Journal of Materials Chemistry B
·
2024
·
IF 6.1
Dengyue Chen,Jieli Yin,Chen Liu,Jiaqi Guo,Mao Li,Baoyin Chen,Xuewen Zhang,Bing Wang,Xuan Zhu
Both chemodynamic therapy and photodynamic therapy, based on the production of reactive oxygen (ROS), have excellent potential in cancer therapy. However, the abnormal redox homeostasis in tumor cells, especially the overexpressed glutathione (GSH) could scavenge ROS and reduce the anti-tumor efficiency. Therefore, it is essential to develop a simple and effective tumor-specific drug delivery system for modulating the tumor microenvironment (TME) and achieving synergistic therapy at the tumor site. In this study, self-assembled nanoparticles (named CDZP NPs) were developed by copper ion (Cu2+), Doxorubicin (Dox), Zinc phthalocyanine (ZnPc) and a trace amount of poly (2-(di-methylamino) ethylmethacrylate)-poly [(R)-3-hydroxybutyrate]-poly (2-(dimethylamino) ethylmethacrylate (PDMAEMA-PHB-PDMAEMA) through chelation, π-π stacking and hydrophobic interaction. This triple factors-responsive (pH, laser and GSH) nanoparticles demonstrated unique advantages through the synergistic effect. Highly controllable drug release ensured its effectiveness at the tumor site, Dox-induced chemotherapy and ZnPc-mediated fluorescence (FL) imaging exhibited the distribution of nanoparticles. Meanwhile, Cu2+-mediated GSH-consumption not only reduced the intracellular ROS elimination but also produced Cu+ to catalyze hydrogen peroxide (H2O2) and generated hydroxyl radical (∙OH), thereby enhancing chemodynamic and photodynamic therapy. Herein, this study provided a green and relatively simple method for preparing multifunctional nanoparticles that can effectively modulate the TME and improve synergetic cancer therapy.
研究领域:
纳米技术
·
癌症治疗
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药物递送系统
·
肿瘤微环境
·
活性氧
·
协同治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-10
·
IF 16.6
Yao Le,Lin Chengjiang,Duan Xiaozheng,Ming Xiaoqing,Chen Zhixuan,Zhu He,Zhu Shiping,Zhang Qi
Underwater adhesives receive extensive attention due to their wide applications in marine explorations and various related industries. However, current adhesives still suffer from excessive water absorption and lack of spontaneity. Herein, we report an autonomous underwater adhesive based on poly(2-hydroxyethyl methacrylate- co -benzyl methacrylate) amphiphilic polymeric matrix swollen by hydrophobic imidazolium ionic liquid. The as-prepared adhesive is tough and flexible, showing little to none instantaneous underwater adhesion onto the PET substrate, whereas its adhesion energy on the substrate can grow more than 5 times to 458 J·m −2 after 24 hours. More importantly, this process is entirely spontaneous, without any external pressing force. Our comprehensive studies based on experimental characterizations and molecular dynamic simulations confirm that such autonomous adhesion process is driven by water-induced rearrangement of the functional groups. It is believed that such material can provide insights into the development of next-generation smart adhesives.
研究领域:
材料科学
·
聚合物化学
·
粘合技术
·
海洋工程
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Heng Zhu,Xiaocheng Hu,Binhong Liu,Zhe Chen,Shaoxing Qu
Electronically conductive hydrogels integrated with dielectric elastomers show great promise in a wide range of applications, such as biomedical devices, soft robotics, and stretchable electronics. However, one big conundrum that impedes the functionality and performance of hydrogel–elastomer-based devices lies in the strict demands of device integration and the requirements for devices with satisfactory mechanical and electrical properties. Herein, the digital light processing three-dimensional (3D) printing method is used to fabricate 3D functional devices that bridge submillimeter-scale device resolution to centimeter-scale object size and simultaneously realize complex hybrid structures with strong adhesion interfaces and desired functionalities. The interconnected poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) network endows the PAAm hydrogel with high conductivity and superior electrical stability and poly(2-hydroxyethyl acrylate) functions as an insulating medium. The strong interfacial bonding between the hydrogel and elastomer is achieved by incomplete photopolymerization that ensures the stability of the hybrid structure. Lastly, applications of stretchable electronics illustrated as 3D-printed electroluminescent devices and 3D-printed capacitive sensors are conceptually demonstrated. This strategy will open up avenues to fabricate conductive hydrogel–elastomer hybrids in next-generation multifunctional stretchable electronics.
