SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Zhengxing Song,Jing Wang,Jing Wang,Jin Liu,Xinzhi Wang,Yao Wang,Abdur Raheem Aleem,Matt J. Kipper,Laurence A. Belfiore,Jianguo Tang
Nanoparticle drug delivery systems are designed to be biocompatible and to control the distribution of poorly soluble drugs. Fluorescent nanoparticle drug carriers have been designed to enable fluorescence tracking. While such particles enable tracking of the carrier, this tracking does not report the local drug concentration. In this article, we report new nanoparticle drug carriers with stable, high-intensity fluorescence that sensitively reports the loaded drug concentration. The dumbbell-shaped nanoparticles are synthesized by combining europium (Eu) complexes with hyaluronic acid. The Eu complexes are superior to organic fluorophores, providing a narrow emission peak, high fluorescence intensity, long fluorescence lifetime, and insensitivity to photobleaching. The hyaluronic acid compatibilizes the nanoparticles with aqueous environments, and provides biocompatibility. We demonstrate that these polysaccharide nano-dumbbell aggregates (PNDAs) can effectively load drugs through structural changes, and sense the amount of drug loaded through changes in fluorescence intensity, enabling precise tracking of drug loading and release.
研究领域:
纳米技术
·
药学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Yongli Zhang,Xingrui Wang,Chen Xu,Weiwei Yan,Qiang Tian,Zhiming Sun,Hongduo Yao,Jianping Gao
Hydrophobic and dispersible functionalized reduced graphene oxide (FrGO) was employed to prepare chitosan gel droplets by crosslinking an inverse Pickering emulsion. The emulsion was prepared using toluene as the continuous phase and a chitosan aqueous solution as the dispersed phase. The effects of the FrGO concentration and the water/oil ratio on the chitosan droplet morphology were studied. At appropriate concentrations, the FrGO acted as a stabilizer and chitosan gel droplets were formed. Decreasing the FrGO concentration or increasing the water/oil ratio was unfavorable to the formation of chitosan droplets. Using this method, drug loaded chitosan gel droplets (microgels) were prepared and their release profiles as well as the factors that influence the drug release were investigated.
研究领域:
材料科学
·
化学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2018
·Vol. 20
·期 17
·2421-2429
·
IF 3.304
Xiaojun Wei,Lihong Jing,Chunyan Liu,Yi Hou,Mingxia Jiao,Mingyuan Gao
Herein, a polyol method has been explored for producing magnetic iron oxide nanoparticle clusters that are potentially useful as contrast agents for magnetic resonance imaging (MRI), as drug carriers in tumor therapy, and for bioseparation. The oriented attachment growth of primary particles is widely accepted as a major driving force for the formation of clusters; on the other hand, the commonly used high-boiling point alcohols are used as high-temperature reaction media and reductants in particular for the formation of primary magnetite nanoparticles. However, the role of alcohols remains far from being understood. Herein, systematic studies were carried out to further reveal the molecular role of the high-boiling point alcohols and that of the commonly used stabilizing agent poly(acrylic acid) (PAA). The impact of the structure of alcohols, e.g., monohydric and dihydric alcohols with different chain lengths, on the morphology of the resulting clusters was investigated in detail. The experimental results reveal that the crosslinking effect of the oxidized dihydric alcohols determines the formation of Fe3O4 particle clusters, whereas PAA helps in the formation of spherical clusters by reducing the surface tension. Based on a combination of magnetic measurements and drug loading tests, the impacts of the structures of dihydric alcohols on the magnetic properties, especially on the magnetic response to external fields and drug loading capacities, have been disclosed; in brief, the current study clearly discloses the role of the high-boiling point alcohols in the formation of magnetite particle clusters for the first time, which is beneficial for fine tuning the overall morphology and internal molecular structure of the resulting particle clusters to improve their magnetic response, drug loading efficiency, and MRI contrast enhancing performance.
