MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·522
·
IF 5.4
Qiao Yuchun,Wu Yiying,He Jiahui,Chen Wen,Fan Jiaqi,Zhang Zhicong,Shen Jialu,Su Mengping,Wang Qidong,Li Shuai,Shen Yingjie,Shang Jizhen,Wang Hua
Glucose is a vital energy source, and its accurate monitoring is crucial for the diagnosis and management of metabolic diseases. Herein, we report a simple colorimetric sensing platform for glucose detection based on MnO 2 /Au-Ag nanozymes, glucose oxidase (GOx), and 3,3′,5,5′-tetramethylbenzidine (TMB). In this cascade system, GOx catalyzes the oxidation of glucose to generate H 2 O 2 , which is subsequently decomposed by MnO 2 /Au-Ag to produce reactive species that oxidize TMB, yielding a visible blue signal. The incorporation of Au-Ag nanoparticles provides additional catalytic sites and promotes interfacial electron transfer, thereby enhancing the catalytic performance of MnO 2 . The platform exhibits a linear response over 0.025-0.20 mM with a detection limit of 0.012 mM. It enables reliable glucose detection in artificial sweat and 80-fold diluted serum samples. In addition, portable nitrocellulose test strips were developed for visual and smartphone-assisted glucose detection. This strategy provides a simple and portable approach for low-concentration glucose analysis and offers potential for point-of-care applications after further validation. Graphical
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Qian Chen,Xiaodong Zhou,Tian Sun,Hantao Li,Siqi Mai,Yong Miao,Sirong Chen,Jinhong Qin,Xunru Liang,Xin Li,Pengchao Zhao,Liming Bian
Current therapies for inflammatory skin diseases predominantly rely on broad systemic immunosuppression and lack precision toward defined immune-cell subsets. Here, we identify CX3CR1 + nonclassical monocytes (NCMs) as an inflammatory monocyte subset that contributes to the amplification of psoriasiform inflammation, as supported by integrated analyses of human single-cell transcriptomics, genetic depletion, and adoptive-transfer models. To preferentially engage these disease-associated NCMs, we engineer an artificial cell–microneedle platform, termed CX3@GUV-DMF, comprising CX3CL1-functionalized, drug-loaded giant unilamellar vesicles (GUVs) embedded within a dissolvable hyaluronic acid (HA) microneedle array. Following intradermal insertion, surface-presented CX3CL1 actively navigates GUVs to pathogenic CX3CR1 + NCMs, facilitating the targeted, sustained release of the loaded drug. In vivo evaluations and transcriptomic profiling demonstrate that this localized immunomodulatory strategy attenuates inflammatory myeloid activation, neutrophil infiltration, and Th17-associated responses while promoting restoration of epidermal barrier-associated programs. These findings establish a materials-enabled strategy for subset-oriented immune modulation and local inflammatory-niche remodeling, advancing inflammatory skin therapy beyond nonspecific immunosuppression.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Li Wang,Hengmei Yang,Zhongyou Lu,Lingchao Li,Yujing Zhang,Kun Xu,Yunqing Tang
This work reports a high-performance vertical organic electrochemical transistor (vOECT) for ultrasensitive sweat glucose monitoring via synergistic molecular and device engineering. The sensor integrates a hydrogen-bonded PEDOT:PSS-PVA channel, enabling record-high transconductance g m (102.5 mS) through enhanced phase separation and charge mobility, and a catalytic gate electrode with Prussian blue/chitosan/graphene/glucose oxidase multilayers for enzymatic signal amplification. It exhibits unprecedented sensitivity of 6.45 mA/dec in artificial sweat (over 5-fold higher than prior OECT-based glucose sensors), robust flexibility with >95% current retention at 1.5-cm bending radius, and a wide detection range (1 μM–5 mM) covering physiological sweat glucose levels with 95.5% accuracy in human trials. Validated in a wearable patch with wireless data transmission, this platform shows significant potential for non-invasive diabetes management, establishing a versatile material-device co-design strategy for multiplexed biomarker detection in personalized healthcare.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Wenjie Shi,Kai Wang,Taotao Li,Xin Guo,Hao Zhu,Xulin Jiang
Osteoarthritis is a chronic degenerative joint disease with local inflammation that needs sustained, localized anti-inflammatory therapy. In this study, a separable drug-loaded microneedle system based on thermosensitive hydroxypropyl chitin (HPCH) was developed via a green fabrication process without using organic solvents or chemical crosslinkers for prolonged transdermal piroxicam delivery. Each PrxC@HPCH microneedle contained a tip loaded with size-controlled piroxicam microcrystals (PrxC), prepared via an alkaline dissolution–acid neutralization antisolvent strategy, and a rapidly separating dissolving layer, could withstand a compressive force of approximately 1.22 N, sufficient for skin penetration. After insertion, the separation layer rapidly dissolved to detach the tips, which remained in the dermis and formed a physically cross-linked gel depot, enabling sustained piroxicam release in vitro for up to 192 h. Meanwhile, the PrxC@HPCH separable microneedles showed long-lasting anti-inflammatory effects for approximately five days after a single administration in vivo. Importantly, in an osteoarthritis rat model, PrxC@HPCH separable microneedles demonstrated superior and sustained therapeutic efficacy once per 3 days for continuous treatment, with effective suppression of synovitis, preservation of cartilage matrix, and alleviation of subchondral bone deterioration. Overall, this biodegradable HPCH-based separable microneedle platform offers a long-acting strategy for localized osteoarthritis therapy and other chronic inflammatory diseases.