研究领域:
材料科学
·
电子工程
·
生物医学工程
·
软体机器人
✓ 已验证
DOI
PubMed
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2025
·
IF 2.5
Chengcheng Zhao,Jian Qin,Dingyu Zhang,Xue Li,Ning Yang,Tingyu Gao,Junliang Song,Yule Song,Shouzhen Huang,Huan Xu
In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (1H-NMR). Pharmacokinetic results showed that the accumulation of QUE in plasma of the NPC-QUE-L group was 1.28 times and 2.43 times that of the QUE Solution and QUE-L groups, respectively. The release amount of NPC-QUE-L in an acidic environment was significantly higher than in physiological pH value. The order of the tumor cell inhibition rate in different pH environments was NPC-QUE-L > PC-QUE-L > QUE-L. In addition, the cellular uptake of NPC-modified liposomes was higher than that of PC-modified and unmodified liposomes, indicating that NPC had good pH-sensitivity and targeting. In the triple-negative breast cancer (TNBC) model, the relative tumor proliferation rate of NPC-QUE-L is about 73%, which is better than that of the QUE solution group. Western blot results show that NPC-QUE-L can effectively reduce the expression of α-smooth actin and transforming growth factor-β1 in tumor tissues, and improve the degree of tumor fibrosis. In this study, NPC could endow QUE liposomes with good stability, pH-sensitivity, and targeting, which provides a reference for improving the solubility and targeting of poorly soluble natural drug components.
研究领域:
肿瘤学
·
药剂学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ChemSusChem
·
2020
·Vol. 13
·期 9
·2239-2244
·
IF 7.962
Yuwen Luo,Feipeng Zheng,Luojia Liu,Kaixiang Lei,Xuesen Hou,Gang Xu,Hui Meng,Jifu Shi,Fujun Li
Graphical Tunable operating voltage : The anion effect induces a varied redox ability of p-type organic radicals, leading to tunable operating voltage of Zn–organic radical batteries. DFT calculations reveal that the stronger interaction of the anion with the organic radical host, the higher the operating voltage of the Zn–organic radical battery. In contrast to traditional rechargeable rock-chair metal-ion batteries, dual-ion batteries (DIBs) involve redox reactions with anions rather than cations in p-type cathodes. In principle, regulating the electrochemical performance of the DIB by different anion species is highly feasible. Herein, the anion effect on the electrochemical performance of a DIB, the aqueous Zn– organic radical battery (Zn-ORB), consisting of a poly(2,2,6,6tetramethylpiperidinyloxy-4-yl vinyl ether) cathode and a Zn anode, was investigated by DFT calculations. SO 4 2− , CF 3 SO 3 − , and ClO 4 − with different molecular electrostatic potential values were selected as anion models. DFT calculations revealed that a stronger electrostatic interaction of the anion with the organic radical resulted in a higher operating voltage of the Zn-ORB, which was consistent with experimental results. These results bring new insight into the redox chemistry of p-type organic radicals with anions and will promote the development of high-power aqueous Zn-ORBs as well as inspire more investigations into the anion effect towards novel battery designs.
研究领域:
电化学
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电池技术
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材料科学
·
计算化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Zhiyan Sui,Zhe Wang,Yan Wang
Using carboxylated graphene oxide (CFGO) as inorganic crosslinking agent, a series of poly (2,6-dimethyl-1,4-phenylene oxide) (PPO) based complex anion exchange membranes (AEMs) with pyridine cations as conduction sites were prepared successfully. The carboxyl modification can improve the dispersibility of inorganic filler in the polymer and provide more crosslinking sites. At the same time, the two-dimensional layered structure of CFGO and a large number of hydrophilic groups provide good ion transport channels. As a result, compared with the original membrane, the crosslinked composite membranes showed better conductivity and chemical stability. Among them, the conductivity of AP-PPO-CFGO2 reached 102.41 mS/cm at 80 °C, and retained about 70% of the conductivity after soaking in 2 M NaOH for 800 h. Furthermore, the AP-PPO-CFGO2 displayed a power density of 277.5 mW/cm 2 in a H 2 /O 2 single cell test at 80 °C.
研究领域:
材料科学
·
化学工程
·
电化学
·
燃料电池
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Feng Yangyang,Li Yong,Lin Jing,Wu Huyue,Zhu Lei,Zhang Xiang,Zhang Linlin,Sun Chuan-Fu,Wu Maoxiang,Wang Yaobing
Stable lithium metal negative electrodes are desirable to produce high-energy batteries. However, when practical testing conditions are applied, lithium metal is unstable during battery cycling. Here, we propose poly(2-hydroxyethyl acrylate-co-sodium benzenesulfonate) (PHS) as negative electrode protective layer. The PHS contains soft poly (2-hydroxyethyl acrylate) and poly(sodium p-styrene sulfonate), which improve electrode flexibility, connection with the Cu current collector and transport of Li ions. Transmission electron cryomicroscopy measurements reveal that PHS induces the formation of a solid electrolyte interphase with a fluorinated rigid and crystalline internal structure. Furthermore, theoretical calculations suggest that the -SO 3 - group of poly(sodium p-styrene sulfonate) promotes Li-ion motion towards interchain migration through cation-dipole interaction, thus, enabling uniform Li-ion diffusion. Electrochemical measurements of Li | |PHS-coated-Cu coin cells demonstrate an average Coulombic efficiency of 99.46% at 1 mA/cm 2 , 6 mAh/cm 2 and 25 °C. Moreover, when the PHS-coated Li metal negative electrode is paired with a high-areal-capacity LiNi 0.83 Co 0.11 Mn 0.06 O 2 -based positive electrode in multi-layer pouch cell configuration, the battery delivers an initial capacity of 6.86 Ah (corresponding to a specific energy of 489.7 Wh/kg) and, a 91.1% discharge capacity retention after 150 cycles at 2.5 mA/cm 2 , 25 °C and 172 kPa.
