Nano Select
·
2020
·Vol. 2
·期 2
·303-312
·
IF 0
Xin Tian,Yue Lang,Dexuan Gao,Xiang-Xiang Zhang,Hai-Yue Dong,Meng-Meng Gu,Lan Yu,Zeng-Fu Shang
Targeted anti-cancer therapy selectively inhibits the growth of malignant cells by interfering with cancer-specific signaling pathways, and inflicts minimal toxicity to normal tissues. Here, the current study demonstrates black phosphorus quantum dots (BPQDs) can target histone deacetylase 1 (HDAC1), which is overexpressed in multiple tumors and involved in cancer progression. The BPQDs inhibit HDAC1 activity and impair HDAC1-mediated deacetylation of the mitotic spindle protein Eg5 in human renal cell carcinoma (RCC) cells, thereby disrupting the mitotic spindle structure and stalling cell cycle progression. Since HDAC1 regulates multiple aspects of cancer progression, BPQDs can neutralize the malignant potential of cancer cells by suppressing their proliferation and migration, and inducing apoptosis. Further in vitro assays demonstrate BPQDs significantly increase the sensitivity of RCC cells to the clinical chemotherapeutic agent, paclitaxel (PTX). Moreover, animal experiments also indicate the combined approach with both BPQDs and PTX displays better efficacy than PTX alone. These findings demonstrate that BPQDs have potential applications in targeted anti-cancer therapy and can be more effectively treated with chemotherapy.
研究领域:
肿瘤学
·
生物医学
·
药理学
✓ 已验证
DOI
Journal of Energy Chemistry
·
2018
·
IF 3.886
Lihong Yu,Feng Lin,Lin Xu,Jingyu Xi
A phosphorous-doped graphite felt (PGF) is fabricated and examined as electrode for vanadium flow battery (VFB). P doping improves the electrolyte wettability of GF and induces more defect sites on its surface, resulting in significantly enhanced activity and reversibility towards VO 2+ /VO 2 + and V 2+ /V 3+ couples. VFB with PGF electrode demonstrates outstanding performance such as high-rate capability under 50–400 mA cm −2 , wide-temperature tolerance at −20 °C–60 °C, and excellent durability over 1000 charge–discharge cycles. These merits enable PGF a promising electrode for the next-generation VFB, which can operate at high-power and all-climate conditions.
研究领域:
能源化学
·
材料科学
·
电化学
·
储能技术
✓ 已验证
DOI
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 6
·2715-2723
·
IF 6.482
Xiaojing Feng,Zhongnan Guo,Xiaoxiao Yan,Jun Deng,Dan Wu,Zijing Zhang,Fan Sun,Wenxia Yuan
Metal phosphorus trichalcogenides (MPX3) are of great interest since these layered materials exhibit wide applications in optical, electrical and magnetic fields. An effective chemical intercalation route for MPX3 which could regulate their physical properties, however, is still lacking. In this work, we show that the liquid ammonia method is an efficient route to co-intercalate alkali metals and NH3 molecules into the gaps in FePS3. After intercalation, the interlayer distance is significantly enlarged by ∼3 Å while the monoclinic lattice (C2/m space group) is still maintained. The structure refinement and EDS measurement suggest that intercalation does not induce any Fe vacancy, thus leading to electron transfer from the alkali metal to [FePS3] layers. Interestingly, magnetic susceptibility shows that the intrinsic anti-ferromagnetic transition in the FePS3 matrix is completely suppressed by this intercalation, whereas a spin-glass state is observed in A(NH3)xFePS3 (A = Li, K) in the lower temperature range (<50 K). The intercalation described in this work is reversible: the alkali metal can be easily de-intercalated using a two-step route and the anti-ferromagnetism reappears accordingly. Meanwhile, the liquid ammonia method is also shown to be efficient at intercalating other MPS3 materials (M = Mn, Co, Ni). Our work not only enriches the intercalation chemistry in the MPX3 system but also provides an excellent route to regulate the magnetic properties of these layered materials.
