POWDER METALLURGY AND METAL CERAMICS
·
2025
·
IF 0.6
Yang Xiao-Hui,Wang Ya-Long,Zhang Guo-Hua
Mo 2 FeB 2 -based cermets exhibit promising industrial manufacturing applications due to their excellent mechanical properties, higher oxidation resistance, and thermal stability. In this study, ternary boride solid solution powders of Mo 2 (Fe x , Ni 1– x )B 2 were successfully prepared with a unique technique via employing B 4 C powder as a boron source, Mo, Fe, and Ni powders as metal sources as well as Ca powder as the decarburization agent. The effect of the Fe/Ni ratio on the phase composition, morphological evolution and average grain size of powders was studied. The shift of diffraction peak in the XRD results and the homogeneous distributions of Mo, Fe, Ni, and B by the EDS energy spectrum validated the successful synthesis of ternary boride solid solution powders. The morphology of solid solution powders varied depending on the Fe/Ni ratio. For compositions with Fe/Ni ratios of 10 : 0, 7 : 3, and 5 : 5, the ternary solid solution powders exhibited pronounced spherical grains with average grain sizes of approximately 3, 1, and 1 μm, respectively. Conversely, when the Fe/Ni ratios were 3 : 7 and 0 : 10, the solid solution powders exhibited mixed morphologies of spherical (with diameters of approximately 1 μm) and prismatic grains (with lengths of about 8 μm and diameters of around 3 μm), corresponding respectively to the tetragonal and orthorhombic crystal structures of Mo 2 NiB 2 . Using ultrafine Mo powder as a raw material to boost reaction kinetics resulted in the product's stable phase being orthorhombic Mo 2 NiB 2 . Nonetheless, at a Fe/Ni ratio of 3 : 7, the product still consisted of orthorhombic and tetragonal Mo 2 NiB 2 phases.
研究领域:
材料科学
·
粉末冶金
✓ 已验证
DOI
高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
·
2020
·
IF 4.352
Yan Wang,Meiling Lian,Xiaoyu Xiu,Zhiwen Zhang,Liping Song,Shengzhou Wu
Metabolism of β-amyloid is critical for healthy brain. Decreased clearance of β-amyloid is associated with ensued accumulation of amyloid peptide, culminating in formation of senile plaques, a neuropathological hallmark of Alzheimer's disease(AD). Apolipoprotein E ( APOE ), a lipoprotein for phospholipid and cholesterol metabolism, is predominantly synthesized by glia in the central nervous system, controlling Aβ aggregation and metabolism. By use of stereotactic injection and a Morris water maze, we found that delivery of Dicer1-expressing adenovirus into the hippocampus of an animal model of AD mice APPswe/PSEN1deltaE9 significantly improved spatial memory. The effect was associated with reduced amyloid peptides in the hippocampus which were analyzed with immunofluorescence and enzyme-linked immunosorbent assay. With western blot, quantitative real-time PCR, fluorescence in situ hybridization, and northern blot,Dicer1 overexpression increased apolipoprotein E (APOE) and concomitantly decreased B2 RNA in the hippocampus of the AD mice and in astrocyte cultures whereas transfection of B2 Mm2 RNA decreased APOE mRNA and protein levels in astrocyte cultures. Further, human or mouse APOE mRNA was found containing Alu RNA or its equivalent, B2 Mm2 RNA, locating downstream of its 3′-untranslated region (UTR), respectively. The 3′-UTR or 3′-UTR in conjunction with the downstream Alu/B2 RNA were cloned into a luciferase reporter; with dual-luciferase assay, we found that simultaneous transfection of Dicer1 siRNA or Alu/B2 RNA decreased the corresponding luciferase activities which suggest that Alu RNA mediated APOE mRNA degradation. Altogether, Dicer1 expression mediated amyloid peptide clearance by increasing APOE via blocking B2 RNA-mediated APOE mRNA degradation.
