LANGMUIR
·
2024
·
IF 3.7
Hui Niu,Xianxiang Chen,Xianwei Chen,Haiming Chen,Zuman Dou,Wenduo Wang,Xiong Fu
Recent studies showed that sugar beet pectin exhibited more excellent emulsifying properties than traditional citrus peel pectin and apple pectin ascribed to the higher content of neutral sugar, protein, ferulic acid, and acetyl groups. It is precisely because of the extremely complex molecular structure of pectin that the emulsifying properties of the pectin–Ca2+ complex are still unclear. In this study, SBP-Ca2+ complexes with different cross-linking degrees were prepared. Subsequently, their interfacial adsorption kinetics, the resistance of interfacial films to external perturbances, and the long-term stability of the emulsions formed by these SBP-Ca2+ complexes were measured. The results indicated that the highly cross-linked SBP-Ca2+ complex exhibited slower interfacial adsorption kinetics than SBP alone. Moreover, compared with SBP alone, the oil–water interfacial film loaded by the highly cross-linked SBP-Ca2+ complex exhibited a lower elasticity and a poorer resistance to external perturbances. This resulted in a larger droplet size, a lower ζ-potential value, a larger continuous viscosity, and a worse long-term stability of the emulsion formed by the highly cross-linked SBP-Ca2+ complex. This study has very important guiding significance for deeply understanding the emulsification mechanism of the pectin–Ca2+ complex.
研究领域:
食品科学
·
胶体化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2020
·
IF 6.155
Shao-Fang Li,Zhen-Yi Gu,Jin-Zhi Guo,Xian-Kun Hou,Xu Yang,Bo Zhao,Xing-Long Wu
In recent years, sodium-ion batteries (SIBs) have been considered as one of the most promising alternatives to lithium-ion batteries (LIBs). Here, a new Na-super-ionic conductor (NASICON) cathode material NaFe 2 PO 4 (SO 4 ) 2 is successfully prepared through solid state method for SIBs. While the poor electronic conductivity of iron-based materials results in its poor rate and cycle performance. Then the electrochemical is effectively promoting via Ca 2+ doping. Na 0.84 Ca 0.08 Fe 2 PO 4 (SO 4 ) 2 have achieved considerable electrochemical properties. The first discharge specific capacity is 121.6 mA h g −1 at 25 mA g −1 with the voltage platform (∼3.1 V) corresponding to Fe 2+/3+ . After 100 cycles, the capacity retention is 55.1 %. The excellent electrochemical performance is caused by some Na + is substituted by Ca 2+ and leading to the fast sodium kinetics, which is well proved by the powder X-ray diffraction pattern and well corresponding to the galvanostatic intermittent titration technique and cyclic voltammetry testing result (the diffusivity values are around at 10 −12 cm 2 s −1 ).
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Molecular Biosciences
·
2025
·
IF 4
Li Ji,Anqi Deng,Huiying Chen,Shuangyan Guo,Pingyu Wang,Ruiyi Zhang,Wenyang Chen,Taotao Fan,Lijuan Jiang,Bing Shen
Introduction BaoTaiyin (BTY) is a traditional Chinese medicine decoction. It has been used to treat recurrent miscarriage (RM). However, there are no comprehensive systematic studies to identify the chemical compositions of BTY and molecular mechanisms on RM. Finding the chemical components of BTY and clarifying the underlying processes in the treatment of RM were the goals of the study. Methods We used ultra-high-performance liquid chromatography coupled with triple quadruple time-of-flight tandem mass spectrometry to analyze the chemical components of BTY, network analysis to predict the pharmacological effects of the identified active ingredients, and cell experiments to identify potential molecular mechanisms. Results We found 12 active ingredients among 61 components identified in BTY. These identified activities were linked to regulatory effects on 127 key signaling pathways, targeting 107 proteins. Through network analysis, we determined that insulin-like growth factor 1 receptor, matrix metalloproteinases, PI3K, and STAT3 may be the core targets of BTY’s therapeutic effects on RM. We further explored this mechanism to find that aqueous extracts of BTY significantly enhanced IGFBP2 and CaMKK2 expression and trophoblast proliferation, whereas inhibitors of IGF1R/PI3K/AKT pathway or CaMKK2 blocked the effect of BTY on trophoblast proliferation. In addition, IGFBP2 siRNA suppressed BTY-induced CaMKK2 expression. Caffeic acid, as one of components of BTY, increased intracellular Ca 2+ concentration and proliferation in trophoblast. Conclusion Our research showed that BTY may have therapeutic benefits on RM through multiple targets and pathways, such as the IGF1R/PI3K/AKT and Ca 2+ /calmodulin signaling pathways.
