Small Methods
·
2022
·Vol. 6
·期 3
·2101391
·
IF 15.367
Huihui Yang,Yanfei Zhang,Leli Zeng,Wen Yin,Yuzhi Xu,Jun Chen,Si-Yang Liu,Xiaoyong Zou,Zhiyu He,Zong Dai
Single-cell encapsulation is an emerging technology to endow cells with various functions, of which developing new applications in vivo is in high demand. Currently, metal–organic frameworks (MOFs) that are used as nanometric shells to coat living cells, however, have not realized cell-selective encapsulation. Here, a biocompatible and selective cell encapsulation strategy based on precursor-functionalized nucleolin aptamer and in situ MOF mineralization on the aptamer-identified cancer cell surface are developed. After MOF coating, the encapsulated cancer cells undergo immunogenic cell death, which is found associated with the changed cell stiffness (indicated by Young's modulus). The immunogenic dead cancer cells are used as whole-cell cancer vaccines (WCCVs), forming the integral WCCV-in-shell structure with enhanced immunogenicity ascribing from the surface-exposed calreticulin to promote dendritic cell recruitment, antigen presentation, and T-cell activation. The major activation pathways in the immune response are identified including tumor necrosis factor signaling pathway, cytokine–cytokine receptor interaction, and Toll-like receptor signaling pathway, suggesting the potential adjuvant effect of the MOF shells. After vaccination, WCCV-in-shell shows much better tumor immunoprophylaxis than either the imperfectly coated cancer cells or the traditional WCCV. This strategy is promising for the universal and facile development of novel whole-cell vaccines.
研究领域:
生物技术
·
癌症研究
·
免疫学
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纳米技术
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药学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 22
·4555-4566
·
IF 6.331
Wenhui Chen,Qiu Han,Yang Liu,Yiwen Wang,Fu Liu
Hyperphosphatemia, a common complication of chronic renal failure patients, is described as an excess amount of serum phosphate >4.5 mg dL−1. Current therapy for hyperphosphatemia is limited by low removal efficiency, secondary hyperparathyroidism, uremic bone disease, and the promotion of vascular and visceral calcifications. Metal organic frameworks (MOFs) have aroused great interest in the field of blood purification because of their strong specific adsorption. Herein, we prepared mixed matrix microspheres (MMMs) encapsulated NH2-MIL-101(Fe) with specific adsorption to blood phosphate. Simultaneously, a heparinoid copolymer poly (acrylic acid-sodium 4-vinylbenzenssulfonate) (P(AA-SSNa)) was incorporated to improve the hemocompatibility. The proposed MMMs exhibited excellent phosphate adsorption capacity both in aqueous and human plasma environments. They also showed comprehensive hemocompatibility e.g. low tendency of protein adsorption, low hemolysis rate and extended blood coagulation time. In general, we envision that the MMMs are potentially suitable as highly efficient hemoperfusion adsorbents for hyperphosphatemia treatment.
研究领域:
药学
·
肾病学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Xiuling Zhang,Xiaoke Hao,Zhenyu Zhai,Jiaona Wang,Huiyu Li,Yaxin Sun,Yue Qin,Ben Niu,Congju Li
Wearable electronics based on metal–organic frameworks (MOFs) capable of monitoring various environmental pollutants is a promising approach for realizing gas sensing of chemical information. However, their sensing application combined with electronic textile with breathable, washable and flexible features has not been completely established yet. Herein, we describe a facile and effective strategy to fabricate flexible gas sensor for rapidly detecting hydrogen sulfide (H 2 S) through integrating NO 2 -UiO-66 on electrospun nanofibers membrane (NO 2 -UiO-66 NM) firmly and uniformly. Different from the inherent brittleness and poor processability of powder MOFs, the achieved NO 2 -UiO-66 NM delivers enhanced porosity and surface area, outstanding flexibility, desirable breathability, stable to washing and strong accessibility, more suitable for practical applications. Consequently, the fabricated NO 2 -UiO-66 NM sensor exhibits a significantly high detection selectivity for H 2 S among various analytes (H 2 S, SO 2 , C 6 H 6 , CO and NH 3 ) and remarkable sensitivity for H 2 S with unprecedentedly ultralow detection limit reaching down to 10 ppb. Moreover, the sensing performance can be greatly remained after around five weeks at concentration down to 1 ppm; also, there are slight impact of deformation on sensing activities, revealing superior H 2 S sensing stability. This study offers a feasible solution to develop electronic textiles for chemical sensing application.
