JOURNAL OF HAZARDOUS MATERIALS
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2023
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IF 13.6
Yao Liu,Qiang Xue,Zeyu Liu,Lin He,Fei Liu,Haijiao Xie
The rapid detection of rare earth elements is crucial in various fields, such as materials science, biomedicine, and water quality assessment . However, no studies have reported on the detection of yttrium (Y) using electrochemical sensor-based devices. In this study, we present an innovative method for detecting Y(III) ions in aquatic environments using an electroanalytical detection platform. We have developed a complexation catalytic method that integrates trans-1,2-cyclohexanediaminetetraacetic acid (CyDTA) and silver nanoparticles (Ag NPs), thereby enhancing the adsorption and electrochemical response of Y(III) ions. The modified electrode demonstrates an 18-fold increase in the response signal of the Y(III) reduction peak compared to the bare LIG electrode. To elucidate the electrocatalytic mechanism, we conducted various interface characterization methods and DFT simulations. The Ag-CyDTA/LIG electrode exhibits excellent detection performance, with a broad linear dynamic range of 1 × 10 −6 to 0.01 g/L and an exceptionally low detection limit of 0.02 μg/L. Significantly, we successfully employed the electrochemical sensing platform to analyze real water samples from rare earth ore, marking the first report on the voltammetric detection of Y(III) ions in real water samples using a flexible electrode. These findings offer a promising technical solution for the practical detection of Y(III) ions.
研究领域:
环境科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Hao Wan,Qiyong Sun,Haibo Li,Fei Sun,Ning Hu,Ping Wang
This paper presents a fast and sensitive approach for simultaneous electrochemical determination of lead and copper based on a commercial screen-printed gold electrode (SPGE) with gold nanoparticles (GNPs) modification. The influence of activation in sulfuric acid was discussed that the active surface area of SPGE was 1.65 times that of SPGE without activation. Deposition time for GNPs modification was optimized to be 150 s with a higher electrochemical response. Significantly enhanced electrochemical performance was observed in both cyclic voltammetry (CV) and square wave anodic stripping voltammetry (SWASV) compared to that of merely activated SPGE. To detect lead and copper qualitatively and quantitatively, deposition potential and deposition time were respectively optimized to be −0.5 V and 120 s. The GNPs modified SPGE presented a sensitivity of 0.154 μA/ppb and 0.084 μA/ppb towards lead and copper with a correlation coefficient of 0.9792 and 0.9896. GNPs modified SPGE revealed a wide detection range of lead from 20 ppb to 200 ppb with a limit of detection of 2.2 ppb and copper from 20 ppb to 300 ppb with a limit of detection of 1.6 ppb. Reproducibility and consistency of different GNPs modified SPGEs were investigated to verify the performance. The electrochemical behaviour of integrated pseudo-reference and counter electrode was compared with that of commercial electrodes in detail. The results exhibited a reliable approach for lead and copper detection simultaneously with high sensitivity, linearity and low limit of detection.
研究领域:
分析化学
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环境科学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 12
·1-11
·
IF 5.833
Wang Xiao,Liao Xiaochen,Zhang Bingjian,Zhang Mengmeng,Mei Lisha,Wang Fangwai,Chen Siyu,Qiao Xiuwen,Hong Chenglin
Abstract Carcinoembryonic antigen levels in the human body reflect the conditions associated with a variety of tumors and can be used for the identification, development, monitoring, and prognosis of lung cancer, colorectal cancer, and breast cancer. In this study, an amperometric immunosensor with CuCo/carbon nanocubes (CuCo/CNC) as the signal label is constructed. The bimetal-doped carbon skeleton structure has a high specific surface area and exhibits good electrocatalytic activity. In addition, Au/g-C 3 N 4 nanosheets (Au/g-C 3 N 4 NSs) are used to modify the substrate platform, facilitating the loading of more capture antibodies. The reaction mechanism was explored through electrochemical methods, X-ray powder diffraction, X-ray photoelectron spectroscopy, and other methods. Kinetic studies have shown that CuCo/CNC have good peroxidase-like activity. In addition, the