COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Cihui Tian,Sajid Asghar,Yurui Xu,Zhipeng Chen,Mei Zhang,Lin Huang,Junxiu Ye,Qineng Ping,Yanyu Xiao
In this study, a redox-sensitive glioma-targeting micelle system was designed to deliver curcumin (CUR) by conjugating it to hyaluronic acid (HA-s-s-CUR, HSC) via disulfide linkage. The effect of the molecular weight of HA on the physicochemical characteristics of HSC conjugates and their in vitro effects in glioma cells were also explored. These conjugates formed nano-scale micelles (209–926 nm) independently in aqueous solution. The micelles greatly increased the solubility of CUR and improved its stability, which is crucial for harnessing the therapeutic potential of this active molecule. The redox sensitivities of different HSC micelles were measured by using a dynamic light scattering method and in vitro release assay, which showed that the low (50 kDa) and medium molecular weight (200 kDa and 500 kD) HA-based conjugates were sensitive to GSH, whereas higher molecular weights (1000 kDa and 2000 kDa) did not show redox-sensitivity. Increased cytotoxicity and uptake of low and medium molecular weight-modified HSC conjugates by the glioma cells further confirmed that the sensitive micelles are more effective for intracellular drug delivery compared to the high molecular weight-modified HSC conjugates or the plain CUR . In summary, the molecular weight of HA affects the physicochemical attributes of HSC conjugates. Only HSC micelles made with HA molecules less than 500 kDa exhibit redox sensitivity.
研究领域:
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2021
·
IF 5.302
Zixin Wang,Hui Lin,Dawei Zhang,Ruijin Hong,Yanna Tian,Jie Chen,Shengming Zhou
In this paper, Ba 0.75 Al 11 O 17.25 was selected as the host for the Eu 2+ and Mn 2+ co-dopants due to the Reidinger defects in its lattice. Upon the 365 nm excitation, the phosphors presented the cyan to green tunable emission by changing the doping concentration of Mn 2+ . Moreover, this phosphor possesses zero-thermal quenching up to 448 K due to the interaction between the traps and Eu 2+ /Mn 2+ . The completely densified ceramic guaranteed the high optical transmittance (∼72 % at 516 nm) and thermal conductivity (4.3 W·m −1 ·K −1 at room temperature). When combined with a 6 W commercial 365 nm emitting LED chip, the temperature of the ceramic eventually stabilized at 428 K and the luminous efficacy of the LED device was almost not influenced by the thermal quenching effect. This work may open a way for exploring new phosphor conversion materials for HP/HB PC solid state lighting.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
ACS Applied Electronic Materials
·
2021
·
IF 3.314
Zhiqiang Lai,Tao Zhao,Pengli Zhu,Dan Liu,Xianwen Liang,Rong Sun
Recently, improving the reliability of silver nanowire (AgNW) has become an interesting topic for promoting working performance and service life of portable electronic devices. In this work, flexible, transparent, and highly conductive AgNW-based films are fabricated by electroplating Cu, Co, or Ni on polyethylene terephthalate. The AgNW network deposited by metal shell (Metal@AgNW) via electroplating exhibits improved conductivity with acceptable transmittance. The Metal@AgNW effectively enhances the chemical reliability of AgNW concerning the electrochemical migration and the UV degradation of Ag, maintaining a superior mechanical property. For the sulfurizing degradation of AgNW, only Ni@AgNW holds a relatively strong resistance. In addition, a high electromagnetic interference (EMI) shielding effectiveness (SE) up to 30 dB of Metal@AgNW with a good stability in the frequency range of 8.2–12.5 GHz is obtained, which