研究领域:
中药学
·
分子生物学
·
生殖医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2019
·Vol. 9
·期 1
·1-11
·
IF 4.011
Sun Saiwu,He Huijun,Yang Chunping,Cheng Yan,Liu Yongpan
In this study, the adsorption and UV photocatalytic degradation of atrazine using nano-TiO 2 particles were studied systematically, and the colloidal stability of nano-TiO 2 particles in solution was also investigated to reveal the removal mechanism. Experiments which contained the first 6.0 hours darkness and 4.0 hours UV illumination later were conducted at different concentrations of Ca 2+ and/or fulvic acids (FA) at pH = 7.0. Results showed that the adsorption rate of atrazine onto nano-TiO 2 particles decreased with the increase of Ca 2+ and/or FA concentrations, which could be explained well by the colloidal stability of nanoparticles. When the solution contained Ca 2+ or Ca 2+ -FA, the nanoparticles were aggregated together leading to the decrease of the contact surface area. Besides, there existed competitive adsorption between FA and atrazine on the particle surface. During photocatalytic degradation, the increase of Ca 2+ and/or FA concentration accelerated the aggregation of nano-TiO 2 particles and that reduced the degradation efficiency of atrazine. The particle sizes by SEM were in accordance with the aggregation degree of nanoparticles in the solutions. Sedimentation experiments of nano-TiO 2 particles displayed that the fastest sedimentation was happened in the CaCl 2 and FA coexistent system and followed by CaCl 2 alone, and the results well demonstrated the photodegradation efficiency trends of atrazine by nano-TiO 2 particles under the different sedimentation conditions.
研究领域:
环境科学
·
化学工程
·
水处理
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 38
·7623-7630
·
IF 4.726
T. Y. Cheang,Z. H. Xing,Z. L. Li,H. Y. Zhou,J. H. Wei,X. Zhou,A. W. Xu,Y. Lin,S. M. Wang
Here, a novel carrier fabricated by the interaction of negatively charged heparin and positively charged PEI and Ca2+ was investigated to deliver AIB1 siRNA into breast cancer cells both in vitro and in vivo. Ca2+/PEI/heparin nanoparticles were prepared by simply mixing heparin, PEI and CaCl2 aqueous solution. Heparin in the Ca2+/PEI/heparin nanoparticles (40.9% heparin, w/w) decreased the cytotoxicity of PEI. According to the MTT assay, Ca2+/PEI/heparin NPs are superior to commercial Lipofectamine 2000 considering the safety. The Ca2+/PEI/heparin NPs are able to deliver siAIB1 into breast cancer cells as effectively as Lipofectamine 2000 both in vitro and in vivo. The in vivo experiment also indicated that the NF-κB/BCL-2 signal pathway might be the downstream signal pathway of AIB1 in regulating breast cancer proliferation and progression.
研究领域:
癌症研究
·
纳米技术
·
分子生物学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Zhen Li,Yanfen Jiang,Hanying Zhao,Li Liu
Thermoresponsive phospholipid–poly(N-isopropylacrylamide) (PL-PNIPAM) conjugates were synthesized via reversible addition fragmentation chain transfer polymerization mediated by a phospholipid-modified trithiocarbonate. Temperature triggered the micellization of the PL-PNIPAM conjugate to form phosphate group-decorated micelles in the aqueous solution. Driven by the chelation of phospholipids and Ca2+, the PL-PNIPAM conjugate and Ca2+ ions formed size-tunable nanoclusters at a temperature beyond the lower critical solution temperature. To fabricate cross-linked nanogels, NIPAM was copolymerized with N-succinimidyl acrylate (NSA) to obtain the PL-P(NIPAM-co-NSA) conjugate bearing pendent cross-linkable functionalities. Subsequently, the size-controllable nanogels containing disulfide linkages were generated at 37 °C by cross-linking the PL-P(NIPAM-co-NSA)/Ca2+ nanoclusters with cystamine through modulation of Ca2+ concentrations. These negatively charged nanogels demonstrate temperature/pH/reduction triple responsiveness. The nanogels can be efficiently loaded with doxorubicin (DOX) and proteins with various isoelectric points. The DOX-loaded nanogels exhibited a temperature/pH/reduction triple-responsive release profile. The immobilized RNase A, BSA, and GOx retained the protein bioactivity. The release of RNase A-loaded nanogels possesses a temperature-responsive profile. The immobilization of Lys and cytochrome C in nanogels inhibited protein bioactivity. However, the addition of NaCl triggered the recovery of bioactivity. These multistimuli-responsive nanogels can provide a versatile platform applicable in biotechnology and drug/protein delivery.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2022
