JOURNAL OF NANOPARTICLE RESEARCH
·
2017
·Vol. 19
·期 12
·1-11
·
IF 2.02
Chen Daquan,Song Xiaoyan,Wang Kaili,Guo Chunjing,Yu Yueming,Fan Huaying,Zhao Feng
In this article, in order to enhance the bioavailiability and tumor targeting of curcumin (Cur), the oligosaccharides of hyaluronan conjugates, folic acid-oligosaccharides of hyaluronan-acetal-menthone 1,2-glycerol ketal (FA-oHA-Ace-MGK) carried oHA as a ligand to CD44 receptor, double-pH-sensitive Ace-MGK as hydrophobic moieties, and FA as the target of folate receptor. The structure characteristics of this smart response multifunctional dual-targeting nano-sized carrier was measured by fourier-transform infrared (FT-IR) and nuclear magnetic resonance ( 1 H–NMR). Cur, an anticancer drug, was successfully loaded in FA-oHA-Ace-MGK micelles by self-assembly. The measurement results of transmission electron microscopy (TEM) presented that the Cur-loaded micelles were spherical in shape with the average size of 166.3 ± 2.12 nm and zeta potential − 30.07 mV. Much more encapsulated Cur could be released at mildly acidic environments than at pH 7.4, from the Cur-FA-oHA-Ace-MGK micelles. Cytotoxicity assay indicated that non-Cur loaded micelles mostly had no cytotoxicity to MCF-7 cells and A549 cells, and Cur-loaded micelles had significantly lower survival rate than Cur suspension in the same concentration, which proved that the drug-loaded micelles can effectively inhibit tumor cell growth. The targeting of CD44 receptors and folate receptors was proved in vitro cellular uptake assay. These results showed the promising potential of FA-oHA-Ace-MGK as an effective nano-sized carrier for anti-tumor drug delivery.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Sisi Fan,Minggang Zhao,Longjiang Ding,Ye Ma,Jingjing Liang,Xingtao Wang,Yawen Song,Shougang Chen
Eggshell membranes were used as biotemplate to fabricate a 3D hierarchical porous Co 3 O 4 /ZnO p-n junction film. Multiple catalysis and accelerated electron transfer were achieved on the Co 3 O 4 /ZnO-GOx electrode by introducing the p-n junction interface into enzyme loading matrix. A stable and well-defined oxidation peak of glucose was obtained with a largely decreased detection potential of 0.25 V. Furthermore, an enhanced sensitivity (116.64 μA·mM −1 ·cm −2 ) was also achieved comparing with the simple biotemplate-synthesized Co 3 O 4 and ZnO film. The results demonstrated it is a novel strategy to improve the biosensing performance by introducing p-n junction interface into enzyme loading matrix.
研究领域:
生物化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2017
·
IF 9.446
Wenhui Li,Xiaowa Nie,Xiao Jiang,Anfeng Zhang,Fanshu Ding,Min Liu,Zhongmin Liu,Xinwen Guo,Chunshan Song
Screening of various supports reveals that Co catalysts supported on ZrO 2 and Al 2 O 3 show good initial activity for CO 2 methanation. Co/ZrO 2 and Co/Al 2 O 3 catalysts prepared by impregnation with different metal loadings were further examined comparatively. The 10Co/ZrO 2 catalyst showed high activity with CO 2 conversion of 92.5% and CH 4 selectivity of 99.9% without deactivation after 300 h time on stream (TOS). However, the 10Co/Al 2 O 3 catalyst gave a lower CO 2 conversion of 77.8% which decreased to 38.6% after 300 h TOS. The catalysts were characterized by STEM/EDS (scanning transmission electron microscopy/energy-dispersive X-ray spectroscopy), in situ XRD(X-ray diffractometer), H 2 -TPR(temperature programmed reduction), XPS (X-ray photoelectron spectroscopy), chemisorption of H 2 , CO, CH 4 , CO 2 and NH 3 -TPD (temperature programmed desorption). Re-dispersion of Co species on the ZrO 2 support during reduction by H 2 was observed by STEM/EDS. New Co-Zr phase formed on the Co-ZrO 2 interface was directly observed by TEM for the first time; the Co/ZrO 2 catalyst exhibited high stability with high activity for CO 2 conversion. In situ XRD, H 2 -TPR and XPS results indicate the promoting effect of ZrO 2 on the reduction of Co 3 O 4 to Co metal along with the negative effect of Al 2 O 3 . The oxygen vacancies on the ZrO 2 detected by XPS may help to activate CO 2 and H 2 O and resist deactivation. Co/Al 2 O 3 catalyst deactivates rapidly due to coke deposition and spinel formation.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2015
·Vol. 8
·期 12
·8701-8713
·
IF 2.651
Kaikai Wang,Juan Wang,Wenwen Hu,Yifan Zhang,Feng Zhi,Zaigang Zhou,Jinhui Wu,Yiqiao Hu
