Advanced Optical Materials
·
2025
·
IF 7.2
Minkun Jin,Wang Chen,Changheng Chen,Yanqi Wu,Lukasz Marciniak,Chongfeng Guo
Chloride double perovskites have sparked significant interest and opened new avenues for luminescent materials hosts due to their lower phonon energy, flexible compositions, and excellent luminescent property. However, the instability to water has limited its fundamental applications, especially in the biological fields, although its stability has been improved in comparison with lead−based perovskites. Here, nanophosphor Cs 2 NaBiCl 6 : Nd 3+ , Yb 3+ (CNBC: Nd 3+ , Yb 3+ ) is prepared by a hot-inject method, and then its stability to water is enhanced by coating a layer of SiO 2 shell. For improving its photothermal conversion ability, organic photothermal agents IR780 is adsorbed on the surface of CNBC: Nd 3+ , Yb 3+ @SiO 2 to form monodispersed temperature self−monitoring photothermal agents CNBC: Nd 3+ , Yb 3+ @SiO 2 @IR780, where the temperature sensing property is based on the temperature−dependent lifetimes of Yb 3+ and the photothermal conversion property comes from the synergistic effect of IR780 and the nonradiative transition of Nd 3+ during luminescence. The maximum relative sensitivity and photothermal conversion efficiency of CNBC: Nd 3+ , Yb 3+ @SiO 2 @IR780 reach 1.44% K −1 at 280 K and 36.8%. Finally, the temperature detection and photothermal antimicrobial ability of CNBC: Nd 3+ , Yb 3+ @SiO 2 @IR780 are evaluated through chicken tissue temperature measurement and photothermal ablation effect against Escherichia coli and Staphylococcus aureus (93.3% and 95.1%).
研究领域:
材料科学
·
纳米技术
·
光学材料
·
生物医学工程
·
光热治疗
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Jing Qian,Duoduo Jiang,Zepeng Cui,Dmitri V. Krysko,Jia Tian,Weian Zhang
Photothermal therapy (PTT) is impeded by limited light penetration depth and cellular heat resistance induced by overexpressed heat shock proteins. Herein, we propose a ferrocene (Fc)-based supramolecular photothermal agent (PTA) to improve the therapeutic efficacy. Cy-Fc/CD-PEG not only had excellent photothermal effect but also possessed the ability to induce ferroptosis and immunotherapy. Cy-Fc/CD-PEG released Fc under intracellular acidic conditions. Then the Fe2+ of Fc could react with endogenous hydrogen peroxide (H2O2) to generate hydroxyl radicals (•OH) and Fe3+. The generated Fe3+ could be reduced to Fe2+ by depletion of intracellular glutathione (GSH), which promoted reactive oxygen species (ROS) generation via triggering the Fenton reaction and consuming GSH, leading to ferroptosis. Meanwhile, apoptotic tumor cells released abundant tumor-associated antigens, activating antitumor immunity. Both in vitro and in vivo experiments demonstrated excellent antitumor effects by the ferrocene-based Cy-Fc/CD-PEG supramolecular PTA. This work provided a PTT–ferroptosis combination strategy that activated antitumor immunity and inhibited tumor growth.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
·
生物化学
·
免疫治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Kexin Fan,Ludan Zhang,Qinqiu Zhong,Yanhe Xiang,Bowei Xu,Yuguang Wang
Although acceptor-donor-acceptor (A-D-A)-type molecules show advantages in constructing NIR absorbing photothermal agents (PTAs) due to their strong intramolecular charge transfer and molecular planarity, their applications in photothermal therapy (PTT) of tumor are insufficiently explored. In particular, the influence of ESP distribution on optical properties of A-D-A photosensitizers has not been investigated. Herein, we utilized the advantages of A-D-A-type molecules with large ESP difference to construct NIR absorbing PTA with sufficient extinction coefficient (ɛ) and high photothermal conversion efficiency (PCE). The calculation results of density functional theory (DFT) indicate that the large ESP difference of Y6 may increase intermolecular interactions and induce tight packing of the A-D-A photosensitizer. As a result, Y6 NP exhibited an obvious bathochromic shift of absorption peak from 711 nm to 822 nm, with a NIR-II emission extended to 1400 nm. Moreover, a sufficient ɛ of 3.34 L·g-1·cm-1 and PCE of 66.3% were attained, making Y6 NP suitable for PTT. With a concentration of 100 μg/mL, Y6 NPs in aqueous dispersion yielded a death rate of 93.4% for 4T1 cells upon an 808 nm laser irradiation (1 W·cm-2) for 10 min, which is comparable with the best results of recently reported PTT agents.