·Vol. 24
·期 27
·4887-4898
·
IF 3.756
Mingzhou Meng,Rui Zhang,Zhenlong Cheng,Xinmeng Fa,Jianghua Yang,Anees A. Ansari,Jun Ou,Christian Wurth,Ute Resch-Genger
A solvothermal method was used to prepare a series of Yb3+/Tm3+/Ca2+ co-doped NaYF4 nanoparticles with different Ca2+ contents. Strong upconversion blue fluorescence could be observed under 980 nm laser excitation of the samples. The effect of different Ca2+ contents on the luminescence intensity was investigated, and it was found that the UV-vis upconversion luminescence increased and then decreased with an increasing Ca2+ concentration during the increase of the Ca2+ content from 0 mol% to 25 mol%, reaching the strongest fluorescence at 15 mol%, which was up to about 28 times stronger than that without Ca2+ doping. Furthermore, the mechanism was investigated, and it was found that the doping of Ca2+ disrupted the symmetry of the crystal field, resulting in a significant enhancement of the overall fluorescence. Applied to fluorescence intensity ratio thermometry, the absolute and relative sensitivities are as high as 0.0418 K−1 and 2.31% K−1, respectively, with a minimum temperature resolution of 0.0129 K.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Ying Peng,Peng Liu,Jinsong Ding,Wenhu Zhou
Disulfiram (DSF), an FDA-approved drug for alcoholism, has demonstrated promising anti-tumor effects combined with Cu 2+ . This combination is achieved through the metabolism of DSF into dithiocarbamate (DTC), which chelates with Cu 2+ to form the active form of DTC-copper complexes (CuET). Interestingly, our investigation revealed that Ca 2+ can serve as another amplifier to enhance the efficacy of DSF by inducing calcium overload in tumor cells. Building upon this finding, we developed biomineralized nanoparticles (CuCaP@DTC) capable of controlled release of DTC, Cu 2+ , and Ca 2+ in response to the acidic tumor microenvironment. These nanoparticles exhibited stability in the bloodstream for prolonged circulation, enabling their passive accumulation in tumors while efficiently releasing Ca 2+ and Cu 2+ /DTC to facilitate CuET generation within tumor cells. The combined effect of in-situ CuET generation and calcium overload resulted in amplified anti-tumor effects. This research underscores the potential of synergistically combining DSF, copper, and calcium as a promising approach for improving treatment outcomes. Furthermore, it emphasizes the importance of rational design in delivery carrier systems based on a comprehensive understanding of the therapeutic mechanisms to enhance the drug efficacy.
研究领域:
纳米技术
·
癌症研究
·
药学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Gaoshang Li,Junqi Zhan,Jiayin Huang,Enbo Xu,Chunhong Yuan,Jianchu Chen,Qian Yao,Yaqin Hu
To solve undiscernible freshness changes of printed functional surimi while maintaining printed shape, 4D printable color-changing material were prepared. Firstly, based on results of printing properties and fresh-keeping of Ca 2+ -NS-L-surimi, it showed better printing effects (enhanced mechanical strength) and good preservation (inhibition of amino acids decomposition, bacterial growth). However, freshness changes of printed Ca 2+ -NS-L-surimi were not distinguished directly. To avoid that, 4D printable color-changing material—anthocyanin-hydroxypropyl methyl cellulose-xanthan gum-carrageenan (AHXK) was prepared for indicating freshness through discoloration. Printing results showed AHX with 5 % K had the most suitable mechanical strength (appropriate gel strength, texture, rheology) for printing. Based on that, AHXK had stable color (ΔE fluctuation <5) and was sensitive to pH and ammonia (obvious discoloration; ΔE > 10). Actual freshness monitoring results (co-printing of AHXK-surimi) exhibited significant discolorations, especially for HXK with 0.75 % A. It became green during refrigeration of 3–5 d (keeping fresh, ΔE < 4), brighter green at 7 d (decreased freshness, ΔE > 6), turned yellow at 9 d (spoilage, ΔE > 16), which were distinguished significantly with naked eyes rather than traditional freshness determining. In conclusion, printed AHXK-functional surimi exhibited good printing, preservation and nondestructive freshness monitoring, facilitating application of 3D printed functional surimi.
