LANGMUIR
·
2025
·
IF 3.9
Zhenyu Wen,Wenjie Zhu,Yongxue Chen,Huanhuan Sun,Lin Zhu,Yuling Yang,Yanping Song,Lei Chen,Jiajun Dong,Bingbing Liu
Surface-enhanced Raman spectroscopy (SERS) holds immense promise for molecular detection, yet the quest for high-performance, plasmon-free substrates remains active. This work pioneers the rational design and engineering of phase-tunable MoS2 nanoclusters─metallic (1T), semiconductor (2H), and, critically, hybrid metal/semiconductor (1T/2H) phases as a novel class of SERS platforms. We demonstrate this exceptional capability for ultrasensitive detection of environmentally hazardous dyes (e.g., rhodamine B, crystal violet, and methylene blue). Remarkably, the optimized 1T/2H-MoS2 substrate achieves an enhancement factor of 1.02 × 109, which ranks among the higher values for SERS substrates derived from semiconductors. Crucially, time-resolved transient photoluminescence decay spectroscopy reveals a dramatic 52% decrease in average exciton lifetime (from 3.88 to 1.86 ns) for RhB adsorbed on 1T/2H-MoS2 substrates. This profound decrease provides direct evidence for highly efficient interfacial charge transfer, predominantly driven by the built-in electric field unique to the engineered phase junction. Furthermore, by leveraging the distinct Raman signatures enabled by this heterophase substrate, we achieve the multiplex detection of all five environmental nucleobases (adenine, guanine, cytosine, thymine, and uracil) in both individual and mixed solutions. This work not only delivers fundamental mechanistic insights into charge transfer-mediated SERS but also provides a practical platform with broad implications for environmental monitoring, biomedical diagnostics, and analytical chemistry.
研究领域:
分析化学
·
环境科学
·
纳米技术
·
光谱学
·
材料科学
·
生物医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 7.3
Yuting Sun,Hui Yang,Jiaqi Yuan,Limin Wang,Shanshan Song,Rongrong Chen,Xubin Bao,Li Jia,Tiantian Yang,Xiaofei Zhang,Qian He,Yong Gan,Zehong Miao,Jinxue He,Chunhao Yang
Poly(ADP-ribose) polymerase inhibitors (PARPi) have significant efficacy in treating BRCA-deficient cancers, although resistance development remains an unsolved challenge. Herein, a series of phthalazin-1(2H)-one derivatives with excellent enzymatic inhibitory activity were designed and synthesized, and the structure–activity relationship was explored. Compared with olaparib and talazoparib, compound YCH1899 exhibited distinct antiproliferation activity against olaparib- and talazoparib-resistant cells, with IC50 values of 0.89 and 1.13 nM, respectively. Studies of the cellular mechanism revealed that YCH1899 retained sensitivity in drug-resistant cells with BRCA1/2 restoration or 53BP1 loss. Furthermore, YCH1899 had acceptable pharmacokinetic properties in rats and showed prominent dose-dependent antitumor activity in olaparib- and talazoparib-resistant cell-derived xenograft models. Overall, this study suggests that YCH1899 is a new-generation antiresistant PARPi that could provide a valuable direction for addressing drug resistance to existing PARPi drugs.
研究领域:
肿瘤学
·
药理学
·
分子生物学
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Medicine Reports
·
2015
·Vol. 11
·期 6
·4671-4677
·
IF 1.554
Qigen Du,Guang Xin,Hai Niu,Wen Huang
The 4[(Tetrahydro‑2H‑pyran‑2‑yl) oxy] phenol (XG‑d) hydroquinone analog, is found in Vaccinium vitis‑idaea L. Although it is known for its antioxidant properties and high level of safety, its antitumor activity remains to be elucidated. In the present study, the anticancer effect of XG‑d was determined in vitro and in vivo. The cytotoxicity of XG‑d against C26 murine colon carcinoma cells was found to occur in a time‑ and concentration‑dependent manner, whereas little effect was observed in the two normal cell lines (HK‑2 and L02) investigated. Oral administration of XG‑d (100 mg/kg) had effects on the tumor growth of tumor‑bearing mice. Furthermore, marked apoptosis was observed using Hoechst 33258 staining and flow cytometric analysis with annexin V/propidium iodide double staining. XG‑d also downregulated the expression of B‑cell lymphoma 2 (Bcl‑2), increased the expression levels of Bcl‑2‑associated X protein and activated caspase‑9, caspase‑3 and poly(adenosine diphosphate‑ribose) polymerase. The present study demonstrated for the first time, to the best of our knowledge, that XG‑d inhibited cancer cell growth via the induction of apoptosis and was also able to inhibit tumor growth in vivo. These results demonstrated that XG‑d may be used as a potential natural agent for cancer therapy with low toxicity.
