Environmental Science-Processes & Impacts
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2024
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IF 4.3
Chang Xu,Bo Gong,Shan Zhao,Xiao-Min Sun,Shu-Guang Wang,Chao Song
Tetracycline (TC) and Cu(II) coexist commonly in various waters, which may infiltrate into the subterranean environment through runoff and leaching, resulting in substantial ecological risks. However, the underlying mechanisms why Cu(II) affects the transport of TC in porous media remain to be further explored and supported by more evidence, especially the role of complexation. In this study, the transport of TC with coexisting Cu(II) was comprehensively explored with column experiments and density functional theory (DFT) calculation. At natural environmental concentrations, Cu(II) significantly inhibited the transport of TC in the quartz sand column. Cu(II) augmented the retention of TC in the column mainly via electrostatic force and complexation. The interaction between TC and TC–Cu complexes on the surface of SiO2 was investigated with first-principles calculations for the first time. There were strong van der Waals forces and coordination bonds on the surface of complexes and SiO2, leading to higher adsorption energy than that of TC and inhibiting its penetration. This study offers novel insights and theoretical framework for the transport of antibiotics in the presence of metal ions to better understand the fate of antibiotics in nature.
研究领域:
环境科学
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理论化学
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DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2024
·
IF 4.3
Pei Huang,Gongfa Wu,Min Huang,Yating Deng,Xuming Chen,Guodong Ye,Xiyong Yu,He Wang,Huaying Wen,Yi Zhou
The resistance of tumor cells to apoptosis often leads to chemoresistance and treatment failure in clinic. In this study, we have developed a Cu 2+ -coordinated lignosulfonate (CLS) /doxorubicin (DOX) biological complex (referred to as LCD) with the aim of overcoming cellular resistance to apoptosis for combined lung cancer therapy. The copper complexes modified by CLS exhibit significant water solubility and excellent in vivo biocompatibility. The proportion of copper in the composite is simultaneously increased. Due to the coordination and π-π stacking effects, the self-assembled LCD exhibits nanometer-scale particle size, a narrow and homogeneous grain distribution, as well as excellent dispersion stability. Furthermore, LCD has the potential to disassemble in the presence of high levels of glutathione (GSH) and low pH, leading to effective drug release. Cu 2+ -mediated cuproptosis can lead to the down-regulation of FDX1 and DLAT protein expression by reducing mitochondrial membrane potential, resulting in non-apoptotic programmed cell death (PCD) regardless of cellular resistance to apoptosis. Moreover, the released DOX not only exhibits a preference for localizing in the cell nucleus to induce apoptosis for combined chemotherapy, but also generates a substantial amount of H 2 O 2 . This H 2 O 2 further produces ROS to induce apoptosis through Fenton reaction with Cu 2+ . LCD demonstrates significant superiority over monotherapy in inhibiting tumor growth while minimizing systemic toxicity through the combined action of cuproptosis and apoptosis. This study may provide a potential avenue for the advancement of self-delivery nanomedicine to overcome resistance to apoptosis in tumor therapy.
研究领域:
肿瘤学
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纳米医学
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药理学
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DOI
PubMed
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 46
·7864-7872
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IF 2.7
Jing Wang,Lu Ren,Qiang Sun,Yanqi Liu,Wanru Jia,Huihong Zhang,Dawei Zhang
A simple turn-off fluorescent probe, 5-(diethylamino)-2-(hydrazonomethyl)phenol (DHP), is designed and synthesized for the sensitive and selective detection of Cu2+. The bright green fluorescence of DHP is quenched after the addition of Cu2+. The probe DHP exhibits good anti-interference performance against Cu2+ in the presence of multiple metal ions. The fluorescence intensity of DHP (10 μM) at 522 nm is well linearized with the Cu2+ concentration at 0–5 μM, and it has a detection limit of 0.29 nM (R2 = 0.9949). The complexation ratio of the probe DHP to Cu2+ is 2 : 1 and the complexation constant is 3.44 × 104 M−1 (R2 = 0.9974). In addition, the probe DHP can be recovered using EDTA and Cu2+ can be effectively monitored at pH 5–11, with good results in dipstick experiments and actual water samples. HepG-2 cells remained viable in excess of 90% after being exposed to DHP (50 μM) for 24 h, which demonstrates the extremely low toxicity of DHP, and it can be used for in vivo cell imaging.