研究领域:
神经科学
·
分子生物学
·
神经退行性疾病
·
基因调控
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Qingyi Kong,Sijia Huo,Lei Chen,Yujin Wang,Jiahu Ouyang,Yu Zhou
Fully dense (Zr, Ti)B 2 -(Zr, Ti)C-SiC ceramics were prepared by reactive hot-pressing using ZrB 2 , TiC, and SiC as the initial materials for the first time. Effects of SiC addition on the microstructure evolution and mechanical properties were reported. The in-situ reaction between ZrB 2 and TiC as well as the SiC addition leads to the grain refinement. Besides, elongated (Zr, Ti)B 2 plate-like grains are obtained due to the occurrence of a transient liquid phase, which leads to the crack deflection in the matrix effectively. Mechanical properties are improved significantly due to grain-refinement and solid solution strengthening, and plate-like grains toughening effects. The ZrB 2 -10 mol%TiC composite with 10 mol% SiC additional exhibits good comprehensive mechanical properties of the hardness of 20.2 GPa, the flexural strength of 803 MPa, and the fracture toughness of 5.7 MPa m 1/2 .
研究领域:
材料科学
·
陶瓷工程
✓ 已验证
产品关联
DOI
高影响因子
Chemosensors
·
2023
·Vol. 11
·期 9
·502
·
IF 4.2
Xinyu Gao,Siyu Chen,Xiaolei Wang,Honglei Liu,Xia Wang
Despite being present in minimal amounts, vitamin B2 (VB2), vitamin C (VC), and vitamin B6 (VB6) each play indispensable roles in human metabolisms. Given that VB2, VC, and VB6 cannot be synthesized by the human body, detections of these three vitamins both in fermentation liquid where vitamins are industrially manufactured and in human serum where vitamin concentrations could be clinically controlled are of significant importance. Here, a nanoporous gold (NPAu) modified screen-printed electrode (NPAu/SPE) was fabricated to detect VB2, VC, and VB6 based on NPAu’s electro-oxidation towards vitamins. Owing to the wide separation of peak potentials among VB2, VC, and VB6, the simultaneous detection of these three vitamins was achieved by the NPAu/SPE within a potential range from −0.8 V to 0.8 V. The achieved limits of detection (LOD) for VB2, VC, and VB6 were 0.46, 6.44, and 1.92 μM, with sensitivities of 68.58, 4.77, and 15.94 μA/μM, respectively. Subsequent reliability experiments suggested that the NPAu/SPE exhibited solid anti-interference capability and repeatability. Additionally, the real-sample detection of the NPAu/SPE towards VB2, VC, and VB6 was achieved both in human serum and in fermentation liquid with comparable accuracy (the recovery rates were from 89.8% to 111.7%) as high-performance liquid chromatography (HPLC). Moreover, the portable NPAu/SPE showed comparable performance in terms of the LOD and linear dynamic range when compared to glassy carbon electrodes (GCE) limited to laboratory detection. The proposed NPAu/SPE possesses various advantageous properties including portability, easy fabrication, high sensitivity, and cost-efficiency, making it a potential candidate for clinical and industrial multi-vitamins analysis.Keywords:screen-printed electrode;simultaneous detection;vitamin B2;vitamin C;vitamin B6
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Yi Liu,Wei-Ming Guo,Yang Liu,Chao Chang,Huan Zhou,Yang You,Kun-Heng Huang,Hua-Tay Lin
Improving the ablation resistance of pressureless liquid phase sintered silicon carbide (PLS-SiC) is of great significance for its application in aerospace. In this paper, the ablation resistance of PLS-SiC ceramics was significantly improved by introducing high-entropy diboride (Hf 0.2 Zr 0.2 Ta 0.2 Nb 0.2 Ti 0.2 )B 2 (HEB) as the second phase. The results showed that the matrix of the PLS-SiC ceramic with HEB addition kept its original dense structure after ablation in the presence of oxygen at high temperature (1300 °C/60min), while the matrix of the ceramic with HEB-free was full of pores after ablation, which indicated that it had failed. The improvement of ablation resistance was due to the formation of liquid phase by the reaction of SiO 2 with the oxidation products of HEB under high temperature and oxygen conditions, which filled the pores generated by the decomposition and migration of CeAlO 3 , inhibited the decomposition and migration of CeAlO 3 in the matrix, and maintained the integrity and performance of the material.
研究领域:
材料科学
·
航空航天工程
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS CHARACTERIZATION
·
2016
·
IF 2.383
Zhaobing Cai,Guo Jin,Xiufang Cui,Zhe Liu,Wei Zheng,Yang Li,Liquan Wang
Ni-Cr-Co-Ti-V-Al high-entropy alloy coating on Ti-6Al-4V was synthesized by laser surface alloying. The coating is composed of a B2 matrix and (Co, Ni)Ti 2 compounds with few β-Ti phases. Focused ion beam technique was utilized to prepare TEM sample and TEM observations agree well with XRD and SEM results. The formation of HEA phases is due to high temperature and rapid cooling rate during laser surface alloying. The thermodynamic parameters, ΔH mix , ΔS mix and δ as well as Δχ, should be used to predict the formation of the BCC solid solution, but they are not the strict criteria. Especially when Δχ reaches a high value (≥ 10%), BCC HEA will be partially decomposed, leading to the formation of (Co, Ni)Ti 2 compound phases.
