ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 14
·12080-12097
·
IF 5.2
Wang Yiran,Gao Liwen,Cao Lulu,Zhang Long,Zhang Hejin,Li Junyin,Tong Zhaohui,Wang Keran,Yang Yuechao,Zhang Shugang
In this work, a castor oil-based
polyurethane-based controlled-release
urea modified with dehydroabietic acid-grafted chitosan was prepared,
overcoming the poor hydrophobicity of traditional coatings. Dehydroabietic
acid-grafted chitosan (HNCSDA) was synthesized and incorporated into
castor oil-based polyurethane to fabricate modified coated fertilizers.
The chemical structure, micromorphology, thermal stability, hydrophobicity,
nitrogen release, phytotoxicity and antifungal performance of the
coatings were systematically characterized. HNCSDA improved coating
compactness and continuity, reduced structural defects and formed
an effective diffusion barrier. Increasing the HNCSDA dosage from
0% to 20% increased the hydrophobicity and thermal stability of the
coating; the water contact angle increased from 80.6 ° to 116.7 ° ,
and the release longevity increased by 15.54%. In the absence of maize
phytotoxicity and effectiveness against Botrytis cinerea and Rhizoctonia solani , the modified coatings increase
seedling growth, offering a feasible route to eco-friendly biobased
slow-release antifungal fertilizers for sustainable agriculture.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Zhao Li,Hongjing Liu,Xingyu Chen,Yuqing Zhou,Pengzhi Bei,Ying Zhang
The development of high-performance mixed-matrix membranes (MMMs) for CO 2 separation requires fillers that simultaneously offer molecular-sieving pathways and favorable interfacial compatibility. Here, ZIF-67 was grafted with a long-chain polyetheramine (M600) to yield ZIF-67-M600, which was then incorporated into a Pebax matrix to fabricate novel MMMs. Comprehensive characterization including FT-IR, XRD, SEM, DSC and TGA confirmed the successful grafting of M600 and the homogeneous dispersion of the filler within the polymer. The microporous framework of ZIF-67 provides size-selective transport channels, while the abundant ether groups in M600 enhance CO 2 affinity and facilitate its preferential diffusion. Gas permeation tests demonstrate that the 4 wt% ZIF-67-M600/Pebax membrane achieves a CO 2 permeability of 110.12 Barrer and a CO 2 /N 2 selectivity of 85.96°C at 30°C and 0.2 MPa, corresponding to increases of 65% and 61%, respectively, compared to the pristine Pebax membrane. This performance surpasses the 2008 Robeson upper bound, highlighting that surface grafting of MOFs with CO 2 -philic polymers is an effective strategy to concurrently boost permeability, selectivity, and interfacial adhesion in MMMs for advanced gas separation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zeyuan He,Xiaoqing Zhao,Hongqi Shi,Tao Yang,Liu Yang,Bin Wang,Lei Huang,Run Huang
A novel ZIF-8@Nar@CS nanocomposite was synthesized by a ternary co-assembly strategy. • ZIF-8@Nar@CS has pH-responsive drug release feature following first-order kinetics. • ZIF-8@Nar@CS revealed strong bactericidal effect against E. coli and S. aureus . • ZIF-8@Nar@CS enhanced cytocompatibility and osteogenic activity as compared to ZIF-8. • The designed drug-delivery platform shows potential to be used in orthopedics field. Development of functional nanocomposites for bone tissue repair is often hampered by their bioinertness and insufficient antibacterial performance. To overcome the limitation, this study developed a novel ZIF-8@Nar@CS composite nanoparticle system via a ternary co-assembly strategy. The microstructure of the ZIF-8@Nar@CS was explored by SEM, XRD, FTIR, UV–Vis, BET, and the interaction mechanism of the composite was elucidated via XPS and zeta potential analysis. In addition, the drug release behavior, antibacterial activity and osteogenic property of the composite were also evaluated in vitro. The results show that the ZIF-8@Nar@CS achieved a naringin (Nar) drug loading efficiency of 19.22% through the electrostatic interactions and exhibited a distinct pH-dependent drug release profile. Its cumulative release reached 98.89% at pH 5.5, in stark contrast to only 13.6% at pH 7.4, following first-order kinetics. Profiting from the concomitant release of Zn 2+ , Nar, and chitosan (CS), the ZIF-8@Nar@CS exerted a strong antibacterial activity of 99.99% against both S. aureus and E. coli . Critically, the ZIF-8@Nar@CS also exhibited favorable cytocompatibility and effectively enhanced the osteo-differentiation of MC3T3-E1 cells as compared to the ZIF-8 nanocarrier. This work might provide a new horizon for developing a safe nanoparticle delivery platform for bone repair and regeneration in clinic.