研究领域:
材料科学
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化学工程
·
环境科学
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纳米技术
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可穿戴技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Si-Yuan Fang,Ji-Lai Gong,Lin Tang,Juan Li,Meng Qin,Huai-Yang Zhou,Liang-Xiu Tang,Jun Zhao
A nanofiltration membrane functionalized with metal–organic frameworks (MOFs) is promising to enhance micropollutant removal and realize wastewater reclamation. However, the current MOF-based nanofiltration membranes still suffer from severe fouling problems with an indefinable mechanism when used for antibiotic wastewater treatment. Hence, we report a nature-inspired MOF-based thin-film nanocomposite (TFN-CU) membrane to explore its rejection and antifouling behavior. Compared with unmodified membranes, the optimal TFN-CU5 membrane (with 5 mg·mL–1 C-UiO-66-NH2) had high water permeance (17.66 ± 1.19 L·m–2·h–1·bar–1), exceptional rejection for norfloxacin (97.92 ± 2.28%) and ofloxacin (95.36 ± 1.03%), and excellent long-term stability for treating synthetic secondary effluent with antibiotic rejection over 90%. Furthermore, it also showed superior antifouling capability (flux recovery up to 95.86 ± 1.28%) in bovine serum albumin (BSA) filtration after fouling cycles. Deriving from the extended Derjaguin–Landau–Verwey–Overbeek (XDLVO) approach, the antifouling mechanism between BSA and the TFN-CU5 membrane was mainly attributed to the inhibited adhesion forces because the growing short-ranged acid–base interaction caused repulsive interfacial interactions. It is further revealed that BSA fouling behavior is slightly retarded under an alkaline environment, while strengthened in the presence of calcium ions and humic acid, as well as high ionic strength. In short, the nature-inspired MOF-based TFN membranes possess exceptional rejection and organic fouling resistance, giving insights into the design of antifouling membranes during antibiotic wastewater reclamation.
研究领域:
环境工程
·
材料科学
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水处理
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yang Wang,Shuaishuai Li,Yanming Shao,Liming Jing,Rongkai Ren,Liweng Ma,Xu Wang,Zhijian Li,Jianzhi Wang,Chen Hou
The smart eco-friendly biomass energy driven electrical degradation system was established by coupling of glucose fuel cells (GFC) and solar photo-electro-Fenton (SPEF) processes, which was proposed for the green, economical and efficient degradation of perfluorooctanic acid (PFOA). The CoFe alloy nanoparticles with oxygen defects (O*) based on metal–organic frameworks (MOFs) were decorated on polyacrylonitrile (PAN)-driven carbon nanofiber (CNF) membrane to obtain the bifunctional photocathode (CoFe-OVs@CNF) with both extraordinary photo-catalytic and electro-catalytic abilities. PFOA was highly mineralized on CoFe-OVs@CNF through the synergy of photocatalytic oxidation and electro-Fenton processes. Moreover, the energy consumption for degradation was generated from direct electro-oxidation of glucose as the clean power on anode (GFC). The possible mechanism and degradation pathway for PFOA mineralization was investigated in detail according to intermediate analysis, active species verification and the valence state change of Co and Fe on cathode. Besides, the toxicity evolution during PFOA degradation was also evaluated to deeper insight into risk assessment of intermedia products and relative toxicity, intending to prove the potential for practical elimination of PFOA and other toxicity recalcitrant pollutants in wastewater by GFC-SPEF system.
研究领域:
环境工程
·
化学工程
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材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Lei Gao,Donghui Kou,Wei Ma,Shufen Zhang
Due to the large specific surface area and continuous pores in structures, metal–organic frameworks (MOFs) show great advantages in the adsorption of volatile organic compounds (VOCs). Photonic crystal (PC) sensors derived from MOFs are promising for the visual detection of VOC gases. However, they still have problems of low sensitivity and poor color saturation and tunability. Here, inspired by vapor-sensitive scales of Tmesisternus isabellae beetle and scattering light absorption of polydopamine, a porous one-dimensional PC sensor is constructed by combining ZIF-8 with TiO2@PDA nanoparticles. The PC sensor shows significant color changes under different concentrations of benzene vapor and reaches a detection limit of 0.8 g/m3. It has a response time of less than 1 s and maintains stable optical performance after 100 times of reuse. Moreover, ZIF-67 and ZIF-7 are both incorporated into the PCs for comparison; it reveals that ZIF-8 shows superior benzene detecting property. Additionally, the synergistic adsorption of VOCs in inner and outer holes of the ZIF-8 layer is demonstrated by real-time mass monitoring with quartz crystal microbalance with dissipation. This study provides a valuable reference for the fabrication of high-quality MOF-based PC sensors and sensing mechanism study between microscopic molecular adsorption and macroscopic performance.