is higher than that of pristine AgNW network. Theoretical calculations in combination with the corresponding experiments are employed to investigate the mechanism of electroplating Cu, Co, or Ni on AgNW. As a result, electroplated Ni on AgNW is the densest and most reliable coating in comparison to other metals due to the relatively strong interaction between electroplated Ni particles and the Ag surface. Therefore, electroplating Ni on AgNW is the preferred approach to obtain flexible, transparent, and high-conductivity films with superior reliability.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2019
·Vol. 102
·期 12
·7491-7499
·
IF 3.094
Ziyu Liu,Guido Toci,Angela Pirri,Barbara Patrizi,Jinbang Li,Zewang Hu,Jiabei Wei,Hongming Pan,Tengfei Xie,Matteo Vannini,Jiang Li
In this article, 5 at.% Yb:Lu 2 O 3 transparent ceramics were fabricated by vacuum sintering combined with hot isostatic pressing (HIP) posttreatment using co-precipitated nano-powders. The influence of precipitant molar ratio, ammonium hydrogen carbonate, to metal ions (AHC/M 3+ , R value) on the properties of Yb:Lu 2 O 3 precursors and calcined powders was investigated systematically. It was found that the powders with different R value calcined at 1100°C for 4 hours were pure cubic Lu 2 O 3 but the morphologies of precursors and powders behaved differently. The opaque samples pre-sintered at 1500°C for 2 hours grew into transparent ceramics after HIP posttreatment at 1750°C for 1 hour. The final ceramic with R = 4.8 showed the best optical quality with the in-line transmittance of 79.7% at 1100 nm. The quasi-CW laser operation was performed at 1034 nm and 1080 nm with a maximum output power up to 8.15 W as well as a corresponding slope efficiency of 58.4%.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Yu Bai,Yun Zhao,Yang Li,Jiachao Xu,Xiaoting Fu,Xin Gao,Xiangzhao Mao,Zhaoyong Li
In this study, we fabricated a soft, transparent UV-shielding film (Alg-Fe 3+ -EDTA) by crosslinking sodium alginate with a ferric ion solution containing EDTA. The obtained films were characterized via SEM, ATR-FTIR, XRD, TG and DTG; the results indicated that the synergistic gelation of ferric alginate and alginic acid existed in Alg-Fe 3+ -EDTA film. The Alg-Fe 3+ -EDTA film performance to be optimized under the following conditions: 1.6% Fe 3+ , 0.8% EDTA, and crosslinking duration of 12 min. The Alg-Fe 3+ -EDTA film had high visible light transmittance, the UV-C (200–280 nm) and UV-B (280–315 nm) shielding rates were 100%, and the UV-A (315–400 nm) shielding rate was 98.37%; the UPF reached 50+; additionally, the tensile strength and elongation-at-break were 56.85 MPa and 10.45%, respectively, and still have ultraviolet shielding effect under water environments or after strong light irradiation. This work provides an efficient method to improve the optical and mechanical ability of ferric alginate films.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2018
·
IF 4.841
Jia Nan Zhang,Bo Zhi Chen,Mohammad Ashfaq,Xiao Peng Zhang,Xin Dong Guo
Hyaluronic acid (HA) has many applications in human medicine and cosmetic industry. This study describes the fabrication and evaluation of cross-linked HA (cHA) based microneedles (HA-cHA-MNs) for anti-ageing treatment. The results suggested that the increasing content of cHA gel particles decrease the mechanical properties of MNs. The in-vitro degradation profile and in-vivo epidermal expansion in mice were also carried out. The data suggested that the proportion of cHA particles decreased the rate of MNs degradation. The prepared HA-cHA-MNs have prolonged effectiveness with high swelling retention time or epidermal expansion time in mice up to 6 days or more.
