Journal of Physical Chemistry C
·
2022
·
IF 4.177
Yun Ling,Ya-ru Chu,Feng Gao,Qing-yun Feng,Hui-qi Xie,Yong Shao,Qing-xiang Wang
The unique chemical and physical properties of metal–organic frameworks (MOFs) endow them with promising applications in the electrochemical sensing field. Herein, a novel label-free electrochemical sensing strategy for cardiac troponin I (cTnI) has been constructed on the basis of immunoaffinity-induced depression of the electrochemical signal of Cu-MOF-74. The electrochemical assay shows that the immunoaffinity reaction between cTnI and anti-cTnI on the electrode surface can effectively inhibit the electrochemical signal of electrode-confined Cu-MOF-74, suggesting that the Cu-MOF-74-based interface may find application in the label-free analysis of cTnI. Thus, Cu-MOF-74 acts as a bifunctional material in this strategy, namely, the immobilization matrix of probe molecules and the signal source of the sensing analysis. In addition, the reason for the electrochemical signal depression of Cu-MOF-74 induced by immunoaffinity reaction is attributed to the increase in the insulation layer and the blocking of the electrolyte diffusion from the bulk solution to the electrode surface. In this strategy, the analytical range of cTnI is from 0.01 pg mL–1 to 1.0 ng mL–1 and the detection limit is 4.5 fg mL–1. The Cu-MOF-74-based sensing interface is also reliable for cTnI analysis in real serum samples, showing that the biosensor has promising application in point-of-care testing (POCT) of myocardial injury-related diseases.
研究领域:
生物传感器
·
医学诊断
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Danxia Lin,Shi Tu,Liang Yu,Yinuo Yuan,Ying Wu,Xin Zhou,Zhong Li,Qibin Xia
The separation of light hydrocarbons like methane, ethane, and propane is an important section of the chemical industry. Herein, we reported a novel porous metal–organic framework (MOF) Cu-IPA and investigated its CH4/C2H6/C3H8 separation performance, particularly for efficient capture of C2H6 and C3H8 at low concentrations. Cu-IPA featured 1D hexagonal channels and triangular channels decorated with extensive oxygen atoms. It showed high C2H6 and C3H8 capacities in the low-pressure region, where C3H8 uptake at 5 kPa was 1.62 mmol/g and C2H6 uptake reached 1.33 mmol/g at 10 kPa, suggesting the strong adsorption affinities toward C2H6 and C3H8. For an equimolar C2H6/CH4 mixture, Cu-IPA exhibited a considerable IAST selectivity of 40, exceeding most reported MOF adsorbents. Excellent CH4/C2H6/C3H8 separation performance for Cu-IPA can be attributed to its appropriate pore size and abundant accessible oxygens atoms in the triangular channel. The molecular simulation revealed that Cu-IPA tended to form stronger C–H···O interactions with C2H6 and C3H8 due to the higher polarizabilities, resulting in larger interaction differences between C2H6/CH4 and C3H8/CH4. Breakthrough tests also supported the excellent dynamic separation performance and recyclability of Cu-IPA.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
Weiwei Qiu,Qingxiang Wang,Natsumi Yano,Yusuke Kataoka,Makoto Handa,Feng Gao,Hidekazu Tanaka
A flexible metal-organic framework (MOF) of Cu 2 ( trans- 1,4 - cyclohexanedicarboxylic acid) 2 (Cu 2 (CHDC) 2 ) has been synthesized by a facile hydrothermal method . The physical characterization experiments show that the Cu 2 (CHDC) 2 presents unique flower-like shape, large surface area and high electroactivity. Then gold nanoparticles (AuNPs)/Cu 2 (CHDC) 2 modified electrode was prepared and utilized as an electroactive matrix for thrombin aptamer immobilization. The electrochemical assay shows that the AuNPs can effectively enhance the electrochemical signal of the Cu 2 (CHDC) 2 . Upon the binding of the electrode-confined aptamer with the thrombin, the electrochemical signal of the Cu 2 (CHDC) 2 decreases obviously due to the change of the microenvironment of the sensing interface. Thus a label-free electrochemical sensing strategy for thrombin was realized. The aptasensor displays excellent performance with wide linear range, ultralow detection limit of 0.01 fM (S/N = 3), and favorable specificity. Also, the aptasensor was applied for determination of thrombin in the human serum samples, and the satisfactory results are obtained. The results imply that the proposed sensor can be potentially used for the early diagnosis of disease and clinical monitoring.