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Future Foods
·
2026
·
IF 10.6
Wang-Wei Zhang,Xiu-Xiu Zhang,Yuan Song,Run-Hui Ma,Zhi-Jing Ni,Kiran Thakur,Jian-Guo Zhang,Yi-Long Ma,Zhao-Jun Wei
Oral administration of probiotic bacteria represents a promising strategy for the prevention and alleviation of colitis; however, its translational potential is frequently constrained by low bacterial viability under gastrointestinal conditions, inadequate mucosal adhesion, oxidative stress, and suboptimal host–microbe interactions at inflamed mucosal sites. To address these limitations, we developed a bilayer nanoencapsulation system for riboflavin-producing L. plantarum B2, consisting of an inner gallic acid–Ca²⁺ metal–polyphenol network and an outer coating of either hyaluronic acid (HA) or bovine serum albumin (BSA). Successful formation of uniform, conformal nanocoatings on the bacterial surface was confirmed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), zeta potential and particle size analyses, and laser scanning confocal microscopy (LSCM). Among the coated formulations, HA-coated L. plantarum B2 (H-G- L. plantarum B2) exhibited markedly improved storage stability, enhanced resistance to simulated gastrointestinal fluids, and greater tolerance to hydrogen peroxide-induced oxidative stress, while largely preserving bacterial growth kinetics, acidification capacity, riboflavin production, and isoflavone biotransformation activity during soymilk fermentation. Furthermore, HA-based nanoencapsulation significantly enhanced bacterial adhesion to Caco-2 intestinal epithelial monolayers in vitro and prolonged gastrointestinal retention in mice. In a dextran sulfate sodium (DSS)-induced colitis model, oral administration of nanoencapsulated L. plantarum B2 attenuated body weight loss, colon shortening, histopathological injury, and colonic oxidative stress. Mechanistically, the treatment suppressed the levels of TNF-α, IL-1β, calprotectin, MPO, and MDA; elevated IL-10, CAT, and reduced GSH; restored the expression of tight junction proteins ZO-1 and occludin; and modulated gut microbiota composition. These findings establish bilayer nanoencapsulation as an effective and biocompatible strategy to enhance probiotic oral delivery and highlight the therapeutic potential of riboflavin-producing L. plantarum B2 as a microbiome-targeted intervention for colitis management.
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2016
·Vol. 41
·期 5
·e13126
·
IF 0.894
L. Xu,W.X. Cai,B.J. Xu
This study aimed to provide comprehensive health beneficial profiles of fermented soy products and further provide reference values of vitamin B 2 and B 12 and GABA enrichment products. High performance liquid chromatography (HPLC) analyses were applied to systemically investigate the vitamins and GABA. The highest vitamin B 2 content of 6.06 μg g −1 was detected in “Wangzhihe” sufu. All natto samples showed relatively higher vitamin B 2 content with an average value of 3.35 μg g −1 compared to the other fermented soy products. “Liubiju” dry yellow soybean paste was detected with the highest vitamin B 12 content of 732.94 ng g −1 . All sufu samples presented relatively higher GABA levels with an average value of 11.58 mg g −1 . Fermented soy products could be used as supplements of vitamins and bioactive substances such as GABA. It can be concluded that fermentation can be used as an alternative method to chemical synthesis of vitamin B 12 and GABA. Practical Applications Presented information will guide consumers to choose fermented soy product to gain health benefit components, especially for vegetarian to find food sources of vitamin B 12 . The study will help food manufacturers to understand secondary metabolites production through fermentation. Current results make food industry commercially feasible to produce special amino acids (such as GABA) and vitamins B 2 and B 12 .