Hemoglobin is a promising drug carrier but lacks extensive investigation. The chemical conjugation of hemoglobin and drugs is costly and complex, so we have developed curcumin-loaded hemoglobin nanoparticles (CCM-Hb-NPs) via self-assembly for the first time. Using the acid-denaturing method, we avoid introducing denaturants and organic solvents. The nanoparticles are stable with uniform size. We have conducted a series of experiments to examine the interaction of hemoglobin and CCM, including hydrophobic characterization, SDS-PAGE. These experiments substantiate that this self-assembly process is mainly driven by hydrophobic forces. Our nanoparticles achieve much higher cell uptake efficiency and cytotoxicity than free CCM solutionin vitro. The uptake inhibition experiments also demonstrate that our nanoparticles were incorporated via the classic clathrin-mediated endocytosis pathway. These results indicate that hemoglobin nanoparticles formed by self-assembly are a promising drug delivery system for cancer therapy.Keywords:drug carrier;hydrophobic forces;self-assemble;cell uptake
研究领域:
生物化学
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 4
·1643-1651
·
IF 5.251
Zhouxiang Zhao,Chunmei Ding,Yaqin Wang,Hong Tan,Jianshu Li
Traditional antibacterial treatments, such as chlorhexidine (CHX), destroy cariogenic biofilms. However, they exert negative effects in clinical applications, for example, teeth staining, taste disturbance and harm to oral tissue after a long-term exposure. Therefore, biocompatible strategies for efficient antibacterial drug delivery are in high demand. In this study, aimed at dental caries therapy enhancement, we designed a pH-responsive nanocarrier system, capable of releasing CHX in an acidic environment within cariogenic biofilms. Cationic poly(ethylene glycol)-block-poly(2-(((2-aminoethyl)carbamoyl)oxy)ethyl methacrylate) (PEG-b-PAECOEMA) was synthesized first. Modification of PAECOEMA by citraconic anhydride (CA) forms negatively charged PEG-b-PAECOEMA/CA, which could assemble into core–shell polyionic complex micelles (PICMs) when mixed with cationic CHX via electrostatic interactions. PICMs are stable in healthy neutral oral microenvironments with CHX encapsulated in the core and PEG shell exposed. Once in acidic milieu within caries-producing biofilms, they rapidly disassemble and release CHX cargo owing to degradation of citraconic amide groups. Molecular structures of the above copolymers were confirmed using 1H NMR and gel permeation chromatography (GPC) analysis. The pH-dependent degradation rates of citraconic amide in PEG-b-PAECOEMA/CA copolymer were measured by fluorescamine method. Atomic force microscopy (AFM) studies confirmed successful assembly of well-defined spherical PICMs in aqueous solution. The disassembly of PICMs in acidic microenvironment was observed using dynamic light scattering (DLS). PICMs showed an obvious pH-dependent drug release profile when the pH changed from 7.4 to 5.5. More importantly, the micellar system could reduce drug toxicity of CHX and exhibited outstanding antibacterial capability in the biofilm of Streptococcus mutans. Micelles constructed from pH-sensitive PEG-b-PAECOEMA/CA are highly promising for dental caries therapy and provide guidelines for drug-delivery system design in other acidic pathologic systems.
研究领域:
牙科学
·
材料科学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Science-Advanced Materials and Devices
·
2022
·
IF 7.382
Xiaoyan Xue,Yan Sun,Qiwen Sun,Weiren Bao,Zongsen Zhang,Liping Chang,Jiancheng Wang,Kechang Xie
As an atom economy technology, the direct esterification reaction of olefins plays a significant role in the production of organic esters. In this work, a series of resin-supported HPW catalysts were prepared using D101, D152, RM027, and A15 as the carriers, and they were used to prepare 1-methylpentyl acetate by the esterification of 1-hexene and acetic acid. The composition, structure, morphology, acid content, and other parameters of catalysts were characterized. In the esterification reaction, the activity order of catalysts is as follows: 20.0%HPW/A15 > 20.0%HPW/D101 ≈ 20.0%HPW/D152 > 20.0%HPW/RM027. It depends on the acid strength of the carrier, the interaction between the carrier and HPW, and the HPW content. Moreover, it can be concluded that the weak acid resin carrier is completely inactive for the esterification reaction of 1-hexene, and the ratio of acetic acid to 1-hexene has a significant influence on the product selectivity. When n (acetic acid)/n (1-hexene) = 2, the optimum 1-methylpentyl acetate selectivity is 38.2%. Results of repeated experiments confirm that the stability of the active constituent is related to the type of functional groups on the carrier.