研究领域:
生物医学工程
·
分析化学
✓ 已验证
DOI
高影响因子
Food Analytical Methods
·
2019
·Vol. 12
·期 8
·1715-1724
·
IF 2.413
Wang Zhipan,Ma Baokai,Shen Cai,Lai Oi-Ming,Tan Chin-Ping,Cheong Ling-Zhi
ATP degradation is an important biochemical change during decomposition of seafood. Hypoxanthine and xanthine which are formed during ATP degradation process can be used for evaluation of chilled seafood freshness. Present study successfully immobilized xanthine oxidase (XOD) onto a type of biocompatible copper-based metal organic framework nanofibers (Cu-MOF) film and used it for fabrication of a hypoxanthine and xanthine electrochemical biosensor. Cu-MOF can efficiently entrap XOD, provide a suitable atmosphere for XOD biocatalysis, and ensure good electron transfer between enzyme and electrode surface. The as-prepared XOD-electrochemical biosensor demonstrated high sensitivity for both hypoxanthine and xanthine with a wide linear range (0.01 to 10 μM) and low limit of detection. During the 3-week storage stability test at 4 °C, the fabricated biosensor demonstrated good reusability (up to 100 times) and excellent storage stability for hypoxanthine and xanthine. When applied for detection of hypoxanthine and xanthine in chilled squid and large yellow croaker, the XOD-electrochemical biosensors demonstrated good recovery rates.
研究领域:
食品科学
·
生物化学
·
传感技术
✓ 已验证
DOI
高影响因子
ANALYST
·
2021
·Vol. 147
·期 1
·40-47
·
IF 4.616
Meihui Ying,Guizeng Yang,Yuanjie Xu,Huiling Ye,Xing Lin,Yi Lu,Haibo Pan,Yang Bai,Min Du
Metal–organic frameworks (MOFs) have attracted extensive attention for the development of colorimetric detection methods due to their ease of modification and high density of active sites. However, most of the reported colorimetric sensors based on MOFs show only a single nanozyme activity. Herein, the bifunctional enzyme activities of a hexagonal prism Cu MOF with fumaric acid as the ligand (Cu FMA), namely laccase-like activity under alkaline conditions (pH = 8) and peroxidase-like activity under acidic conditions (pH = 4), were verified. The specificity of Cu FMA at different pH values may be due to the presence of the Cu+ active center introduced by the weak reducibility of FMA. At pH = 8, Cu+ active centers are beneficial for dissociating the H–O bonds of phenolic compounds for the laccase system. In contrast, the dissociation of H–O is weakened at pH = 4, which prompts the breaking of the O–O bonds of H2O2 as a Fenton-like reaction for the peroxidase system. Based on the dual enzyme activities, Cu FMA sensors exhibit outstanding detectability for epinephrine and glucose with linear ranges of 2.7–54.6 μM and 0.01–0.8 mM and detection limits of 1.1 μM and 2.28 × 10−7 M, respectively. The Cu FMA colorimetric sensor can be applied for detecting and measuring glucose and epinephrine in human serum samples. This work paves the way for Cu MOFs to be used as the basis for rational regulation of the activity of dual nanozymes and for multifunctional applications under completely independent conditions.
