JOURNAL OF ORGANIC CHEMISTRY
·
2025
·
IF 3.6
Qiujie Shan,Lu-Lu Chai,David James Young,Zhi-Gang Ren,Hong-Xi Li
The light-promoted, nickel-catalyzed hydrogen-evolution C(sp3)–H acylation of simple alkanes with aromatic aldehydes has been achieved without the need for additional photosensitizers or oxidants. This reliable and atom-economical reaction afforded a broad range of aryl alkyl ketones in good yields, with H2 as the sole byproduct. It was successfully demonstrated on a gram scale as well as for the postfunctionalization of drug molecules. Aromatic aldehydes play multiple roles, including a photosensitizer, a coupling partner, and a hydrogen atom transfer agent.
研究领域:
有机化学
·
催化化学
·
光化学
·
绿色化学
·
药物化学
·
合成化学
✓ 已验证
DOI
PubMed
高影响因子
Batteries & Supercaps
·
2025
·
IF 4.7
Haiyan Qin,Xia Sun,Tingzhou Yang,Pengrong Zhang,Haochen Dong,Ning Liu,Yongguang Zhang,Zhongwei Chen
Graphical This study presents a scalable cathode recycling method using a continuous stirred-tank reactor to produce high-performance Li-rich Mn-based cathodes, which achieves 97.38% metal recovery rate and over 500 cycles of superior cycling stability, 22.74% longer lifespan than commercial materials. Life-cycle and economic analyses indicate a 44.22% reduction in costs and significant ecobenefits across all midpoint and endpoint impact categories. As a vital urban mineral resource, the efficient recycling of spent lithium-ion batteries (LIBs) is crucial for mitigating resource scarcity and environmental pollution, especially for obtaining high-value cathode materials through various regeneration methods. Herein, a large-scale recyclable and sustainable direct cathode regeneration strategy is explored to obtain stable lithium-rich manganese-based cathode materials via a customized continuous stirred tank reactor, enabling the transition to next-generation high-energy-density LIBs via battery recycling. A high recycling efficiency between 97.38% and 99.93% is achieved for high-value transition metal elements, and the regenerated next-generation higher-specific capacity cathode materials with higher lattice oxygen and lower oxygen vacancy demonstrate better structural stability and improved electrochemical performance than corresponding commercial materials. Life cycle and technoeconomic analysis are used to highlight the cathode regeneration method, which exhibits significant advantages across all 18 midpoint and 3 endpoint environmental impact categories, with a 44.22% cost reduction compared to commercial materials. This commercialization strategy holds significant promise for advancing closed-loop battery recycling and minimizing environmental pollution in LIB production, offering a new perspective for sustainable battery recycling.
研究领域:
材料科学
·
化学工程
·
环境科学
·
能源技术
·
电化学
·
可持续资源管理
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2023
·Vol. 25
·期 13
·5296-5303
·
IF 9.8
Huanhuan Jin,Shuyun Ju,Haoran Yu,Lirong Yang,Wenlong Zheng,Jianping Wu
Quinolines are important building blocks for the synthesis of natural products and pharmaceuticals. In comparison with classical methods, dehydroaromatization of 1,2,3,4-tetrahydroquinolines has emerged in recent years as an efficient and straightforward way to access quinolines due to its high atom economy and sustainability. However, existing chemical methods suffer from the use of transition metal catalysts and harsh reaction conditions. Herein, we report a novel biocatalytic route for the efficient oxidative dehydrogenation of 1,2,3,4-tetrahydroquinolines employing monoamine oxidase from Pseudomonas putida KT2440 (PpMAO) with molecular oxygen, affording the corresponding quinolines with moderate to excellent yields (up to 99%) combined with the adjustment of the microenvironment for deprotonation and the supplied amount of molecular oxygen. Unlike other common one-step aromatizations of N-heterocycles, mechanism studies have suggested that PpMAO-catalyzed aromatization involves at least two-step C–N bond dehydrogenation reactions. The first step is the formation of an imine intermediate catalyzed by enzymes, followed by enzyme-mediated aromatization in the second step. Furthermore, preparative-scale biotransformation of tetrahydroquinolines was successfully demonstrated with good isolated yields (up to 95%). This system not only provided an efficient and facile method for the synthesis of quinolines under mild conditions but also enriched the redox biocatalytic approaches to N-heterocycles.