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Advanced Membranes
·
2026
·
IF 12.6
Wan-Ting Lin,Xuan-Ce Jin,Si-Yuan Zhang,Wan-Long Li,Zi-Lu Zhang,Xiao-Wei Luo,Zi-Jun Zhang,Zhi-Kang Xu,Ling-Shu Wan
Traditional thin-film composite (TFC) polymer membranes suffer performance deterioration in high-temperature liquid separation due to insufficient thermal stability. Herein, a facile and effective strategy was proposed to fabricate TFC nanofiltration membranes with enhanced thermal stability by using mono- n -dodecyl phosphate (MDP) as an oil-soluble surfactant to regulate the interfacial polymerization. MDP molecules markedly reduce the water/hexane interfacial tension and act as transport carriers to promote the diffusion of amine monomers, as validated by density functional theory (DFT) calculations. By adjusting the concentration of MDP in the organic phase, the polyamide thickness and compactness, surface properties, and the separation performance of the TFC membranes at high temperature can be effectively modulated. The optimal TFC membrane exhibits exceptional thermal stability, maintaining rejection to MgSO 4 > 98.5% and water permeance >35 L m −2 h −1 bar −1 during a continuous operation at 85 °C for 100 h. Temperature-dependent pore size analysis further confirms the enhanced structural integrity of the MDP-regulated TFC membranes under high temperature. This research establishes a novel paradigm for developing nanofiltration membranes with high thermal stability.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Qiang Zhou,Jian Wang,Yangmingxu Meng,Yi Li,Xianglong Zhao,Zexuan Meng,Jiuxi Sui,Lu Yang,Jiajia Chen,Xuanbing Wang,Ji Gong,Guangqiang Pan,Yuchan Zhang,Guangchao Zang
Silicon carbide (SiC) nanoelectrodes show promise for intracellular molecule monitoring but face challenges due to high resistance and chemical inertness, which necessitate functional surface modification to improve detection Performance. In this study, we address the bottlenecks of insufficient functional groups in nanowires prepared by traditional chemical vapor deposition (CVD) and poor conductivity of polymer modification methods, via a novel conductive functionalized hydrothermal carbon coating (HTCC) interface engineering approach. Rooted in the inherent tendency of carbon nanospheres to self-assemble and adhere tightly via intermolecular interactions during hydrothermal synthesis, the approach uniformly coats the surface of inert SiC nanowires with a hydrothermal carbon layer endowed with high conductivity, stability, and abundant functional groups. The Pt/Pd-Cs-HTCC@SiC constructed based on this strategy has been successfully applied to the in-situ monitoring of intracellular reactive oxygen species (ROS), revealing the mechanism by which glutathione (GSH) blocks tau protein phosphorylation by inhibiting the p38 mitogen-activated protein kinase (p38-MAPK) pathway, thereby alleviating the hepatotoxicity of microcystin-LR (MC-LR). This study provides a surface engineering approach for SiC nanoelectrodes and offers crucial scientific insight into the hepatotoxicity mechanisms of environmental toxins.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Zhongbiao Wang,Qiuyan Bi,Xin Shi,Zizhen Peng,Zhicheng Wang,Wenzhong Ma,Yakai Lin,Shiai Xu
In this work, we proposed a staged interfacial reaction strategy to regulate the formation of the polyamide selective layer by separating nascent-layer formation from subsequent densification, thereby addressing the mismatch between monomer diffusion and reaction kinetics in conventional interfacial polymerization (IP) and enabling high permeability and selectivity in nanofiltration (NF) membranes for Mg 2+ /Li + separation. The optimized membrane (SIP) was fabricated using 0.2 wt% BAPP and 0.1 wt% TMC for 120 s in Stage-I, followed by 0.5 wt% BAPP for 120 s in Stage-II. Compared with membranes prepared by conventional one-step IP, the SIP membrane exhibited a thinner selective layer (14.89 ± 1.16 nm), a higher amide-related O C–N content (50.96 at%), a more favorable hydration state, and a lower molecular weight cut-off (330 Da), indicating the formation of a thinner yet more compact and uniform polyamide network. Benefiting from these tailored structural and physicochemical features, the SIP membrane exhibited robust Mg 2+ /Li + separation over a broad range of feed Mg 2+ /Li + mass ratios, with high Mg 2+ rejection, low Li + rejection, and stable water flux. During long-term filtration tests, the Mg 2+ /Li + mass ratio in the permeate remained below 0.68, while the Mg 2+ rejection and separation factor were maintained at 95.57%–97.79% and 25.50–35.34, respectively. These results demonstrate that the staged interfacial reaction strategy is an effective platform for regulating polyamide selective layer formation and offers a promising route for lithium extraction from brines with high Mg 2+ /Li + mass ratios.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Shiwei Guo,Liang Gou,Yuhan Wang,Haoran Xiong,Xiaoying Ma,Ming Li,Chungang Yuan
