Systems Microbiology and Biomanufacturing
·
2023
·
IF 0
Lin Rui,Chen Xingguang,Peng Zhengcong,Li Wenzhe,Chu Jiyang,Lu Jian,Xie Guangfa,Wu Dianhui
Herbs are rich in polyphenols compounds that are often added to beer to boost its antioxidant ability. To prove herbs can efficiently enhance the antioxidant ability of beer, the total polyphenols and flavonoids content, the distribution of phenolics profile, and antioxidant ability in commercial herbal beers were analyzed in this work. The results showed that most herbal beers had stronger antioxidant ability than conventional beers. The total polyphenols content in most herbal beers (250.8–1063.5 mg/L) was higher than that in conventional beers (179.2–308.4 mg/L), especially free phenolic acids (3.151–26.469 mg/L) such as gallic acid (0.248–2.853 mg/L), chlorogenic acid (0.422–6.420 mg/L), vanillic acid (0.567–10.256 mg/L), and caffeic acid (0.422–10.093 mg/L), which can explain the strong antioxidant ability of herbal beers to a certain extent. Among them, roselle beer (ROL) and jasmine beer (JAS) performed the strongest antioxidant ability. Furthermore, according to the distribution of phenolics profile, it was found that ROL and JAS had highest content of flavonoids including catechol, epicatechin, and quercetin compared with all beers. This was an important reason why ROL and JAS had the strongest antioxidant ability. In a word, the addition of herbs in beer brewing can effectively improve the content of polyphenols and antioxidant ability of beer, especially the herbs rich in flavonoids have the most significant contribution to the antioxidant ability of beer, which is helpful to improve beer quality.
研究领域:
食品科学
·
植物化学
·
营养学
·
酿造工艺
✓ 已验证
DOI
SCIENCE OF THE TOTAL ENVIRONMENT
·
2025
·
IF 8
Xincong Su,Li Kai,Xiaowen Han,Rongzhi Wang,Xiao Yang,Xuedong Wang,Jin Yan,Qiuhui Qian,Zejun Wang,Huili Wang
Bisphenol S (BPS) and Bisphenol F (BPF), as alternatives to bisphenol A (BPA), are recognized for their endocrine-disrupting properties, but their combined immune toxicity mechanisms remain poorly understood. This study systematically evaluates the individual and joint immune toxicity effects of BPS and BPF through ADMET predictions, transgenic zebrafish models, and molecular docking analyses. The results indicate that equal effect concentration BPS and BPF act through distinct immune pathways: BPS primarily targets macrophages to mediate immune responses, while BPF significantly stimulates neutrophil proliferation and induces a stronger inflammatory response through chemokine signaling. Molecular docking studies show that BPF binds more stably to pro-apoptotic protein Mapk8 and oxidative stress-related protein Hsp90aa1, leading to significantly higher levels of apoptosis and reactive oxygen species (ROS) compared to BPS. The similarity of modes of action (MOA)between BPS and BPF based on relevant immune indicators calculated and experimentally is about 0.3; this quantitative result also proves that modes of action differ widely. Nonetheless, most of the indicators showed superimposed effects in the combined experiments, and it is noteworthy that the oxidative stress indicators (SOD, MDA) showed synergistic effects, suggesting that BPS and BPF, which have very different modes of action, are able to be risk assessed using an additive model with respect to immunity, but may exhibit synergistic risks with respect to oxidative stress. This research demonstrates that BPS and BPF induce immune toxicity via different molecular targets and pathways and highlights the need to account for their synergistic effects in risk assessments. These findings provide important insights into the immune toxicity mechanisms of BPA substitutes and the potential risks of combined exposures.