研究领域:
生物医学工程
·
纳米技术
·
光疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Xianqi Zhu,Lin Li,Jin Tang,Chunyu Yang,Hao Yu,Kunpeng Liu,Ziyan Zheng,Xinggui Gu,Qingsong Yu,Fu-Jian Xu,Zhihua Gan
Metastasis has been widely recognized as the most lethal threats for cancer patients . Due to their special genetic and environmental context, cancer stem cells (CSCs) which are resistant to most cytotoxic drugs and radiation, are considered as the dominant culprit for metastasis. Thus, the efficient targeting and thorough elimination of CSCs are significantly urgent for the enhancement of therapeutic efficacy. Herein, we developed a facile and smart photothermal-chemo therapeutic nano-assembly system, of which the surface was modified by a sheddable PEG shell and acid-activatable pro-penetration peptide, to surmount the physiological barriers in targeting CSCs. A highly-efficient diradical-featured croconium-based photothermal agent and a natural cytotoxic heat shock protein (HSP) inhibitor were co-loaded in redox-sensitive chitosan matrices to realize the synergistic photothermal-chemo therapy. Within solid tumors, the PEG shell that prevents the nano-assembly from mononuclear phagocytic clearance could rapidly leave to expose the positively charged chitosan, and the detached iRGD could further actuate the tumor penetration of chitosan nanoparticles , and allow the CSCs targeting by selective recognition of CD44 protein. Owing to the HSP inhibition and chemo-sensitization, both the CSCs and non-CSCs could be thoroughly eliminated by the designed nano-assembly, largely inhibiting the tumor growth and metastasis. This work provides a potential strategy for CSCs-targeting drug delivery to solve the CSCs-related metastasis.
研究领域:
肿瘤学
·
纳米技术
·
药物递送系统
·
癌症生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jiayi Qin,Jia Su,Hong Li,Ling Zhang,Ling Zhang,Ke Jiang
The development of novel antibacterial strategies as alternatives to antibiotics is of great significance but remains considerable challenges due to the lack of safe, effective, and broad-spectrum agents. Here, we explored the potential of a biocompatible metal–organic framework Fe-MIL-53-NH 2 (FM) for reactive oxygen species (ROS)-based antibacterial applications. However, FM was found to be catalytically inert due to the very weak reducibility of Fe 3+ toward H 2 O 2 . To address this challenge, we incorporated a small amount of Co 2+ (0.98 %) into FM (CFM), successfully activating Fenton chemistry and achieving a notable 5.5-fold improvement in Fenton activity. Density functional theory (DFT) calculations revealed that a very small amount of Co 2+ doping significantly reduces the energy barrier of the Fenton reaction by shifting the d-band center to the Fermi level and optimizing the charge density of active Co atoms. We further enhanced the antibacterial properties of CFM by modifying it with the photothermal agent polydopamine (PDA), resulting in CFMP. Through the synergistic effects of ROS and photothermal properties, CFMP exhibited remarkable antibacterial activity, with bacterial eradication rates exceeding 99 % against both E. coli and S. aureus . Moreover, in vivo experiments demonstrated the exceptional efficacy of CFMP in sterilizing S. aureus -infected wounds, while causing negligible damage to other major organs. This study not only highlights the role of atom engineering in activating Fenton reaction, but also provides rational designs for a synergistic antibacterial strategy via powerful MOFs chemistry.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
化学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jinzhe Liang,Yanting Yang,Yanni Luo,Lixian Huang,Shulin Zhao
Elevating photothermal conversion efficiency (PCE) is the key to enhance curative efficacy during photothermal therapy. Nevertheless, current functionalized or synthetic methods for preparing photothermal agents with high PCE are too complicated, greatly hindering the development of photothermal therapy. In this study, we developed a tumor-targeting flower-like nanocomposite termed mesoporous platinum nanoparticles@Cu 2- x Se-AS1411 (MPNPs@Cu 2- x Se-AS1411, denoted as MPCSA) with remarkable PCE for high-resolution photoacoustic (PA) imaging guided photothermal/chemodynamic therapy for tumor ablation. We discovered that MPNPs served as carriers for delivering PA contrast agents. Cu 2- x Se nanosheets emerged as promising near-infrared-II (NIR-II) PA imaging and photothermal/chemodynamic therapy agents owing to their strong localized surface plasmon resonance property in the NIR-II region. The amine-modified AS1411 aptamer, which is connected to the surface of the flower-like MPNPs@Cu 2- x Se can target the nucleolar protein on the surface of 4T1 cells, achieving the accumulation of MPCSA at the tumor site in mice. Notably, these MPCSA nano-flowers exhibited an excellent PCE up to 82.33 % under 1064 nm laser irradiation, resulting in highly efficient cancer cell ablation and greatly hindering in vivo tumor growth. This study has paved the way for imaging-guided accurate cancer diagnosis and targeted cancer therapy.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