The permeability–selectivity trade-off and the permanent hydraulic resistance introduced by conventional interlayers remain critical challenges for thin-film composite polyamide nanofiltration (NF) membranes. In this paper, we present a low-cost, transient polyester interlayer strategy that utilizes pyrogallol (PG) and trimesoyl chloride (TMC) to regulate interfacial polymerization (IP). A transient polyester interlayer strategy is presented, in which the PG-TMC layer serves as a temporary regulatory scaffold: it suppresses piperazine diffusion during interfacial polymerization and subsequently undergoes partial structural disintegration in aqueous environments, leaving behind a residual porous sublayer with tunable content, thereby avoiding the formation of dense, permanent mass-transfer barriers. This process of kinetic suppression resulted in the compression of the IP reaction zone, thereby yielding a significantly thinner (∼60 nm), smoother (Rq = 25.6 nm), and more uniformly porous polyamide selective layer in comparison to the pristine membrane (83 nm, Rq = 33.3 nm). Consequently, the optimized membrane achieved a ∼ 64% increase in pure water permeability (from 11.4 to 18.7 L m −2 h −1 bar −1 ) while maintaining high Na₂SO₄ rejection (95.0%). It is noteworthy that pharmaceutical rejection was significantly enhanced owing to the narrowed pore size distribution and reduced defect density, with cefalexin rejection rising from 82.6% to 95.0%. In the context of cyclic cross-flow fouling conditions, the modified membrane exhibited enhanced flux and favorable flux recovery, thereby substantiating that the observed permeability enhancement was not attained at the expense of antifouling efficacy. The stability of the separation selectivity was verified over a period of 32 h by conducting long-term cross-flow tests. In contrast to conventional permanent interlayers, the PG-TMC layer functions as a transient regulatory layer and undergoes partial structural disintegration in aqueous environments. This prevents the formation of dense permanent mass-transfer barriers. Utilizing commercially available reagents and a simple dip-coating process that is fully compatible with existing manufacturing lines, this strategy offers a scalable route toward high-performance NF membranes.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 30
·41834-41843
·
IF 7.8
Lin Wan-Ting,Chen Xiaohong,Luo Xiao-Wei,Li Wan-Long,Zhang Si-Yuan,Zhang Zi-Lu,Zhang Zi-Jun,Xu Zhi-Kang,Wan Ling-Shu
Separating monovalent ions from divalent ions remains a central challenge in resource recovery. While the classic poly(piperazine-amide) nanofiltration membrane exhibits superior rejection of divalent anion, the application in cation separation is constrained by the strongly negatively charged surface and limited size-sieving precision. To address this limitation, we propose a solvent treatment-induced optimization strategy for surfactant-tailored polyamide networks. The surfactant-assisted interfacial polymerization yields a dense and uniform nascent polyamide network that can withstand solvent treatment while preserving its cross-linked structure. Subsequent solvent treatment selectively removes oligomers trapped within the network, thereby refining the polyamide network architecture. This strategy facilitates the formation of a thinner polyamide selective layer that exhibits an attenuated negative surface charge and a more uniform pore size distribution. The optimized membrane achieves a dual enhancement in performance, exhibiting high mono-/divalent ion selectivity (Li + /Mg 2+ selectivity of 96.1 and Cl – /SO 4 2– selectivity of 1351) coupled with a high water permeance of 14.9 L m –2 h –1 bar –1 . This work provides a straightforward and effective method to refine surface properties and internal architecture of polyamide networks for efficient mono-/divalent ion separation.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·Vol. 60
·期 30
·21320-21331
·
IF 12.2
Ma Likun,Sun Peng-Fei,Deng Yuling,Zhu Zhiyang,Liang Huaxing,Yang Yi,Lu Xinglin
Achieving stringent boron compliance in seawater desalination
has
long depended on energy-intensive multipass reverse osmosis (RO) with
alkaline dosing, creating a trade-off between energy consumption and
water quality. This work breaks this bottleneck by developing a hybrid
single-pass multistage (HSPM) system with selectivity-optimized loose
RO membranes. Tailoring commercial RO membranes into high-flux variants
via a 5 h controlled chlorination achieves an optimal balance, whereas
an extended 20-h modification causes an impractical 24.1-fold increase
in boron passage. Mechanistic analysis reveals that the 4-fold increase
in apparent activation energy ( E a ) for
B(OH) 4 – transport at pH 11 fails to fully
offset the intrinsic loss of steric selectivity under neutral conditions.