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SYNTHESIS-STUTTGART
·
2022
·Vol. 54
·期 11
·2707-2723
·
IF 2.969
Jiahui Fu,Xingxing Cai,Yihuo Liu,Jinghua Li,Dongping Cheng,Xiaoliang Xu
An efficient visible-light-mediated tandem reaction of acryloylbenzamides with alkylboronic acids, arylsulfonyl hydrazides and oxime esters has been developed. The reaction proceeds via radical addition and cyclization to give various isoquinoline-1,3(2H,4H)-diones in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds.
研究领域:
有机化学
·
光化学
·
合成化学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Qing-rui Zeng,Zi-ang Jia,Xu Liu,Bo-wen Xiu,Jin-ping Cheng
The rational application of piezoelectric polarization properties in non-centrosymmetric heterojunctions to improve charge separation efficiency is a novel approach for enhancing their photoelectrocatalytic capabilities for environmental purification. Herein, a noval 1T-2H MoS 2 QDs/Y-NaBi(MoO 4 ) 2 multiple heterostructures with two types S-scheme heterojunctions was formed by multi-functional materials NaBi(MoO 4 ) 2 with Y 3+ ion-doping and multi-phase state (1T, 2H and 1T-2H) MoS 2 quantum dots multi-interface polarization engineering. Material characterization and DFT calculations revealed that 1T-2H MoS 2 QDs/Y-NaBi(MoO 4 ) 2 multiple heterostructures produce highly-efficient Bi-S-Mo(IV) and Mo(IV)-S-Mo(VI) charge-transfer channels induced by multi-interface polarization engineering. 1T-2H MoS 2 QDs/Y-NaBi(MoO 4 ) 2 heterostructures were developed as photoanodes using the pressed tablet stainless-steel mesh (PT-SSM) method, and demonstrated conspicuous piezoelectric-photoelectrocatalytic (PZ-PEC) efficiency (99.88% removal within 40 min) for the degradation of organic pollutant phosphodiesterase-5 inhibitor (PDE-5i) under visible light illumination, direct-current external bias and mechanical force. This work provides new insight for synergy and mechanism between piezoelectric effect and photoelectrocatalysis for environmental clean-up.
研究领域:
材料科学
·
环境科学
·
电化学
·
纳米技术
·
催化
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Yao Yao,Yue Zhao,Huijuan Zhang,Wenting Pan,Wei Liang,Yijian Jiang,Xinlong Yan,Yinzhou Yan
The development of surface-enhanced Raman spectroscopy (SERS) as an ultrasensitive fingerprint analysis technique in precision medicine requires high-performance SERS substrates with controllable nanostructure (hot-spot) distribution, simple fabrication, superior stability, biocompatibility, and extraordinary optical responses. Unfortunately, fabrication of arbitrary nanostructures with high homogeneity on a large scale for SERS is still challenging. Herein, we report an ultrafast laser parallel fabrication protocol for Au/2D-transition-metal dichalcogenide hybrid SERS biosensors. The leveraged photonic nanojets (PNJs) are generated by a micron-sized microsphere monolayer to simultaneously trigger localized phase transition in 2H-MoTe2, achieving a 1T′-MoTe2 nanopattern array with a density of 1 million per mm2 by a single laser shot. The Au nanoparticle clusters (AuNCs) are subsequently grown in situ from the 1T′ regions, creating a AuNCs on 1T′/2H-MoTe2 (AuNCs@1T’/2H-MoTe2) hybrid SERS substrate. The fabricated feature diameter and overlay accuracy of the patterned AuNCs are 210.1 ± 3.4 and 9.2 ± 1.7 nm, respectively. To eliminate background noise, we designed dimer-AuNCs@1T′/2H-MoTe2 (dAuNCs@1T′/2H-MoTe2), achieving a detection limit of 10–13 M with an enhancement factor of 4.9 × 108 for the methylene blue (MB) analyte. The strong localized surface plasmon resonances in the dAuNCs as well as efficient charge transfers between Au, 2H-MoTe2, and MB contribute to the majority of Raman enhancement. The multiscale dAuNCs@1T′/2H-MoTe2 array provides a powerful SERSome (comprising multiple SERS spectra) platform for therapeutic drug monitoring, by which we successfully identified the metabolic behaviors of living gastric adenocarcinoma cells administered with two drugs, i.e., capecitabine, oxaliplatin, and their combination. The present work establishes opportunities for creating a highly ordered nanopattern array for ultrasensitive SERSome analysis of cell metabolism in cancer therapy.