癌症研究
·
诊疗学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Boshu Ouyang,Funan Liu,Shuangrong Ruan,Yao Liu,Huishu Guo,Zhengxu Cai,Xiangrong Yu,Zhiqing Pang,Shun Shen
As a novel treatment modality of tumors, hypothermal hyperthermia employed relatively lower temperature (<45 °C) to damage cancer cells with mild toxicity to normal tissues. However, beyond that inducible heat resistance of tumor cells, the discounted therapeutic effect of low temperature hyperthermia was also ascribed to poor penetration of exogenous light stimulation and low accumulation of photothermal agents in tumor sites. Herein, we constructed a multifunctional in situ hydrogel of sodium alginate (ALG) via Ca2+ coordinated with ALG to encapsulate the photothermal agent of Ink and azo initiator of 2,2′-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride (AIPH) for effective tumor treatment. The designed ALG hydrogel was used to improve the therapeutic effect by increased accumulation of Ink and AIPH and avoid potential side-effects caused by the unexpected spread to the surrounding normal tissues. After injection, local low temperature stimulation was generated with near-infrared-II irradiation by a 1064 nm laser, triggering rapid decomposition of AIPH to produce alkyl radicals. The synergistic low temperature photothermal therapy and cytotoxic-free radicals enhanced the apoptosis of tumor cells via physical heat damage and lipid peroxidation. Thus, remarkable inhibition of tumor growth was observed in a subcutaneous colorectal cancer with negligible side effects. Furthermore, the formulation could also exert strong photoacoustic signals, which were utilized to monitor the stability of the composite hydrogel.
研究领域:
生物医学工程
·
癌症治疗
·
光热疗法
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Hao Fu,Yongxin Zhang,Cheng Wang,Zhencheng Sun,Shuyi Lv,Minghui Xiao,Kaiyu Wu,Linqi Shi,Chunlei Zhu
Photothermal therapy (PTT) has emerged as a promising approach for treating bacterial infections. However, achieving a high photothermal conversion efficiency (PCE) of photothermal agents (PTAs) remains a challenge. Such a problem is usually compensated by the use of a high-intensity laser, which inevitably causes tissue damage. Here, we present a universal strategy to enhance PCE by regulating the molecular aggregation states of PTAs within thermoresponsive nanogels. We demonstrate the effectiveness of this approach using aggregation-induced emission (AIE) and aggregation-caused quenching (ACQ) PTAs, showing significant enhancements in PCE without the need for intricate molecular modifications. Notably, the highest PCEs reach up to 80.9% and 64.4% for AIE-NG and ACQ-NG, respectively, which are nearly 2-fold of their self-aggregate counterparts. Moreover, we elucidate the mechanism underlying PCE enhancement, highlighting the role of strong intermolecular π−π interactions facilitated by nanogel-induced volume contraction. Furthermore, we validate the safety and efficacy of this strategy in in vitro and in vivo models of bacterial infections at safe laser power densities, demonstrating its potential for clinical translation. Our findings offer a straightforward, universal, and versatile method to improve PTT outcomes while minimizing cytotoxicity, paving the way for enhanced treatment of bacterial infections with safe PTT protocols.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Yingao Ma,Jingyu Xiao,Gina Jinna Chen,Hong Dang,Yaran Zhang,Xiaoqin He,Perry Ping Shum,Qiongyu Guo
Photothermal treatment has garnered immense interest as a promising approach for biomedical applications such as cancer ablation, yet its effectiveness is often limited by insufficient laser penetration and challenges in achieving efficient targeting of photothermal agents. Here we developed a transvascular interventional photothermal therapy (Ti-PTT), which employed a small-sized microcatheter (outer diameter: 0.63 mm, 1.9 Fr) equipped with an ultrafine optical fiber (diameter: 100 m) capable of simultaneously delivering photothermal agents while performing 808 nm laser irradiation via an endovascular route. Specifically, we employed two types of indocyanine green (ICG)-based photothermal agent, i.e. ICG solution serving as purely photothermal agent and ICG-ethiodized oil (ICG-EO) emulsion acting as radiopaque photothermal embolic agent. Using the customized microcatheter with the ICG solution, both proximal and distal embolization were able to executed in a rat liver model. Compared to the ICG solution, the ICG-EO emulsion dramatically enhanced the ICG retention time, enabling photothermally triggered precision vascular blockade to induce local embolization of large tissue volumes in a rat kidney model with unfavored ICG leakage rate. The Ti-PTT paves a way to broaden the potential applications of photothermal therapy through combining with clinical intervention-based approaches.