electrocatalytic reduction ability of CuCo/CNC on hydrogen peroxide can be monitored using amperometric i – t curve (− 0.2 V, vs. SCE), and the response current value is positively correlated with the CEA antigen concentration. The prepared electrochemical immunosensor has good selectivity, precision, and stability. The dynamic range of the sensor was 0.0001–80 ng/mL, and the detection limit was 0.031 pg/mL. In addition, the recovery and relative standard deviation in real serum samples were 97.7–103 % and 3.25–4.13 %, respectively. The results show that the sensor has good analytical capabilities and can provide a new method for the clinical monitoring of CEA. Graphic abstract
研究领域:
生物医学工程
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肿瘤学
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分析化学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2011
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IF 3.37
Cheng Fang,Jishan He,Zhencheng Chen
A disposable amperometric biosensor for detecting the total cholesterol was fabricated which comprises a sensing electrode and a reference electrode in simultaneous contact with an integrated reagent layer. The integrated reagent layer formed by coating a working ink containing cholesterol esterase, cholesterol dehydrogenase, coenzyme , redox mediator , surfactant, stabilizer, filler and at least one aqueous thickening agent . The biosensor showed the linearity for 50–500 mg/dL cholesterol acetate. The minimum detection limit of the cholesterol was 50 mg/dL. The effects of temperature and the stability of immobilized enzymes were also studied. A good correlation was found among cholesterol values obtained by commercial colorimetric test strip and clinical/laboratory methods. The biosensor showed an acceptable reproducibility, good stability and low interferences.
研究领域:
生物医学工程
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分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
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2025
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IF 3.3
Huang Yilu,Luo Huili,Zhao Jia,Xiang Yuhang
Electrochemical detection is an applicable rapid detection technology, but it is always limited by sample treatment and matrix interference. In this study, two gel/graphite paper electrodes were obtained by drop coating of sodium alginate gel and chitosan gel onto 0.1 mm graphite paper. Comparations of anti-interference performance and stability indicated that sodium alginate gel/graphite paper electrode (GGPBE) was the preferred term for establishing a rapid determination method for Pb in fruits. Based on the contents of organic acids and main metal ions in fruits, analysis and control of matrix interference were conducted. Organic acids, such as ascorbic acid, citric acid and quinic acid, caused greater interferences than metal ions. Mg(II) and Fe(III) were the notable factors of co-interference with organic acids. Matrix interference could be controlled in 3.92% by chemical oxidation using H 2 O 2 combined with HNO 3 ultrasonic extraction. The established linear range of Pb(II) was 0.1 ∽ 21.0 µg/L and LOD was 0.0274 µg/L under square wave anodic stripping voltammetry method. In the detection of 9 fruits, the contents of Pb were below 0.1 mg/kg. This work developed an easily prepared gel/graphite paper electrode and provided a rapid sample treating-detection method of lead in fruits.
研究领域:
分析化学
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食品科学
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产品关联
DOI
高影响因子
IONICS
·
2019
·Vol. 25
·期 12
·6051-6059
·
IF 2.289
Zhang Yanqing,Huang Yanli,Feng Chuanqi,Zhang Yimin,Wu Huimin
In this work, Co 3 O 4 was synthesized by a simple hydrothermal and subsequent calcination treatment for electrochemical detection of H 2 O 2 . In order to improve the electrochemical performance of Co 3 O 4 , it is compounded with the carbon materials derived from cypress leaves, loofah sponge, and pine needles. The electrochemical tests suggested that Co 3 O 4 /loofah sponge-derived carbon showed higher electrochemical activity towards H 2 O 2 than the other two composites. The sensor based on Co 3 O 4 /loofah sponge-derived carbon exhibited a broad linear range from 5.00 μM to 11.40 mM, with a sensitivity of 47.83 μA mM −1 cm −2 and a detection limit of 1.50 μM ( S / N = 3). Thus, this novel nonenzymatic sensor had potential application in H 2 O 2 detection.