研究领域:
食品科学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2020
·
IF 4.605
Xuteng Xing,Dan Zhou,Erjun Tang,Shaojie Liu,Xiaomeng Chu,Xiaodong Xu,Yongquan Xu
The natural halloysite nanotubes were used as the nanocontainer to load Na 2 MoO 4 corrosion inhibitor , and the release rate of Na 2 MoO 4 was further controlled by wrapped with the CaMoO 4 end stopper through adding with Ca 2+ . The variable release rates were fulfilled by the formation of CaMoO 4 end stopper with different strength, and the release time can be adjusted from one to dozens of hours. Moreover, the prepared complex corrosion inhibitor is also an acid-responsive smart material, which can quickly release the large amount of corrosion inhibitors under acidic conditions through the decomposition of insoluble CaMoO 4 complex on the surface or end of halloysite. In addition, the epoxy coating mixed with 10 wt% Ca 2+ treated Na 2 MoO 4 loaded halloysite can provide the highest corrosion resistance and sustained release of the corrosion inhibitor to achieve corrosion healing in the coating defects.
研究领域:
材料科学
·
腐蚀与防护
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2025
·
IF 4
Siye Zhou,Jiayun Li,Dongping Chen,Zhixuan Xu,Kudousi Kuerban,Qiang Liu,Muhammad Irfan Waris,Wenwu Wu,Nannan Lv,Jianting Fan
Hyphantria cunea , a globally significant quarantine pest, causes severe ecological and economic impacts in invaded regions. Attractants are environment-friendly and valuable pest management tools for H. cunea control. In this study, we identified that the combination of β-ocimene with sex pheromone components was strongly attractive to H. cunea males. This attractant combination activates the Ras signaling pathway and stimulates Ca 2+ in male adults following exposure. Feeding and oviposition behavior results demonstrated that H. cunea prefers Morus alba over Platanus × acerifolia , Metasequoia glyptostroboides , and Taxodium distichum . In the fresh branches of M. alba with leaves, the relative abundance of β-ocimene (36.33 ± 0.41 %) was significantly higher than the other hosts. Electroantennography recordings, behavioral choice assays, and field trapping trials showed that the combination of β-ocimene with sex pheromone components significantly enhanced male response and attraction. The number of trapped males using β-ocimene/ sex pheromone blend was 3.7-fold higher than that of sex pheromone or β-ocimene alone in the field, indicating a synergistic effect of adding β-ocimene to sex pheromone. The molecular mechanism of β-ocimene/sex pheromone synergism was further analyzed. After exposure to the attractant, the Ras signaling pathway in the heads of males are activated ( HcILP and HcPLCε1 are upregulated, while HcRasGAP and HcPLD are downregulated), which further stimulates the expression of IP3 and Ca 2+ . The activation of Ca 2+ may be the key reason for its higher attraction to males. These findings provide a theoretical basis for the selection and mechanistic understanding of attractants for H. cunea , offering insights for attractant-based pest control strategies.
研究领域:
昆虫学
·
害虫管理
·
分子生物学
·
生态学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Yiran Fan,Ziyou Ding,Jia Chen,Chengyu Li,Yingchao Han
Alkaline phosphatase (ALP) is an essential enzyme widely distributed in the human body, and it can hydrolyze pyrophosphate (PPi) under alkaline conditions. Therefore, ALP and PPi activities are associated with many diseases and it is crucial to develop sensitive and selective methods for detecting ALP and PPi. Herein, poly(acrylic acid) (PAA)-Ca2+(Ce3+) nanoclusters fluorescent probe was synthesized aiming to detect PPi and ALP quantitatively. The nanoclusters present monodisperse, and their particle size is 0.9–2.4 nm. The probe exhibits no fluorescence due to electron transfer; whereas it can combine with PPi to yield fluorescence increase, arising from the enhanced electric-dipole transition of Ce3+ under the ligand effect of PPi. Moreover, the probe displays good selectivity to PPi, and the fluorescence changes display a linear relationship with PPi concentration of 3–20 mM (y = 11.29x – 23.47, R2 = 0.994). Furthermore, the probe was mixed with PPi to form PAA-Ca(Ce):PPi nanoparticle (Monodisperse, average size: 1.94 nm) and showed high fluorescence selectivity and responsiveness to ALP due to the ALP hydrolyzing effect and the fluorescence difference between PAA-Ca(Ce):PPi and PAA-Ca(Ce):Pi. Based on the relationship between the fluorescence reduction rate of the probe and the logarithm of ALP concentration (y = 0.0594x – 0.00111, 5–200 U/L, R2 = 0.996), ALP was successfully detected quantitatively, and the detection limit is calculated to be 0.62 U/L. Through this approach, we developed a fluorescence “turn-on” for PPi detection and “turn-off” for ALP detection. This study provides a promising strategy for the diagnosis of diseases related to PPi and ALP.
研究领域:
分析化学
·
生物材料
·
生物医学工程
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）