TALANTA
·
2014
·
IF 3.511
Shan Zhang,Tao Yu,Mingtai Sun,Huan Yu,Zhongping Zhang,Suhua Wang,Hui Jiang
A fluorescent probe was synthesized and demonstrated to be highly selective and sensitive in the reaction with copper (II) ion, generating a large variation of the fluorescence intensity in a dose–response manner. The probe contains a dansyl moiety as fluorophore and a multidentate ligand for copper (II) ion recognition. The reaction of the molecular probe with copper (II) ion proceeds rapidly and irreversibly in a 1 to 1 stoichiometric way, leading to the production of stable copper (II) complex, which subsequently results in the quenching of fluorescence. The detection limit for copper (II) ion was measured to be about 2 ppb. It was also shown that the probe has high selectivity for copper (II) ion and good anti-interference ability against other transition metal ions . The herein reported very simple and reliable fluorescence probe could be employed for copper (II) ion detection in many aspects.
研究领域:
分析化学
·
生物医学
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产品关联
DOI
PubMed
高影响因子
Chemosensors
·
2022
·Vol. 10
·期 11
·464
·
IF 4.229
Zhaonan Hou,Zhiyan Ma,Xin Guan,Hongran Zhao,Sen Liu,Teng Fei,Tong Zhang
Humidity sensors with high sensitivity and fast response characteristics are of great interest for researchers. In this work, capacitive humidity sensors were fabricated using ionic liquid/cellulose nanofibers (CNFs) as the composited sensing film. The porous CNFs are beneficial for preparing sensing films via a solution process, and the ionic liquid could be uniformly dispersed in the films. The humidity-sensing performance of the as-prepared sensors was investigated. The optimized sensor showed a high response (27.95 pF/% RH) in a wide humidity range (11–95% RH) and a fast response speed in the adsorption process (the recovery time was only ~1 s). The high response of the sensors was attributed to the polarization at the interface between the electrolyte and the metal electrode, while the fast recovery was due to the rapid desorption of water molecules on the sensing films. Finally, the application of the obtained sensors in human breath monitoring was explored.Keywords:humidity sensor;high sensitivity;fast recovery;breath monitoring
研究领域:
材料科学
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传感器技术
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产品关联
DOI
高影响因子
Frontiers in Nutrition
·
2022
·
IF 6.59
Leng Xin,She Mengyao,Jin Xilang,Chen Jiao,Ma Xuehao,Chen Fulin,Li Jianli,Yang Bingqin
Copper is a vital trace metal in human body, which plays the significant roles in amounts of physiological and pathological processes. The application of copper-selective probe has attracted great interests from environmental tests to life process research, yet a few of sensitive Cu2+ tests based on on-site analysis have been reported. In this paper, a novel fluorescein-based fluorescent probe N4 was designed, synthesized, and characterized, which exhibited high selectivity and sensitivity to Cu2+ comparing with other metal ions in ethanol–water (1/1, v/v) solution. The probe N4 bonded with Cu2+ to facilitate the ring-opening, and an obvious new band at 525 nm in the fluorescence spectroscopy appeared, which could be used for naked-eye detection of Cu2+ within a broad pH range of 6–9. Meanwhile, a good linearity between the fluorescence intensity and the concentrations of Cu2+ ranged 0.1–1.5 eq. was observed, and the limit of detection of N4 to Cu2+ was calculated to be as low as 1.20 μm. In addition, the interaction mode between N4 and Cu2+ was found to be 1:1 by the Job's plot and mass experiment. Biological experiments showed that the probe N4 exhibited low biological toxicity and could be applied for Cu2+ imaging in living cells. The significant color shift associated with the production of the N4-Cu2+ complex at low micromolar concentrations under UV light endows N4 with a promising probe for field testing of trace Cu2+ ions.