研究领域:
材料科学
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分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD PROCESS ENGINEERING
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2024
·Vol. 47
·期 6
·e14654
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IF 2.7
Chengquan Wang,Chengdong Gu,yanna Rong,Xin Zhao,Lu Qian,Mengting Liu,Xingyi Huang,Jing Qian
In this work, a paper-based electrochemical aptamer sensor was developed for the detection of aflatoxin B1 (AFB1) using a combination of MXene–Ti 3 C 2 T x and nucleic acid aptamers. The prepared single-layer or few-layer MXene suspension is suction-filtered onto MXene paper, which is cut to prepare MXene electrodes. To accomplish AFB1 specific detection, an amino-labeled AFB1 aptamer is mounted on the surface of the carboxy-functionalized MXene electrode. When AFB1 is present, it particularly binds to the aptamer to form a 3D structure, reducing the efficiency of electron transmission on the sensor surface. The difference in impedance signal change at the electrode/electrolyte interface is used to quantify AFB1. The results indicated that the detection range is 0.05–100 ng/mL, the detection limit is 0.04 ng/mL, and the recovery rate of AFB1 in corn samples is 97.8%–111.52% with the optimal detection conditions. The MXene paper-based label-free aptasensor is versatile and can detect different targets by simply swapping out the aptamers of different targets. The sensor also has a wide range of applications in food analysis and environmental testing. Practical applications A paper-based electrochemical aptamer sensor was developed to detect aflatoxin B1 using a combination of MXene–Ti 3 C 2 T x and nucleic acid aptamers.The design is based on the preparation of MXene electrodes by pumping and filtering monolayer or multilayer MXene suspensions onto MXene paper and cutting.The MXene paper-based label-free aptamer sensor was designed to be versatile, allowing the detection of different targets by simply replacing the aptamer with one from a different targets.
研究领域:
食品安全
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环境科学
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生物传感技术
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2025
·
IF 5.7
Hangxi Liu,Haorong Sun,Peng Zhao,Kangle Shang,Ming Fang,Xiaoli Tan,Long Yu,Bin Ma
Nitrite ions originate from various natural and anthropogenic sources and can cause health issues including methemoglobinemia and potential carcinogenic effects. As the nitrite in water has become an increasing threat to human health, the accurate evaluation of nitrite is urgently needed for environmental quality and safety management. In this paper, we designed a CTAB/SF5/GCE sensor, which exhibited an obvious enhancement compared to the pristine glassy carbon electrode (GCE). The morphology characterization confirmed the hexagonal nanosheets of SnS 2 and the even distribution of Fe element. The energy band, Tafel plots, and EIS spectroscopy were employed to investigate the enhancement mechanism, demonstrating that improving charge transfer on the sensing interface is crucial in enhanced signals. Cyclic voltammetry (CV) was adopted as the electrochemical method to measure the nitrite in water and a sensitivity of 0.129 μA·μM −1 was exhibited in the range of 30–500 μM, and the limit of detection (LOD) was calculated to be 6.51 μM. The reliability including the repeatability, reproducibility, and stability of this sensor were estimated and showed satisfactory results. The test in real samples and the assessment of interfering substances showed the CTAB/SF5/GCE possesses a large potential in the practical application of electrochemical sensing of nitrite.
研究领域:
环境科学
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材料科学
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分析化学
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产品关联
DOI
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Yujiu Jiang,Peng Zhu,Jiangyue Bai,Zihang Wang,Xiuxia Li,Shiqi Xu,Chunpan Zhang,Shanshan Li,Tinglu Song,Fan Tan,Zhiwei Wang,Aiqin Luo,Bingteng Xie,Yanbo Yang,Junfeng Han
Accurate and rapid detection of the causative agent of a disease is of great importance in controlling the spread of the disease. This work developed a biosensor with the Bi2Te3 family of topological insulators for detection of the SARS-CoV-2 virulence factor. The Bi2Te3 family is a three-dimensional topological insulator material with topologically protected surface states; the presence of these surface states facilitates charge transfer between the electrode and electrolyte interface. Compared with the detection performance of Bi2Se3, BiSbTeSe2, and a trivial insulator like Sb2Se3, Bi2Te3 exhibits superior characteristics. A Bi2Te3 electrochemical detection platform is utilized to fabricate a sensor that can detect SARS-CoV-2 DNA, RNA, and antigen for label-free target detection. The concentration range of DNA detection by the biosensor using Bi2Te3 is between 1.0 × 10–15 and 1.0 × 10–10 M, and the detection limit can reach 1.41 × 10–16 M. Furthermore, it exhibits excellent selectivity and maintains good stability even after being stored for 14 days. This study provides a new way to apply topological insulator materials in the field of biosensors and use their unique electronic structure to improve the accuracy and speed of disease detection and diagnosis.
