CERAMICS INTERNATIONAL
·
2015
·
IF 2.605
Long Fan,Xiaoyan Shu,Xirui Lu,Yi Xie,Yi Ding,Tao Duan,Bingrong Dang,Yanlin Wu
The present work explores the potential of Gd 2 Zr 2 O 7 pyrochlore based materials for incorporation of trialkyl phosphine oxides (TRPO) waste which is a mixture of multi-nuclides with multi-valence. A series of (Gd,A) 2 (Zr,B) 2 O 7 ceramics were synthesized to investigate the influence of multi-nuclides incorporation on phase structure and aqueous stability of Gd 2 Zr 2 O 7 . XRD and BSE results show that all the ceramics exhibit a single pyrochlore structure. Raman spectroscopy reveals that the degree of structural order for (Gd,A) 2 (Zr,B) 2 O 7 solid solutions increases with enhanced TRPO waste content. In addition, aqueous stability testing was carried out using the MCC-1 static leach test method. The results demonstrate that the normalized release rates of the elements in TRPO waste are kept in a low value below 10 −4 g m −2 d −1 . La shows the highest normalized release rate of all the involved elements, while Zr exhibits the best chemical stability.
研究领域:
材料科学
·
核化学与放射化学
·
环境科学
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Xian Liu,Qiwu Yuan,Yang Yang,Ming Yang,Yuhuan Qing,Xia Li,Xuepin Liao,Bi Shi
Plant polyphenols, particularly lignin-derived polyphenols, exhibit considerable potential in the development of novel antimicrobial agents against multidrug-resistant (MDR) pathogenic bacteria, but their application has been limited by the inherent instability and low bactericidal activity. Here, we developed a high-efficiency and low-resistance strategy for combating MDR bacteria based on gallic acid (GA)- gadolinium (Gd) complex. The antibacterial circle diameters of GA, Gd, and GA-Gd against Salmonella enterica 6819 were 10.50, 16.25 and 24.15 mm, when initial inoculum was 1 × 10 8 CFU/mL, indicating that the combination of GA and Gd synergistically enhances their bactericidal activity. Additionally, GA-Gd showed potent antibacterial activity against two sensitive and ten MDR Salmonella strains with the low minimum inhibitory concentration (0.5 mmol/L) and minimum bactericidal concentration values (1.0 mmol/L). GA-Gd can disrupt bacterial wall, membrane, and DNA, contributing to its efficient antibacterial activity . Notably, the RNA-seq analysis showed that GA-Gd downregulated drug resistance genes related to biofilm formation, cationic antimicrobial peptides resistance, beta-lactam resistance and vancomycin resistance. These results suggest that GA-Gd is a promising antibacterial agent to address the threat of antibiotic resistance and MDR Salmonella infections.
研究领域:
微生物学
·
药理学
·
植物化学
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产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2024
·
IF 8.1
Mengxia Shen,Xinyu Xu,Jiale Qi,Xiaojie Li,Bailiang Xue,Meng Zhu,Zhengliang Zhang,Xunfei Zheng,Bin Li,Zhen Shang
With the miniaturization of electronic devices, the creation of efficient and lightweight electromagnetic interference (EMI) shielding materials is of imminent significance. In this context, we reported an electromagnetic shielding membrane with hydrophobic, antioxidative, and high temperature stability. The chemically cross-linked Aramid nanofibers (ANF)/MXene@Ga/Gd 2 O 3 (CAMG) nanocomposite membranes exhibit a considerable tensile strength and possess exceptional flexibility. The CAMG shielding membranes demonstrate multiple heterogeneous interfaces and a magnetic-dielectric synergistic system, thereby effectively enhancing the absorption shielding efficiency, with the specific shielding effectiveness per unit volume (SSE/t) reaching 6788 dB cm 2 g −1 . Furthermore, the composite membranes demonstrate remarkable electrothermal capabilities, acting as pliable heaters with notable, swiftly replicable, and consistent electrothermal effects at reduced voltages. Additionally, they possess superior heat dissipation efficiency and ensure a uniform heat dispersion. The exceptional electromagnetic shielding performance and multifunctionality of the C-ANF/MXene@Ga/Gd 2 O 3 shielding membranes imply their instructive relevance in next-generation fields such as flexible electronics and aerospace.