研究领域:
材料科学
·
纳米医学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2014
·Vol. 14
·期 10
·1495-1504
·
IF 3.65
Pan Zhang,Xiaoxue Song,Weijun Tong,Changyou Gao
The dual-labeled microcapsules via nanoparticle/polymer assembly based on polyamine–salt aggregates can be fabricated for the ratiometric intracellular pH sensing. After deposition of SiO 2 nanoparticles on the poly(allylamine hydrochloride)/multivalent anionic salt aggregates followed by silicic acid treatment, the generated microcapsules are stable in a wide pH range (3.0 ∼ 8.0). pH sensitive dye and pH insensitive dye are simultaneously labeled on the capsules, which enable the ratiometric pH sensing. Due to the rough and positively charged surface, the microcapsules can be internalized by several kinds of cells naturally. Real-time measurement of intracellular pH in several living cells shows that the capsules are all located in acidic organelles after being taken up. Furthermore, the negatively charged DNA and dyes can be easily encapsulated into the capsules via charge interaction. The microcapsules with combination of localized pH sensing and drug loading abilities have many advantages, such as following the real-time transportation and processing of the carriers in cells.
研究领域:
材料科学
·
生物医学工程
·
分析化学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL PHYSICS LETTERS
·
2019
·
IF 1.901
Si-Ming Wu,Nan Jiang,Zhi-Yi Hu,Tao Yan,Jun Jin,Wei Geng,Xiao-Yu Yang
Core-shell structured [email protected] @meso-Silica nanoparticles have been synthesized via a layer-by-layer approach. The magnetic cobalt core makes the nanoparticles easy to separate with an external magnetic field. The inner dense silica layer prevents the Co from oxidation and leaching. The outer mesoporous silica presents high surface area and pore volume, endowing the material with superior adsorption properties of organic molecules. The core-shell structure prevents the direct contact of cobalt with living cells, thus enhancing the biocompatibility remarkably. This dual encapsulation provides a golden opportunity to the nanocarrier design with easy magnetic separation, high drug loading, and high biocompatibility.
研究领域:
纳米技术
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Fengyuan Liu,Jiashan Xia,Chun Tao,Changmei Chen,Xiangshu Cheng,Rongchun Yi,Lulu Wang,Yue Wang,Tao Deng
Chirality is a ubiquitous phenomenon in nature. The advent of nanomaterials has led to a gradual evolution of chiral studies from the molecular scale to the nanoscale. The emergence of carbon dots (CDs) has inaugurated a novel domain in the scientific and technological realms of carbon nanomaterials. In recent years, CDs have attracted increasing attention due to their luminescent properties, excellent biocompatibility and remarkable bioactivity. However, little attention has been paid to the chirality of the CDs and, in particular, the differences between CDs synthesized from racemic compounds and other chiral CDs, as well as the differences in the biological effects of chiral CDs, remain to be explored. Here, chiral CDs were synthesized from L-/D-/DL-arginine, and the differences in various aspects of chiral CDs were evaluated. We found that L-CDs without extreme differences in structure had brighter fluorescence and a more significant ability of NO generation and lipid droplet inhibition than the other two chiral CDs. Combined with its better drug loading and release ability, we validated its superior efficacy in tumor treatment. Therefore, this study provides a basis for further research on chiral carbon dots and their differences.
研究领域:
纳米材料
·
生物技术
·
生物化学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 27
·2209407
·
IF 19
Lili Qian,Fei Jin,Zhidong Wei,Tong Li,Ziying Sun,Chengteng Lai,Juan Ma,Ruiying Xiong,Xiying Ma,Fuyi Wang,Fengyu Sun,Weiying Zheng,Wei Dong,Kangjian Sun,Ting Wang,Zhang-Qi Feng
Electrical stimulation (ES) is widely used in physiological and medical sciences, while its application to treat inflammatory skin diseases (ISDs) remains a challenge owing to their natural pathological cuticle barrier and lack of an effective combination with chemotherapy to achieve specific immunomodulation. Here, a wearable, battery-free, multi-component drug-loaded electronic microneedle (mD-eMN) system is developed by integrating remodeled metal microneedles loaded with multi-component chemical drugs and flexible triboelectric nanogenerators (TENGs). The system can rapidly release drugs into the site of ISDs and then realize an efficient penetration into cell body and specific immunomodulation under the synergism of pulsed electrons originating from the TENG. Also, the pulsed electrons can promote skin tissue homeostasis reconstruction to alleviate the inflammatory process of ISDs. Sufficient evidence shows that a significant skin inflammation regression of psoriasis (a typical ISDs model) is achieved using the mD-eMN system compared to traditional ES or chemotherapy alone. This innovative wearable mD-eMN system provides an effective flexible electronic and chemical drug joint technological platform for the treatment of ISDs, which is not only suitable for the treatment of psoriasis in this study but also maybe for other ISDs such as diabetic ulcers and skin tumors.
