid-state ion pump that mimics the delicate ion transport behaviors of a biological protein-based ion pump is drawing more and more research attention due to its potential applications in energy conversion, biosensor, and desalination. However, the reported bioinspired double-gated ion pump systems are generally very primary and can only realize nonselective ion pumping functions with no directionality and uncontrollable ion gating functions, which are far from their biological counterparts. To make the bioinspired device “smart” in a real sense, the implementation of high-level selectivity and directionality in the ion pumping process, while achieving great controllability in the ion gating process, is a necessity. Here, we developed a bioinspired heterogeneous ion pump membrane by combining block copolymer membrane sacrificial coating and plasma grafting technique. The system has unidirectional selective ion pumping and controllable ion gating properties. The introduction of asymmetric ionic group distribution is the key reason for its novel transport behaviors. Such a heterogeneous ion pump could not only provide a basic platform that potentially sparks further efforts to simulate the smart ion transport processes in living bodies but also promote the application of artificial nanofluidic devices in energy conversion, water treatment, and biosensing.
研究领域:
材料科学
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纳米技术
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生物物理学
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化学工程
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环境科学
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产品关联
DOI
PubMed
高影响因子
Research
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2023
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IF 11
Yaxin Chen,Rong Wang,Minbiao Ji
Jade is most valued in Chinese culture since ancient times. For unearthed jade artifacts, the alteration color resulting from weathering effects and human activities provides information for cultural heritage conservation, archaeology, and history. Currently, the noninvasive 3-dimensional characterization of jade artifacts with high chemical and spatial resolution remains challenging. In this work, we applied femtosecond pump–probe microscopy and second harmonic generation microscopy techniques to study the black alteration of an ancient jade artifact of the late Spring and Autumn period (546 to 476 BC). The direct cause of the “mercury alteration” phenomena was discovered to be the conversion of metacinnabar from buried cinnabar in the tomb. Furthermore, a 3-dimensional optical reconstruction of the black alteration was achieved, providing a high-resolution method for analyzing the blackening mechanism without the need of sample damage. Our approach opens up new opportunities to extract microscopic spatiochemical information for a broad range of alteration colors in jade artifacts.
研究领域:
考古学
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材料科学
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光学
✓ 已验证
DOI
高影响因子
Cell Reports Physical Science
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2023
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IF 8.9
Akram Entezari,He Lin,Oladapo Christopher Esan,Weili Luo,Ruzhu Wang,Ruoyu You,Liang An
Dehumidification not only regulates the relative humidity (RH) of buildings with reduced cooling costs but also provides a potential drinking water source for residents. Desiccant-based dehumidification has a lower energy consumption than the condensation-based method; however, the former requires successive regeneration of used sorbents and is, therefore, bulky. In this study, by mimicking transpiration in trees, we propose a humidity pump (HP) that continuously dehumidifies rooms by creating a continuous driving force for water wicking. Meanwhile, we investigate the potential of the HP by combining it with atmospheric water harvesting systems. We use activated carbon-lithium chloride composites since they have proven to possess high sorption capacity and strong capillary effect. We develop a small prototype, and our results show that it can maintain the RH between 50% and 70% while producing 1.3–3.25 g water per day. By advancing these techniques, we create an opportunity for developing more energy-efficient humidity regulation and atmospheric water harvesting systems.
研究领域:
能源与环境工程
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材料科学
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DOI
高影响因子
ELECTROPHORESIS
·
2015
·Vol. 36
·期 23
·2881-2887
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IF 3.028
Yue Wu,Wenpeng Zhang,Ying Chen,Zilin Chen
In this work, a novel molecularly imprinted polymer (MIP) monolithic column with integrated in-column electroosmotic pump (EOP) was designed and successfully prepared to facilitate the capillary chromatography with MIP column. A silica-based EOP was synthesized at the detection end of the MIP monolithic capillary column by so-gel to provide the hydrodynamic driven force for the capillary chromatography. Because of large surface area and low fluidic resistance of the silica monolith,a strong and steady EOF was generated by silica-based EOP, indicating that the EOP was quite compatible with MIP capillary column. With the sufficient EOF provided by EOP, the electro-driven based capillary chromatographic separation of nitrophenol isomers was achieved in 4-vinylpyridine-based MIP monolithic capillary, which was originally proved infeasible because of the EOF shortage. No significant influence upon the specific recognition of the MIP was found due to the setting of EOP after the detection window of the column. The influence of experimental parameters on the EOF such as voltage and pH value of running buffer was investigated. The column was also evaluated by capillary liquid chromatographic mode to compare with EOP-driven capillary chromatography. Higher column efficiency was obtained by EOP-driven separation with improved peak shape. The results suggested that EOP-supported technique would be a good way to solve the problem of weak EOF generation in electro-driven capillary chromatography.