研究领域:
材料科学
·
无机化学
·
凝聚态物理
·
纳米技术
·
功能材料
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2019
·Vol. 22
·期 2
·311-319
·
IF 3.382
Wei Wang,Hang Yang,Yixin Liu,Xiaohan Yun,Yi Wei,Guogang Li
Establishing effective methods to optimize luminescent materials has been a significant challenge for white light-emitting-diode (WLED) applications. Herein, we successfully realized the adjustment of the photoluminescence and enhancement of the thermal stability of Ln3+ (Ln3+ = Ce3+, Eu3+)-doped Ca10−x/yBax/y(PO4)6O phosphors. First, Ba2+ ions from raw BaCO3 material realized a spectral red shift from 464 nm to 506 nm, which we suggested to be due to a synergistic effect from a centroid shift and crystal field splitting. When using BaHPO4 as a raw material, the PL intensity was 6.5 times that of the initial intensity. Surprisingly, the thermal stability was also improved, which was attributed to the increasing lattice distortion introducing many traps. Second, the Ca10(PO4)6O:Eu3+ red phosphor exhibited an abnormal emission phenomenon involving the 5D0 → 7F0 peak at 575 nm becoming the strongest emission peak and the 5D0 → 7F1 peak at 585 nm becoming particularly weak. The site symmetry and charge transfer states were speculated to be closely related to this phenomenon. The charge transfer states were not only correlated with the crystal field strength, but also related to f-electron delocalization, which significantly influenced the energy-level structure of Eu3+. More importantly, according to the relationship between the I(5D0 → 7F0)/I(5D0 → 7F1) ratio and the lattice structure, Eu3+ in the Ca10(PO4)6O compound could be applied as a probe to explore the matrix information, which would provide a helpful method to investigate the lattice structures of compounds and also guide researchers to design new suitable red phosphors.
研究领域:
材料科学
·
光学材料
·
无机化学
·
固体物理
·
发光学
✓ 已验证
DOI
高影响因子
Nanoscale Research Letters
·
2016
·Vol. 11
·期 1
·1-7
·
IF 2.584
Xia Fangqing,Yong Huaisong,Han Xiao,Sun Dazhi
Exfoliation of layered inorganic nanomaterials into single-layered sheets has been widely interested in materials chemistry and composite fabrication. Here, we report the exfoliation of layered zirconium phosphate nanoplatelets by using small molecule intercalating agents in ionic liquids, which opens a new platform for fabricating single-layered inorganic materials from synthetic layered compounds.
研究领域:
材料化学
·
纳米材料科学
·
复合材料制备
✓ 已验证
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 13
·3941-3949
·
IF 6.1
Guocheng Pan,Yaowu Wang,Jianfeng Wang,Zhenping Wu,Yiheng Yue,Nan Lin,Shiqing Xu,Gongxun Bai
Near-infrared (NIR) phosphor-converted light emitting diodes (pc-LEDs) highly demand broadband NIR phosphors for applications in food safety and smart detection. However, the lack of tunable NIR luminescent materials limits their development. Herein, we constructed a series of NIR Cr3+ doped Ga2O3-based materials with broadband, tunable, efficient emissions by utilizing [Zn2+–Ge4+] and [Ga3+–Ga3+] co-unit substitution. The obtained results show that the emission peak of NIR phosphors can be modulated from 713 to 765 nm. Meanwhile, the excitation peak remains in the blue light region. NIR phosphor-converted devices were prepared with 450 nm LED chips, which were studied using NIR imaging, penetration imaging, anti-counterfeiting, and pupil recognition technologies. Interestingly, NIR mechanoluminescence (ML) was realized based on the developed phosphors, which were successfully applied for non-destructive measurements of solids and in vivo bioimaging. Our study proposes a series of tunable and broadband luminescent materials and devices for NIR applications.