研究领域:
生物医学工程
·
药学
·
皮肤科
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Chinese Medicine
·
2022
·Vol. 17
·期 1
·1-17
·
IF 4.546
Yi Qingqing,Liang Pengchen,Liang Dongyu,Cao Liou,Sha Shuang,Jiang Xinquan,Chang Qing
Background Microarc oxidation (MAO) on the surface of medical pure titanium can improve its histocompatibility, and loading drugs on the surface can resist excessive intimal hyperplasia.Methods In this study, salidroside (SAL) was loaded on the surface of porous titanium (Ti) with polydopamine (PDA) carrier. The effects of SAL on the osteogenesis and angiogenesis of Ti implants were studied by phalloidin staining, alizarin red staining, ALP staining, wound-healing assay, cell transwell assay, matrigel tube formation, and osteogenic and angiogenic genes and proteins expression detected by PCR and western blot in vitro. The bone defect model experiments in rats was established in vivo including X-ray, micro CT, hematoxylin and eosin staining (HE), immunohistochemistry (IHC), Goldner's trichrome analysis, Safranin O-fast green staining and determination of contents of TNF-α and IL-6 in serum.Results EDS and EDS mapping showed that SAL could be loaded on the surface of the MAO coating by PDA. A drug release experiment showed that SAL loaded on the Ti coating could release slowly and stably without sudden release risk. In vitro cell experiments showed that the SAL coating could promote the proliferation, morphology, calcification and alkaline phosphate activity of MC3T3-E1 cells. At the same time, it promoted the migration and tube formation of HUVEC cells. The SAL coating promoted osteogenesis and angiogenesis by promoting the expression of genes and proteins related to. In vivo experiments, HE and IHC showed that SAL significantly promoted the expression of COL-1 and CD31. Goldner's trichrome and Safranin O-fast green staining showed that SAL coating could increase the new bone tissue around the implantation site. The SAL coating had anti-inflammatory activity by reducing the levels of TNF-α and IL-6 in vivo.Conclusion Therefore, SAL could improve osteogenesis and angiogenesis in conjunction with the Ti-PDA coating.
研究领域:
生物材料
·
组织工程
·
骨科
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Wanying Cui,Chunmiao Xia,Sheng Xu,Xinke Ye,Yihao Wu,Shukai Cheng,Rongli Zhang,Cuige Zhang,Zongcheng Miao
Dextran (Dex) and poly(ethylene glycol) (PEG)-based aqueous emulsions were stabilized using the self-assembled chitosan colloidal particles (CS CPs). Besides, the effects of pH, CS CPs concentration, polymer concentration, volume ratio of PEG solution to Dex solution, temperature, homogenizing speed and homogenizing time on the property of the W/W emulsions were investigated, respectively. In order to enhance the stability of the PEG-Dex emulsion, sodium tripolyphosphate was used to cross-link the CS CPs at the interface of emulsion droplets, which resulted in the stability duration for >1 year. Finally, the CS CPs were used as a support to immobilize urease and bovine serum albumin and a stabilizer to prepare W/W emulsion, which were then adopted as a catalysis system and as a spinning solution to fabricate drug-loaded nanofiber . This strategy potentially provides a new opportunity to encapsulate the active molecules at the water-water interface, and enrich the types of usable active molecules in the encapsulation in the W/W emulsions.