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Lu Han,Xueling Huang,Shilu Zhu,Jing Zheng,Xue-bo Yin
A dual-emission COFs@AuNCs@CDs probe for Al 3 ⁺ detection was developed. • Ratiometric fluorescence improves accuracy and anti-interference ability. • Strong coordination-induced enhancement enables sensitive Al 3 ⁺ sensing. • Low detection limit of 0.47 μM achieved with high selectivity. • Smartphone platform enables rapid visual and on-site Al 3 ⁺ monitoring. Aluminum is a prevalent environmental contaminant with known toxicity to humans. However, despite the existence of various detection methods, a facile and rapid sensor for Al 3+ in aqueous environments has yet to be developed. In this work, a two-dimensional porphyrin COF was employed as a host for the encapsulation of carbon dots (CDs) and the uniform assembly of gold nanoclusters (AuNCs) within its pores. AuNCs were covalently linked to amino-functionalized COF nanospheres, while the incorporated CDs enhanced both the visible absorption and charge-transfer efficiency of the COF matrix. The as-prepared COFs@AuNCs@CDs showed blue emission of CDs at 468 nm and red emission of COFs at 687 nm at excitation of 410 nm. Consequently, a novel ratiometric fluorescence sensor was constructed to detect Al 3+ , owing to the strong complexation-induced fluorescence enhancement to achieve highly selective and accurate analysis with a limit of detection (LOD) of 0.47 µM. Furthermore, a smartphone visual sensing platform integrated with COFs@AuNCs@CDs was developed based on the color transformation and successfully applied to visual smart real-time monitoring of Al 3+ . This study is expected to offer valuable insights into the formation mechanism of fluorescent nanostructures, thereby facilitating their applications in the development of high-performance biosensors for precise monitoring. Here, we successfully constructed a novel ratiometric fluorescent sensor, COFs@AuNCs@CDs, for the sensitive and accurate detection of Al 3 ⁺. A portable smartphone-assisted visual analysis platform was designed for on-site determination of Al 3 ⁺. This work provides new ideas for the future design of intelligent and integrated smartphone-based fluorescent sensing platforms for environmental monitoring and point-of-care testing, and expands the application of COFs composites in fluorescent sensing. Download: Download high-res image (194KB) Download: Download full-size image
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Jihang Zhang,Yihui Luo,Siwen Ji,Jinming Zhang,Xiang Chen,Lei Ge,Jinglan Wu,Zhuotao Tan,Sheng Xu,Bin Wu,Hanjie Ying,Wei Zhuang
Sequential coupling of hydrophobic orientation and rapid covalent locking. • Immobilized TLL exhibits >4000% relative activity via conformational tuning. • Interfacial microenvironment regulates partitioning and methanol tolerance. • Biocatalyst demonstrates exceptional durability and efficient conversion. Efficient multiphase bioprocessing for sustainable lipid valorization and biodiesel synthesis relies on robust solid–liquid biointerfaces. Their rational design is fundamentally constrained by severe reaction–diffusion constraints and the intrinsic activity–stability trade-off. Herein, we report a synergistic “orient-and-lock” strategy on bifunctional mesoporous SBA-15 to decouple these limitations. Hydrophobic domains first drive the oriented adsorption and “lid-opening” hyperactivation of Thermomyces lanuginosus lipase, followed by rapid isocyanide-mediated covalent