研究领域:
生物医学工程
·
药剂学
·
皮肤科学
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2015
·Vol. 8
·期 8
·5363-5375
·
IF 2.651
Liangjie Pan,Benxue Jiang,Jintai Fan,Qiuhong Yang,Chunlin Zhou,Pande Zhang,Xiaojian Mao,Long Zhang
The synthesis of pure and well dispersed lutetium aluminum garnet (LuAG) powder is crucial and important for the preparation of LuAG transparent ceramics. In this paper, high purity and well dispersed LuAG powders have been synthesized via co-precipitation method with lutetium nitrate and aluminum nitrate as raw materials. Ammonium hydrogen carbonate (AHC) was used as the precipitant. The influence of aging time, pH value, and dripping speed on the prepared LuAG powders were investigated. It showed that long aging duration (>15 h) with high terminal pH value (>7.80) resulted in segregation of rhombus Lu precipitate and Al precipitate. By decreasing the initial pH value or accelerating the dripping speed, rhombus Lu precipitate was eliminated and pure LuAG nano powders were synthesized. High quality LuAG transparent ceramics with transmission >75% at 1064 nm were fabricated using these well dispersed nano LuAG powders.Keywords:co-precipitation method;single phase;pH values;LuAG powder;transparent ceramics
研究领域:
材料科学
·
无机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2019
·
IF 3.771
Bo Wu,Zhimeng Liu,Yuan Lei,Yi Wang,Qinfeng Liu,Anqian Yuan,Yuanyang Zhao,Xi Zhang,Jingxin Lei
Achieving good transparency, high strength and superior extensibility simultaneously in autonomic self-healing elastomers remains challenging and fascinating. Herein, a complementary design strategy of combining densely distributed multiple hydrogen bonds (H bonds) and loosely packed spacer units in supramolecular elastomer was reported to address the inherent contradiction of robust strength and room temperature self-healing. The chemical structure can be tuned to achieve a good compromise between the mechanical properties and self-healing efficiency. The representative elastomers can achieve robust strength (6.81 MPa), high extensibility (2520%) and superior toughness with the dissipated energy up to 63.7 MJ/m 3 . Moreover, this elastomer is capable of recovering mechanical fractures and routine scratches with the self-healing efficiency up to 90%, which are comparable to that of room-temperature self-healable counterparts. Spacer units with steric hindrance effect can facilitate segmental motions and dynamic changes of H-bonds. Meanwhile, the randomly distributed multiple H bonds crosslinking such spacers contribute to the good mechanical performance and intriguing self-healing. In contrast to previous reports, this strategy provides an uncomplicated and cost-effective route to prepare robust elastomers that can self-heal at room temperature without any need of external assistance.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Pharmacology & Translational Science
·
2024
·
IF 4.9
Shuo Yu,Lu Zhang,Yanshen Yang,Meijuan Wang,Tingting Liu,Wenwen Ji,Yang Liu,Hao Lv,Yang Zhao,Xi Chen,Tinghua Hu
The dense storm microenvironment formed by an excessively cross-linked extracellular matrix, such as hyaluronic acid and collagens, serves as a major barrier that prevents drugs from reaching the deeper tumor. Current traditional two-dimensional (2D) cultures are not capable of modeling this drug delivery barrier in vitro. Thus, tumor spheroids have become increasingly important in cancer research due to their three-dimensional structure. Currently, various methods have been developed to construct tumor spheroids. However, there are still challenges, such as lengthy construction time, complex composition of added growth factors, and high cultivation costs. To address this technical bottleneck, our study combined the GelMA hydrogel system to develop a rapid and high-yield method for tumor spheroids generation. Additionally, we proposed an evaluation scheme to assess the effects of drugs on tumor spheroids. Building on the hyaluronic acid-rich pathological tumor microenvironment, we constructed a resveratrol-loaded nano-drug delivery system with tumor stroma modulation capability and used a three-dimensional (3D) tumor sphere model to simulate in vivo tumor conditions. This process was utilized to completely evaluate the ability of the nano-drug delivery system to enhance the deep penetration of resveratrol in the tumor microenvironment, providing new insights into future oncology drug screening, efficacy assessment, and drug delivery methods.
研究领域:
肿瘤学
·
药学
·
纳米技术
·
癌症生物学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Tianci Ma,Jinglei Xing,Lei Yang,Long Wang,Xingzhong Fang,Guofei Chen
As is known to all, it is an effective strategy to achieve transparent aromatic polyimides by introduction of fluorine-containing monomer. However, due to the prohibition of perfluoroalkyl and polyfluoroalkyl substances (PFAS), fluorine-free polyimides have attracted more and more attention. In order to investigate the structure-properties relationship of fluorine-free transparent polyimides, a new diamine monomer, 2′,3,3'',5′-tetramethyl-[1,1′:4′,1''-terphenyl]-4,4''-diamine (3TMTD) containing methyl group and terphenyl structure, was successfully synthesized, and a series of highly heat-resistant polyimides were synthesized by 3,3′,4,4′-diphenylsulfone tetracarboxylic acid anhydride (DSDA) with 2,2′-bis(methyl)-4,4′-benzidine (2,2′-DMBZ), 3,3′-bis(methyl)-4,4′-benzidine (3,3′-DMBZ), 3TMTD, 9,9-bis(4-aminophenyl)fluorene (FDA) and 9,9-bis(3-methyl-4-aminophenyl)fluorene (MFDA). And the polyimide containing fluorine element derived from DSDA and 2,2′-bis(trifluoromethyl)-4,4′-benzidine (TFDB) was also prepared for comparison. The effects of different methyl substitution positions and numbers, as well as fluorine-containing diamine and fluorine-free diamines, on the properties were well studied. The resulting polyimides exhibited high T g s of 373–426 °C, transmittances at 450 nm of 66–87 %, and tensile moduli of 2.8–4.0 GPa. Among them, PI-3 derived from DSDA and 3,3′-DMBZ showed the highest T g of 426 °C, while PI-4 derived from DSDA and 3TMTD dispalyed the best comprehensive performance with T g of 405 °C, transmittance of 80 % at 450 nm, tensile strength of 167.6 MPa and tensile modulus of 4.0 GPa.