研究领域:
化学工程
·
催化材料科学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 15
·2998
·
IF 4.967
Zhou Wan,Chunlin Jiao,Qilin Feng,Jue Wang,Jianhua Xiong,Guoning Chen,Shuangfei Wang,Hongxiang Zhu
Intimate coupling photocatalysis and biodegradation treatment technology is an emerging technology in the treatment of refractory organic matter, and the carrier plays an important role in this technology. In this paper, sugarcane cellulose was used as the basic skeleton, absorbent cotton was used as a reinforcing agent, anhydrous sodium sulfate was used as a pore-forming agent to prepare a cellulose porous support with good photocatalytic performance, and nano-TiO2was loaded onto it by a low-temperature bonding method. The results showed that the optimal preparation conditions of cellulose carriers were: cellulose mass fraction 1.0%; absorbent cotton 0.6 g; and Na2SO460 g. The SEM, EDS and XPS characterization further indicated that the nano-TiO2was uniformly loaded onto the cellulose support. The degradation experiments of Rhodamine B showed that the nano-TiO2-loaded composite supports had good photocatalytic performance. The degradation rate of 1,2,4-trichlorobenzene was more than 92% after 6 cycles, and the experiment of adhering a large number of microorganisms on the carriers before and after the reaction showed that the cellulose-based carriers obtained the required photocatalytic performance and stability, which is a good cellulose porous carrier.Keywords:carrier;cellulose;degradation;photocatalysis;1,2,4-trichlorobenzene
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xiaoling Liu,Sibin zhu,Shuodan Li,Letian Li,Xiaoming Zhu,Haolin Tang,Yadong Wang
Commercial Pt/C catalyst in Proton exchange membrane fuel cells (PEMFCs) usually suffers from Pt agglomeration, dissolution, and carbon support corrosion—exacerbated by Pt-catalyzed carbon oxidation. To address these challenges, composite supports combining high stability and electronic synergy with Pt have emerged as a promising solution. Herein, a platinum nanoparticle catalyst supported on a nitrogen-doped titania/carbon composite (Pt NPs/TiO₂-N/C) was successfully fabricated via a two-step hydrothermal method, aiming to optimize both oxygen reduction reaction (ORR) kinetics and durability through regulated support structures and interfacial interactions. Experimental results demonstrate that strong metal-support interactions (SMSI) between Pt and TiO₂-N/C play a critical role. On one hand, SMSI induces electron transfer from the support to Pt, enhances ORR kinetics. On the other hand, this interaction promotes preference nucleation and distribution of Pt on TiO₂-N surfaces, reducing direct Pt-carbon contact and effectively inhibiting Pt-catalyzed carbon corrosion, thereby improving durability. The Pt NPs/TiO₂-N/C catalyst exhibits excellent ORR activity with a half-wave potential of 0.842 V (vs. RHE) and remarkable stability, showing only a 33 mV decay in half-wave potential after 5000 accelerated degradation test cycles. This study validates that precise regulation of metal-support electronic interactions enables synergistic optimization of catalytic activity, stability, providing a theoretical basis and practical strategies for the rational design of high-performance PEMFC catalysts.
研究领域:
材料科学
·
电化学
·
能源材料
·
催化化学
·
纳米科技
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2017
·
IF 2.813
Honggen Peng,Jiawei Ying,Jingyan Zhang,Xianhua Zhang,Cheng Peng,Cheng Rao,Wenming Liu,Ning Zhang,Xiang Wang
Catalytic oxidation of formaldehyde (HCHO) is the most efficient way to purify indoor air of HCHO pollutant. This work investigated rare earth La-doped Pt/TiO 2 for low concentration HCHO oxidation at room temperature . La-doped Pt/TiO 2 had a dramatically promoted catalytic performance for HCHO oxidation. The reasons for the La promotion effect were investigated by N 2 adsorption, X-ray diffraction, CO chemisorption , X-ray photoelectron spectroscopy, transmission electron microscopy (TEM) and high-angle annular dark field scanning TEM . The Pt nanoparticle size was reduced to 1.7 nm from 2.2 nm after modification by La, which led to higher Pt dispersion, more exposed active sites and enhanced metal-support interaction. Thus a superior activity for indoor low concentration HCHO oxidation was obtained. Moreover, the La-doped TiO 2 can be wash-coated on a cordierite monolith so that very low amounts of Pt (0.01 wt%) can be used. The catalyst was evaluated in a simulated indoor HCHO elimination environment and displayed high purifying efficiency and stability. It can be potentially used as a commercial catalyst for indoor HCHO elimination.