研究领域:
材料科学
·
化学传感器
·
纳米技术
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2024
·
IF 9.5
Li Rushuo,Ban Tao,Zhao Danfeng,Lin Jing,Liu Zhiyuan,Wang Linmeng,Huang Xiubing,Tao Zhiping,Wang Ge
Olefin hydrogenation under mild condition is crucial and challenging for industrial applications. Herein, defective UiO-66(Ce) was constructed by using cyanuric acid as the molecular etching “scissors” and further to synthesize heterogeneous catalyst with highly dispersed RuNi nanoparticles (Ru 1 Ni 1.5 @UiO-66(Ce)-12 h). The construction of Ce-O-Ru/Ni heterogeneous interfaces and Ni–Ru bonds provide electron transfer channels from Ce-oxo clusters and Ni species to Ru species. Furthermore, the microenvironment and electronic structure of Ru 0 active sites were synergistically regulated by adjusting the content of metal-organic frameworks (MOFs) defects and Ni promoter, thereby enhancing the adsorption and activation ability of H–H and C=C bonds. Therefore, Ru 1 Ni 1.5 @UiO-66(Ce)-12 h achieved dicyclopentadiene saturated hydrogenation (100% conversion) to tetrahydrodicyclopentadiene (∼ 100% selectivity) under mild condition (35 °C, 1 MPa) with only 25 min. Meanwhile, the sample exhibited excellent structural stability after 6 cycles test. This study provides a promising strategy for the rational design of remarkable noble metal-based catalysts for practical applications.
研究领域:
催化
·
化学工程
·
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2022
·
IF 4.889
Lu Long,Kaiji Xu,Kok Bing Tan,Dongren Cai,Yucheng Yang,Shu-Feng Zhou,Guowu Zhan
Catalytically agitating paddles are essential to perform liquid-solid heterogeneous catalytic reactions on an industrial scale due to the improved mass transfer and easy catalyst recovery. Herein, bimetallic oxides were formed after the calcination of nanomaterials derived from metal-organic frameworks (MOFs). Particularly, Mn(M)-BTC nanomaterials were synthesized by self-assembly of Mn 2+ ions (mixed with various dopants such as Cu 2+ , Ce 3+ , or Fe 2+ ) and H 3 BTC ligands in a mixed solvent of ethanol and water. It was found that in the powdery form, the Mn-Cu oxide derivate exhibited the highest degradation rate in the catalytic wet peroxide oxidation process (CWPO process), which was significantly higher than that of single metal oxide as well as Mn-Fe and Mn-Ce oxide derivates. The reason was caused by the synergistic effect between Mn-Cu promoted the formation of Mn 3+ and Cu + species to boost the CWPO reaction. Furthermore, the obtained Mn-Cu powdery catalysts were 3D-printed to obtain monolithic agitating paddles with different geometries, which were then mounted on a central shaft in the stirred reactor. An advanced oxidation process was used to investigate the effect of 3D patterns on the degradation efficiency of various organic dyes. It was discovered that the 3D-printed grid with higher cell density (484 cpsi) had better liquid mixing efficiency and thus better catalytic performance, which could be repeatedly used more than seven times. Additionally, the numerical simulation analysis (computational fluid dynamics) revealed a good mixing efficiency and improved mass transfer in the entire reactor equipped with the designed monolithic agitating impellers.
研究领域:
化学工程
·
材料科学
·
环境工程
·
催化
✓ 已验证
DOI
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
ZhaoGuo Wu,XueZhi Zhou,Hao Chen,AiWu Zhao,Jin Wang
Controlling formation of metal organic frameworks (MOFs) with embedded enzymes on magnetic surface has been achieved by a confined growth with particle attachment driven self-sieving approach for the first time. Specifically, a versatile route of silica encapsulation guided enzyme assembly for formation of ZIF-8 shell has been successfully demonstrated by shaped-controllable Fe 3 O 4 nanoparticles , e.g., nanorod and nanocube. Interestingly, silica encapsulation can lead to structural diversity of ZIF-8 shell on the shaped-controllable Fe 3 O 4 nanoparticles for affecting properties of the nanocomposites. Furthermore, embedded enzymes confined between silica endoskeleton and ZIF-8 exoskeleton can participate in cascade reaction with different activities and stabilities in the terms of plasmonic assemblies fabrication and cancer cell catalytic therapy. As a result, a circulation plasmonic fabrication and cancer therapy can be achieved via the magnetic nanocomposites. It can be expected that the confined growth with particle attachment driven self-sieving method can be versatile to generate diverse MOFs shell encapsulated shaped-controllable nanoparticles for efficiently embedding enzyme in the nanocomposites.