研究领域:
材料科学
·
光学工程
·
生物医学工程
·
传感器技术
·
固体物理
✓ 已验证
DOI
高影响因子
CHEMICAL PAPERS
·
2021
·Vol. 76
·期 1
·351-359
·
IF 2.097
Wang Mei,Wang Guanglin,Xu Yunfei,Song Xianghai,Bu Quan
PVC materials grafted with ricinoleic acid-derived phosphate ester (PVC-AR-g, g = 1 ~ 4, where ricinoleic acid-derived phosphate ester grafts are abbreviated as AR) were prepared via a green and effective synthetic method. These materials were developed with the aim of overcoming the toxicity limits and environmental pollution issues caused by toxic dioctyl phthalate, which is traditionally used for plasticizing PVC materials. In this study, 3-aminopropyltri ethoxysilane (APTES) and AR, which contains phosphate ester groups, hydroxyl groups, linear alkyl groups, highly flexible long carbon chains and siloxane were introduced into the chains of PVC to efficiently plasticize PVC materials. Dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC) were used to investigate the mechanical and plasticization properties, respectively, of the plasticized PVC films. Meanwhile, the leaching properties were also examined. The good plasticization behavior of the PVC-AR-g materials was attributed to the numerous hydroxyl, ester, linear siloxane and highly flexible long carbon chain present simultaneously in the branched segments, which formed strong hydrogen bonding and dipole–dipole interactions with the PVC main chains. Moreover, the PVC-AR-g materials showed improved thermal stability and outstanding anti-migration ability because of the covalent bonds between the PVC and graft intermediate.
研究领域:
高分子材料科学
·
生物医学工程
·
环境毒理学
·
绿色化学
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2015
·Vol. 22
·期 4
·2787-2796
·
IF 3.573
Gao Wei-Wei,Zhang Guang-Xian,Zhang Feng-Xiu
In this study, a novel, halogen-free, formaldehyde-free, organic phosphorus-based flame retardant, ammonium salt of hexamethylenediamine- N , N , N ′, N ′-tetra(methylphosphonic acid) (AHDTMPA), was synthesized using urea and hexamethylenediamine- N , N , N ′, N ′-tetra(methylphosphonic acid) (HDTMPA). AHDTMPA reacted with the O-6 hydroxyls of glucose residues in the cellulose of cotton fabric to form P–O–C covalent bonds. This ability was confirmed by Fourier-transform infrared (FTIR) spectroscopy, attenuated total reflection FTIR spectroscopy, and X-ray diffraction. Cotton fabric treated with 70 g/L AHDTMPA had a limiting oxygen index (LOI) value of 36.0 %, which remained relatively stable after 50 laundering cycles with a 28.0 % LOI value. The surface morphology and thermal stability of treated cotton fabrics were investigated using scanning electron microscopy and thermogravimetric analysis (TGA), respectively. TGA showed that AHDTMPA could exhibit flame retardancy at temperatures lower than the pyrolysis temperature of cotton fabrics. Additionally, the cotton fabric was treated with AHDTMPA through a pad-cure process, as its ease of operation, high efficiency, and excellent application made it an attractive treatment.
研究领域:
材料科学
·
纺织工程
·
高分子化学
·
阻燃技术
·
表面改性
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2012
·Vol. 28
·期 9
·887-892
·
IF 1.255
Yun ZHANG,Shengdong PAN,Haoyu SHEN,Meiqin HU
An efficient analytical method for the preconcentration and determination of phosphate in water samples at trace levels was proposed. The method was based on sample enrichment using dispersive solid-phase extraction (dSPE) with tetraethylenepentamine (TEPA)-functionalized nano-size composite materials (TEPA-NCMs) as sorbents, which were fully characterized. Various parameters affecting the extraction efficiency were systematically investigated. After extraction, the post-adsorbed TEPA-NCMs were eluted by a NaOH solution for desorption of the phosphate. The resulting eluate containing phosphate was determined by a spectrophotometric method. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.29 and 0.96 μg L−1, respectively. The relative standard deviations (RSDs) were lower than 8.0% with average recoveries ranging from 91 to 118%. The present method was successfully applied to the determination of phosphate at trace levels in real water samples, and it was confirmed that the TEPA-NCMs are highly effective dSPE materials.