研究领域:
有机化学
·
生物催化
·
药物化学
·
绿色化学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Xu Shuai,Wang Shu-hong,Lou Long-wei,Ji Yu,Schwaneberg Ulrich,Li Zhi-min,Cheng Feng,Li Zong-lin
Non-canonical amino acids (ncAAs) bearing diverse functional groups hold transformative potential in drug discovery, protein engineering, and biomaterial science. However, their industrial-scale production remains constrained by the inefficiency, high cost, and environmental burden of conventional chemical and enzymatic methods. Here, we present a modular multi-enzyme cascade platform that leverages glycerol—an abundant and sustainable byproduct of biodiesel production—as a low-cost substrate for ncAAs synthesis. Directed evolution of O -phospho- l -serine sulfhydrylase (OPSS) enhances the catalytic efficiency of C–N bond formation by 5.6-fold, enabling the efficient synthesis of triazole-functionalized ncAAs. By integrating a plug-and-play enzymatic strategy, our system enables gram- to decagram-scale production of 22 ncAAs with C–S, C–Se, and C–N side chains and can be readily scaled up to a 2 liter reaction system. Notably, water is the sole byproduct, and all products exhibit an atomic economy of >75%, highlighting the environmental compatibility of this platform. This work establishes a green, cost-effective, and industrially viable approach to expanding amino acid diversity, providing a versatile toolkit for applications in pharmaceuticals, synthetic biology, and next-generation biomaterials.
研究领域:
合成生物学
·
生物催化
·
绿色化学
·
酶工程
·
工业生物技术
·
药学
·
生物材料
·
蛋白质工程
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 39
·16741-16751
·
IF 3.288
Jiacheng Wang,Wenshu Qiao,Haitian Zhao,Jianjun Cheng,Ying Han,Xin Yang
The development and application of nano-drug carrier systems have opened up unprecedented opportunities for tumor treatment. However, eliminating the related liver toxicity is still very challenging because hepatotoxicity is the most severe adverse effect of chemotherapy and nanotherapy. Herein, a highly atom-economical bioactive nanocarrier delivery system is shown. This carrier is assembled from oleanolic acid (OA), which is abundantly present in Chinese medicinal plants and has shown potent antioxidant, antitumor, and hepatoprotective properties. Molecular simulation and experimental characterization have demonstrated that the assembly process of OA-encapsulated paclitaxel (PTX) to form OA–PTX nanoparticles is mainly through hydrophobic interactions and hydrogen bonding interactions. In vitro and in vivo experiments confirmed that OA and PTX have synergistic antitumor effects due to their different antitumor mechanisms. As expected, liver injury induced by PTX was significantly reduced due to the hepatoprotective activity of OA. The prepared nanomedicine has high drug loading capacity and excellent targeting, as well as good biocompatibility and low in vivo toxicity, which ensure the effectiveness of the tumor treatment and the safety of the body. The present study provides new ideas for the development of nanocarriers and avenues for active natural products in reducing drug side effects.
研究领域:
药学
·
纳米技术
·
癌症研究
·
毒理学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Chem Catalysis
·
2023
·
IF 9.4
Jinhui Han,Xirong Liu,Hao Jin,Panchi Guo,Liang Xu,Pengfei Li,Miao Zhan
Summary Transition-metal-catalyzed allylic alkylation of α -boryl metallic reagents has provided unique access to chiral homoallylic organoboron compounds . However, these organoboron products possess only one stereogenic center, which is derived exclusively from either allylic electrophiles or gem -diborylalkanes. The construction of contiguous stereocenters from both α -boryl metallic reagents and allylic electrophiles has remained elusive. We report a straightforward method to prepare secondary α -monoboryl organozinc reagents through α -deprotonation of benzylboronates and in situ Li/Zn exchange that was then applied in the iridium-catalyzed allylic alkylation reaction through a doubly stereoconvergent process. Various boron-containing 1,2-stereodiads were obtained in good yields with decent diastereo- and enantioselectivities . Compared to the deborylative allylic alkylation using gem -diborylalkane, this study demonstrates high atom economy and a wide substrate scope. A preliminary mechanism study demonstrated that the stereoconvergent and kinetic resolutions of racemic carbonates proceed simultaneously.
研究领域:
有机化学
·
催化
·
合成化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）