研究领域:
材料科学
·
纳米技术
·
生物技术
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2021
·Vol. 17
·期 7
·2005865
·
IF 13.281
Peipei Yang,Jia Tao,Fengfeng Chen,Yuying Chen,Jiaqi He,Kui Shen,Peng Zhao,Yingwei Li
Nanozyme-based chemodynamic therapy (CDT) has emerged as an effective cancer treatment because of its low side effects and without the requirement of exogenous energy. The therapeutic effect of CDT highlights the pivotal importance of active sites, H 2 O 2 supplement and the glutathione (GSH) depletion of a nanozyme. The construction of a single kind of catalyst with multiple functions for the enhanced CDT is still a big challenge. In this work, seven types of bimetallic nanoparticles are synthesized using a metal–organic framework (MOF) as a stable host instead of a Fenton or Fenton-like ions supplier. Among them, Cu-Pd@MIL-101 with an alloy loading of 9.5 wt% modified by PEG (9.5% CPMP) is found to exhibit the highest peroxidase (POD) like activity combined with a superoxide dismutase (SOD) mimic activity and the function of GSH depletion. The in vivo results suggest that the stable and ultrafine nanoparticles possess favorable CDT effect for tumor and good biosafety as well as biocompatibility. This work has provided a credible strategy to construct nanozymes with an excellent activity and may pave a new way for the design of enhanced tumor CDT treatment.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2021
·
IF 4.311
Juan Cui,Yiming Leng,Zhonghua Xiang
Developing low-cost and excellent performance bifunctional catalysts for Oxygen Reduction Reaction (ORR) and Oxygen Evolution Reaction (OER) in rechargeable Zn-air batteries is of great significance. Recently, metal organic frameworks (MOFs)-derived electrocatalysts have been widely studied in ORR and OER due to their large specific surface area and tunable pore structure. However, it is still a challenge to prepare hierarchical porous structure catalysts via facile approach, which is desired in the device manner. Herein, we synthesized a MOF-derived FeNi co-doped catalyst (termed as B-FeNi-N/C-1000) using the binary ligand strategy with a large specific area and suitable hierarchical pore structures which efficiently improves mass transfer to boost the high device performance. As a result, the B-FeNi-N/C-1000 exhibits an outstanding ORR performance with a half potential of 0.9 V vs. RHE and a low potential of 1.62 V vs. RHE at 10 mA cm −2 in alkaline media, which exceeds FeNi catalyst (i.e., FeNi-N/C-1000) via single ligand method and commercial Pt/C + IrO 2 . Additionally, the B-FeNi-N/C-1000 presents a higher power density of 102 mW cm −2 and a long-term stability that only losses 2% after 95 h in the self-assembly Zn-air battery. Accordingly, this work can provide a facile method to synthesize efficient bifunctional catalyst for, but not limit to Zn-air flow batteries.
研究领域:
电化学
·
材料科学
·
能源存储与转换
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2025
·
IF 7.2
Ming Qian,Jiarui Du,Qichuan Jiang,Wei Tao,Jiayi Zhang,Liang Gong
Early diagnosis and treatment of cancer are key problems for effective cancer therapy. Therefore, the development of multifunctional materials that can integrate imaging and therapeutic functions is of great importance. Lanthanide-doped nanoparticles@metal-organic frameworks (Ln-NPs@MOFs) offer an unprecedented opportunity to address this challenge, by combining the imaging capabilities of rare earth-doped nanoparticles with the photosensitizing properties of MOFs for photodynamic therapy (PDT). Here, we report a near-infrared (NIR) light-responsive nanoparticle based on a zirconium-porphyrin metal-organic framework (PCN-224) for synergistic photothermal and photodynamic therapy. Tetra(4-carboxyphenyl)porphyrin (TCPP) that constitutes the MOF framework serves as a natural photosensitizer, enabling efficient photodynamic therapy through Förster resonance energy transfer (FRET). The dye indocyanine green (ICG) was loaded into the MOF pores to sensitize the Ln nanoparticles, enhancing the upconversion fluorescence by 41 times and the downconversion fluorescence by 5 times, which is beneficial to the biological efficacy for imaging diagnosis. Meanwhile, ICG, a traditional photothermal agent, also imparts photothermal therapy capabilities to the system. Furthermore, the encapsulation of cancer cell membranes not only enhances biocompatibility but also improves the material's targeting towards cancer cells, thereby greatly enhancing the therapeutic effect. This dual-functional material provides a promising platform for the integration of cancer diagnosis and therapy.
研究领域:
生物医学工程
·
纳米医学
·
癌症诊疗一体化
·
光学成像
·
光疗
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）