PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2018
·Vol. 20
·期 43
·27261-27271
·
IF 3.906
Baohuan Jia,Ying Sun,Lujuan Yang,Yang Yu,Haoran Fan,Gang Ma
Rational design of amyloid-based materials requires structural insight into such materials. Here, we explore the use of a side-chain-based infrared (IR) probe technique combined with atomic force microscopy, Raman spectroscopy, UV-Vis spectroscopy, and thermogravimetric analysis coupled with mass spectrometry to elucidate the structural details of an amyloid nanosheet formed by an Aβ(16–22) variant, KLVXFAK, where X is p-cyanophenylalanine with its side-chain cyano group being an IR probe. Through the structural constraints obtained with the combined tools, we are able to propose a novel structural model for the amyloid nanosheet. The nanosheet can be viewed as a stack of class 7-type steric-zipper-like amyloid structures with a unique sheared intersheet arrangement: the β-sheets are stacked along a zippering axis with each individual β-sheet sheared relative to its adjacent β-sheets by two residues through the cyano–lysine intersheet hydrogen bond. With such a configuration, the side view of the nanosheet is similar to that of a stack of tilted-aligned roof tiles with each individual β-sheet being each tile. In addition, this work provides a nice example of how to utilize the side-chain-based IR probe technique combined with other supplemental tools to build a hierarchical structural model for a complex amyloid assembly.
研究领域:
生物物理学
·
材料科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Minmin Gou,Ruili Guo,Hengheng Cao,Weifang Zhu,Fu Liu,Zhong Wei
Mixed matrix membranes (MMMs) for separating CO 2 /CH 4 mixture were prepared through incorporating Cu@Al(bpydc) into a Pebax polymer in which Cu@Al(bpydc) synthesized through a competitive coordination method achieved a controllable micro/mesopores structure and abundant functional sites for CO 2 . The hierarchical pores of Cu@Al(bpydc) provided multidimensional diffusion channels in the Pebax matrix, which increased the diffusion of CO 2 . In addition, the abundant chemical groups, such as the polar group COO – and nitrogen Lewis basic groups, created a microenvironment with multiple CO 2 affinity sites in the membrane, increasing the selectivity of CO 2 . A MMM loaded with 5 wt% Cu@Al(bpydc) exhibited excellent CO 2 separating property under wet mixed-gas test conditions. In particular, the CO 2 permeability and selectivity of the MMMs were increased by 92.90% and 27.10% respectively, compared with those of pure Pebax, showing exceptional potential for the separation and capture of CO 2 from biological natural gas.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 108
·88973-88978
·
IF 3.84
Di Li,Yanli Chen,Peng Du,Zhao Zhao,Haifeng Zhao,Yuejia Ma,Zaicheng Sun
Anatase TiO2 film, which is traditionally fabricated by high-temperature annealing of TiOx precursors, has been widely used as an electron collection layer in photovoltaics. In order to avoid the undesired high temperature treatment, in this work, we developed a convenient and moderate procedure to fabricate anatase TiO2 nanocrystal films at room temperature. Ultrafine, clean and high-quality anatase TiO2 nanocrystals have been pre-prepared in a simple solvothermal route and subsequent spin-coating of the nanocrystal dispersion provides a well formed TiO2 nanocrystal film without any further thermal treatment. The characteristics of the TiO2 nanocrystal film, in terms of crystallization phase, film morphology, optical and electronic properties, have been carefully studied, and then a typical [ITO/TiO2/P3HT:PCBM/MoO3/Ag] inverted photovoltaic device using TiO2 nanocrystals as the ECL has been fabricated and exhibits a comparable power conversion efficiency (PCE) of 3.35% to that of the conventional device (3.39% PCE).