研究领域:
分析化学
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生物医学
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DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Danni Wu,Haonan Wu,Yan Lyu,Huiying Zhang,Jiade Wang,Xiang Li,Xiaobing Pang
Atmospheric particulate matter (PM) poses adverse effects on human via producing reactive oxygen species (ROS). Oxidative potential (OP, ability to generate ROS) can be induced by various chemicals in PM, while their interplay remains poorly characterized. Here, we systematically assessed influences of Cu 2+ on OP of Brown carbon (BrC) (e.g., imidazoles) using dithiothreitol (DTT) assay. Results showed DTT consumption rate exhibited an initial rise and later decline (0.25 −0.56 µM/min) along with increase of BrC concentration (0.1 − 2 µM), while no general trend was observed for • OH formation. Although Cu 2+ showed either antagonism or synergism with BrC against DTT consumption, Cu 2+ displayed antagonism with most BrC against • OH generation. Fluorescence quenching experiments provided evidence of complexation between Cu 2+ and water-soluble organic compounds (WSOCs, from ambient PM 2.5 ), which was influenced by Cu 2+ concentration. Further parallel factor analysis of spectra showed that polycarboxylate-type humic acid-like substances (complexation site number ( n ): 0.46, complexation equilibrium constant ( k ): 0.51) and fulvic acid-like compounds ( n : 0.42, k : 0.62) were the main components in WSOCs that complexed with Cu 2+ . Our results suggest the interactions of BrC and copper play a crucial role in PM OP and highlight complexation in evaluation of PM OP.
研究领域:
环境科学
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生物化学
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Yuefeng Gao,Sai Xu,Yanbiao Li,Baojiu Chen
The low photoluminescence quantum yield (PLQY) of CsPbCl 3 perovskite quantum dots (PQDs) poses a significant challenge to their application as ion detection probes. To address this issue, we enhanced the PLQY of CsPbCl 3 PQDs through Mn doping. These enhanced PQDs were then employed as probes for the highly sensitive detection of Cu 2+ ions and temperature. CsPbCl 3 :Mn PQDs with varying Mn/Pb ratios were synthesized via hot injection. The Mn doping introduced an emission band near 600 nm, with intensity increasing alongside doping concentration. At an Mn/Pb ratio of 2.0, the PLQY was enhanced nearly tenfold, from 5.46 % for undoped CsPbCl 3 to 52.48 % for CsPbCl 3 :Mn. CsPbCl 3 :Mn PQDs with the highest PLQY were employed as luminescent probes, utilizing the fluorescence intensity ratio (FIR) technique for copper detection and temperature sensing. The experimental results demonstrated a linear relationship between the FIR and Cu 2+ concentration over the range of 22.12 nM–1600 nM, with 22.12 nM being the calculated limit of detection. Analysis of the emission spectra and fluorescence lifetimes at varying Cu 2+ concentrations revealed that electron transfer from CsPbCl 3 to Cu 2+ induced fluorescence quenching. CsPbCl 3 :Mn exhibits a high relative sensitivity of 15.89 % K −1 at 298 K, along with excellent reversibility. These findings highlight the potential application of CsPbCl 3 :Mn PQDs in both temperature sensing and the analysis of wear metals in engine lubricating oils.