研究领域:
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Jia Deng,Shaoge Fu,Yifan Zhong,Ming Jiang,Tao Chen,Haili Zhao
Photonic crystal (PC) hydrogels with unique micro/nanostructures have excellent prospects in many fields, such as sensing, displays, anticounterfeiting, information encryption, and adaptive camouflage. Herein, magnetic core–shell Fe3O4/SiO2 nanoparticles with a controlled size were synthesized, followed by PC hydrogels of arbitrary structures that were fabricated via the magnetically inducing self-assembly of magnetic nanoparticles in the poly(ethylene glycol) diacrylate (PEGDA) pregel solution and a subsequent digital micromirror device (DMD)-based UV polymerization process. By controlling the size of nanoparticles and magnetic field intensity, various PC hydrogel patterns with tunable structural colors were fabricated. Combining magnetic field control with DMD-based light modulation, high-throughput preparation of structural color PC hydrogels was achieved. Furthermore, the Fe3O4/SiO2 nanoparticles were assembled into poly(2-hydroxyethyl methacrylate) (PHEMA) with solvent responsiveness. Interestingly, the obtained PC hydrogels could swell in ethanol, resulting in a change in the structural color. Meaningfully, a dual-component PC hydrogel consisting of a PEGDA pattern and a PHEMA background was fabricated, and the invisible pattern in the initial state could be displayed and hidden through cyclic exposure to ethanol and ethylene glycol. The presented strategy for constructing the PC hydrogels from Fe3O4/SiO2 nanoparticles could provide valuable insights for the development of intelligent structural color materials, which exhibit significant potential in applications such as information storage, visual sensing, and anticounterfeiting.
研究领域:
材料科学
·
纳米技术
·
光学
·
化学
·
防伪技术
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2024
·
IF 4.1
Ying-Zi Wu,Yu-Zhuang Gao,Cong-Lei Zhao,Meng-Ying Wu,Yi-Xian Wu
A series of amphiphilic polyisobutylene- b -poly(2-ethyl-2-oxazoline) (PIB- b -PEOX) diblock copolymer/Ag nanoparticle composites were successfully in-situ synthesized via cationic ring-opening polymerization of 2-ethyl-2-oxazoline (EOX) with high initiation efficiency by using allyl bromide end functionalized polyisobutylene (PIB-allylBr) as a macroinitiator and AgClO 4 as a coinitiator. The microphase separation formed in the resulting PIB- b -PEOX diblock copolymers due to the thermodynamic imcompability of hydrophilic PEOX segments and hydrophobic PIB segments. The micromorphology of phase separation is dependent on the copolymer composition, in which sea-island micromorphology formed for PIB 118 - b -PEOX 80 and bicontinuous phase micromorphology formed for PIB 118 - b -PEOX 97 . The micelles with nano-scale size in the range of 15 - 80 nm and having high drug loading rate of ca. 48.9% can be formed by self-assembly of the amphiphilic diblock copolymers in n-hexane. The drug cumulative release rate can be increased with an increase in the proportion of PEOX segments, due to the strong interaction between ibuprofen and the PEOX segments. The hydrophilicity of the PIB- b -PEOX diblock copolymer surfaces can be improved after ethanol vapor induction. The PIB- b -PEOX diblock copolymers behave biocompatibility and good anti-protein adsorption property. The amphiphilic PIB- b -PEOX) diblock copolymer /Ag nanoparticle composites exhibit high antibacterial efficiency for Gram-negative bacterium ( E. coli) and Gram-positive bacterium (S. aureus) . To the best of our knowledge, this is the first example of PIB- b -PEOX diblock copolymer/Ag nanoparticle (6.4 ±2.6 nm) composites synthesized in-situ with good biocompatibility, anti-protein adsorption, and antibacterial properties, which would have potential applications for drug delivery and anti-protein coating in biomedical areas
研究领域:
高分子化学
·
纳米技术
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 133
·期 16
·
IF 1.768
Yu Sun,Junhui Zhou,Qiang Cheng,Daoshu Lin,Qian Jiang,Anjie Dong,Zicai Liang,Liandong Deng