研究领域:
分析化学
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色谱技术
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY
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2013
·Vol. 29
·期 12
·1460-1470
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IF 2.708
Mingbao Feng,Ruijuan Qu,Ying Li,Zhongbo Wei,Zunyao Wang
Hexabromobenzene (HBB) is a novel brominated flame retardant (BFR) with ample evidence of its ubiquitous existence in the aquatic ecosystems. However, to date, the toxicological effects of this BFR on fish have been inadequately researched. The present study was conducted, based on an in vivo model, to investigate HBB-induced biochemical changes in liver and gill tissues of Carassius auratus after medium-term exposure to different concentrations (10, 150, and 300 mg/kg) for 7, 14, and 25 days. Oxidative stress was evoked evidently for the prolonged exposure, demonstrated by significant inhibition in antioxidant enzymes activities including superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and glutathione S-transferase, and a decrease in reduced glutathione level, as well as simultaneous elevation in malondialdehyde content. Moreover, Na + , K + -ATPase activity, and protein level were remarkably reduced in fish tissues. Based on the integrated biomarker response, the toxic potency in each treatment was distinguished, and the more severe stress was mainly noted with the increasing concentrations and the extending durations. It was also observed that liver exhibited more pronounced alterations in biochemical parameters than gill, probably indicating the vulnerability of liver to HBB-triggered oxidative stress. Taken together, the results of this study clearly showed that HBB was capable of inducing oxidative stress and inhibiting Na + , K + -ATPase activity in different tissues of C. auratus after medium-term exposure. © 2013 Wiley Periodicals, Inc. Environ Toxicol 29: 1460–1470, 2014.
研究领域:
环境毒理学
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水生生态学
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生物化学
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产品关联
DOI
PubMed
高影响因子
Pharmacogenomics & Personalized Medicine
·
2021
·
IF 3.912
Magesa Mafuru,Sanlan Wu,Henry Mayala,Zaituni Msengwa,Amani Phillip,Charles Mgone
Purpose To analyze the combined effect of CYP2C19 genetic polymorphism and PPIs coadministration on voriconazole trough concentration (VCZ-Ctrough) in Chinese patients with hematological disorders.Patients and Methods A prospective observational study involved 250 plasma samples from 114 adult patients receiving voriconazole with or without PPIs were analyzed. Demographics and clinical characteristics were obtained from patient’s records. A validated LC-MS/MS was used to quantify the plasma VCZ-Ctrough. Genotyping for CYP2C19*2 and CYP2C19*3 variant alleles was performed by PCR-RFLP followed by DNA sequencing. The combined total score (from 2 to 5) was calculated for each patient. The higher the score, the lesser the metabolism of the patient.Findings Fifty percent of patients administered with voriconazole were coadministered with PPIs, predominantly omeprazole or esomeprazole. Patients exhibiting CYP2C19 poor metabolizer phenotype showed a significantly higher median VCZ-Ctrough, (4.31µg/mL [IQR, 1.64µg/mL–7.36µg/mL]) than patients with normal metabolizer (1.38µg/mL, [IQR, 0.79µg/mL–2.14µg/mL], p < 0.0001). Similarly, patients co-administration with PPIs had higher median VCZ-Ctrough (2.86µg/mL [IQR 1.33µg/mL–4.66µg/mL]), than PPIs non-users (1.71µg/mL, [IQR, 0.86µg/mL–3.48µg/mL], p = 0.001). However, we noted that the median VCZ-Ctrough for each factor was ranging within the normal recommended therapeutic range in the Chinese population (0.5µg/mL–5µg/mL). But when the two factors were combined, the median VCZ-Ctrough was steadily increasing as the metabolic capacity (reflected by combined total score) was increasing. Importantly, the median VCZ-Ctrough in PM/PPIs user (total score 5) was significantly elevated to supra-therapeutic levels compared to NM/PPI non-user group (total score 2) (5.83µg/mL [IQR, 2.19µg/mL–9.51µg/mL] versus 1.13µg/mL [IQR, 0.67µg/mL–1.82µg/mL]), respectively, P < 0.0001. Furthermore, we observed that the elevation of median VCZ-Ctrough to supra-therapeutic levels was largely contributed by omeprazole or esomeprazole compared to lansoprazole or pantoprazole.Conclusion Coadministration with PPIs significantly increased voriconazole trough concentrations and there was an additive effect in CYP2C19 PMs, who were most likely to have supra-therapeutic levels.