研究领域:
分析化学
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生物医学
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环境科学
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 13
·2219
·
IF 5.719
Haoyuan Cai,Mengwei Wang,Zhuohui Wu,Jing Liu,Xiaoping Wang
We investigate a high-sensitivity surface plasmon resonance (SPR) biosensor consisting of a Au layer, four-layer MoS2, and monolayer graphene. The numerical simulations, by the transfer matrix method (TMM), demonstrate the sensor has a maximum sensitivity of 282°/RIU, which is approximately 2 times greater than the conventional Au-based SPR sensor. The finite difference time domain (FDTD) indicates that the presence of MoS2film generates a strong surface electric field and enhances the sensitivity of the proposed SPR sensor. In addition, the influence of the number of MoS2layers on the sensitivity of the proposed sensor is investigated by simulations and experiments. In the experiment, MoS2and graphene films are transferred on the Au-based substrate by the PMMA-based wet transfer method, and the fabricated samples are characterized by Raman spectroscopy. Furthermore, the fabricated sensors with the Kretschmann configuration are used to detect okadaic acid (OA). The okadaic acid–bovine serum albumin bioconjugate (OA-BSA) is immobilized on the graphene layer of the sensors to develop a competitive inhibition immunoassay. The results show that the sensor has a very low limit of detection (LOD) of 1.18 ng/mL for OA, which is about 22.6 times lower than that of a conventional Au biosensor. We believe that such a high-sensitivity SPR biosensor has potential applications for clinical diagnosis and immunoassays.Keywords:biosensor;MoS2;graphene;SPR sensor;high sensitivity
研究领域:
生物医学工程
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材料科学
·
光学传感
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Yue Qu,Tao Chen,Yuanhong Xu
It is in urgent to develop a facile sulfur ion (S 2- ) detection platform with good selectivity, sensitivity and portability, since the abnormal concentration of S 2- poses a serious threat to human health and environment. Nanozymes are expected as promising colorimetric probe for visual assays, but the selectivity is challenged since the mostly typical nanozymes are oxidoreductase-like ones while various analytes possess equivalent redox capacity. Herein, one-platform-two-channels detection method with both excellent selectivity and sensitivity was constructed based on the bifunctions of tin telluride (SnTe) nanobelts. On one hand, SnTe and S 2- can react rapidly to form a special brown product SnS to assure the selectivity; On the other hand, SnTe with peroxidase-like activity can oxidize 3,3’,5,5’-tetramethylbenzidine (TMB) to blue ox-TMB in the presence of H 2 O 2 , while strong reducing S 2- could inversely convert the solution from blue to colorless and then brown, enabling a wider range of S 2- detection (10 nM-900 μM) and low detection limit of 7.1 nM. In addition, this detection platform could still show excellent specificity against 19 other interfering substances in sulfur soaps with complex components. With the assistance of the color-to-value conversion function of a smartphone, a portable signal reading-out platform was established, which can successfully achieve the accurate visualization of the S 2− in 10 min
研究领域:
分析化学
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环境科学
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生物医学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Chao Li,Tongtong Yun,Yehan Tao,Jie Lu,Chaoxu Li,Jian Du,Haisong Wang
Incorporating biopolymers into two-dimensional transition metal carbides and/or nitrides (2D MXene) has been demonstrated as an effective strategy to improve the mechanical behaviors of MXene-based composites. However, the insulate nature of biopolymers inevitably deteriorated the electrical conductivity and the sensitivity of assembled sensors. Herein, a novel cellulose nanofiber (CNF)/MXene/carbon black (CB) composite was demonstrated as the conductive layer in eco-friendly cellulose paper-based sensors by intercalating the CB into the MXene/CNF interlayer, followed by coating hydrophobic SiO 2 for encapsulation. Befitting from the high-density crack-microstructures between CB and MXene, the fabricated superhydrophobic paper CB/CNF/MXene/SiO 2 sensor delivered ultrahigh sensitivity of 729.52 kPa −1 , low detect limit of 0.29 Pa, rapid response time of 80 ms and excellent stability over 10,000 cycles. Moreover, the fabricated sensor was capable of detecting the physiological parameter of human ( e.g. huge/subtle movements) and spatial pressure distribution. Furthermore, the presence of SiO 2 layer endowed the sensor with superhydrophobic performance (water contact angle ∼158.2 o ) and stable electrical signals under high moisture conditions or even under water. Our work proposed a novel strategy to boost the sensitivity of MXene-based conductive layer in flexible electronic devices.