研究领域:
纳米技术
·
生物医学工程
·
分析化学
·
癌症研究
·
材料科学
·
光学与光子学
·
精准医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2019
·Vol. 42
·期 15
·2482-2490
·
IF 2.516
Lingping Cheng,Jianfeng Cai,Qing Fu,Yanxiong Ke
6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone is a key synthetic intermediate for cardiotonic agent levosimendan. Very few studies address the use of chiral stationary phases in chromatography for the enantioseparation of this intermediate. This study presents two efficient preparative methods for the isolation of ( R )(−)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone in polar organic solvent chromatography and supercritical fluid chromatography using polysaccharide-based chiral stationary phases and volatile organic mobile phases without additives in isocratic mode. Under optimum conditions, Chiralcel OJ column showed the best performance ( α = 1.71, Rs = 5.47) in polar organic solvent chromatography, while Chiralpak AS column exhibited remarkable separations ( α = 1.81 and Rs = 6.51) in supercritical fluid chromatography with an opposite enantiomer elution order. Considering the sample solubility, runtime and solvent cost, the preparations were carried out on Chiralcel OJ column and Chiralpak AS column (250 × 20 mm i.d.; 10 µm) in polar organic mode and supercritical fluid chromatography mode with methanol and CO 2 /methanol as mobile phases, respectively. By utilizing the advantages of chromatographic techniques and polysaccharide-based chiral stationary phases, this work provides two methods for the fast and economic preparation of ( R )(−)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone, which are suitable for the pharmaceutical industry.
研究领域:
药物化学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2021
·
IF 5.858
Xiaohua Lu,Ge Yan,Sabine M. Klauck,Edmond Fleischer,Anette Klinger,Yoshikazu Sugimoto,Letian Shan,Thomas Efferth
After decades of research, multidrug resistance (MDR) remains a huge challenge in cancer treatment. In this study, the cytotoxic of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide (MCC1734) has been investigated towards multidrug-resistant cancer cell lines. MCC1734 exerted cytotoxicity on cell lines expressing different mechanisms of drug resistance (P-glycoprotein, BCRP, ABCB5, EGFR, p53 knockout) to a different extent. Interestingly, sensitive CCRF-CEM cells and multidrug-resistant P-gp-overexpressing CEM/ADR5000 cells represented similar sensitivity towards MCC1734, indicating MCC1734 can bypass P-gp-mediated resistance. Microarray-based mRNA expression revealed that MCC1734 affected cells by multiple pathways, including cell cycle regulation, mitochondrial dysfunction, apoptosis signaling, and EIF2 signaling. MCC1734 stimulated the generation of excessive reactive oxygen species and the collapse of mitochondria membrane potential in CCRF-CEM cells, companied by the arrest of the cell cycle in the G 2 M phase and apoptosis induction as determined by flow cytometry. In addition, our immunoblotting analysis highlighted that MCC1734 triggered endoplasmic reticulum (ER) stress, evidenced by the activation of p-PERK, p-eIF2α, ATF4 and CHOP. The anti-cancer effects of MCC1734 were further observed in vivo using human xenograft tumors transplanted to zebrafish, providing further support for MCC1734 as a promising new candidate for cancer drug development.
