JOURNAL OF ORGANIC CHEMISTRY
·
2021
·
IF 4.354
Hao Song,Yao Xiao,Zhuohua Zhang,Wanjin Xiong,Ren Wang,Liangcheng Guo,Taigang Zhou
A simple and efficient copper-catalyzed selective transfer hydrogenation of nitriles to primary amine-boranes and secondary amines with an oxazaborolidine–BH3 complex is reported. The selectivity control was achieved under mild conditions by switching the solvent and the copper catalysts. More than 30 primary amine-boranes and 40 secondary amines were synthesized via this strategy in high selectivity and yields of up to 95%. The strategy was applied to the synthesis of 15N labeled in 89% yield.
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CONTROL
·
2024
·
IF 5.6
Xiaohan Hua,Tingting Yan,Shuyi Liu,Lijun Yin,Xin Jia
The high protein content in sufu provides a substrate for microorganisms to produce biogenic amines (BAs), thereby posing a potential risk to food safety. The aim of this study was to identify the main BAs produced by different types of sufu (red, white and grey sufu) and investigate the relationship between bacterial diversity and BA production using high-throughput sequencing. The results revealed significant differences in the total BA content of the three types of sufu at the post-fermentation stage, with grey sufu exhibiting the highest total BA content (ranging from 6389.00 mg/kg to 7255.49 mg/kg). The main BAs found in all three types of sufu were tyramine, putrescine and cadaverine. Enterococcus genus produced high levels of tyramine and phenylethylamine in all three types of sufu. The predominant cadaverine-producing bacteria in red sufu was Enterobacter genus, whereas Klebsiella pneumoniae was the primary producer of cadaverine in white and grey sufu. Putrescine was primarily associated with the Bacillus and Enterobacter genera in red and grey sufu. Acinetobacter , Enterococcus and Enterobacter were the common dominant genera during the post-fermentation stage of the three kinds of sufu, which were positively correlated with the production of various BAs. These findings will help to understand the mechanism of BAs production by bacterial communities in different types of sufu to ensure safe production.
研究领域:
食品科学
·
微生物学
·
发酵技术
·
食品安全
✓ 已验证
产品关联
DOI
高影响因子
POLYMER SCIENCE SERIES B
·
2021
·Vol. 63
·期 3
·239-244
·
IF 1.049
Huanhuan Zhu,Niu Mingkang,Feng Zhongtai,Li Chengjie,Li Yonghao,Jiao Qingze,Wang Shanshan,Feng Caihong,Zhao Yun,Lv Yuzhen
Abstract To obtain aromatic polyamides with reduced dielectric constant, a series of aromatic polyamide copolymers derived from the reaction between m -phenylenediamine to trans -1,2-cyclohexanediamine and isophthaloyl chloride were synthesized using the low-temperature solution polymerization in the presence of 2-methylpyridine. The influence of the content of trans -1,2-cyclohexanediamine on the structure and properties of aromatic copolyamides was evaluated. With increasing the content of trans -1,2-cyclohexanediamine, the inherent viscosities of copolymers decrease from 1.95 to 1.14 dL/g. The copolymer with 25 mol % of trans -1,2-cyclohexanediamine has a reduced dielectric constant ε r of 4.61 at 1 MHz, which is 26% lower than homopolyamide. Meanwhile, as-synthesized aromatic polyamides and copolyamides show good thermal stability and mechanical properties.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
CANCER LETTERS
·
2018
·
IF 6.491
Jianqin Tang,Huige Zhou,Xiaoyang Hou,Liming Wang,Yaxi Li,Yanyu Pang,Chunying Chen,Guan Jiang,Yanqun Liu
Chemotherapy is an important treatment for malignant tumors; however, its efficacy and clinical application are limited by its side effects and drug resistance properties. Chemotherapy and phototherapy exhibit synergistic anti-tumor effects. In the present study, a carboxylated poly(amido-amine) (PAMAM) with low cytotoxicity was synthesized as a delivery nanocarrier for loading chemotherapeutic drugs, temozolomide (TMZ), and fluorescent dye indocyanine green (ICG). Hyaluronic acid (HA), which targets the CD44-overexpressing cancer cells, was modified on the nanocarrier surface to enhance the selective killing of melanoma cells. Temperature effect and singlet oxygen production experiments showed that the ICG-loaded nanoparticles exhibited good capability to generate heat and singlet oxygen under near-infrared (NIR) light (808 nm) irradiation. In vivo imaging measurement confirmed that the ICG-encapsulated nanoparticle was delivered successfully and effectively accumulated in the tumor site. In vitro and in vivo experiments revealed that the joint application of TMZ- and ICG-loaded nanoparticle can kill melanoma cells and suppress growth after NIR light irradiation. Thus, HA-modified carboxylated PAMAM loaded with TMZ and ICG serves as a promising nanoplatform for melanoma treatment.