研究领域:
生物医学工程
·
诊疗学
·
癌症治疗
·
介入放射学
·
光热科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 18
·11119-11127
·
IF 4.036
Bei Liu,Lirong Sun,Xijian Lu,Yuping Yang,Hongshang Peng,Zhaogang Sun,Juan Xu,Hongqian Chu
Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal–organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, will potentially enhance the performance in cancer therapy.
研究领域:
纳米技术
·
癌症治疗
·
药物递送系统
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Doudou Hu,Hongxia Xu,Wei Zhang,Xiaodan Xu,Bing Xiao,Xueying Shi,Zhuxian Zhou,Nigel K.H. Slater,Youqing Shen,Jianbin Tang
Conventional photothermal therapy (PTT) is insufficient to induce a strong and potent anti-tumor immune response. Herein, we present a vanadyl nanocomplex, which simultaneously serves as a photothermal agent (PTA) and an immunogenic cell death (ICD) inducer to enhance the anti-tumor immunity of PTT. The vanadyl nanocomplex (STVN) is constructed via facile one-step coordination assembly under ambient conditions. STVN not only has a strong and stable photothermal effect under near-infrared (NIR) irradiation, but also can cause severe endoplasmic reticulum (ER) stress by itself, leading to ICD and activating the systemic immune responses. In the absence of any adjuvants, NIR-irradiated STVN almost completely ablates primary tumors and simultaneously inhibits distant tumors in mice bearing bilateral melanoma. Meanwhile, the intratumorally injected STVN combined with NIR effectively suppressed melanoma lung metastasis as well as tumor recurrence, displaying that local STVN-mediated PTT could trigger a systemic anti-tumor immunity. Therefore, STVN, as a novel immunogenicity-enhanced PTA, affords a “one stone two birds” strategy for improved photothermia-induced cancer immunotherapy .
研究领域:
癌症研究
·
纳米技术
·
免疫治疗
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2020
·Vol. 16
·期 24
·2000436
·
IF 11.459
Changyu Cao,Wei Ge,Jiajia Yin,Dongliang Yang,Wenjun Wang,Xuejiao Song,Yanling Hu,Jie Yin,Xiaochen Dong
The emergence of multidrug resistant bacteria has resulted in plenty of stubborn nosocomial infections and severely threatens human health. Developing novel bactericide and therapeutic strategy is urgently needed. Herein, mesoporous silica supported silver–bismuth nanoparticles (Ag-Bi@SiO 2 NPs) are constructed for synergistic antibacterial therapy. In vitro experiments indicate that the hyperthermia originating from Bi NPs can disrupt cell integrity and accelerate the Ag ions release, further exhibiting an excellent antibacterial performance toward methicillin-resistant Staphylococcus aureus (MRSA). Besides, under laser irradiation, Ag-Bi@SiO 2 NPs at 100 µg mL −1 can effectively obliterate mature MRSA biofilm and cause a 69.5% decrease in the biomass, showing a better therapeutic effect than Bi@SiO 2 NPs with laser (26.8%) or Ag-Bi@SiO 2 NPs without laser treatment (30.8%) groups. More importantly, in vivo results confirm that ≈95.4% of bacteria in abscess are killed and the abscess ablation is accelerated using the Ag-Bi@SiO 2 NPs antibacterial platform. Therefore, Ag-Bi@SiO 2 NPs with photothermal-enhanced antibacterial activity are a potential nano-antibacterial agent for the treatment of skin infections.
研究领域:
纳米技术
·
生物医学工程
·
微生物学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）