研究领域:
材料科学
·
电子工程
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产品关联
DOI
高影响因子
Science of Advanced Materials
·
2015
·Vol. 7
·期 9
·1708-1716
·
IF 2.598
Zhou Jing,Wang Xuejiao,Li Luoyuan,Lu Zhigao,Li Kai
To improve the efficacy of therapies and reduce side effects, theranostics integrated imaging and therapy can achieve an optimized therapeutic outcome. Polypyrrole nanorods (PPy) were synthesized using a hydrothermal method and stabilized by both sodium oleate and 6-aminocaproic acid.
Following modification with PEG and Gd-DTPA, the developed nanorods (PPy-PEG-Gd) were well dispersed in water and demonstrated excellent biocompatibility, high photothermal conversion efficiency (53.5%), and magnetic properties (r
1 = 4.56 mM–1 · s–1).
T
1-weighted MR and photothermal imaging were integrated into the system to visualize the location of the cancer, or for real-time monitoring of photothermal therapy (PTT). Finally, PPy-PEG-Gd were successfully used as an efficient coupling agent for imaging-guided PTT in
vitro and in vivo under NIR laser irradiation. Therefore, PPy-PEG-Gd has great potential for use in T
1-weighted MR and/or infrared thermal imaging-guided PTT of cancer.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2017
·Vol. 7
·期 1
·1-9
·
IF 4.259
Hua Yongquan,Pu Guojuan,Ou Caiwen,Zhang Xiaoli,Wang Ling,Sun Jiangtao,Yang Zhimou,Chen Minsheng
Here we report a supramolecular hydrogel based on Gd(III)-peptide complexes with dramatically enhanced magnetic resonance (MR) performance. The hydrogelations were formed by adding Gd(III) ion to the nanofiber dispersion of self-assembling peptides naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Asp (Nap-GFFYGRGD) or naphthalene-Gly-Phe-Phe-Tyr-Gly-Arg-Gly-Glu (Nap-GFFYGRGE). We further showed that, by adjusting the molar ratio between Gd(III) and the corresponding peptide, the mechanical property of resulting gels could be fine-tuned. The longitudinal relaxivity (r 1 ) of the Nap-GFFYGRGE-Gd(III) was 58.9 mM −1 S −1 , which to our knowledge is the highest value for such peptide-Gd(III) complexes so far. Such an enhancement of r 1 value could be applied for enzyme detection in aqueous solutions and cell lysates.
研究领域:
生物材料学
·
医学影像学
·
生物化学
✓ 已验证
DOI
高影响因子
Materials Research Express
·
2017
·Vol. 4
·期 3
·035035
·
IF 1.068
Ran Li,Yizhuo Gu,Yidong Wang,Zhongjia Yang,Min Li,Zuoguang Zhang
Epoxy resin matrix composites filled with dispersed micro and nano gadolinium oxide (Gd2O3) particles of different contents were fabricated in this study. The γ radiation shielding and mechanical properties of these micro and nano composites were evaluated by measuring mass attenuation coefficients at photon energies from 31 keV to 356 keV and flexural performances. Adding Gd2O3 obviously increases mass attenuation coefficients of composites, and the enhancement is stronger at low photon energy because of dominating photoelectric effect and k-edge of element gadolinium. Effect of Gd2O3 particle size on shielding property of composite was also discussed. The results show that nano-Gd2O3 composites have better ability to shield X and γ ray than micro-Gd2O3 composites, and an enhanced effect of ~28% is obtained with Gd2O3 content of around 5 wt.% at 59.5 keV. The reason is attributed to higher probability of interaction between γ-ray and nano particles. Especially, this effect is prominent in low particle concentration. For flexural property, nano-Gd2O3/epoxy composite show equivalent flexural strength and up to15% higher flexural modulus compared with micro-Gd2O3/epoxy composite. Based on these experimental results, nano-Gd2O3 reinforced epoxy composite is believed to be a promising novel radiation shielding material.