研究领域:
肿瘤学
·
纳米医学
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
·
2025
·Vol. 61
·期 5
·872-880
·
IF 0.9
Tong Mengnan
A versatile, convenient, mild, and efficient method for the synthesis of N-benzoyloxyamines containing alkenone or allyl ester groups, starting from hydroxylamine derivatives, is developed and successfully extended to a broader range of tertiary amine analogs.
研究领域:
有机化学
·
药物化学
·
合成化学
·
生物医学化学
·
分子设计
✓ 已验证
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Rui Zhang,Jingjing Xue,Yuan Li,Bing Cao,Pei Li
To suppress pore collapsing and selective layer thickening of Poly (pyromellitic dianhydride-co-4,4’-oxydianiline) (PMDA-ODA) nanofiltration (NF) membrane during imidization, we proposed a novel two step method. Specifically, a PMDA-ODA polyamic acid (PAA) polymer dope was cast on top of a non-woven polyester fabric and then underwent non-solvent induced phase inversion to form a PMDA-ODA PAA membrane. The membrane was subsequently dried by solvent exchange and chemically imidized to form PMDA-ODA PI membrane. Compared with the thermally imidized PMDA-ODA PI membrane, which had a thick selective layer of 14.5 μm and pure water permeability of 1.5 L/(m 2 ·h·bar), membrane fabricated using the new method had a thinner selective layer of 1.04 μm and 7 times higher pure water permeability of 10.4 L/(m 2 ·h·bar) without losing rejections. Other than that, the NF membrane also showed good separation properties in organic solvent systems. It showed rejections of 87%~95% to Rose Bengal in DMF, THF, and DMSO, with stable permeabilities of 6.1–8.0 L/(m 2 ·h·bar), at a trans-membrane pressure of 20 bar for at least 24 h. Therefore, the PMDAODA PI membranes had great potential for NF in both water and organic solvent systems.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
POLYMERS & POLYMER COMPOSITES
·
2020
·
IF 1.023
Yawen Fang,Yanbin Wang,Yongchao Li,Huang Yu,Changlong Zhuang,Zhonglin Luo,Zicheng Fan,Biaobing Wang
A series of novel ternary conductive composites have been prepared by incorporating functionalized multiwalled carbon nanotubes (FMWCNTs) into the binary composites of poly(amide-imide) (PAI) and poly(o-methoxyaniline) (POMA) to further improve the conductivity of PAI composites. With increasing the weight ratio of FMWCNTs, the conductivity of PAI/POMA/FMWCNTs ternary composites has been significantly enhanced from 10−3 S m−1 to 90 S m−1, much higher than that of the sum of PAI/POMA and PAI/FMWCNTs binary composites. The enhanced conductivity is mainly ascribed from a much more intensive conductive network formed in the PAI/POMA/FMWCNTs ternary composites. It is found that the N–H bending of amide group in the Fourier transform infrared spectrometry spectra is observed at 3298 cm−1 for PAI, 3296 cm−1 for PAI/POMA binary composites, and further blue shifted to 3292 cm−1 for PAI/POMA/FMWCNTs ternary composites. Moreover, the glass transition temperature has been increased from 82.5°C to 117.7°C. These results suggested that the hydrogen bonding interaction has been strengthened among PAI, POMA, and FMWCNTs, which is useful for dispersion of condcutive fillers into the polymer matrix.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 12
·1-9
·
IF 5.705
Tang Juan,Huang Lulu,Cheng Yu,Zhuang Junyang,Li Ping,Tang Dianping
A highly sensitive electrochemical sensor is described for the determination of H 2 O 2 . It is based on based on the use of polyaniline that was generated in-situ and within 1 min on a glassy carbon electrode (GCE) with the aid of the Fe(II)/H 2 O 2 system. Initially, a 2-dimensional composite was prepared from graphene oxide and polyamidoamine dendrimer through covalent interaction. It was employed as a carrier for Fe(II) ions. Then, the nanocomposite was drop-coated onto the surface of the GCE. When exposed to H 2 O 2 , the Fe(II) on the GCE is converted to Fe(III), and free hydroxy radicals are formed. The Fe(III) ions and the hydroxy radicals catalyze the oxidation of aniline to produce electroactive polyaniline on the GCE. The resulting sensor, best operated at a working potential as low as 50 mV (vs. SCE) which excludes interference by dissolved oxygen, has a linear response in the 500 nM to 2 mM H 2 O 2 concentration range, and the detection limit is 180 nM. The sensor was successfully applied to the determination of H 2 O 2 in spiked milk and fetal bovine serum samples.