研究领域:
环境科学
·
毒理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2024
·
IF 3.6
Hongxia Chen,Hao Zhou,Zhiwen Qi,Xingying Xue,Chengzhang Wang
There have been studies published on the composition and coating uses of raw lacquers following enzymatic oxidative polymerization. The change of urushiol’ thermal stability and biological activity following polymerization to create oligomer, however, has received little attention. This work using silica gel column chromatography to separate urushiol and urushiol oligomer from polymerized raw lacquer and assessed its antibacterial, antioxidant, and thermal stability in an effort to decrease the allergenicity of urushiol and increase its application. By using gel chromatography, the urushiol oligomer were discovered to be polymers with 2–5 degrees of polymerization. According to characterization results from techniques like UV, FT-IR, and 1H NMR, urushiol was converted into urushiol oligomer by addition reactions, and C–C coupling. The findings demonstrated that the urushiol oligomer’ IC50 values for scavenging DPPH and ABTS free radicals were 40.8 and 27.4 μg/mL, respectively, and that their minimum inhibitory concentrations against Staphylococcus aureus and Staphylococcus epidermidis were 250 and 125 μg/mL. The urushiol oligomer’s thermogravimetric differential curve peak temperature (461.8 °C) was higher than urushiol’s (239.5 °C), indicating that urushiol undergoes polymerization with enhanced thermal stability. The study’s findings establish a foundation for the use of polymerized urushiol and urushiol oligomer in applications including functional materials and additives.
研究领域:
材料科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION SCIENCE AND TECHNOLOGY
·
2025
·
IF 2.3
Caidi Zhang,Wanchuan Shang,Xiaoning Zhang,Xueli Huang,Xueying Wang
Cresol is an important phenolic compound derived primarily from low-temperature coal tar. The presence of m/p-cresol increases the unsaturated bonds in coal tar. This increases the hydrogen consumption in the hydrogenation process. Separation and further purification of m/p-cresol can improve the value of coal tar. The boiling points of m-cresol and p-cresol are similar and therefore difficult to separate. It has become a major problem in the development of crude phenol refining. In this work, a novel complexing agent, hexamethylenetetramine, was used to complex and separate cresols. The effects of crystallization temperature, complexing agent dosage, solvent dosage and crystallization time were investigated. The process was optimized using response the surface methodology. As a result, the purity of m-cresol could reach more than 94.2% and the yield reached more than 30.4%, indicating that the process could effectively separate the mixture of m-cresol and p-cresol.
研究领域:
化学工程
·
煤化工
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Uddin Sk Raihan,Jingqi Zhang,Jingbo Chao,Qing Hu,Frederic Coulon,Xiao Jin Yang
Chlorinated phenols are highly toxic to human and ecosystem and their biological degradation is difficult. In this work, a novel MgAlNi alloy catalyst was developed for rapid chemical degradation of p-chlorophenol (4-CP) in water under mild conditions via in situ hydrodechlorination ( i HDC) without external hydrogen gas supply. A complete conversion of 0.195 mM 4-CP to phenol was achieved within 15 min with a reaction rate constant of 7.65 h −1 , 19.4 times higher than that of the traditional Raney Nickel (AlNi alloy) catalyst. The excellent performance of MgAlNi alloy catalyst is attributed to enhanced H 2 generation by Mg etching, surface self-reconstruction by growth of in situ layered double hydroxide ( i LDH) nanosheets of 0.08–1 nm, exposed active sites of AlNi intermetallic compounds Al 3 Ni 2 and Al 3 Ni. The findings of this study provide new insights into broader applications of nanoconfinement catalysis to environmental remediation and open a new domain of in situ nanoconfinement catalysis ( i NCC).
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Zhejiang University-SCIENCE B
·
2016
·Vol. 17
·期 5
·391
·
IF 1.303
Yun Xing,Le Cai,Tian-peng Yin,Yang Chen,Jing Yu,Ya-rong Wang,Zhong-tao Ding
The antioxidant activities and total phenolic content of fermented Salvia miltiorrhiza with fungus Geomyces luteus were investigated. The results revealed that G. luteus fermentation could significantly improve the antioxidant activity and total phenolic content of S. miltiorrhiza . The main antioxidant constituents were characterized by spectroscopic analysis as salvianolic acids. High-performance liquid chromatography (HPLC) quantification also showed the enhanced content of salvianolic acid B after fermentation. The present study suggests that G. luteus fermentations are effective in the S. miltiorrhiza salvianolic acids’ enrichment process.