研究领域:
生物化学
·
材料科学
·
医学检测
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Xia Wang,Qingxiang Wang,Qinghua Wang,Feng Gao,Fei Gao,Yizhen Yang,Hongxu Guo
A highly dispersible and stable nanocomposite of Cu(tpa)-GO (Cu(tpa) = copper terephthalate metal–organic framework, GO = graphene oxide) was prepared through a simple ultrasonication method. The morphology and structure of the obtained composite were characterized via scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV–vis, Fourier-transform infrared (FT-IR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). On the basis of the characterization results, the binding mechanism of the Cu(tpa) and GO was speculated to be the cooperative interaction of π–π stacking, hydrogen bonding, and Cu–O coordination. The electrochemical sensing property of Cu(tpa)-GO composite was investigated through casting the composite on a glassy carbon electrode (GCE), followed by an electro-reduction treatment to transfer the GO in the composite to the highly conductive reduced form (electrochemically reduced graphene, EGR). The results demonstrated that the electrochemical signals and peak profiles of the two drugs of acetaminophen (ACOP) and dopamine (DA) were significantly improved by the modified material, owing to the synergistic effect from high conductivity of EGR and unique electron mediating action of Cu(tpa). Under the optimum conditions, the oxidation peak currents of ACOP and DA were linearly correlated to their concentrations in the ranges of 1–100 and 1–50 μM, respectively. The detection limits for ACOP and DA were estimated to be as low as 0.36 and 0.21 μM, respectively.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
NANO
·
2021
·
IF 1.556
Chengxiang Chu,Rui Huang,Xianfeng Wang,Yuanyi Deng,Tao Gu,Danqun Huo,Liang Zhang,Daidi Zhong,Changjun Hou
As an important amino acid in the body, L-histidine participates in various physiological processes. Therefore, it is of great necessity to establish a rapid and effective method for L-histidine sensing, especially in blood and urine. In this work, a fluorescence sensor for detection of L-histidine was successfully developed using Cu-MOFs/Fe 3 + sensor. Cu-MOFs with blue emission served as the identification unit and signal source, and Fe 3 + played the role of “quencher” in this system. Fe 3 + induced the fluorescence quenching of Cu-MOFs to form Cu-MOFs/Fe 3 + sensor due to the effect of photoinduced electron transfer (PET). After the addition of L-histidine, Fe 3 + was captured by L-histidine to form L-histidine-Fe 3 + complex, which inhibited the PET effect from Cu-MOFs to Fe 3 + , resulting in the fluorescence recovery of Cu-MOFs. With such a design, L-histidine detection was realized with a wide linear range from 1 μ M to 190 μ M. The limit of detection (LOD) was calculated as low as 0.156 μ M. In addition, successful detection of L-histidine in blood serum with high selectivity and sensitivity indicated the real applications and potential diagnostic value of Cu-MOFs/Fe 3 + system.
研究领域:
分析化学
·
生物传感器
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 6
·1-9
·
IF 5.705
Wang Yong,Cao Wei,Wang Luyao,Zhuang Qianfen,Ni Yongnian
A metal organic framework (MOF) of the type copper(II)-1,3,5-benzenetricarboxylic acid (Cu-BTC) was electrodeposited on electroreduced graphene oxide (ERGO) placed on a glassy carbon electrode (GCE). The modified GCE was used for highly sensitive electrochemical determination of 2,4,6-trinitrophenol (TNP). The fabrication process of the modified electrode was characterized by scanning electron microscopy and electrochemical impedance spectroscopy. Differential pulse voltammetry (DPV) demonstrates that the Cu-BTC/ERGO/GCE gives stronger signals for TNP reduction than Cu-BTC/GCE or ERGO/GCE alone. DPV also shows TNP to exhibit three reduction peaks, the first at a potential of −0.42 V (vs. SCE). This potential was selected because the other three similarly-structured compounds (2-nitrophenol, 4-nitrophenol, 2,4-dinitrophenol) do not give a signal at this potential. Response is linear in the 0.2 to 10 μM TNP concentration range, with a 0.1 μM detection limit (at S/ N = 3) and a 15.98 μA∙μM −1 ∙cm −2 sensitivity under optimal conditions. The applicability of the sensor was evaluated by detecting TNP in spiked tap water and lake water samples. Recoveries ranged between 95 and 101%.
Schematic presentation of an electrochemical sensor that was fabricated by electrodeposition of the metal-organic framework (MOF) of copper(II)-1,3,5-benzenetricarboxylic acid (Cu-BTC) onto the surface of electroreduced graphene oxide (ERGO) modified glassy carbon electrode (GCE). It was applied to sensitive and selective detection of 2,4,6-trinitrophenol (TNP).
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CONTROL
·
2019
·
IF 4.248
Baoshan He,Dandan Yan
In this work, an electrode which comprises Au nanoparticles (AuNPs) and electrochemically reduced graphene oxide (ERGO) recombined Cu based metal-organic framework (Cu-TDPAT) was prepared for nitrite detection. The structure and constituent of the modified material were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD) and FT-IR. The electrochemical behavior of nitrite at the modified electrode was performed by cyclic voltammetry and electrochemical impedance spectroscopy. The results indicated that the oxidation process of nitrite happened at recommended electrode had a superior response. The proposed electrode showed high electrocatalytic capacity toward nitrite oxidation with a wide linear working range (0.001–1000 μmol·L −1 ) and a detection limit of 0.006 μmol·L −1 . Finally, the sensor was successfully applied to detect nitrite in real sample and achieved desirable recovery rate, showing its potential application in real-time detection of food .