Graphene oxide (GO)-based nanohybrids were designed for small interfering RNA (siRNA) delivery for their high water dispensability, good biocompatibility, easily tunable surface functionalization, and particular optical properties. In this study, novel nanohybrids based on GO were fabricated. Methoxypoly(ethylene glycol) (mPEG) was covalently conjugated to GO via amide bonds. Then, poly(2-dimethyl aminoethyl methacrylate) (PDMAEMA), which was synthesized via reversible addition–fragmentation chain transfer polymerization (RAFT) with 2-(dodecyl thiocarbonothioyl thio)-2-methyl propionic acid (DTM) as the RAFT agent, was attached onto GO via physical interaction between DTM and GO. Compared with Lipofectamine 2000, the novel mPEG–GO/PDMAEMA nanohybrids showed comparable gene transfection efficiency and a low cytotoxicity. Moreover, the mPEG–GO/PDMAEMA nanohybrids showed enhanced optical properties compared to the original GO because of the presence of mPEG and PDMAEMA. Our work encouraged further exploration of the novel nanovector for combined photothermal and siRNA delivery. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43303.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
·
分子生物学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-15
·
IF 17.694
Su Yun,Rong Xiaohui,Gao Ang,Liu Yuan,Li Jianwei,Mao Minglei,Qi Xingguo,Chai Guoliang,Zhang Qinghua,Suo Liumin,Gu Lin,Li Hong,Huang Xuejie,Chen Liquan,Liu Binyuan,Hu Yong-Sheng
Poly(ethylene oxide)-based solid-state electrolytes are widely considered promising candidates for the next generation of lithium and sodium metal batteries. However, several challenges, including low oxidation resistance and low cation transference number, hinder poly(ethylene oxide)-based electrolytes for broad applications. To circumvent these issues, here, we propose the design, synthesis and application of a fluoropolymer, i.e., poly(2,2,2-trifluoroethyl methacrylate). This polymer, when introduced into a poly(ethylene oxide)-based solid electrolyte, improves the electrochemical window stability and transference number. Via multiple physicochemical and theoretical characterizations, we identify the presence of tailored supramolecular bonds and peculiar morphological structures as the main factors responsible for the improved electrochemical performances. The polymeric solid electrolyte is also investigated in full lithium and sodium metal lab-scale cells. Interestingly, when tested in a single-layer pouch cell configuration in combination with a Li metal negative electrode and a LiMn 0.6 Fe 0.4 PO 4 -based positive electrode, the polymeric solid-state electrolyte enables 200 cycles at 42 mA·g −1 and 70 °C with a stable discharge capacity of approximately 2.5 mAh when an external pressure of 0.28 MPa is applied.
研究领域:
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
PubMed
高影响因子
Theranostics
·
2024
·
IF 12.4
Muzi Li,Nan Wang,Ruiyuan Liu,Xinyue Zhang,Wei He,Wen Zhang,Jiaxin Li,Chen Peng,Yan Li
Background: Oral insulin delivery is considered a revolutionary alternative to daily subcutaneous injection. However, the oral bioavailability of insulin is very low due to the poor oral absorption into blood circulation. Methods: To promote penetration across the intestinal epithelium and achieve enhanced and safe glucose-responsive oral insulin delivery, pH and H 2 O 2 dual-sensitive nanoparticles (NPs) were constructed. The NPs were loaded of glucose oxidase (GOx) and insulin by pH and H 2 O 2 dual-sensitive amphiphilic polymer incorporated with phenylboronic ester-conjugated poly(2-hydroxyethyl methacrylate) and poly(carboxybetaine) (PCB). The dual-sensitive NPs were utilized for the treatment of type 1 diabetes mellitus (T1DM) after oral administration. Results: The dual-sensitive NPs could enhance the transport of insulin across the intestinal epithelium into blood facilitated by zwitterionic PCB. By virtue of the generated low pH and high H 2 O 2 with GOx in hyperglycemic environment, the pH and H 2 O 2 dual-sensitive NPs were disassembled to achieve rapid and sustained release of insulin. After oral administration of the dual-sensitive NPs in enteric capsules into T1DM mouse model, the oral bioavailability of insulin reached 20.24%, and the NPs achieved hypoglycemic effect for a few hours longer than subcutaneously injected insulin. Importantly, the pH and H 2 O 2 dual-sensitive NPs could ameliorate the local decline of pH and rise of H 2 O 2 to avoid the toxic side effect. Conclusion: Therefore, this work would provide a promising platform for the enhanced and safe treatment of diabetes mellitus.
研究领域:
药学
·
纳米技术
·
糖尿病研究
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）