研究领域:
高分子科学
·
材料工程
·
有机合成
·
光学材料
·
高性能聚合物
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Hui Ma,Ruixiu Qin,Qiufeng Yao,Yier Li,Chao Luo,Wenhui Wu,Hui Luo,Qi Zhao,Kefeng Wu
Gel-based tissue clearing technologies represent a significant advancement in three-dimensional imaging. However, the challenge of achieving consistent high resolution across large tissue samples remains an issue. We present a phase-separated eutectogel constructed through radical copolymerization of acrylamide and N,N-dimethylacrylamide in a eutectic solvent (antipyrine/erythritol/imidazole) (AEI/ES) with dynamically tunable polymer–solvent interactions. The prepared eutectogel exhibits high transparency (above 90%) and facilitates rapid clearing of thick tissues and whole organs to a high degree of transparency, while preserving their original size and compatibility with multiple fluorescence. The eutectogel demonstrates high strength (4.2 MPa), favorable Young’s modulus (9.8 MPa), and large toughness (0.78 MJ m–3). The strong mechanical strength of the eutectogel improves tissue strength by more than 120-fold, facilitating the procurement of high-resolution two-dimensional images of cells and subcellular structures. It also offers a wide range of dynamic tunability, thereby providing a universal platform for diverse applications spanning biomedicine to tissue engineering.
研究领域:
生物医学工程
·
组织工程
·
生物成像
·
高分子科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2018
·
IF 7.877
Qiuling Dong,Huaqing Zhang,Yue Han,Aouameur Djamila,Hao Cheng,Zhiyuan Tang,Jianping Zhou,Yang Ding
Metastatic cancer is difficult to defeat with current treatments due to lack of etiological therapeutics and efficient delivery platforms. Employing tumor microenvironment in programming intelligent nanosystems has attracted considerable attention for combinative antitumor therapy. Herein, we proposed a core-shell based drug depot consisting of micellar core and crosslinked-gel shell for site-specific shuttling of paclitaxel (PTX) and KIAA1199 specific shRNA (shKIAA). Poly (e-caprolactone) were grafted with branched polyethylenimine (PEI-PCL) as micellar core, into which hydrophobic PTX was embedded; while shKIAA, a reliable RNAi regimen for metastatic cell inhibition was condensed with PEI through electrostatic interaction ; and then photo-crosslinked hyaluronic acid (m-HA) was further coated as shell. The nanoscale drug depot shared HAase-triggered charge switching and desirable release profile. Upon reaching tumor region, HA shell was degraded by concentrated HAase , and facilitated drug shuttling to individual subcellular targeting site. Rapid intracellular trafficking of micellar core achieved endo/lysosomal escape and cytoplasmic liberation. The half-maximal inhibitory concentration (IC 50 ) of “nanodepot” toward human breast cancer cell line MDA-MB-231 was 0.016 μg/mL (PTX concentration), approximately 3-fold decrease compared to that of monotherapy group (0.043 μg/mL). The tumor weight inhibition (TWI) is 83.30% in xenografted MDA-MB-231 tumor model and metastasis was effectively inhibited in 4T1 orthotopic tumors. Moreover, knockdown of KIAA1199 via sustainable RNAi affected a broad range of cellular functions including apoptosis , migration and invasion. Collectively, tumor environment differentiated spatiotemporal co-delivery fashion holds a great promise for combinative treatment with enhanced efficacy on metastatic cancer cases.
研究领域:
肿瘤学
·
药剂学
·
纳米技术
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）