研究领域:
肿瘤学
·
药理学
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2016
·
IF 4.803
Qingliang Feng,Kaiyue Duan,Hong Xie,Muyin Xue,Yongling Du,Chunming Wang
Two dimensional (2D) transition metal dichalcogenides have attracted intense potential application in catalytic because of its fantastic physical and chemical properties. But, how the metal oxide affects the catalytic performance of transition metal dichalcogenides was not clear yet, which always exists as main byproduct in the synthesized process of hydrothermal method . Herein, we report synthesis of 2H-MoSe 2 nanoflower and 2H-MoSe 2 /α-MoO 3 heterostructure by hydrothermal method. The chemical composition , morphology and crystalline structure of nano-composite were characterized by field-emission scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The 2H-MoSe 2 nanoflower shows more positive onset overpotential around −150 mV and a current density of 32.5 mA cm −2 at −300 mV. The smaller Tafel slope of 2H-MoSe 2 nanoflower is around 69 mV dec −1 reveals the Volmer-Heyrovsky mechanism for HER. The results of linear scan voltammetry (LSV) curves demonstrated that both of them displayed good stability. This work demonstrated that the metal oxide can reduce the catalysis performance of transition metal dichalcogenides towards HER.
研究领域:
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Lijia Zhou,Xiangjiang Dong,Qiang Li,Xianran Xing
We systematically investigated the superconducting properties of 2H-PtxTaS2 (0 ≤ x ≤ 0.08). As the platinum (Pt) content increases, the charge density wave (CDW) in 2H-TaS2, which appears at approximately 75 K, is progressively suppressed and completely disappears in Pt0.06TaS2. Meanwhile, the superconducting transition temperature (Tc) first increases and then decreases, reaching its maximum value of approximately 4.85 K at x = 0.06. This phenomenon suggests a competitive interplay between CDW and superconductivity (SC) in this system. Further measurements of the superconducting parameters of Pt0.06TaS2 indicate that the enhancement of Tc is primarily attributed to an increase in the density of states at the Fermi level.
研究领域:
凝聚态物理
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
·
2021
·Vol. 219
·期 3
·2100568
·
IF 1.981
Ling Lan,Haidou Wang,Lina Zhu,Yuelan Di,Jiajie Kang,Junhong Qiu
Herein, a grid-like microstructure is prepared on the surface of 3Cr13 stainless steel through nanosecond laser etching, and the self-assembled 1 H ,1 H ,2 H ,2 H -perfluorodecyltriethoxysilane (PFDS) coating is further composited to prepare a superhydrophobic surface with a contact angle of 164° and a rolling angle of 3°. The effect of laser etching cycles on the surface microstructure and surface wettability before and after the self-assembly is studied. With an increase in the etching cycles, a stable grid-like microstructure is gradually formed on the surface, and subsequently, a composite structure of grooves and pits is formed. After the self-assembly of the PFDS coating, two superhydrophobic surfaces with different wetting properties are obtained. Furthermore, as the etching cycles increase, the surface changes from a superhydrophobic and high-adhesion state to a superhydrophobic and low-adhesion state. The decrease in surface energy is mainly attributed to the C−F group in the PFDS molecule. The experimental results show that PFDS molecules are deposited easily in case of the convex surface, thereby facilitating the formation of superhydrophobic low-adhesion surfaces. Finally, the superhydrophobic surface is still maintained after cumulative ultrasonic cleaning in deionized water for 75 min, showing good reusability and stability.
研究领域:
材料科学
·
表面工程学
✓ 已验证
DOI
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Tengyang Zhang,Jie Fei,Jifeng Yan,Zhaoxi Gou,Peng Cheng,Lehua Qi
At low temperature (−60°C), increased brittleness and surface grease adhesion promote significant adhesive wear in the composites. 1H,1H,2H,2H-perfluorooctane trichlorosilane (PFOTS) was coated onto carbon fibers to enhance the tribological performance at low temperature of the composites. Compared to the original material, the shear strength of the modified sample was increased by 31.9% to 20.16 MPa, while the wear rate under −60°C was decreased significantly by 87.5% to 1.72 × 10 −8 cm 3 /J. The low-temperature adhesive wear mechanisms were first revealed by combining experimental measurements with molecular dynamics simulations, and the simulations further clarified how a PFOTS coating modifies the tribological response of the material.
研究领域:
材料科学
·
复合材料工程
·
表面科学
·
摩擦学
·
低温工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）