研究领域:
材料科学
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分析化学
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DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
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2024
·
IF 2.6
Gong Yafei,Fu Yan,Lou Dawei
Abnormal tryptophan (Trp) metabolism can be used as an important indicator of chronic hepatitis, paranoia, Parkinson’s disease and other diseases. Deficiency or excessive accumulation of Cu 2+ can cause diseases such as Wilson’s disease and Alzheimer’s disease. Eu-based metal-organic framework (Eu-MOF) was successfully prepared for fluorescence sensing of Trp and Cu 2+ in an aqueous solution (pH = 7.4). Eu-MOF showed high selectivity and sensitivity for Trp and Cu 2+ with detection limits of 0.22 µM and 0.09 µM and K sv of 6.17 × 103 M − 1 and 2.37 × 10 4 M − 1 respectively. Trp and Cu2+ had overlapped UV absorption spectra with that of Eu-MOF and competed for the excitation light source. Trp also attenuated the antennae effect of organic ligands on Eu-MOF, thus quenching the red fluorescence of Eu-MOF. This study provides insights into the application of MOFs in bioanalysis and diagnostics.
研究领域:
生物分析
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诊断学
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材料科学
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
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IF 3.573
Ying Wang,Jian He,Pan Wu,Dingyuan Luo,Runhua Yan,Hao Zhang,Wei Jiang
In this study, a common refractory aquaculture hybrid wastewater containing copper and tetracycline (TC) was treated to simultaneously remove such pollutants through a formic-acid-assisted photocatalysis process with TiO2 as the photocatalyst. The results show that pure aqueous TC can be completely photodecomposed by TiO2, although the removal rate of pure Cu ions through photocatalysis without the addition of a scavenger can be neglected. For simultaneously photodegrading TC–Cu(II) hybrid wastewater, the TC degradation rate is accelerated, whereas the Cu(II) removal rate remains at 20% through adsorption. TC cannot promote the photoreduction of Cu(II) as a sacrificial agent, and its intermediate products form a stable complex with Cu(II), hindering further reduction. The addition of formic acid effectively releases Cu ions from the complex as a pH regulator and enhances the photocatalysis process as a hole scavenger. Through the addition of formic acid after complete TC photooxidation, the final chemical oxygen demand (COD) and Cu concentration were only 8 and 0.4 mg/L, respectively. This study provides a simple and promising method for simultaneously treating TC–Cu(II) hybrid wastewater using formic-acid-assisted TiO2 photocatalysis.
研究领域:
环境科学
·
污染控制
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DOI
高影响因子
RSC Advances
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2020
·Vol. 10
·期 18
·10972-10979
·
IF 3.119
Yixin Zhang,Jianping Ge
A traditional hydrogel photonic crystal sensor is prepared by multiple steps, including colloidal assembly, polymerization, and recognition group modification, and its measurement repeatability is a challenge due to the inevitable deviations in sensor fabrication and application. In this work, a salicylic acid-containing “SiO2/propylene carbonate” liquid photonic crystal (Sal-LPC), as a new photonic sensing material, was developed to demonstrate reliable measurement of Cu2+ in water. When the Sal-LPC reagent was mixed with the test sample, the Cu2+ promoted the release of H+ from Sal and shrank the photonic crystal lattice, so that the Cu2+ concentration could be determined by the reflection blueshift of liquid PC. The Sal-LPC reagent showed a stronger response to Cu2+ than to other cations, and its sensitivity and measurement range could be optimized by the particle fraction and Sal dosage. Compared to traditional PC hydrogel sensors, the liquid PC reagent was composed of colloidal particles and responsive species, which required no strict control in synthesis. More importantly, the optical response of the liquid PC reagent was scarcely affected by changes in synthesis, storage, or application, and it could interact with the analyte quickly and quantitatively, which ensured accurate and repeatable measurement in either chemical analysis or environmental monitoring.
研究领域:
分析化学
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环境科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL SCIENCES
·
2019
·Vol. 35
·期 2
·159-163
·
IF 1.618
Yue YALING,He YI
We report a visual chronometric method for the detection of copper(II) ions (Cu2+) using the clock reaction between methylene blue (MB) and hydrazine (N2H4). The addition of Cu2+ greatly accelerates the clock reaction due to the formation of the Cu cluster between Cu2+ and N2H4. By recording the change of the reaction time and solution color, different concentrations of Cu2+ in buffer and environmental water have been detected. As low as 300 nM Cu2+ can be visually identified by the naked eye without the assistance of any advanced instruments. This visual chronometric assay shows a dynamic range from 0.2 to 16 μM with a limit of detection of 20 nM. Additionally, it has good selectivity toward Cu2+ and against other common metal cations.