研究领域:
药用植物学
·
天然产物化学
·
发酵工程
✓ 已验证
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2017
·
IF 1.174
Jianhua Chen,Xue Sun,Lijing Lin,Xinfei Dong,Yasan He
In the present paper, a metal–organic framework Cr-BDC was prepared and used as adsorbent for adsorption of o -nitrophenol (ONP) and p -nitrophenol (PNP) from aqueous solutions. Cr-BDC was characterized by scanning electron microscopy, transmission electron microscope, X-ray diffraction and BET methods. The results indicate that Cr-BDC gets a very large specific surface area of 4128 m 2 ·g − 1 and pore sizes are concentrated in 1 nm, which is a benefit for using for wastewater treatment . The influences of the adsorption conditions, such as temperature, solution concentration, adsorption time and reusability on adsorption performance were investigated. Cr-BDC exhibited an encouraging uptake capacity of 310.0 mg·g − 1 for ONP, and adsorption capacity of Cr-BDC for ONP is significantly higher than that for PNP under suitable adsorption conditions. The characterizations of adsorption process were examined with the Lagergren pseudo-first-order, the pseudo-second-order kinetic model, and the intra-particular diffusion model. Kinetics experiments indicated that the pseudo-second-order model displayed the best correlation with adsorption kinetics data. Furthermore, our adsorption equilibrium data could be better described by the Freundlich equation. The results indicate that the as-prepared Cr-BDC is promising for use as an effective and economical adsorbent for ONP removal.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2014
·
IF 1.862
Ping Jiang,Yu-chen Sheng,Yu-hao Chen,Li-li Ji,Zheng-tao Wang
This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological evaluation of the liver further confirms the protection of FL against AP-induced hepatotoxicity. TdT-mediated biotin-dUTP nick-end labeling (TUNEL) assay shows that FL reduces AP-increased apoptotic cells. Furthermore, AP-decreased liver glutamate-cysteine ligase (GCL) enzymatic activity and glutathione (GSH) amount are both reversed by FL because of the increased expression of the catalytic subunit of GCL (GCLC) protein. The amount of chlorogenic acid (CGA), caffeic acid, and luteolin, the main active compounds in FL, is detected by high-performance liquid chromatography (HPLC). In addition, cell viability assay demonstrates that polyphenols in FL, such as CGA, caffeic acid, as well as isochlorogenic acids A, B, and C, can reverse AP-induced cytotoxicity. In conclusion, FL can prevent AP-induced liver injury by inhibiting apoptosis. The cellular antioxidant enzyme GCL is also involved in such protection. Polyphenols may be the main active hepato-protective ingredients in FL.
研究领域:
药理学
·
肝脏病学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CEREAL SCIENCE
·
2017
·
IF 2.223
Zicong Zeng,Yuting Li,Rong Yang,Chengmei Liu,Xiuting Hu,Shunjing Luo,Ersheng Gong,Jiangping Ye
To investigate the relationship between reducing sugars and phenolic retention of brown rice after enzymatic extrusion, reducing sugars, total phenolic content, total antioxidant activity , and individual phenolic acids of brown rice extruded with different α-amylase concentrations (0.1%, 0.5%, 1%, w/w) were evaluated. Reducing sugars were produced during enzymatic extrusion and significantly increased with the increasing enzyme concentration. Compared with traditional extrusion, the enzymatic extrusion with 1% amylase significantly increased the phenolic retention, DPPH value, FRAP value, and ABTS value by 22.4%, 19.5%, 14.7%, and 41.5%, respectively. The retention of most free phenolic acids was also increased with the increasing enzyme concentration. Besides, the correlation analysis indicated that the content of reducing sugars was positively correlated with total phenolic content (r = 0.915), DPPH value (r = 0.882), FRAP value (r = 0.861), ABTS value (r = 0.867) and free individual phenolic acids (r = 0.595–0.943) of treated brown rice. These results suggested that reducing sugars might protect phenolic compounds during enzymatic extrusion.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2023
·Vol. 12
·期 13
·2560
·
IF 5.2
Wu Wang,Tingting Li,Jing Chen,Yingwang Ye