研究领域:
环境催化
·
材料化学
·
纳米科学
·
大气污染控制
·
表面化学
·
多相催化
✓ 已验证
DOI
高影响因子
Sustainable Materials and Technologies
·
2025
·
IF 9.2
Qipu Xin,Ruihao Niu,Zhaojing Huang,Jing Yu,Qihe Chen,Donghong Liu,Enbo Xu
Microcarriers (MCs) play a crucial role in promoting cells to expand in culture systems for the industries as regenerative medicine products and cell-derived alternative proteins. However, high-performance and biosafe MCs are still urgently needed for cell scale-up expansion under the dynamic shearing environment of bioreactor and pipeline. Here, gelatin was used which is of high biocompatibility and edibility as MC matrix, by TGase-induced crosslinking in combination with emulsification method for piscine satellite cells (PSCs) cultivation. MCs cultivation conditions were optimized in the spinner flasks (6000 MCs/mL, 8:1 ratio of cells to MCs, 50 rpm speed), to achieve about 5 fold of PSCs on Day 9. To further increase the proliferation efficiency, solid MCs were modified to porous MCs through ice templating method, which could lead to ∼6.32 proliferation multiple on Day 9 with high-efficiency differentiation. Also, transcriptome analysis showed that the genes related to cell cycle and DNA replication were obviously upregulated in the MCs groups in comparison to the 2D cultivation group of PSCs. Collectively, these findings demonstrate the ability of porous MCs in realizing large-scale cell expansion and even differentiation.
研究领域:
细胞培养
·
再生医学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
BioNanoScience
·
2025
·Vol. 15
·期 2
·1-10
·
IF 3.2
Cai He-Qing,Han Lu,Xue Xin-Yu,Zhang Kou,Wang Tian-Hao,Pan Fu-Hong,Sun Zhi-Cheng,Liu Ru-Ping,Hu Kun,Wei Yen
Gold nanocages (AuNCs) exhibit tunable local surface plasmon resonance (LSPR) properties and exceptional drug loading and releasing capabilities, attributes stemming from their hollow interiors and ultra-thin porous walls. These features underscore their promising applications in the biomedical field. In this study, we fabricated AuNCs with LSPR peaks at 810 nm via chemical etching of Ag nanocube templates with sharp edges using a precisely controlled volume of chloroauric acid. To impart gene-loading functionality, we chemically anchored thiol-modified polyethyleneimine (PEI) onto the surfaces of AuNCs through robust Au–S bonds, generating a novel gene carrier, AuNCs-PEI. Subsequently, we evaluated its photothermal efficacy using a femtosecond laser and assessed cytotoxicity via MTT assay. The binding affinity of AuNCs-PEI for EGFP plasmids was characterized by gel retardation assays. Furthermore, the gene delivery efficiency of AuNCs-PEI was examined in 293 T cells by quantifying green fluorescence protein signals using inverted fluorescence microscopy. These findings demonstrate that engineered AuNCs-PEI not only facilitates gene loading for therapeutic applications but also enables photothermal therapy (PTT).
研究领域:
生物医学工程
·
纳米医学
·
基因治疗
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Wei Gu,Qinfu Zhao,Ye He,Shengyu Wang,Yuanqi Yang,Yian Li,Shuaipeng Feng,Siling Wang
Mesoporous carriers have gained significant attention for enhancing the solubility and bioavailability of Biopharmaceutics Classification System (BCS) Class II drugs. However, the contribution of mesoporous carriers with varying morphologies to the physical stability of these drugs is not well-defined. In this work, mesoporous carbon nanoparticles (MCN) and hollow carbon mesoporous nanoparticles (HMC) were prepared, while the weakly acidic Indomethacin (IMC) and alkaline Celecoxib (CXB) were incorporated into these carriers in the amorphous state by the solvent evaporation method. Notably, HMC demonstrated superior drug loading efficiencies (approximately 43 %) for both IMC and CXB owning to its hollow structure. The mesoporous drug loading systems significantly enhanced dissolution rates in comparison with both self-made amorphous drugs and raw drugs. Furthermore, under accelerated and long-term storage conditions, the mesoporous carriers effectively prevented drugs loaded from crystallization, maintaining constant dissolution profiles for over 12 months. Intriguingly, CXB exhibited a slower rate of crystallization after loading into the mesoporous carriers, likely due to the formation of hydrogen bonds between the carbonaceous carrier material and the amino groups of CXB. Compared with loaded drugs, the self-made amorphous drugs exhibited a crystallinity increase beyond 60 % within the initial month. Collectively, these findings highlighted the potential of mesoporous carbon carriers to elevate the dissolution behaviors of BCS Class II drugs while preserving the physical stability of the loaded amorphous drugs.
研究领域:
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）