研究领域:
食品科学
·
营养学
·
生物化学
✓ 已验证
DOI
高影响因子
TALANTA
·
2017
·
IF 4.162
Man Jia,Jian Yang,Yong-Xin Zhao,Zhao-Sheng Liu,Haji Akber Aisa
The topic in the present work is to prepare molecularly imprinted polymer (MIP) in heterogeneous crowding surrounding for improving imprinting effect. For the first time, heterogeneous crowding surrounding was made up of a tetrahydrofuran (THF) solution of low molecular weight polyethene glycol (PEG) and high molecular weight polystyrene (PS). The MIP prepared in heterogeneous crowding surrounding against procyanidin B2 can display apparent imprinting effect (imprinting factor of 5.13) in the situation of difficult imprinting at single crowding surrounding or non-crowding surrounding. The necessity of simultaneous use of low and high molecular weight crowding agents for enhanced imprinting effect was further proved. NMR peak shifts of active hydrogen of procyanidin B2 strongly suggested that the interaction between functional monomer and template can be enhanced due to the effect of heterogeneous crowding in the self-assembly process. The influence of molecular weight and amount of PEG, molecular weight of PS, as well as the ratio of procyanidin B2 to functional monomer on the imprinting factor was investigated. The MIP was then used to extract purify procyanidin B2 from extract of grape seed. The recovery of procyanidin B2 obtained was 87% with relative standard deviation of less than 5%.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.9
Wenjuan Qi,Junjie Xu,Rong Li,Zhuo Zhao,Jun Zhang,Hongmin Zhu,Weiliang Jin,Saijun Xiao
Efficiently fabricating high-performance ultra-high temperature ceramics (UHTCs), especially ternary boride coatings, remains a critical bottleneck. Herein, a novel molten salt electrophoretic deposition (MS-EPD) strategy overcomes this challenge using ultrasmall (∼3.3 nm) (Hf 0.5 Zr 0.5 )B 2 nanocrystals (NCs) as building blocks. These (Hf 0.5 Zr 0.5 )B 2 nanocrystals are formed in situ via borothermal reduction of HfO 2 and ZrO 2 with B in the NaF-AlF 3 molten salt, and are subsequently used for MS-EPD to deposit dense coatings. This approach enables the rapid (1.02 μm min −1 ) and controllable growth of dense coatings on graphite. The resulting films exhibited a unique gradient columnar structure, yielding a high nano-hardness (31 GPa), robust adhesion (10.6 N), and effective oxidation resistance at 1200℃. Crucially, multi-scale characterization revealed that the growth is governed by an oriented attachment (OA) mechanism, where individual NCs crystallographically align and fuse at the growth front. This discovery of direct, cross-scale assembly in molten salt provides a new paradigm for the bottom-up fabrication of advanced materials with precisely engineered microstructures.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2022
·Vol. 106
·期 2
·860-866
·
IF 4.186
Weiliang Jin,Jie Pang,Qian Kou,Chuntao Ge,Hongmin Zhu,Geir Martin Haarberg,Saijun Xiao,Jun Zhang
This paper demonstrates the availability of electro-codeposition (i.e., the simultaneous occurrence of electrophoretic deposition of nanoparticles and electrochemical deposition of metal ions) in molten salts without the assistance of stirring of the bath. In molten NaCl–KCl–AlCl 3 –MoO 3 system containing TiB 2 nanoparticles at 710°C, the electro-codeposition of TiB 2 nanoparticles and Mo(VI) ions has been achieved, and a (Ti, Mo)B 2 coating has been prepared.
研究领域:
材料科学
·
电化学
·
表面工程
·
纳米材料
✓ 已验证
DOI
高影响因子
CORROSION SCIENCE
·
2025
·
IF 8.5
Huan Guo,Bingzhu Wang,Ruifeng Li,Cheng Su,Jixiang Dai,Yong She,Yongzhong Zhao,Jianjun Sha
Aiming at forming a stable ablation layer for hafnium-based ultrahigh-temperature ceramics under ablation environment, in this work, the Ta-based ceramic was introduced into the Hf-based ceramic, and the effect of Hf/Ta molar ratios on the ablation response behavior and mechanism of (Hf, Ta)B 2 -(Hf, Ta)C-SiC ceramics was investigated. It was found that the introduction of Ta could form a continuous and dense ablation layer. When Hf/Ta= 0.9:0.1, the ceramic composite presented excellent ablation resistance, and the linear ablation rate was −0.083 μm/s, which was only 5.85 % of that of Hf-based ceramics (HfB 2 -HfC-SiC). The excellent ablation resistance attributed to that the ablation products (Ta 2 O 5 and Hf 6 Ta 2 O 17 ) could strongly bonded to the substrate, which was conducive to enhance the stability of the ablation layer.
研究领域:
材料科学
·
航空航天工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）