anchoring to kinetically trap this metastable state without compromising structural flexibility. Molecular dynamics simulations elucidate a critical microenvironmental compartmentalization effect. This spatial partitioning selectively enriches lipophilic substrates while isolating polar inhibitors through localized hydrogen-bond networks and hydrophobic compartments, thereby effectively reducing substrate transfer resistance and minimizing active site blockage. Consequently, the immobilized biocatalyst exhibits an unprecedented 40-fold enhancement in apparent specific activity and a 57-fold increase in catalytic efficiency ( k cat / K m ) compared to the free enzyme. Its excellent tolerance to methanol enables a highly efficient one-step methanol addition reaction. The system demonstrates exceptional operational robustness, retaining 80% activity over 25 consecutive cycles and achieving a 96.8% biodiesel yield, establishing a synergistic paradigm of conformational engineering and transport regulation for high-performance heterogeneous biocatalysts. Download: Download high-res image (141KB) Download: Download full-size image
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Biomedicines
·
2026
·Vol. 14
·期 7
·1586
·
IF 4.5
Xiaofei Tong,Meina Sun,Xin Gan,Xin Chen,Shiyang Liu,Ieong Sun,Lin Zhang,Weihong Zheng
Background: Capsular contracture is driven by self-amplifying foreign body response (FBR) where inflammatory and fibrotic signals from fibroblasts and macrophages reinforce each other. We hypothesized that cogradient simultaneous blockade of NF-κB as an inflammatory node and TGF-β/Smad as fibrotic node could attenuate the FBR. Emodin has dual inhibitory activity but suffers from poor delivery.Methods: Emodin liposomes (Emo-Lip) were characterized and tested on TGF-β1-stimulated NIH/3T3 fibroblasts and LPS-stimulated RAW264.7 macrophages. In a rat silicone implant model, periprosthetic injections were given for four weeks. Fibrous capsule formation was evaluated by histology, immunofluorescence, and FAPI-PET/CT. Transcriptomic analyses were performed to verify and predict relevant pathways.Results: Emo-Lip had uniform size and high encapsulation efficiency. In vitro, Emo-Lip inhibited fibroblast migration, ROS production, myofibroblast differentiation (α-SMA+) as well asCtgfexpression, while suppressing M1 polarization and reduced IL-12/IL-6 secretion in macrophages. In vivo, Emo-Lip reduced capsule thickness, collagen area, and α-SMA/Col I expression, comparable to dexamethasone. Transcriptomics showed coordinated downregulation of inflammatory/fibrotic genes, and Western blot confirmed suppressed phosphorylation of Smad3.Conclusions: Coordinated two-node blockade of NF-κB and TGF-β/Smad by liposomal emodin reprograms the FBR and effectively prevents capsular contracture in rats, offering a translational strategy for implant-associated fibrosis.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Mengting Yang,Faqian Sun,Xiao Xiao,Xiaomei Su
Rpf significantly enhances aerobic biodegradation and defluorination of PFOA • Core PFOA biotransformation pathways remain unchanged by Rpf • Defluorination-associated functions are transcriptionally activated • Transcriptionally active PFOA-degrading taxa expanded after Rpf amendment • Rpf upregulates key enzymes across multiple PFOA biodegradation pathways Biodegradation of perfluorooctanoic acid (PFOA) represents a promising strategy for sustainable remediation of per- and polyfluoroalkyl substances (PFAS), yet its efficiency is often constrained by low microbial activity and the prevalence of viable but non-culturable (VBNC) degraders. This study investigated whether the resuscitation-promoting factor (Rpf) from Micrococcus luteus could enhance aerobic PFOA biodegradation and elucidated the underlying microbial mechanisms. An enriched culture (PG5) dominated by Pseudomonadota was established and achieved 55.5% degradation of 10 mg/L PFOA within 48 h, accompanied by fluoride release. Rpf supplementation significantly enhanced PFOA degradation, increasing removal to 68.1% at 10 mg/L