TALANTA
·
2019
·
IF 4.916
Yuanyuan Xia,Faqiong Zhao,Baizhao Zeng
A novel L -tryptophan ( L -Trp) electrochemical sensor is fabricated, which is based on the molecularly imprinted copolymer (MIP) of dual –functional monomers and ionic liquid (i.e. 1-butyl-3-methylimidazolium hexafluorophosphate) functionalized multi-walled carbon nanotubes (MWCNTs@IL). The MWCNTs@IL is prepared via ion exchange, while the MIP is synthesized by using L -Trp as template, styrene and 4-vinylbenzoic acid as functional monomers, Triton X-100 as emulsifier , 1, 2-divinylbenzene as cross-linking reagent and K 2 S 2 O 8 as initiator. Prior to copolymerization the functional monomer 4-vinylbenzoic acid is combined with the template molecule by forming amide bond. The template molecule is eluted by hydrolysis, and rebound by electrostatic, hydrogen-bond and π-π interaction. To construct L -Trp sensor a little of Nafion is introduced to enhance the stability and to promote rebinding. The resulting sensor Nafion-MIP-MWCNTs@IL/GCE shows a wide linear range (8 nM–26 μM) and a low detection limit (6 nM). It is successfully applied to the determination of L -Trp in oral liquid and human serum samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2019
·
IF 2.584
Xiang Zhou,Fusheng Xu,Zhibing Wu,Hu Li,Song Yang
Sulfur-containing compounds are a class of important motifs extensively applied in pharmaceutical and pesticidal industries as well as in electrochemistry, toxicant separation, and organic syntheses. Herein, we describe a novel and efficient metal-free catalytic strategy for the rapid synthesis of β-thioketones from sustainable enone derivatives and thiols via thia-Michael addition enabled by heterogeneous prolinamide. At room temperature, up to 98% yield of β-thioketones could be obtained over the solid UiO-66-NH-proline catalyst facilely prepared by the covalent immobilization of proline onto UiO-66-NH2 (a well-known metal–organic framework) via a stable amido linkage. A cooperative effect of proline (amino group) and UiO-66-NH2 (in situ-derived amide species) was observed to play a promotional role in the proceeding of thia-Michael addition, resulting in a high TOF value of 1124.3 h–1. A three-component “iminium” intermediate was illustrated to the key species approaching the product β-thioketone. Moreover, the UiO-66-NH-proline could be easily recovered from the reaction mixture and recycled for at least five times with a slight loss of activity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2018
·
IF 4.92
Yun-Fei Zhang,Fei-Peng Du,Ling Chen,Wing-Cheung Law,Chak-Yin Tang
Stimuli-responsive hydrogel actuators, which can swell and shrink reversibly, have attracted great attention. In this paper, a bilayer hydrogel actuator based on multi-walled carbon nanotubes (MWCNTs)/host-guest polymer composites was prepared. The surface compatibility of MWCNTs was improved by the oxidization process and vinyl functionalization. Fourier transform infrared (FTIR) and Raman analysis revealed that the modifications conferred the hydrophilic groups and disorder structures to MWCNTs, which can enhance the hydrophilicity of poly(acrylamide) matrix. The host and guest hydrogels bilayer structured actuator shows a bending movement in water, providing a new route to design and fabricate high performance hydrogel based actuators.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 136
·期 37
·47946
·
IF 2.188
Xiao Ma,Jiangtao Liu,Lei Lei,Hong Yang,Zhongli Lei
Stimulus-responsive polymeric nanoparticles have great potential as nanocarriers. Here, triple-stimuli-responsive core-crosslinked (CCL) micelles were developed that were convenient for drug delivery by taking advantage of dual-redox and UV light synergistic triggers. Amphiphilic block copolymers methoxy poly(ethylene glycol)- b -poly(3-azido-2-hydroxy-propyl methacrylate- co - ο -nitrobenzyl methacrylate) [mPEG- b -P(GMA-N 3 - co -NBM)] were synthesized via atom transfer radical polymerization and ring-opening reaction of ethylene oxide; these block copolymers can spontaneously self-assemble into noncrosslinked (NCL) micelles. Afterward, CCL micelles were prepared using an alkyne-functionalized crosslinking agent. Furthermore, the CCL micelles showed an excellent Nile Red dye molecule encapsulation, light and dual-redox-responsive performance, and increasing release rate of the dye as the concentration of glutathione and light irradiation increased. The triple-stimuli-responsive CCL micelles showed excellent stability and controllable release compared to NCL micelles. Therefore, we have developed a new smart nanocarrier, and the triple-stimuli-responsive CCL micelles could also be a potential delivery system in cancer therapy. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47946.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Ling Wang,Yitong Wang,Yuanyuan Hu,Guangzhen Wang,Shuli Dong,Jingcheng Hao