To overcome this material-level limitation, a multidimensional performance
map identifies the operational sweet spot of the HSPM system, enabling
membranes with moderate boron rejection and high water permeance to
meet the 1.0 mg L –1 threshold via multistage blending
and energy recovery. Coupling the 5 h chlorinated membrane with an
optimized 3-stage configuration theoretically yields a ∼42.5%
energy saving versus conventional two-pass RO. This research establishes
a novel paradigm for application-specific membrane selection and process
synergy, offering a scalable, low-carbon blueprint for desalination
and water reuse.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124471
·
IF 7.5
Sijun Chen,Yang Liu,Jingrong Liu,Tingwei Zhang,Yongcan Jin,Huining Xiao
Sulfonated carbon materials are promising heterogeneous Brønsted acid catalysts for biomass valorization, but the facile construction of carbon frameworks with accessible acid sites remains challenging. Herein, a sulfonated fructose-based porous nanosheet carbon (SPC) was synthesized via a facile and energy-efficient two-step strategy involving P 2 O 5 -assisted rapid self-propagating carbonization and concentrated sulfuric acid sulfonation, and subsequently employed for fructose dehydration to HMF in a low-boiling 1,4-dioxane/H 2 O solvent system. During carbonization, P 2 O 5 simultaneously promoted fructose carbonization and directed the formation of a porous nanosheet architecture, avoiding conventional high-temperature activation processes. The resulting porous nanosheets provided abundant sites for -SO 3 H grafting and enhanced Brønsted acid site accessibility. Consequently, SPC exhibited efficient catalytic performance for the selective dehydration of fructose, affording an HMF yield of 70.1% at 140 ℃ for 30 min. Moreover, SPC efficiently converted concentrated fructose (1.0 g fructose) to HMF with a 59.4% yield and exhibited moderate recyclability. This work provides a facile strategy for constructing biomass-derived sulfonated carbon solid acids with effectively utilized Brønsted acid sites for biomass upgrading.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhicheng Wang,Xin Shi,Zizhen Peng,Wenzhong Ma,Yakai Lin,Hideto Matsuyama,Qiuyan Bi
A SISAIP strategy was developed to regulate interfacial PA formation. • SDS/NaCl regulation produced ultrathin PA layers with sub-nanometer pathways. • The membrane achieved S Li, Mg of 90.9 and permeance of 9.5 L m −2 h −1 bar −1 . • Stable operation and strong flux recovery were obtained under brine-relevant tests. The rapidly increasing global demand for lithium has stimulated the development of advanced membrane technologies for lithium extraction from salt-lake brines. Nanofiltration (NF) membranes with precisely regulated subnanometer transport pathways are highly attractive for Li + /Mg 2+ separation; however, the rational construction of selective layers that simultaneously deliver high ion selectivity and fast water transport remains challenging. Herein, we report a scalable surfactant–inorganic salt–assisted interfacial polymerization (IP) strategy, termed SISAIP, to fabricate high-performance polyamide NF membranes. Interfacial tension, dynamic light scattering, and UV–vis analyses indicated that sodium dodecyl sulfate enriched at the water/oil interface and regulated PEI transport across the interface, whereas NaCl modified the aqueous-phase microenvironment, moderated PEI diffusion toward the interface, and helped confine the interfacial reaction zone. This coordinated regulation produced an ultrathin PA selective layer with an apparent thickness of 11.2 ± 0.6 nm and compact subnanometer transport pathways. The optimized membrane achieved a water permeance of 9.5 L·m −2 ·h −1 ·bar −1 , an S Li,Mg of 90.9, and Mg 2+ rejection above 99.5%, corresponding to 578.6% and 437.9% increases in water permeance and S Li,Mg over the control T-IP membrane, respectively. The membrane also maintained stable performance during 120 h of continuous filtration and exhibited favorable fouling/scaling resistance, with a flux recovery ratio of 100% under organic-conditioned CaSO 4 scaling conditions. This SISAIP strategy provides a promising and scalable route for designing advanced NF membranes toward efficient lithium recovery from salt-lake brines.
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