Cancer Nanotechnology
·
2023
·Vol. 14
·期 1
·1-21
·
IF 5.7
Luo Wenli,Li Zhaojian,Zhang Ling,Xie Xingyi
Background Due to their porous structure and capability to degrade under acidic conditions, CaCO3 nanoparticles in vaterite form can be used as carriers to effectively deliver drugs to low-pH sites such as tumors. The usually used intravenous administration requires long-term vaterite phase and colloidal stability for storage and blood circulation. While passive accumulation in tumors can be achieved via the enhanced permeation and retention effect, active accumulation requires reactive groups on vaterite nanoparticles to conjugate targeting molecules. Both requirements are hard to achieve in one simple and economical vaterite formulation. Herein, we used polyethylenimine (PEI)-based CO2 adduct as both a CO2 source and a template for vaterite mineralization to generate PEI-CO2@CaCO3 colloidal particles, with reactive amino groups from the PEI template.Results The obtained nanoparticles with a hydrodynamic diameter of 200–300 nm have a vaterite phase and colloidal stability in an aqueous solution for over 8 months. These nanoparticles could effectively load anticancer drug doxorubicin via coprecipitation and be surface-modified with polyethylene glycol (PEG) and folic acid for long-term blood circulation and tumor targeting purposes, respectively. After being endocytosed, the PEI-CO2 adduct accelerates the dissolution of drug-loaded nanoparticles to generate CO2 bubbles to break the lysosomes, leading to rapid doxorubicin delivery inside tumor cells. The degradation of PEI-CO2 in the CaCO3 nanoparticles could also release PEI and CO2 and may contribute to the disruption of normal cellular functions. As a result, the drug-loaded PEI-CO2@CaCO3 nanoparticles strongly suppressed tumor growth in mice with HeLa tumor xenografts.Conclusion sA new and effective vaterite drug carrier for anticancer therapy has been developed using PEI-CO2 adduct as both a CO2 source and vaterite template for CaCO3 mineralization. This delivery system illustrates an application of CO2 generation materials in drug delivery and has the potential for further development.
研究领域:
纳米技术
·
药学
·
癌症研究
·
材料科学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Energy
·
2022
·
IF 9.257
Xianglei Liu,Changjian Yuan,Hangbin Zheng,Chao Song,Cheng Tian,Ke Gao,Nan Sun,Zhixing Jiang,Yimin Xuan,Yulong Ding
Calcium carbonate (CaCO 3 ) pellets are suitable for scalable solar thermochemical energy storage but suffer from low solar absorptance, poor stability, and slow reaction kinetics, which lead to low solar energy storage efficiency. Here, for the first time, we successfully achieve fast and efficient solar thermochemical energy storage via synergistically employing Al, Mn, and Fe stabilizers for improving both cyclic stability and solar absorptance, and Li 2 CO 3 promoters for accelerating decomposition of CaCO 3 pellets. The average solar absorptance is 1500% higher than that of pure CaCO 3 pellets. After 60 cycles, the energy storage density is still as high as 1671 kJ/kg with a decay rate of only 4.14%, in stark contrast to energy density of 1121 kJ/kg and decay rate of 56.73% for pure CaCO 3 pellets. The average decomposition rate is about twice as fast as that of pure CaCO 3 pellets due to enhanced Ca 2+ diffusion by doped Li 2 CO 3 . Under direct light irradiation, novel CaCO 3 pellets demonstrate high energy storage rate due to both high solar absorptance and fast decomposition rate, while pure CaCO 3 pellets cannot even reach the decomposition temperature. This work opens new opportunities for scalable deployment of direct solar-driven thermochemical energy storage techniques based on Li 2 CO 3 -doped dark CaCO 3 pellets.