研究领域:
材料科学
·
辐射防护
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Yi-Bing Zhang,Jin Wang,Jun-Xia Wang,Yi Huang,Ping Luo,Xiao-Feng Liang,Hong-Bin Tan
In order to ascertain the structural relationship of zirconolite and pyrochlore for their potential application in HLW immobilization, the Gd-doped zirconolite-pyrochlore composite ceramics (Ca 1- x Zr 1- x Gd 2 x Ti 2 O 7 ) were systematically synthesized with x = 0.0–1.0 by traditional solid-phase reaction method. The phase evolution and microstructure of the as-prepared samples have been elucidated by XRD and Rietveld refinement , Raman spectroscopy , BSE-EDS and HRTEM analysis. The results showed that zirconolite-2M, zirconolite-4M, perovskite and pyrochlore, four phases were identified in Ca 1- x Zr 1- x Gd 2 x Ti 2 O 7 system and could be coexisted at x = 0.4 composition. With the increase of Gd 3+ substitution, the phase evolution was followed by zirconolite-2M→zirconolite-4M→pyrochlore. It is illustrated that the phase transformation from zirconolite-2M to zirconolite-4M was promoted by the preferential substitution of Gd 3+ for Ca 2+ . And the solubility of Gd 3+ in zirconolite-2M, zirconolite-4M and pyrochlore increased in sequence. The chemical stability test was also measured by the PCT leaching method. The normalized elemental release rates of Ca, Zr, Ti and Gd in Ca 1- x Zr 1- x Gd 2 x Ti 2 O 7 system were fairly low and in the range of 10 −6 −10 −8 g m −2 d −1 , which indicated a potential ceramics composite ensemble of CaZrTi 2 O 7 -Gd 2 Ti 2 O 7 system for nuclear HLW immobilization.
研究领域:
材料科学
·
核能工程
·
化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Wenxiu Hou,Fangfang Xia,Gabriel Alfranca,Hao Yan,Xiao Zhi,Yanlei Liu,Chen Peng,Chunlei Zhang,Jesus Martinez de la Fuente,Daxiang Cui
It is essential to develop a simple synthetic strategy to improve the quality of multifunctional contrast agents for cancer diagnosis. Herein, we report a time-saving method for gadolinium (Gd 3+ ) ions-mediated self-assembly of gold nanoclusters (GNCs) into monodisperse spherical nanoparticles (GNCNs) under mild conditions. The monodisperse, regular and colloidal stable GNCNs were formed via selectively inducing electrostatic interactions between negatively-charged carboxylic groups of gold nanoclusters and trivalent cations of gadolinium in aqueous solution. In this way, the Gd 3+ ions were chelated into GNCNs without the use of molecular gadolinium chelates. With the co-existence of GNCs and Gd 3+ ions, the formed GNCNs exhibit significant luminescence intensity enhancement for near-infrared fluorescence (NIRF) imaging, high X-ray attenuation for computed tomography (CT) imaging and reasonable r1 relaxivity for magnetic resonance (MR) imaging. The excellent biocompatibility of the GNCNs was proved both in vitro and in vivo . Meanwhile, the GNCNs also possess unique NIRF/CT/MR imaging ability in A549 tumor-bearing mice. In a nutshell, the simple and safe GNCNs hold great potential for tumor multi-modality clinical diagnosis.
研究领域:
纳米医学
·
生物医学工程
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2019
·
IF 2.584
Simin Cui,Xianglei He,Dan Wang,Jie-Xin Wang,Yuan Pu,Jian-Feng Chen
The ideal product of rare-earth-doped phosphors should have uniform particle size distribution and homogeneous doping ions in each particle, and therefore, intensified micromixing at mesoscale is highly required. In this article, inspired by the concept of “mesoscience”, we demonstrate the tuning of Eu3+ doping in GdBO3 microparticles at mesoscale by a high-gravity-assisted reactive precipitation-coupled calcination process. The high-gravity environment and tiny droplets generated by the high-gravity rotating packed bed (RPB) reactor lead to significant intensification of mass transfer and micromixing, which are beneficial for the homogeneous doping of Eu3+ in the host material during reactive precipitation in liquid solution. Under excitation at 395 nm, the emission spectra of the Eu3+-doped phosphors exhibit a narrow-band red emission centered at 625 nm and the highest intensity was observed at x = 0.2. The RPB products show higher intensity than that of the control group even when the reaction time was shortened to 1/6. After calculation, the quenching in the sample most likely results from dipole–dipole interactions. The chromaticity coordinates for the RPB sample was measured as (0.598, 0.341) with a quantum yield of up to 78.11%, and the phosphors exhibit good thermal stability at 423 K. The phosphors were used as the luminescent materials for light-emitting diodes (LEDs), and the devices showed good performance. Our preliminary study illustrated that high-gravity-assisted approaches are promising for tuning the doping of rare-earth ions in microparticles at mesoscale toward efficient production of phosphors for LEDs.