研究领域:
材料科学
·
能源技术
·
光电化学
✓ 已验证
产品关联
DOI
高影响因子
Electrocatalysis
·
2014
·Vol. 6
·期 2
·211-219
·
IF 2.089
Ouyang Lei,Miao Yuqing,Xu Lina,Xiao Mingshu,Liang Xiaocai,Li Weiwei,Yang Yang
Molecular self-assembly is an important aspect of bottom-up approaches for the nanofabrication of functional materials. The self-assembly of smaller-size units like ions has yet to be studied further. The self-adsorption of Bi III without applied potential and electrochemical deposition of Bi/Bi III were studied and compared through cyclic voltammetry. Both of them exhibit two pairs of redox peaks assigned to the (2 × 2)-Bi adlayer and incommensurate ( p × √3)-2 Bi adlayer. The adsorption of two Bi surface phases is related with the Bi salt concentration and adsorption time. Within a certain concentration or time range, the adsorption approaches to be saturated due to the surface limitation of self-adsorbed surface layers. The (2 × 2)-Bi adlayer firstly adsorbs to the active sites of Au where there is strong interaction between Bi and Au. With the increase of time, more Bi adsorbs onto the unoccupied sites of Au with a relatively weak interaction force to form a denser ( p × √3)-2 Bi layer. A new pair of redox peaks appears for the electrodeposition of the Bi/Bi III bulky layer which is easily stripped from the Au surface through a consecutive potential scan. Comparatively speaking, the adsorbed (2 × 2) and ( p × √3)-2 Bi adlayers are stable in the same potential scanning condition due to the strong interaction between the two surface Bi layers and the below Au atoms. Such a controllable self-adsorption of the Bi III ultrathin layer on foreign substrates exhibits a potential for the modification of materials in the size of ions.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE BIOLOGY
·
2017
·Vol. 250
·期 5
·483-492
·
IF 1.696
Chai Ran,Chen Yafei,Yuan Hongbo,Wang Xuzhao,Guo Shuai,Qi Jinlong,Zhang Hailin,Zhan Yong,An Hailong
Calcium-activated chloride channels (CaCCs) play vital roles in a variety of physiological processes. Dysfunction of the CaCCs is implicated in many diseases. Drug discovery targeting at CaCCs has recently become possible with the determination that TMEM16A is the molecular identity of CaCCs. In this study, we demonstrated that resveratrol (RES), a Chinese traditional medicine compound, is a novel activator of TMEM16A. The yellow fluorescence protein quenching assay and measurement of intracellular calcium fluorescence intensity show that RES activates TMEM16A channels in an intracellular Ca 2+ -independent way. The data of inside-out patch clamp revealed that RES dose-dependently activates TMEM16A (EC 50 = 47.92 ± 9.35 μM). Furthermore, RES enhanced the contractions of the ileum of guinea pigs by activating the TMEM16A channel, which indicated that RES might be a promising drug for the treatment of gastrointestinal hypomotility. As RES was able to induce TMEM16A channel activation, TMEM16A can be added to the list of RES drug targets.
研究领域:
药理学
·
生理学
·
药物发现
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
·
IF 2.843
Meijuan Wang,Wenjun Yan,Wei Kong,Zhijun Wu,Xiaowei An,Zhongde Wang,Xiaogang Hao,Guoqing Guan
An electrochemically regenerable Fe3O4@polypyrrole (PPy) core–shell nanocomposite with superparamagnetism for selective fluoride ion removal from wastewater is fabricated. The rapid fluoride ion uptake kinetics is realized in a batch experiment due to the good affinity of PPy toward fluoride ions. It is found that the pseudo-second-order model can well describe the adsorption kinetics and the equilibrium data fits well with the Freundlich isotherm model. The spontaneity and exothermic nature of the fluoride ion adsorption are confirmed based on thermodynamic parameter analysis. In an electromagnetic coupling system, the nanocomposites exhibit a high regeneration efficiency around 95% in each cycle and only a slight drop in the capacity retention rate of fluoride ion adsorption even after 20 adsorption–regeneration cycles. This intelligently magnetic nanocomposite should be a promising alternative material for fluoride ion removal from wastewater.