This research investigates the antibacterial potential of plant essential oil components including thymol, carvacrol, citral, cinnamaldehyde, limonene, and β-pinene againstSalmonellaEnteritidis (S.Enteritidis). Through the determination of minimum inhibitory concentration, three kinds of natural antibacterial agents with the best inhibitory effect onS.Enteritidis were determined, namely thymol (128 μg/mL), carvacrol (256 μg/mL), and cinnamaldehyde (128 μg/mL). Physical, chemical, microbial, and sensory characteristics were regularly monitored on days 0, 2, 4, and 6. The findings of this study reveal that both thymol at MIC of 128 μg/mL and carvacrol at MIC of 256 μg/mL not only maintained the sensory quality of chicken, but also decreased the pH, moisture content, and TVB-N value. Additionally, thymol, carvacrol and cinnamaldehyde successfully inhibited the formation ofS.Enteritidis biofilm, thereby minimizing the number ofS.Enteritidis and the total aerobic plate count in chicken. Hence, thymol, carvacrol, and cinnamaldehyde have more effective inhibitory activities againstS.Enteritidis, which can effectively prevent the spoilage of chicken and reduce the loss of its functional components.Keywords:SalmonellaEnteritidis;thymol;carvacrol;cinnamaldehyde
研究领域:
食品安全
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Xiaowen Xie,Xiaoguo Ma,Lihui Guo,Yinming Fan,Guolong Zeng,Mengyuan Zhang,Jing Li
A novel multi-templates molecularly imprinted polymer (MIP) was prepared on the surface of mesoporous silica coated magnetic graphene oxide (MGO@mSiO 2 ), and applied for the rapid and selective detection of alkylphenol compounds including bisphenol A (BPA), 4-tert-octylphenol (4-tert-OP) and 4-nonylphenol (4-NP) in water. The synthesized composite was characterized by Fourier transform infrared spectrometer, vibrating sample magnetometer, transmission electron microscopy and Brunauer-Emett-Teller surface area analyzer. The MIP showed high adsorption capacity, good selectivity and fast kinetic for these alkylphenols. The maximum adsorption capacities of the MIP for BPA, 4-tert-OP and 4-NP were 16.81, 35.97 and 61.73 mg g −1 , respectively, which were significantly higher than those of the non-molecularly imprinted polymer (NIP) due to the imprinting effect. The adsorption of alkylphenols reached equilibrium within 30 min, and followed pseudo-second-order kinetic model and Langmuir model well. The MIP exhibited good sorption selectivity towards BPA, 4-tert-OP and 4-NP, and could be reused 5 times. Furthermore, a new method for ultrasensitive determination of BPA, 4-tert-OP and 4-NP in water by high performance liquid chromatography was developed, using MIP-based magnetic solid-phase extraction coupled with dispersive liquid-liquid microextraction. Under the optimum conditions, the limits of detection (LODs) for BPA, 4-tert-OP and 4-NP were 0.013, 0.010 and 0.010 μg L −1 , respectively. The proposed method was used to the detection of BPA, 4-tert-OP and 4-NP in real water samples, with spiked recoveries of 81.5–104.1% and relative standard deviations (RSDs) of 1.0–7.6%, indicating the multi-templates MIP could be a promising adsorbent for separation and analysis of alkylphenols.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Duanduan Yin,Jian Liu,Xiangjie Bo,Liping Guo
In this study, cobalt-iron selenides embedded in porous carbon nanofibers (CoFe 2 Se 4 /PCF), derived from Prussian blue analogues, was prepared as a novel phenolic sensor. The obtained CoFe 2 Se 4 /PCF nanocomposites show three-dimensional (3D) networks nanostructures that can supply a desirable conductive network to accelerate electron transfer and avoid the aggregation of CoFe 2 Se 4 nanoparticles . Electrochemical detection of hydroquinone (HQ), catechol (CC) and resorcinol (RS), at CoFe 2 Se 4 /PCF modified glassy carbon electrode (GCE) were researched. The results show the obtained 3D CoFe 2 Se 4 /PCF/GCE exhibits excellent electrochemical properties towards the simultaneous testing trace of HQ, CC and RS. The obtained electrode provides wide linear ranges of 0.5–200, 0.5–190 and 5–350 μM and low detection limit of 0.13, 0.15 and 1.36 μM for HQ, CC and RS, respectively. The as-prepared phenolic sensor displays satisfied selectivity and long-term storage stability. In addition, the constructed sensor can be used to determine HQ, CC and RS in actual samples.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）