研究领域:
材料科学
·
能源工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
NEW CARBON MATERIALS
·
2018
·
IF 1.171
Ming-jie Liu,Feng Wei,Xue-mei Yang,Shi-an Dong,Ying-jie Li,Xiao-jun He
Porous graphene-like carbon materials (PGCMs) for supercapacitors were synthesized from petroleum pitch by a nano-CaCO 3 template strategy combined with KOH activation. The PGCMs were characterized by TEM, XPS, Raman spectroscopy and N 2 adsorption. Results show that their specific surface areas are 1542-2305 m 2 ·g −1 , depending on the template/pitch ratio, KOH/pitch ratio and activation temperature. The PGCMs feature interconnected graphene-like carbon layers with abundant small pores. The optimum supercapacitor electrode is produced when the PGCM is synthesized with a template/pitch ratio of 1.5, a KOH/pitch ratio of 1.5 at 850 °C for 1h. It has a specific capacitance of 293 F·g −1 at a current density of 0.05 A·g −1 , an excellent rate capability with a capacitance of 231 F·g −1 at a current density of 20 A·g −1 and an outstanding cycling stability with a 97.4% capacitance retention after 7000 cycles in a 6 M KOH aqueous electrolyte. It also exhibits a high specific capacitance of 267 F·g −1 at a current density of 0.05 A·g −1 , and a high energy density of 148.3 Wh·kg −1 at a power density of 204.2 W·kg −1 in a BMIMPF6 ionic liquid electrolyte. This is a possible method for the synthesis of PGCMs for high-performance supercapacitors.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Zheng Fang,Wei He,Tao Tu,Niuniu Lv,Chuanhong Qiu,Xin Li,Ning Zhu,Li Wan,Kai Guo
α-Fe 2 O 3 nanoparticles were prepared by using a continuous precipitation method with a valve assisted micromixer in the presence of iron (III) sulfate and ammonia water. The resulting nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM). Meanwhile, CaCO 3 nanoparticles were synthesized in a tube-in-tube flow reactor AF-2400. The acylation process catalyzed by modified lipophilic α-Fe 2 O 3 and CaCO 3 nanoparticles in the flow reactor were systematically investigated. Under the optimal conditions, a yield of 97.8% was obtained. Addition of CaCO 3 nanoparticles resulted in higher catalytic efficiency compared with pure modified α-Fe 2 O 3 nanoparticles. Moreover, this novel acylation also worked well for other substrates.
研究领域:
化学工程
·
材料科学
·
绿色化学
✓ 已验证
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Gang Huang,Danlin Zeng,Mengcheng Wei,Yang Chen,Aoxue Ma,Sirong Cheng
A novel nonmetal-based nanocomposite, protonated g-C 3 N 4 @CaCO 3 (CN-BPCC), was synthesized using a simple calcination method. The construction of this binary composite photocatalyst enhanced the adsorption and photocatalytic degradation performances of pure g-C 3 N 4 . The adsorption and photocatalytic degradation efficiencies under visible-light irradiation were analyzed using methylene blue (MB) as the target organic pollutant. The binary nanocomposite with 1.5 g of CaCO 3 (BPCC) exhibited high adsorption and photocatalytic performance, achieving approximately 100 % degradation of MB under 90 min of xenon lamp irradiation. Furthermore, the nanocomposite displayed enhanced visible-light utilization efficiency and improved separation efficiency of photogenerated carriers. The adsorption and photocatalytic degradation mechanisms were investigated through radical trapping experiments and electron spin resonance (ESR) spectroscopy. Furthermore, the binary CN-BPCC nanocomposite exhibited exceptional reusability after regeneration, indicating its potential as a promising photocatalyst for the treatment of wastewater containing organic pollutants.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTAL RESEARCH AND TECHNOLOGY
·
2021
·Vol. 56
·期 4
·2000187
·
IF 1.639
Huifeng Hu,Fugen Liang,Haidong Zhu,Xiumei Zhang,Kecong Cui,Hridam Deb,Yong Zhang
The single crystal form and uncontrollable topography of CaCO 3 in nature severely restrict its product grade and application. Meanwhile, lignin is still not utilized efficiently. In order to improve this, three types of lignin monomer model compounds as p -coumaric acid (PCA), ferulic acid (FA), and sinapic acid (SA) are employed to induce the growth of CaCO 3 to investigate the relationship between lignin structure and CaCO 3 crystallization. The synthesized PCA and CaCO 3 composite crystals (PC-ACCs), FA and CaCO 3 composite crystals (F-ACCs), and SA and CaCO 3 composite crystals (S-ACCs) are characterized by field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), and Fourier transmission infrared spectroscopy (FTIR) to ascertain their molecular structures and crystal information. The growth rule of the acid and CaCO 3 composite crystals (ACCs) induced by the three units is also explored. The results show that the vaterite and calcite of ACCs can be formed selectively. In the presence of PCA, FA, and SA, pH is the key factor on the phase selection of ACCs. The temperature and organic acid type also play important roles on the formation of CaCO 3 . The ACCs present distinguishing surface topographies at different temperatures. The number of methoxyl in the PCA, FA, and SA decides the phase ratio of vaterite and calcite in the ACCs.