研究领域:
分析化学
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环境科学
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Shenghong Yang,Ke Wang,Xin Wang,Xiaohan Sun
In-depth research on surface functionalization of carbon dots (CDs) has opened new horizons for their application in chemosensing and biosensing. However, the practicability of CDs is still limited due to their unmanageable fluorescence properties. In this study, organic acid was employed to regulate and control the fluorescence performance of CDs. A remarkable enhancement of fluorescence and redshift of the fluorescent band of CDs was observed via organic acids’ participation in the water phase preparation process. Furthermore, a colorimetric and fluorescent dual-readout strategy was constructed for the analysis of copper ions (Cu 2+ ) based on ethylenediaminetetraacetic acid (EDTA)-regulated carbon dots. The proposed sensing system can be used in the fast detection of Cu 2+ via an obvious solution color change from yellow to brown under natural light, and the trace analysis of Cu 2+ can be realized by quenching the green fluorescence band with detection limit of 21 nM. The designed sensor has been employed to the analysis of Cu 2+ in water and urine samples successfully, and cell imaging experiment was performed to evaluate the feasibility of biomedical applications.
研究领域:
材料科学
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分析化学
·
生物医学工程
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Ya Dan Li,Hui Hui Chai,Shu Jie Zhang,Zhi Song Lu,Chang Ming Li,Ling Yu
A sensitive and portable on-thread pre-concentration and colorimetric detection method of copper ions was proposed. Commercial cotton thread was proposed as a solid sorbent for effectively extracting copper ions (Cu 2+ ) from solution. The adsorbed Cu 2+ was converted to Cu + by ascorbic acid . The Cu + on the threads was visualized by horseradish-peroxidase-catalyzed color changes of a chromogenic oxidized tetramethylbenzidine substrate. The adsorption of Cu 2+ on the plasma- and Na 2 CO 3 -treated thread was verified by scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, and zeta potential characterization. The Cu + -induced dysfunction of HRP on the thread was verified by X-ray photoelectron spectroscopy. With optimized reaction conditions, the concentration-dependent colorimetric response plot was characterized, where the linear detection range was 2–400 nM and the detection limit was about 0.15 nM. Measurements of a group of possible interfering ions and spiked real-water samples demonstrated the good selectivity of the proposed method. The proposed on-thread pre-concentration and colorimetric detection offers a low-cost and effective alternative for detecting of copper ions in real applications.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Haodong Sun,Nannan Xia,Zhongming Liu,Fangong Kong,Shoujuan Wang
We successfully absorbed the copper ion (Cu 2+ ) and cadmium ion (Cd 2+ ) from alkaline aqueous solutions using the prepared chitosan-tannin (CTS/TA) functional paper as absorbent materials. The kinetics of the adsorption, the adsorption isotherms, and the influence of the solution flow rate and pH were investigated detailly. The adsorption data were described well by Langmuir isotherms, with maximum copper (Cu 2+ ) and cadmium (Cd 2+ ) adsorption capacities of 684.93 and 813.01 mg/m 2 , respectively. The experimental results also showed that the adsorption of these heavy metals was selective in the order of Cu 2+ > Cd 2+ , as Cu 2+ competed with Cd 2+ for bonding sites at solution concentrations greater than or equal to 200 mg/L. The results of this study illustrated that the chitosan-tannin functional paper materials mainly followed a complexation-adsorption model, and the best adsorption capacity was achieved at pH = 9. The desorption of heavy ions from this adsorbent and its reusability of functional paper was also involved. Therefore, this novel, environment-friendly functional paper can surely act as an effective adsorbent for the removal and recovery of heavy metals in alkaline aqueous solutions.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
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