研究领域:
药理学
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临床医学
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遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2023
·
IF 22.1
Peiyun Zhou,Guangtong Hai,Gongchi Zhao,Rushuo Li,Xiubing Huang,Yunfeng Lu,Ge Wang
Developing multifunctional electrocatalysts with excellent hydrogen evolution reaction (HER), oxygen evolution reaction (OER) and 5-hydroxymethylfurfural oxidation reaction (HMFOR) activities will contribute to "carbon neutrality". Here, CeO 2 is introduced into the Co 4 N system as an "electron pump" to attract electrons to transfer from Co 4 N to CeO 2 . The interface electronic structure optimization enables Co 4 N@CeO 2 to exhibit excellent HER, OER, and HMFOR performance. Specifically, to deliver 10 mA cm −2 current density, (1) it only requires low overpotentials of 49 and 263 mV for HER and OER in 1.0 M KOH, respectively; (2) it merely needs an ultra-low potential of 1.22 V RHE for HMFOR in 1.0 M KOH + 300 mM HMF, which is 273 mV lower than the required potential in 1.0 M KOH. Theoretical calculation results show that the introduction of CeO 2 effectively reduces the barriers for potential-determining steps of HER and OER, and optimizes OH - adsorption to promote the HMFOR process.
研究领域:
材料科学
·
能源化学
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产品关联
DOI
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 7
·e202302231
·
IF 1.9
Yupu Meng,Chuanyu Zhu,Zhiwei Huang,Genhua Wu,Zhuqing Wang
Graphical A superhydrophobic/superoleophilic modified polyurethane sponge was prepared to remove oil slicks on the water surface. The prepared sponge material has good selectivity for the recovery of oil and organic pollutants. In addition, we connect the modified sponge with a self-priming pump, which can recover oil with a viscosity in the range of 0–172 CP in situ and efficiently, while avoiding damage to the adsorption material due to extrusion and distillation operations in traditional oil recovery methods. This technology has broad application prospects in the face of large-scale oil spills and other emergency events. We have prepared a super-hydrophobic/super-oleophilic modified sponge material (C-PDMS-PU) by attaching carbon powder and polydimethylsiloxane (PDMS) to a sponge skeleton by a simple dip-coating method using a low-cost polyurethane sponge as the raw material. The material has a C-PDMS composite hydrophobic coating, which can efficiently and selectively absorb oil slicks on the water surface or organic solvents underwater that are 21–26 times its weight. Relying on this adsorbent, we have built an oil collection device that can in-situ absorb/desorb oil with a dynamic viscosity ranging from 0 CP to 172 CP on the water surface or underwater. This oil collection device is small, simple to operate, and portable, thus freeing the adsorbent from the limits of adsorption capacity while continuously and efficiently recovering the oil from the sea surface, hence achieving the integration of adsorption and separation. This new adsorbent and the oil collection device have promising applications in emergencies, such as organic solvent spills, tanker spills, and oil spills from offshore rigs.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Bin Wang,Hailong Chen,Fangcheng Huang,Jinyuan Liu,Gaopeng Liu,Yu-Xiang Weng,Yuanbin She,Xingwang Zhu,Huaming Li,Jiexiang Xia,Paul K. Chu
In order to enhance the efficiency of artificial photosynthesis, it is imperative to improve the hysteretic migration and separation efficiency of photogenerated charge carriers. Herein, ultrathin Bi 4 O 5 Br 2 (BOB) nanosheets are prepared vertically and uniformly on the surface of hollow N-doped carbon spheres (NC) to produce a hollow confined nanoreactor (BOB@NC). The graphite layer and N in NC act as a tandem electron pump for the rapid transfer of photogenerated electrons from BOB to the NC surface via the Bi-C bridging bond between BOB and NC, and the electrons on the NC surface continue to move to the N-induced defect energy levels. This NC electron pump facilitates the transfer of the photogenerated electrons in a directional, rapid, and efficient manner. Meanwhile, the adsorption of CO 2 molecules and hydrogenation of *CO to *CHO at the N site on NC are kinetically spontaneous, thereby significantly reducing the CO 2 reduction reaction energy barrier of BOB. As a result, the efficiency of CO 2 hydrogenation reduction to CO and CH 4 by BOB@NC is 3.31 and 11.15 times higher than that by the BOB monomer, respectively. The hollow confined electron pump reactor reveals a novel strategy for the design and fabrication of catalysts for high-performance artificial photosynthesis.
研究领域:
材料科学
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环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）