Self-assembly exploits a facile non-covalent way to couple structurally different building blocks for creating soft materials with synergetic novel properties and functions. Taking advantage of magneto-properties from magnetic surfactants as well as versatile functional ligand formed by carbon quantum dots with cysteine (cys-CQDs), the magnetic network materials were firstly constructed by using magnetic surfactants and cys-CQDs as self-assembly building blocks. Counterions of Br − , [GdCl 3 Br] − , [HoCl 3 Br] − in surfactants could control the morphology of magnetic network structures, and the concentration of magnetic surfactants manoeuvres a versatile scenario of self-assembly behavior. Self-assembly of cys-CQDs and CTAHo brought out a 10-fold increase in magnetic moment of CTAHo. The fluorescent property of carbon quantum dots firstly served as an effective indicator element to dissect the collective effect in self-assembly process. For the sake of capturing the target sequence-specific DNA molecules, in situ growth of Ag nanoparticles (AgNPs) upon the magnetic network structures was realized by synergetically electrostatic and coordinated interaction of carboxyl groups and Ag ions . The magnetic Ag self-assemblies anchored thiol-containing DNA, serving as a magnetic separation booster for the target sequence-specific DNA molecules under an applied magnetic field, which will bring light on designing magneto-functional self-assembly materials according to practical application requirements.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 39
·10472-10479
·
IF 5.976
Man Du,Baolong Huo,Jiemin Liu,Mengwen Li,Ao Shen,Xue Bai,Yaru Lai,Leqiu Fang,Yunxu Yang
In this paper, a new near-infrared and fluorogenic fluorescent probe (SiR-amide) based on Si-rhodamine for the detection of phosgene is reported. The fast and sensitive phosgene detection was achieved by the conversion reaction of an amide to a nitrile, which resulted in a large fluorescence turn-on response. The response time of SiR-amide to phosgene was 4 min with a detection limit of 8.9 nM in solution. Moreover, easy-to-use paper test strips for fluorescence detection of phosgene gas had also been prepared. All of this work provided a very promising fluorescent probe for rapid, selective and sensitive detection of phosgene both in solution and in the gas phase.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2018
·Vol. 14
·期 9
·1568-1577
·
IF 5.068
Yu Yueming,Zou Shaohua,Wang Kaili,Liang Rongcai,Fan Xinxin,Wang Bingjie,Liu Mengna,Fang Lei,Liu Wanhui,Wu Zimei,Chen Daquan
In order to improve the anti-cancer therapy efficiency of hydrophobic drugs such as curcumin (Cur), a novel dual pH/redox sensitive marine laminarin-based nanomedicine carrier biomaterial with photo-dynamic therapy (PDT) was synthesized in this study. The new synthetic chemical structure,
named as Hematin-Laminarin-Dithiodipropionic Acid-MGK (HLDM), was characterized by 1H-NMR and IR. The Cur-loaded micelles were then prepared via dialysis method. The HLDM could self-assemble into micelles in water with hydrodynamic diameter of 135±15 nm. The particle size,
zeta potential and morphology of micelles were detected by transmission electron microscope (TEM). Interestingly, the in vitro release experiment showed that the release amount of Cur-loaded HLDM micelles could reach 80% in the pH and redox sensitive environment. Furthermore, cell study
showed that the Cur-loaded HLDM micelles had stronger cellular uptake and cytotoxicity to MCF-7 cells than that of HLDM. The multifunctional marine laminarin based nanomedicine carrier biomaterial can be used for new drug delivery systems with dual pH/redox sensitivity for cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2013
·
IF 2.906
Dan Wan,Lingli Huang,Yuanhu Pan,Qinghua Wu,Dongmei Chen,Yanfei Tao,Xu Wang,Zhenli Liu,Juan Li,Liye Wang,Zonghui Yuan
Dispositions of deoxynivalenol (DON) in rats and chickens were investigated, using a radiotracer method coupled with a novel γ-accurate radioisotope counting (γ-ARC) radio-high-performance liquid chromatography ion trap time-of-flight tandem mass spectrometry (radio-HPLC-IT-TOF-MS/MS) system. 3β-3H-DON was chemically synthesized and orally administrated to both sexes of rats and chickens as single or multiple doses. The results showed that DON was widely distributed and quickly eliminated in all tissues. The highest concentration was found in the gastrointestinal tract at 6 h post-administration. Substantially lower levels were detected in the kidney, liver, heart, lung, spleen, and brain. Three new metabolites were identified tentatively as 10-deoxynivalenol-sulfonate, 10-deepoxy-deoxynivalenol (DOM-1)-sulfonate, and deoxynivalenol-3α-sulfate. Deoxynivalenol-3α-sulfate was a major metabolite in chickens, while the major forms in rats were DOM-1 and DON. Additionally, a higher excretion rate in urine was observed in female rats than in male rats. The differences in metabolite profiles and excretion rates, which suggested diverse ways to detoxify, may relate to the different tolerances in different genders or species.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE CHEMICAL LETTERS
·
2014
·
IF 1.178
Ming-Hui He,Mei-Lin Su,Zhao-Hui Yu,Guang-Xue Chen,Zhao-Hua Zeng,Jian-Wen Yang