研究领域:
材料科学
·
发光材料
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2016
·
IF 4.035
Chunli Jiang,Zhitao Shen,Chunhua Luo,Hechun Lin,Rong Huang,Yiting Wang,Hui Peng
A facile one-pot strategy has been developed for the aqueous synthesis of Gd doped CdTe (Gd:CdTe) QDs as fluorescence and magnetic resonance imaging dual-modal agent. The prepared Gd:CdTe QDs showed narrow size distribution and the average size was less than 5 nm. The amount of Gd 3+ dopant in Gd:CdTe QDs significantly affected the optical properties of obtained QDs. The highest PL QY for the prepared Gd:CdTe QDs was up to 42.5%. The QDs showed the weak toxicity and significant enhancement in MRI signal. The specific relaxivity value ( r1 ) was determined to be 4.22 mM −1 s −1 . These properties make the prepared Gd:CdTe QDs be an effective dual-modal imaging agent and have great potential applications in biomedical field.
研究领域:
材料科学
·
医学影像
·
纳米生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED PHYSICS
·
2014
·Vol. 115
·期 4
·
IF 2.185
Wang Pei,He Duanwei,Xu Chao,Ren Xiangting,Lei Li,Wang Shanmin,Peng Fang,Yan Xiaozhi,Liu Dongqiong,Wang Qiming,Xiong Lun,Liu Jing
Angle-dispersive synchrotron X-ray diffraction measurements were performed on vaterite-type YBO 3 /Eu 3+ , GdBO 3 , and EuBO 3 , respectively, up to 41 GPa at room temperature using a diamond-anvil cell. Pressure-induced amorphization was observed in hexagonal GdBO 3 with a significant compression along the c -axis. Compared to the ions of the distorted GdBO 3 phase, its anions may lose their long-range order prior to the cations at high pressures. Based on the experimental pressure-volume data, the obtained bulk moduli of YBO 3 /Eu 3+ and GdBO 3 are 329 and 321 GPa, respectively, which are more than 90% larger than that of EuBO 3 (167 GPa) and are presumably attributed to Gd 3+ and Y 3+ with a high density of d valence electrons.
研究领域:
材料科学
·
物理学
✓ 已验证
产品关联
DOI
高影响因子
Regenerative Biomaterials
·
2021
·Vol. 8
·期 6
·
IF 6.353
Yang Li,Fu Shengxiang,Cai Zhongyuan,Liu Li,Xia Chunchao,Gong Qiyong,Song Bin,Ai Hua
The T1−T2 dual-mode probes for magnetic resonance imaging (MRI) can non-invasively acquire comprehensive information of different tissues or generate self-complementary information of the same tissue at the same time, making MRI a more flexible imaging modality for complicated applications. In this work, three Gadolinium-diethylene-triaminepentaaceticacid (Gd-DTPA) complex conjugated superparamagnetic iron oxide (SPIO) nanoparticles with different Gd/Fe molar ratio (0.94, 1.28 and 1.67) were prepared as T1–T2 dual-mode MRI probes, named as SPIO@PEG-GdDTPA0.94, SPIO@PEG-GdDTPA1.28 and SPIO@PEG-GdDTPA1.67, respectively. All SPIO@PEG-GdDTPA nanocomposites with 8 nm spherical SPIO nanocrystals showed good Gd3+ chelate stability. SPIO@PEG-GdDTPA0.94 nanocomposites with lowest Gd/Fe molar ratio show no cytotoxicity to Raw 264.7 cells as compared to SPIO@PEG-GdDTPA1.28 and SPIO@PEG-GdDTPA1.67. SPIO@PEG-GdDTPA0.94 nanocomposites with r1 (8.4 mM−1s−1), r2 (83.2 mM−1s−1) and relatively ideal r2/r1 ratio (9.9) were selected for T1–T2 dual-mode MRI of blood vessels and liver tissue in vivo. Good contrast images were obtained for both cardiovascular system and liver in animal studies under a clinical 3 T scanner. Importantly, one can get high-quality contrast-enhanced blood vessel images within the first 2 h after contrast agent administration and acquire liver tissue anatomy information up to 24 h. Overall, the strategy of one shot of the dual mode MRI agent could bring numerous benefits not only for patients but also to the radiologists and clinicians, e.g. saving time, lowering side effects and collecting data of different organs sequentially.
研究领域:
医学影像学
·
纳米医学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）