研究领域:
生物医学工程
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材料科学
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病毒学
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产品关联
DOI
PubMed
高影响因子
Biomedical Materials
·
2024
·
IF 3.9
Chunsheng He,Zhisong Qiu,Feng Jin,Lifang Weng,Libin Chen,Lijuan Wang,Sicong Jiang,Jin Shi
This study presents a novel electrochemical immunosensor for the detection of pepsinogen I, a potential biomarker for gastric cancer, based on a PdAgPt/MoS2 nanocomposite. The nanocomposite was synthesized and characterized, demonstrating enhanced electron transfer properties and a large electroactive surface area. The optimized immunosensor exhibited a wide linear range of 0.5-200 ng/mL and a low detection limit of 0.167 ng/mL. The sensor showed excellent selectivity, with interfering substances exhibiting relative responses below 5%. Reproducibility tests yielded a relative standard deviation of 3.8%, and the sensor retained 95.6% of its initial response after 30 days of storage. Analysis of spiked serum samples resulted in recoveries ranging from 96.8% to 104.5%, demonstrating the sensor's potential for clinical applications in early gastric cancer detection.
研究领域:
医学诊断
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生物传感
·
材料科学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 35
·25561-25570
·
IF 3.9
Chen Chen,Mei Zhao,Jingyi Guo,Xia Kuang,Zilin Chen,Fang Wang
N6-Methyladenosine (m6A) is a prevalent modification in eukaryotic mRNAs and is linked to various human cancers. The fat mass and obesity-associated protein (FTO), a key m6A demethylase, is crucial in m6A regulation, affecting many biological processes and diseases. Detecting FTO is vital for clinical and research applications. Our study leverages the specific cleavage properties of the MazF endoribonuclease to design an electrochemical method with signal amplification guided by streptavidin-horseradish peroxidase (SA-HRP), intended for FTO detection. Initially, the compound N3-kethoxal is employed for its reversible tagging ability, selectively attaching to guanine (G) bases. Subsequently, dibenzocyclooctyne polyethylene glycol biotin (DBCO-PEG4-Biotin), is introduced through a reaction with N3-kethoxal. HRP is then employed to catalyze the redox system to enhance the current response further. A promising linear correlation between the peak current and the FTO concentration was observed within the range of 7.90 × 10−8 to 3.50 × 10−7 M, with a detection limit of 5.80 × 10−8 M. Moreover, this method assessed the FTO inhibitor FB23's inhibitory effect, revealing a final IC50 value of 54.73 nM. This result aligns with the IC50 value of 60 nM obtained through alternative methods and is very close to the values reported in the literature. The study provides reference value for research into obesity, diabetes, cancer, and other FTO-related diseases, as well as for the screening of potential therapeutic drugs.
研究领域:
分子生物学
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医学检验
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Di Wu,Lingxia Qin,Yeping Cen,Jin Lu,Shaohua Ma,Yufang Hu
The necessity for precise delineation and quantitation of pyrophosphatase (PPase) activities is underscored, especially in aggressive prostate cancer, driving the demand for more refined analytical techniques due to challenges associated with inadequate sensitivity and poor signal amplification. In response, a novel electrochemical method utilizing in-situ copper(II) (Cu(II))-based Fast Scan Cyclic Voltammetry (FSCV) is introduced for the advanced detection of PPase in LNCaP prostate cancer cells. This technique is characterized by the exploitation of competitive binding between Cu(II) and L-Phenylalanine (L-Phe) versus pyrophosphate (PPi), with FSCV technology enhanced by ohmic drop compensation to improve detection sensitivity and signal reliability. Through the application of the FSCV technique transitioned to Current(I)-Voltage(V) analysis, the signal generation is facilitated by an L-Phe-Cu(II) complex, driven by the redox reaction of in-situ Cu(II), specifically its rapid transition from the Cu(0) state back to the Cu(II) state. When this complex is anchored onto a gold substrate modified with cucurbit[7]uril (CB[7]) through supramolecular host–guest interactions, a significant FSCV signal is elicited. A detection limit of 0.05 mU/mL (S/N = 3) is subsequently achieved when the method is applied to the quantification of PPase concentration. Leveraging the FSCV method, we have effectively analyzed PPase activity in LNCaP cells, offering a fresh perspective on tumor marker analysis and fostering advancements in drug development.
研究领域:
生物化学
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医学诊断
·
癌症研究
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）