研究领域:
材料科学
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电子工程
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 23
·5722
·
IF 4.2
Cuimei Chen,Ping Ding
Purposes: To explore the optimization method and application of Au-NP-enhanced luminol––H2O2luminescence system in TORCH (TOX, RV, CMV, HSVI, and HSVII) detection. Method: 4.5 × 10−5mmol/L gold nano solution was prepared with chloroauric acid as the reducing agent and trisodium citrate as the stabilizer. After curing for 3 days, Au NPs participate in the luminal–H2O2luminescence system to detect TORCH antibodies and establish the cut off value. SPSS 18.0 software was used to analyze the TORCH antibodies detected by the nano-gold-enhanced luminol luminescence method and TORCH kit. Additionally, its detection performance is studied. Results: The results of a pairedt-test for the absorbance values of samples with and without gold nanoparticles showed that there were statistically significant differences (p< 0.001) between the two methods in the detection of TOX, RV, CMV, HSVI, and HSVII. The luminescence values with the addition of gold nanoparticles were significantly higher than those without gold nanoparticles. Using the Au NP–luminol–H2O2chemiluminescence method, 127 serum samples were tested for TORCH antibodies. The sensitivities were 84.6%, 83.3%, 90.9%, 85.7%, and 84.6%, while the specificities were 94.7%, 96.5%, 96.6%, 97.3%, and 95.6%, respectively. The sensitivity and specificity of the chemiluminescence method enhanced by gold nanoparticles are significantly improved compared to the chemiluminescence method without enhancers. Conclusions: Au NPs participate in the luminal–H2O2luminescent system. The absorbance, sensitivity, and specificity of TORCH antibodies show that Au NPs can enhance the luminol–H2O2luminescent system. Au NP–luminol–H2O2luminescence system has broad application prospects in the detection of eugenics.
研究领域:
生物医学
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免疫学
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2025
·
IF 10.5
Tao Jing,Yaolei Zhang,Zhongtao Li,Xinyu Tao,Xiong Xiong,Chaoming Xie,Weili Deng,Feng Lin,Hongyu Sun,Shuxin Qu
Monitoring cardiac rhythm is crucial for diagnosis of heart failure. However, the deficient sensitivity of polyvinylidene fluoride (PVDF) sensors impede their application in monitoring of cardiac rhythm due to the limited piezoelectricity. Here, doping of CoFe 2 O 4 and aligning fibers were jointly adopted to enhance the piezoelectricity of PVDF, attributed to the transformation of α-PVDF to β-PVDF from 51.54 to 82.36 % confirmed by FTIR and First Principles simulation. Then the higher sensitivity piezoelectric sensors were developed based on aligned PVDF/CoFe 2 O 4 accompanying with the superior frequency characteristics, rapid response, endurance stability, permeability and self-cleaning capabilities, compared to that of random PVDF/CoFe 2 O 4 and PVDF sensors, which were 17.28, 13.40 and 2.16 mV kPa −1 , respectively. Thus, the sensitivity of PVDF/CoFe 2 O 4 sensors was sufficient to distinguish the variations of cardiac rhythm or arrhythmia of the established and verified heart failure rat model, including amplitude, cycle and frequency. The notable characteristic of an evolving heart failure was the significantly decreased amplitude initially, followed by a dramatic drop in the cycles of cardiac impulse. Hence, this non-invasive method is promise in providing valuable warning signs for predicting heart failure based on aligned PVDF/CoFe 2 O 4 sensors, as well as in the prevention its occurrence.
研究领域:
生物医学工程
·
心血管疾病
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2018
·
IF 4.244
Xiang Han,Chang Tian,Jingjing Jiang,Mao-Sen Yuan,Shu-Wei Chen,Juan Xu,Tianbao Li,Jinyi Wang
Hypochlorous acid plays a very important role in living cells, because it can resist microorganism attack and has a lethal effect on pathogens. The unnormal generation of ClO - can cause tissue damage and corresponding diseases. Detection of ClO - is very necessary in biological systems. In this article, we respectively hybridized the two different water-soluble coumarin (7-hydroxycoumarin and 7-diethylaminocoumarin) fluorophores with a longer-wavelength emissive rhodamine fluorophore to construct an intergrant, and then isothiocyanate was modified with the intergrant to recognized ClO - . The two ratiometric fluorescent probes RHClO-1 and RHClO-2 were developed for ClO - detecting with high selectivity and sensitivity. Especially, the probe RHClO-2 has lower detection limit (42 nM) for ClO - in 5 s. What's more, the probe RHClO-2 was successfully used in monitoring endogenous ClO - in living cells.