PFOA (12.9% increase) and 35.8% at 100 mg/L PFOA (5.2% increase), with corresponding increases in defluorination. Pathway analyses demonstrated that Rpf accelerated degradation without altering the core transformation pathway involving decarboxylation, hydrolytic elimination, and hydrogen exchange. Metatranscriptomic profiling revealed extensive transcriptional reprogramming following Rpf amendment, including the upregulation of genes encoding haloacid dehalogenases, enoyl-CoA hydratase, haloalkane dehalogenase, and fluoride exporters involved in PFOA biotransformation. Genes associated with VBNC-state regulation were also induced, suggesting the potential for reactivation of VBNC populations. Rpf further expanded the transcriptionally active community, with Hyphomicrobium , Aquamicrobium , Pusillimonas , and Chryseobacterium emerging as key functional taxa associated with defluorination and downstream transformation processes. These results demonstrate that Rpf enhances PFOA biodegradation by stimulating functional gene expression and activating diverse microbial populations, providing mechanistic insight into Rpf-mediated enhancement of PFAS biodegradation and highlighting a promising strategy for PFAS bioremediation. Download: Download high-res image (143KB) Download: Download full-size image
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Foods
·
2026
·Vol. 15
·期 13
·2396
·
IF 6
Huiling Huang,Zhichao Yang,Lin Ye,Xujie Hou,Yiming Jia,Shenghuizi Chen,Ying Huang
In this study,Apocynum venetumwas employed as the raw material to optimize protein extraction and enzymatic hydrolysis processes for the preparation of highly active angiotensin-converting enzyme (ACE)-inhibitory peptides, achieving an ACE inhibition rate of 92.34%. Multispectral analyses and microstructural characterization demonstrated that enzymatic hydrolysis induced the unfolding of protein secondary structures, resulting in a looser and more porous morphology enriched with characteristic amino acids. A total of 2567 peptide sequences were identified by LC–MS/MS, among which 18 potential bioactive peptides were screened. Molecular docking analysis revealed that these peptides interact with the active site of ACE primarily through hydrogen bonding and hydrophobic interactions, with WLRDFL exhibiting the strongest binding affinity. This study systematically elucidates the structural characteristics and antihypertensive molecular mechanisms of ACE-inhibitory peptides derived fromApocynum venetum, providing both theoretical insights and experimental support for the development of natural antihypertensive functional foods and the high-value utilization of this plant.
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ACS Sustainable Chemistry & Engineering
·
2026
·Vol. 14
·期 30
·13689-13698
·
IF 7.6
Xu Yanling,Zhou Yue-Wen,Cai Zhen-Feng,Liu Qinlei
Imines are valuable intermediates and building blocks in fine chemicals and pharmaceutical synthesis. Oxidative coupling of amines represents an attractive route to imine formation. However, conventional methods rely on metal catalysts, external oxidants, or thermal and photochemical activation, involving multistep processes, harsh conditions, and environmental concerns. Here, we report that amines undergo oxidative coupling to imines within aqueous microdroplets at room temperature, without any catalyst or oxidant. The molecular structures of products were confirmed by mass spectrometry, UV–vis spectroscopy, and 1 H NMR analysis. Substrate scope studies revealed that the microdroplet system enables both self-coupling and cross-coupling of amines, highlighting its broad generality. Radical trapping experiments and density functional theory calculations suggest reactive oxygen species, including hydroxyl radicals and hydrogen peroxide, are likely involved in the oxidative process occurring at the microdroplet interface. This work introduces a simple, rapid, and environmentally benign strategy for imine synthesis and underscores the unique potential of microdroplet chemistry in advancing green oxidative coupling reactions.