Benzoylformamide (BFA) derivatives are proposed as new photocaged bases with good solubility in epoxy resin. Initially their structures were confirmed by 1 H NMR, 13 C NMR, and elemental analysis. Next, we detail their thermal stability, solubility behavior, and photolysis products. Furthermore, the model photo-latent anion polymerization (AP) of epoxide system in the presence of BFA-dBA ( N , N -dibenzyl-2-oxo-2-phenylacetamide) as a photocaged base has been investigated, and excellent photopolymerization profile is obtained.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 40
·31972-31983
·
IF 3.84
Yanjuan Wu,Dongfang Zhou,Yanxin Qi,Zhigang Xie,Xuesi Chen,Xiabin Jing,Yubin Huang
Novel intracellular pH, glutathione (GSH) and reactive oxygen species (ROS)-responsive nanoparticles were obtained using mPEG2k-block-redox dual sensitive chain-block-mPEG2k (PRDSP) which was prepared by Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click polymerization. The disulfide bond, peroxalate ester and triazole units were regularly and repeatedly arranged in the hydrophobic blocks. The disulfide bond was GSH-sensitive and the peroxalate ester structure could be disrupted by acid and hydrogen peroxide. In addition, the triazole units are capable of forming pH-responsive hydrogen bonds. Dynamic Light Scattering (DLS) and transmission electron microscopy (TEM) were used to investigate the pH, GSH and ROS sensitivity of the PRDSP nanoparticles (NPs). The results indicated that the average diameter, size distribution and morphology greatly changed upon adding GSH/H2O2 or modulating the pH. As the preloaded model anticancer drug, doxorubicin (DOX) was quickly released from DOX-loaded PRDSP (PRDSP@DOX) NPs by addition of 10 mM glutathione (GSH), or 10 mM H2O2 or under acidic conditions rather than under physiological conditions. Confocal laser scanning microscopy (CLSM) and flow cytometric analyses revealed that PRDSP@DOX could effectively deliver DOX into the cytoplasm and nucleus of cells. Therefore, PRDSP NPs may be a promising redox heterogeneity-sensitive carrier for efficient and controlled anticancer drug release.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Wuxia Zhang,Dongqi Dong,Peng Li,Dongdong Wang,Haibo Mu,Hong Niu,Jinyou Duan
Polysialic acid (PSA), a non-immunogenic and biodegradable natural polymer, is prone to hydrolysis under endo-lysosomal pH conditions. Here, we synthesized an intracellular pH-sensitive polysialic acid-ursolic acid conjugate by a condensation reaction. To further test the drug loading capability, we prepared paclitaxel-loaded polysialic acid-based amphiphilic copolymer micelle (PTX-loaded-PSAU) by a nanoprecipitation method. Results showed PTX-loaded-PSAU exhibited well-defined spherical shape and homogeneous distribution. The drug-loading was 4.5% with an entrapment efficiency of 67.5%. PTX released from PTX-loaded-PSAU was 15% and 42% in 72 h under simulated physiological condition (pH 7.4) and mild acidic conditions (pH 5.0), respectively. In addition, In vitro cytotoxicity assay showed that PTX-loaded-PSAU retained anti-tumor (SGC-7901) activity with a cell viability of 53.8% following 72 h incubation, indicating PTX-loaded-PSAU could efficiently release PTX into the tumor cells. These results indicated that the pH-responsive biodegradable PTX-loaded-PSAU possess superior extracellular stability and intracellular drug release ability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2014
·Vol. 32
·期 6
·498-506
·
IF 1.04
Xiangju Ye,Yun Zheng,Xinchen Wang
A polymeric Fc-CO-NH-C 3 N 4 (Fc-CN) material was synthesized by amidation reaction of ferrocenecarboxylic acid (Fc-COOH) with NH 2 groups on the surface of mesoporous graphitic carbon nitride (MCN). The properties of the as-synthesized samples were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, UV-Vis diffuse reflectance spectra, N 2 adsorption-desorption isotherm, photoluminescence spectroscopy, transmission electron microscopy, electron paramagnetic resonance, (photo)electrochemical measurement and X-ray photoelectron spectroscopy. The resultant catalysts were investigated as heterogeneous catalysts for the selective oxidation of benzene to phenol using H 2 O 2 as a green oxidant under visible light irradiation. The results reveal that Fc-modified samples can not only extend the visible light absorption, but also accelerate the bulk-to-surface charge transfer and separation via surface dyadic structures, both of which are favorable for phenol production from benzene photocatalytic hydroxylation with H 2 O 2 . Under the optimal conditions, up to 16.9 % phenol yield (based on benzene) is obtained by Fc-CN /1.5 -5 sample, and the corresponding Fe content is about 0.64 wt%. Furthermore, after the second run, no significant decrease of the activity (in term of TOF) and the selectivity is found in Fc-CN /1.0 -5 sample. Combined with the experimental results and Fenton-chemistry, a possible photocatalytic reaction mechanism on the hydroxylation of benzene to phenol at neutral medium with visible light is proposed.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）