研究领域:
生物化学
·
医学检测
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DOI
PubMed
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2022
·
IF 5.572
Ahmet Şenocak,Vildan Sanko,Süreyya Oğuz Tümay,Yasin Orooji,Erhan Demirbas,Yeojoon Yoon,Alireza Khataee
MAX phases have attracted great attention due to unique features such as thermal and electrical conductivity, easy fabrication, heat resistant, and lightweight. In this study, an easy and green method was employed to successfully develop a Ti 3 Al 0.5 Cu 0.5 C 2 MAX phase structure, and a Ti 3 Al 0.5 Cu 0.5 C 2 based glassy carbon electrode (GCE) was applied for the electrochemical determination of rutin antioxidants in mandarin and kiwi samples. The developed Ti 3 Al 0.5 Cu 0.5 C 2 MAX phase was characterized by different techniques such as X-ray photoelectron spectroscopy (XPS), thermogravimetry and differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), diffuse reflectance spectroscopy (DRS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) to obtain information on the structural and morphological properties. Electrochemical methods such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were employed for the determination of rutin using Ti 3 Al 0.5 Cu 0.5 C 2 /GCE. The GCE modified with Ti 3 Al 0.5 Cu 0.5 C 2 demonstrated amplified electrochemical response (ca. 4.25 times) in comparison to the bare GCE towards rutin, and exhibited ultra-sensitivity and selectivity in the presence of other interfering antioxidants. Under the optimum conditions, good linearity in the range of 0.02–50.00 μmol L −1 was obtained for rutin analysis by the Ti 3 Al 0.5 Cu 0.5 C 2 -based sensor with a limit of detection (LOD, 3σ/K) as low as 0.015 μmol L −1 . The fabricated Ti 3 Al 0.5 Cu 0.5 C 2 MAX phase was applied to determine trace levels of rutin in mandarin and kiwi samples with validation by high-performance liquid chromatography (HPLC), thus highlighting its potential for the electrochemical determination of small molecules in the agricultural field.
研究领域:
食品科学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2022
·Vol. 169
·期 1
·016514
·
IF 4.386
Yuandong Liu,Limin Zhang,Jingwen Mo,Yi Zhou,Yang Tian
A Ca2+ selective microelectrode was proposed through electrodepositing graphene oxide (GO) on carbon fiber as an efficient ion-electron transfer layer. The gold leaves were further synthesized at GO surface to increase the specific surface area, and provide a substrate for assembly of the specific ligands for Ca2+. GO with negatively charges greatly facilitated the electron transfer process from the recognition center to electrode surface, resulting in the apparently enhanced sensitivity towards Ca2+. Moreover, the developed ion-selective microelectrode exhibited good selectivity to Ca2+, and a good linear range from 10 μM to 10 mM with a detection limit of 5.91 ± 0.46 μM.
研究领域:
分析化学
·
生物医学工程
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Stanislas Nsanzamahoro,Félicité Pacifique Mutuyimana,Yangxia Han,Sudai Ma,Min Na,Juanjuan Liu,Yunxia Ma,Cuiling Ren,Hongli Chen,Xingguo Chen
Because the chemical properties and structures of catechol and its analogues (hydroquinone and resorcinol) are similar, it still is a great challenge to detect catechol from other hydroxybenzene isomers with high accuracy and reliability. Herein, a selective and sensitive method based on the water soluble silicon nanoparticles (Si NPs) was established for catechol detection, and to the best of our knowledge, this is the first time using Si NPs for catechol measurement. The synthesis of Si NPs was very cheap and simple, no time-consuming, and no need for high temperature processing, or special instrument. The as-synthesized Si NPs, with high salt and temperature stabilities emitted yellow-green fluorescence (540 nm). A good linear relationship was observed from 0.06 to 40 μM and the limit of detection (based on 3 s / k ) was calculated as 20 nM, and the sensor displayed a significant selectivity toward catechol over other dihydroxybenzene isomers. Moreover, the Si NPs were applied in tap water, human serum samples and Yellow River water for catechol measurement.
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）