Schematic presentation of a sensitive electrochemical sensor employed for detection of H 2 O 2 in sophisticated matrices by using graphene oxide-PAMAM dendrimer as initiator container and Fe 2+ /H 2 O 2 system as signal enhancer.
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2017
·
IF 4.162
Dandan Guo,Chaoyan Lou,Nani Wang,Meilan Chen,Peimin Zhang,Shuchao Wu,Yan Zhu
A novel high performance liquid stationary phase was prepared by grafting poly amidoamine (PAMAM) dendrimers to poly (styrene-divinyl benzene-glycidylmethacrylate) matrix in this work. Different generations of PAMAM dendrimers grafted to polymer matrices containing different glycidylmethacrylate amounts by reacting with epoxy groups in glycidylmethacrylate molecules. The synthesized PAMAM dendrimers and stationary phase were characterized by fourier transform infrared spectroscopy, scanning electron microscope, N 2 adsorption/desorption, elemental analysis and thermo gravimetric analyzer. The proposed stationary phase was suitable for rapid separation of phenylene diamine isomers and aminobenzene . The separation mechanism of benzene rings attraction and amino repulsion was verified by retention behaviors of methylamine , phenylamine, phenylene diamine, naphthylamine and toluene. The reliability of the stationary phase was demonstrated by separation and determination of phenylene diamine isomers including m -phenylene diamine, o -phenylene diamine and p -phenylene diamine in hair dye precursors within 10 min. Satisfactory resolution and short analysis time make the columns promising for determination of aniline compounds in various fields.
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Guangcun Qian,Deliang Zhu,Jiangnan Li,Yu Li,Hongyan Tang
In practical applications, Nanofiltration (NF) membranes are confronted with inevitable challenges, including the terrible fouling and the deterioration by chlorine, which hinders the wider application. In this study, 2-aminophenol-4-sulfonamide (APSA) was incorporated to form the polyamide-sulfonamide active layer, thus highly stable antifouling NF membranes with chlorine resistance were fabricated. Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) results showed APSA successfully grafted on the membrane surface. Scanning electron microscope (SEM) and atomic force microscope (AFM) images indicated a smooth membrane surface. Water contact angle of the PA-SA NF membranes declined to 19.7° compared with the PA NF membranes. Flux recovery rates (FRR) of bovine albumin (BSA), humic acid (HA), sodium alginate (SA) and oil/water emulsion were 96.4%, 96.8%, 96.0% and 94.6%, respectively. Besides, slight decline occurred to FRR value for BSA after three fouling cycles. No obvious decline of the rejection and water flux was observed on long-term stability. Notably, slight rejection rate decline and no obvious FRR value decline were observed after chlorination. Overall, the PA-SA NF membranes possessed highly stable antifouling property and chlorine resistance. It might be due to the fact that APSA including various hydrophilic groups grafted onto the active layer. N–H bonds of sulfonamide could act as a sacrificial unit against free chlorine. It is anticipated that this work could provide a facile strategy to develop NF membranes with highly stable antifouling property and chlorine resistance.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS COMMUNICATIONS
·
2014
·
IF 3.32
Qian Han,Xingquan Xiong,Sizhong Li
An efficient, green and scale-up synthesis of amides from esters and amines has been developed using Ru-MACHO as a readily available catalyst. A diverse range of amides were obtained in moderate to excellent yields (55–98%). Furthermore, when the scale of the amidation reaction was increased to 240.0 mmol, the desired amide still could be obtained in high yield (48.2 g of N -benzylbenzamide, 95%).
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
高影响因子
ChemistryOpen
·
2020
·Vol. 9
·期 10
·996-1000
·
IF 2.37
Fangjun He,Rumeng Qu,Jie Su,Muyao Du,Junqiang Liu,Yiping Chen,Bo Wang
Graphical Solving the puzzle : The role of the amine in direct amidation of aromatic ketones has been investigated. Amines act as both the reactant and catalyst, as such the excess amount (two or more equivalents) of amines are required to afford reasonable conversions/yields in the classical amidation. The direct amidation of aromatic ketones has been achieved at mild reaction conditions. In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for a long time. In this work, we disclosed that the amine acts as both reactant and catalyst. Specifically, the determination of reaction intermediates revealed the full mechanism, based on which, the introduction of one equivalent base in the amidation is showcased here that a high yield (∼95 %) can be afforded using only 1.1 equiv. of amine.
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
PubMed
高影响因子
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