研究领域:
分析化学
·
材料科学
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 14
·5307
·
IF 4.6
Hanle Li,Jinhai Wu,Jialei Bai,Jianhu Wu,Jin Wu
Antibiotic drug residues can adversely affect the human body. Lincomycin is a common veterinary drug that can form residues in foods of animal origin. However, the detection of trace residue levels of lincomycin residues in real samples is challenging. Here, a simple solid phase extraction (SPE) method was developed for the enrichment of lincomycin from cow milk samples before its detection by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The adsorbent used in the SPE was a Cu-based metal-organic framework (Cu-MOF) prepared by the solvothermal synthesis approach. The prepared MOFs were characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), differential thermogravimetric analysis (TG-DTA), and N2 adsorption-desorption experiments. The adsorption capacity (adsorption equilibrium, extraction time, pH), and elution solvent parameters were investigated. Under the optimized conditions of the HPLC-MS/MS method, lincomycin was detected in the linear range of 10–200 g/L with a detection limit of 0.013 ng/mL. Commercial milk samples were spiked with lincomycin, and a recovery rate between 92.3% and 97.2% was achieved. Therefore, the current method can be successfully applied for the enrichment and determination of lincomycin from milk samples.Keywords:Cu-based metal-organic framework;liquid chromatography-tandem mass spectrometry;sampling preparation technique;solid-phase extraction;lincomycin
研究领域:
分析化学
·
食品科学
·
兽医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 17
·4407-4416
·
IF 4.157
Yang Hongjing,Liu Jiao,Feng Xuan,Nie Fei,Yang Guoping
A novel copper-based metal-organic framework (Cu-MOF) with a large specific surface area and high porosity was synthesized. The Cu-MOF was a good peroxidase-mimicking enzyme and showed a high affinity with hydrogen peroxide in a wide pH range. The catalytic mechanism of Cu-MOF has been studied further based on comparing the characteristic of the Cu-MOF with some isomorphic MOFs. The catalytic activity center of Cu-MOF was determined to be the cupric ion rather than the ligand, which effectively promoted the generation of free radicals and electron transfer in the reaction progress. The high affinity of Cu-MOF to hydrogen peroxide proved it as an ideal catalyst for the chemiluminescence (CL) reaction involving hydrogen peroxide. Therefore, the CL method with high sensitivity could be established for detecting various substrates. A double-enzyme CL glucose biosensing platform was constructed for the determination of serum glucose employing the peroxidase-mimicking properties of Cu-MOF as well as glucose oxidase (GOx). Graphical abstract
研究领域:
生物化学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 8
·632
·
IF 4.3
Yucheng Li,Xia Zhao,Tao Hu,Lingxiao Li,Xiaopeng Huang,Junping Zhang
Solar-driven interfacial water evaporation technology coupled with photocatalytic function is regarded as an emerging approach for treating high-salinity organic wastewater, but it remains challenging to design high-performance solar evaporators with excellent photocatalytic properties. Here, we designed a two-dimensional flexible solar interfacial evaporator with photocatalytic function for the purification of high-salinity organic wastewater. The solar evaporator was prepared by the deposition of Cu-based metal organic frameworks (Cu-MOFs) onto a polyester fabric by solvothermal reaction, during which graphitic carbon nitride was also deposited as carried by Cu-MOFs. The solar evaporator achieves an outstanding evaporation rate of 1.95 kg m−2h−1for simulated seawater (3.5 wt% NaCl) under 1 sun. The evaporator also shows efficient evaporation performance and salt resistance for high-concentration saline water due to its outstanding water transport capacity and efficient light absorption ability. Furthermore, salt ions and organic pollutants can be simultaneously removed from high-salinity organic wastewater by the evaporator due to the synergistic effects of adsorption, the photothermal effect and photocatalytic performance. This study successfully integrated photocatalytic technology with solar-driven interfacial evaporation, extending the multifunctionality of solar evaporators for treating high-salinity organic wastewater.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）