研究领域:
材料科学
·
化学工程
·
生物技术
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2020
·Vol. 109
·期 2
·219-231
·
IF 3.525
Tingting Liang,Jingwen Wu,Fuyao Li,Zhu Huang,Yixing Pi,Guohou Miao,Wen Ren,Tiantao Liu,Qianzhou Jiang,Lvhua Guo
Bone tissue engineering is a promising approach for tackling clinical challenges. Osteoprogenitor cells, osteogenic factors, and osteoinductive/osteoconductive scaffolds are employed in bone tissue engineering. However, scaffold materials remain limited due to their source, low biocompatibility, and so on. In this study, a composite hydrogel scaffold composed of hydroxyapatite (HA) and sodium alginate (SA) was manufactured using three-dimensional printing. Naringin (NG) and calcitonin-gene-related peptide (CGRP) were used as osteogenic factors in the fabrication of drug-loaded scaffolds. Investigation using animal experiments, as well as scanning electron microscopy, cell counting kit-8 testing, alkaline phosphatase staining, and alizarin red-D staining of bone marrow mesenchymal stem cell culture showed that the three scaffolds displayed similar physicochemical properties and that the HA/SA/NG and HA/SA/CGRP scaffolds displayed better osteogenesis than that of the HA/SA scaffold. Thus, the HA/SA scaffold could be a biocompatible material with potential applications in bone regeneration. Meanwhile, NG and CGRP doping could result in better and more positive proliferation and differentiation.
研究领域:
组织工程
·
生物材料
·
骨再生
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Ding Shen,Jingbin Hao,Siyu Liu,Md Thowfiqure Rahman,Shuaihang Wang,Sameer Hussain Jhatial
Chronic wounds are often aggravated by bacterial infection and prolonged inflammation, presenting major challenges in clinical wound management. To address these issues, a novel 3D-printed multilayer hydrogel was developed, based on a GelMA-PVA dual-network system incorporating graded concentrations of andrographolide (Andro), a phytochemical with proven antibacterial and anti-inflammatory activity. The GelMA component was photocrosslinked, while the PVA network was physically crosslinked via freeze–thaw cycles, forming a robust interpenetrating structure. The hydrogels were characteriazed using FTIR, XPS, SEM, mechanical testing, swelling analysis, and in vitro release and antibacterial assays. The multilayer patches demonstrated tunable swelling capacity (up to 1938 %), excellent tensile strength (up to 46.7 kPa) and compressive strength (up to 94.3 kPa), and a sustained drug release profile. In vitro studies confirmed enhanced L929 fibroblast proliferation and significant antibacterial activity against E. coli and S. aureus , particularly in the gradient Andro-loaded groups. These results suggest that the 3D-printed GelMA-PVA-Andro patches are promising candidates for advanced wound dressings with integrated mechanical, biological, and pharmaceutical functionalities.
研究领域:
生物材料
·
组织工程
·
药剂学
·
生物医学工程
·
微生物学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Mengxia Xu,Shengqian Wang,Chaochao Tao,Songsong Ding,Hualan Xu,Shengliang Zhong
Here, we report a synthesis method of Zn2SiO4@SiO2 hollow nanoparticles with adjustable thickness. A core–shell structured coordination polymer (CP) @ silica precursor was constructed by encapsulating silica on the surface of the CP through surface adsorption induced self-assembly. Then, the ideal shapes and large hollow cavities were produced through high-temperature calcination, and the formation process of hollow spheres was studied. Thanks to the hollow structure of the material, it has excellent drug loading capacity. It is worth noting that the thickness of the silica shell can be modulated by adjusting reagent amounts, calcination temperature, and time. Furthermore, this method exhibits broad applicability and can be extended to the synthesis of other hollow metal oxide materials. Persistent luminescence (PresL) was achieved through a simple ion-doping strategy. Notably, the silica shell thickness was found to regulate luminescence performance, and its underlying mechanism was further explored. This study not only establishes a synthetic route for designing hollow-structured PersL materials, but also offers perspectives on regulating the structure–performance relationships in multiphase composite materials. We hope the methodology developed and luminescent properties observed in this study will inspire the development of other innovative architectures integrating both physiological compatibility and theranostic capabilities.
研究领域:
材料科学
·
纳米技术
·
无机化学
·
药物递送
·
发光材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）