研究领域:
环境科学
·
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD AND AGRICULTURAL IMMUNOLOGY
·
2018
·
IF 2.568
Jiajia Sun,Liqiang Liu,Shanshan Song,Gang Cui,Hua Kuang
The problem of waste oil is a food safety issue that requires urgent resolution. In this study, a novel hapten was designed for the rapid detection of capsaicinoids, a marker of waste oil, and a monoclonal antibody (MAb) 5D7 was generated that is specific for three major capsaicinoids: capsaicin (CPC), dihydrocapsaicin (DCPC), and N-vanillylnonanamide (N-V). The half maximal inhibitory concentrations of MAb 5D7 for CPC, DCPC, and N-V were 1.12, 0.8, and 0.87 ng/mL, respectively. An immunochromatographic strip test based on MAb 5D7 was established for these three capsaicinoids, with visual inspection limits of <1.0 ng/mL, which satisfies the requirement for the rapid on-site inspection of waste oil.
研究领域:
食品安全
·
免疫学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Tong-Bao Jiang,Wen-Wen Zhang,Kai-Li Wu,Ming Wu,Han-Min Wang,Wei Liu,Qing-Xi Hou
The growing demand for energy, coupled with the environmental pollution induced by traditional energy production, is pushing to find solutions for renewable energy storage. Herein, hierarchical porous carbon with a high specific surface area (2449.6 m 2 /g) has been synthesized from poplar wood chips by the molten salt activation. Simultaneously, a gel polymer electrolyte with excellent mechanical properties, thermal stability and biodegradability was prepared from α-cellulose. A simple all-solid-state supercapacitor was fabricated via hierarchical porous structure carbon electrodes and a gel polymer electrolyte, and the resultant device exhibited a high specific capacitance (133.0 F/g at 0.5 A/g) and an ideal capacitance retention rate (90.4% after 10,000 cycles). In addition, the device presented superior energy density (18.5 Wh/kg) and power density (500.0 W/kg) as compared with other supercapacitors. Interestingly, the gel polymer electrolyte showed a favorable natural degradation rate under aerobic sludge condition. Therefore, this fabricated electric double layer capacitor is expected to be used as a green and sustainable electronic device with amiable economic availability and environmental friendliness.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Suozhu Wu,Yuemin Liang,Hongyuan Guo
In this work, an electrochemical sensor was developed for ultra-sensitive determination of aluminum ion (Al 3+ ) using poly(3-aminophenylboronic acid)-gold nanoparticles (PAPBA-AuNPs) modified electrode. The proposed PAPBA-AuNPs modified electrode was prepared by two steps including electrodeposition of gold chloride hydrate and electropolymerization of 3-aminophenylboronic acid. The peak current for PAPBA reduction was recorded by square-wave voltammetry and employed for electrochemical determination of Al 3+ based on the coordination reaction between them. With the increasing concentration of Al 3+ , the peak current for PAPBA reduction diminished. Under the optimized conditions, the proposed electrochemical sensor exhibited a wide response range of 0.10 aM to 10.00 μM and a low limit of detection of 0.019 aM, which is much superior to those of conventional methods. Moreover, this electrochemical sensor was successfully used for Al 3+ detection in tap water and instant noodle samples.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yaoting Mou,Lu Han,Yanhao Yin,Yuhang Tian,Jianghua Liu,Yanqing Xu,Dongfei Chen,Yemin Guo,Xia Sun,Falan Li,Yanfang Wu
In this study, an electrochemical aptasensor dedicated to the sensitive detection of kanamycin (KAN) was constructed based on an Nb. Bbv CI-driven DNA walker-enabled signal amplification strategy. The sensor employed a gold electrode modified with polyethyleneimine-wrapped, nitrogen-doped multi-wall carbon nanotubes decorated with gold nanoparticles (N-MWCNTs-PEI-AuNPs). This composite was used to modify the gold electrode, providing an enhanced conductive interface and increasing the specific surface area for aptasensor construction. Meanwhile, a zirconium-based metal-organic framework decorated with gold nanoparticles (AuNPs@NH₂-UiO-66) was used both as an electrocatalyst and as a carrier for hairpin DNA (HP2), exhibiting strong catalytic activity toward the redox