研究领域:
环境科学
·
分析化学
·
材料科学
·
水资源管理
·
污染物检测
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Zhihao Wu,Ruchun Chen,Shuang Pan,Hui Liu,Xiaoli Hu
Herein, a convenient method is developed for ratiometric fluorescence detection of ATP (adenosine triphosphate) based on CDs-OPD (carbon dots- o-phenylenediamine). In the absence of ATP, oxOPD, the colored oxidation product of OPD fabricated by a redox reaction occurred between OPD and Cu 2+ , not only quenches the fluorescence of CDs, but also emits a yellow fluorescence which acts as another signal element. However, ATP will compete with OPD to chelate Cu 2+ inhibiting the redox reaction, which hampers the formation of oxOPD resulting in the diminution of IFE (inner filter effect) between CDs and oxOPD, then the fluorescence of CDs restores. ATP-induced dual-signal response of the CDs-OPD/Cu 2+ system makes ratiometric assay possible. The method exhibits high sensitivity toward ATP with a detection limit of 0.43 μmol L −1 . Furthermore, the semi-quantitative measurement of ATP is available by naked eyes through the color of fluorescence and solution. Finally, the developed method is employed for the quantification of ATP in practical samples with satisfactory results.
研究领域:
分析化学
·
生物传感
·
纳米材料
·
分子生物学
·
临床检验
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Jin Yang,Jianhao Zha,Qinan Mao,Heyi Yang,Lang Pei,Jiasong Zhong
Indoor plant cultivation has been receiving increased attention due to concerns about sustainable agricultural production. Phosphor-converted light-emitting diodes (pc-LEDs) offer substantial promise as lighting solutions for regulating plant growth. However, the quest for high-performance phosphors with precise responsiveness to far-red phytochromes poses a challenge. Our study proposes a chemical substitution strategy to develop near-infrared (NIR) phosphors, YAl3–xGax(BO3)4:Cr3+. Benefiting from Ga3+ replacement of Al3+, a red shift in the NIR emission of YAl3–xGax(BO3)4:Cr3+ is realized to attain a good alignment with far-red phytochrome absorption centering at 730 nm. The optimized YAl2.5Ga0.5(BO3)4:Cr3+ exhibits a favorable quantum yield of 71.8% and robust thermal stability of 101.0%@423 K, owing to local structural distortion and thermal repopulation caused by Ga3+ incorporation. The fabricated pc-LED combined with the phosphor yields an NIR output power of 40.9 mW and a photoelectric conversion efficiency of 15.4% at 100 mA. Plant growth experiments demonstrate that under NIR illumination from the devices, the average lengths of pea roots and stems gain 127 and 225% promotion, respectively, further highlighting the potential of YAl2.5Ga0.5(BO3)4:Cr3+ phosphors for applications in plant cultivation.
研究领域:
材料科学
·
光电子学
·
园艺照明
·
固态照明
·
光生物学
✓ 已验证
DOI
高影响因子
Aging and Disease
·
2024
·Vol. 16
·期 3
·1652
·
IF 7
Cheng Zhuang,Ruiqi Sun,Yuchen Zhang,Qing Zou,Jianxin Zhou,Naijun Dong,Xuyu Zhao,Wenjun Fu,Xiaoke Geng,Jiao Wang,Qian Li,Robert Chunhua Zhao
Rheumatoid arthritis (RA) is an autoimmune disease that affects the living quality of patients, especially the elderly population. RA-related morbidity and mortality increase significantly with age, while current clinical drugs for RA are far from satisfactory and may have serious side effects. Therefore, the development of new drugs with higher biosafety and efficacy is demanding. Black phosphorus nanosheets (BPNSs) have been widely studied because of their excellent biocompatibility. Here, we focus on the inherent bioactivity of BPNSs, report the potential of BPNSs as a therapeutic drug for RA and elucidate the underlying therapeutic mechanism. We find that BPNSs inhibit autophagy at an early stage via the AMPK-mTOR pathway, switch the energy metabolic pathway to oxidative phosphorylation, increase intracellular ATP levels, suppress apoptosis, reduce inflammation and oxidative stress, and down-regulate senescence-associated secretory phenotype (SASP)-related genes in rheumatoid arthritis synovial fibroblasts (RA-SFs). Further, BPNSs induce the apoptosis of macrophages and promote their transition from the M1 to the M2 phenotype by regulating related cytokines. Significantly, the administration of BPNSs can alleviate key pathological features of RA in mice, revealing great therapeutic potential. This study provides a novel option for treating RA, with BPNSs emerging as a promising therapeutic candidate.
研究领域:
纳米医学
·
免疫学
·
药理学
·
细胞生物学
·
生物医学工程
·
风湿病学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）