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BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Xinyu Yang,Demeng Liu,Siyu Pan,Delong Hou,Yao Jin,Zhonghui Wang,Yi Chen
Bio-derived C 2 -C 4 SCFAs and methyl acrylate were converted into SAF alkanes. • Electrocatalysis enabled C 8 -C 16 branched alkane synthesis under mild conditions. • C 8 -C 16 branched alkanes were obtained in overall yields of up to 72.5 %. • This route provides a complementary route to mainstream HEFA technology. Branched C 8 -C 16 alkanes are highly desirable sustainable aviation fuel (SAF) components, as they confer low freezing points and favorable combustion properties. Currently, these alkanes are produced predominantly via the hydroprocessed esters and fatty acids (HEFA) pathway, which requires harsh hydrogenation and hydroisomerization conditions that often promote cracking and carbon loss, resulting in high energy consumption and limited yields (20–40 %). Here, we present a mild electrocatalytic strategy that converts bio-derived C 2 -C 4 fatty acids and methyl acrylate into C 8 -C 16 branched alkanes. Using a platinum electrode at ambient pressure and ice-bath temperature, this strategy integrates radical addition, hydrolysis, and decarboxylative coupling in a tandem sequence to achieve efficient carbon-chain growth from short-chain feedstocks. In contrast to HEFA, the process is driven by electrochemical radical generation and selective C- C bond formation rather than hydrogenation, thereby avoiding external H 2 and suppressing the cracking reactions. As a result, the target branched alkanes are obtained in yields of up to 72.5 %, while the mild operating conditions also substantially reduce both energy input and carbon footprint. This work establishes a mild electrosynthetic paradigm for upgrading bio-based chemicals into SAF-range branched alkanes, thereby offering a complement to mainstream HEFA technology. Download: Download high-res image (169KB) Download: Download full-size image
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Food Chemistry-X
·
2026
·
IF 9.2
Chen Yang,Minghui Xu,Wei Jiang,Jiaqi Wang,Xu Zhong,Kaikai Wei,Guijie Chen,Qianying Dai,Chuanjian Cui,Ruyan Hou
This study investigated the feasibility of ultrasound-assisted cold brewing (UACB) for enhancing the efficiency of cold-brewed tea production while preserving its sensory qualities (color, aroma, taste). Scanning electron microscopy (SEM) revealed that UACB promoted tea leaf hydration and disrupted the surface morphology, providing more diffusion channels for metabolites. Metabolomics and quantitative analysis confirmed that UACB achieved higher extraction efficiency than cold-brewed, with alcohols, aldehydes, flavonoids, and chlorophylls exhibiting maximum increases of 3.91, 9.89, 1.53, and 1.43 fold, respectively. After 8 min of UACB, the extraction of major taste compounds such as L-theanine (55.46 μg/mL) and EGCG (72.10 μg/mL) was comparable to that after 1 h cold brewing (56.29 and 64.90 μg/mL, respectively). The rapid leaching of these compounds drives swift formation of floral and bean-like aroma, umami-sweetness, and green color of cold-brewed tea. These findings highlight UACB as an efficient method for enhancing cold-brewed tea production efficiency and quality control.
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2026
·
IF 5
Jianmin Chen,Wanhui Wu,Baozhu Feng,Meilian Ning,Ziyan Cai,Qiulong Zhang,Liyang Du,Yunhua Gao
SPFX-SLNs were systematically optimized using BBD-RSM for infected wounds. • Optimized SLNs showed uniform spherical morphology with a size of ∼87 nm. • SPFX-SLNs exhibited 2-fold higher antibacterial potency than the free drug. • MNs enabled efficient skin penetration for targeted SLNs delivery. • Optimized MNs achieved a 98.61% wound closure rate by Day 14. The efficient management of infected skin wounds is severely limited by the thick bacterial biofilm within the lesion, the intractable stratum corneum barrier of the perilesional skin, and the high toxicities of potent antibiotics. Sparfloxacin (SPFX) was withdrawn from the market due to its severe systemic side effects and UV-induced phototoxicity, while its severe hydrophobicity causes localized crystalline cytotoxicity upon topical application. To safely rejuvenate this potent drug, an integrated transdermal system combining photoshielding, SPFX-loaded solid lipid nanoparticles (SPFX-SLNs) with dissolving microneedles (MNs) was developed. This study primarily focuses on the systematic screening, formulation development, and optimization of SPFX-SLNs via Box-Behnken Design-Response Surface Methodology (BBD-RSM). The optimized nanocarriers exhibited a uniform size (86.85 ± 1.89 nm) and a two-fold higher antibacterial potency against Escherichia coli ( E. coli ) than free SPFX. Mechanistically, the solid lipid core locked SPFX in a safe amorphous state to preclude crystal-induced irritation, while functioning as a physical photoshield against UV activation. By depositing the nanomedicine exclusively into infected dermis, the MN platform minimized systemic drug exposure. In a rat model of E. coli -infected biofilm wounds, the formulated SPFX-SLNs MNs achieved over 50% (58.44%) wound closure within 3 days and near-complete re-epithelialization by day 11, and a 98.61% final closure rate by day 14. Ultimately, this work establishes a comprehensive formulation development strategy for a safety-enhanced, biofilm-penetrable nanomedicine-MN hybrid that successfully repurposes a clinically restricted antibiotic for advanced wound regeneration. Download: Download high-res image (242KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）