mediator thionine. In differential pulse voltammetry measurements, at the surface of the electrode, thionine undergoes a reversible, pH-dependent two-electron/two-proton transfer process at approximately −0.25 V on the electrode surface, generating a well-defined reduction current that serves as the analytical signal. Upon addition of KAN, the aptamer selectively binds to the analyte and dissociates from its complementary DNA (cDNA). The freed cDNA subsequently hybridizes with HP2 anchored on AuNPs@NH₂-UiO-66, thereby activating the Nb. Bbv CI-driven DNA walker, catalyzing the site-specific cleavage of HP2 and releasing multiple AuNPs@NH₂-UiO-66 labels. These released probes then hybridize with the captured hairpin DNA (HP1) fixed on the N-MWCNTs-PEI-AuNPs-modified gold electrode. The synergistic electrocatalytic effects of NH₂-UiO-66 and AuNPs significantly accelerate the electron transfer kinetics of thionine, leading to amplified voltammetric current responses that correlate proportionally with KAN concentration. The aptasensor demonstrated highly sensitive performance, including a linear detection range of 10 pM to 5 μM and a detection limit of 1.65 pM and a quantitation limit of 5.46 pM. The aptasensor also showed satisfactory selectivity and reproducibility and was successfully applied for KAN determination in real milk samples. This approach provides a robust signal amplification strategy and offers a promising tool for the rapid and sensitive detection of KAN in real-world samples.
研究领域:
分析化学
·
生物传感器
·
环境监测
·
食品安全
·
纳米技术
·
电化学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 48
·19422-19428
·
IF 3.069
Zihao Liang,Xingbo Ge,Jia Liu
The oxygen evolution reaction (OER) plays a critical part in natural and artificial water splitting reactions and also facilitates realization of the sunlight-to-fuel light-harvesting process. Because this procedure is regarded as a hindrance of electron transfer, finding robust and low-cost OER catalysts to fulfill the requirements of increasing the rate of the reaction is favored. In this work, we first developed the anodic cyclic voltammetry (CV) electrodeposition method and obtained amorphous iron nickel oxide thin films (FeNiOx); we then performed a systematic study of the electrochemical conditions and the optimization results. The crystallinity and morphology of the thin film with superior electrochemical performance were characterized by X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). In addition, investigation of the electrochemical OER performance suggested that FeNiOx has the highest activity among these samples. A small onset overpotential of 300 mV was achieved, and the Tafel slope was as low as 38 mV dec−1. The significance of this study is the systematic investigation of the catalytic composition, the simple deposition conditions, the facile and fast anodic CV electrodeposition method, and the remarkable performance and stability of the catalyst in alkaline media.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
NANOTECHNOLOGY
·
2018
·Vol. 29
·期 6
·065501
·
IF 3.404
Xiang Ran,Zhenzhen Wang,Enguo Ju,Fang Pu,Yanqiu Song,Jinsong Ren,Xiaogang Qu
The logic device demultiplexer can convey a single input signal into one of multiple output channels. The choice of the output channel is controlled by a selector. Several molecules and biomolecules have been used to mimic the function of a demultiplexer. However, the practical application of logic devices still remains a big challenge. Herein, we design and construct an intelligent 1:2 demultiplexer as a theranostic device based on azobenzene (azo)-modified and DNA/Ag cluster-gated nanovehicles. The configuration of azo and the conformation of the DNA ensemble can be regulated by light irradiation and pH, respectively. The demultiplexer which uses light as the input and acid as the selector can emit red fluorescence or a release drug under different conditions. Depending on different cells, the intelligent logic device can select the mode of cellular imaging in healthy cells or tumor therapy in tumor cells. The study incorporates the logic gate with the theranostic device, paving the way for tangible applications of logic gates in the future.
研究领域:
生物化学
·
分子生物学
·
纳米医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）