研究领域:
材料科学
·
化学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2021
·
IF 3.498
Falong Wang,Yaqiang Dong,Liang Chang,Yan Pan,Qiang Chi,Mengji Gong,Jiawei Li,Aina He,Xinmin Wang
In this paper, a novel type of nano-CaCO 3 /epoxy nanocomposites insulating layer for the FeSiCr/carbonyl-iron soft magnetic composites (SMCs) has been successfully developed. The novel inorganic/resin nanocomposites can greatly reduce the core loss of the SMCs while maintain other excellent magnetic properties . By optimizing the content of insulating layer, the FeSiCr/carbonyl-iron SMCs exhibits the lowest core loss of 466.5 mW/cm 3 at a maximum magnetic induction of 50 mT and frequency of 100 kHz, which is greatly reduced by 24.2%, compared with the sample only coated by epoxy resin . Meanwhile, the effective permeability and quality factor remains high. In addition, the production process of the novel nano-CaCO 3 /epoxy nanocomposites insulating layer exhibits the advantages of simplicity, convenience and low cost compared with other ceramic coatings (Al 2 O 3 , MgO , SiO 2 , etc.) and surface nitride coatings, which is more suitable for the industrialization of molded inductors, and therefore has a variety of industrial application prospects.
研究领域:
材料科学
·
电磁学
✓ 已验证
产品关联
DOI
高影响因子
FUEL PROCESSING TECHNOLOGY
·
2023
·
IF 7.5
Yi Yuan,Lijia Huang,Tian C. Zhang,Yuan Wang,Shaojun Yuan
Metal oxide loaded carbon-based materials have attracted extensive attention as promising desulfurizers to solve the problem of H 2 S emission at room temperature . However, low desulfurization capacity, difficult regeneration and high economic cost are the main problems of metal oxide loaded carbon-based desulfurizers, which limit their industrial application. Herein, a novel and low-cost CaCO 3 -ZnO loaded biochar (RCZ) was synthesized by one-step pyrolysis of scrap rice and metal salts for highly efficient H 2 S removal at room-temperature. The optimized RCZ-1-1-1-800 sample showed an excellent H 2 S removal ability of 834.48 mg/g at the reaction temperature of 25 °C, oxygen content of 10%, and relative humidity of 70% as compared to 29.31 mg/g achieved by the inactivated biochar (prepared without activator). Such an RCZ-1-1-1-800 desulfurizer also delivered a high H 2 S removal ability under different desulfurization conditions. The associated desulfurization mechanism of RCZ was the coupling of reactive adsorption and catalytic oxidation with sulfur being the main desulfurization product. Moreover, the as-fabricated RCZ also exhibited a high reusability , retaining about 95% of the initial H 2 S removal capacity after five adsorption/regeneration cycles. This work provides a promising idea for the preparation of low-cost and high-capacity metal oxide- and carbonate-loaded carbon-based desulfurizers.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Runzi Zhang,Shunbi Xie,Qianyan Zhang,Ying Gao,Xiang He,Shanshan Jin,Junhao Leng,lian Zhang,Yi He
Background Chloramphenicol (CAP) is a broad-spectrum antibiotic, and its continuous use in human medicine, livestock has resulted disturbances in ecosystem stability. The complex background and low concentration of CAP in aquatic environments present significant scientific challenges for its sensitive detection. Currently detection techniques such as high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) are hindered by their complex procedures and high costs. Surface-enhanced Raman spectroscopy (SERS), due to its unique ability for fingerprint recognition, has emerged as a powerful tool for analysis and detection. However, it is often limited by the low kurtosis expression of the target. Result The water-soluble explosive polyethylenimide grafted calcium carbonate (PEI@CaCO3) microcapsule was utilized to encapsulate the signal probe Ag@4-NTP and combine it with a semiconductor SERS substrate Zn 0.995 Ce 0.005 O, enabling ultra-sensitive detection of CAP through a signal attenuation strategy. Moreover, magnetic molecularly imprinted polymers (MMIP) and nucleic acid aptamers were employed as capture probes for achieving rapid and direct magnetic separation, followed by layer-by-layer assembly to construct the sensor probe. In the presence of CAP, the aptamers and rMMIPs selectively recognized the target, forming a PEI@CaCO 3 @Ag@4-NTP@Apt@CAP@rMMIPs "sandwich" structure (Microcapsule@Apt@rMMIPs). After multiple magnetic separations, the "igniter" EDTA solution was added, causing the CaCO 3 capsules to rapidly "explode" and release a significant amount of Ag@4-NTP. This was then applied to the "signal booster" semiconductor SERS substrate. Under optimal conditions, this method exhibited a detection range of 1.0 × 10 −5 M to 1.0 × 10 −15 M, with a detection limit of 6.84 × 10 −16 M. Significant The unite of magnetic MIP and nucleic acid aptamer to form a “sandwich” structure, in combination with a semiconductor SERS substrate, not only enhances the sensor's sensitivity but also offers significant economic advantages. Moreover, this innovative technology holds great promise for accurate and highly sensitive detection of pollutants in complex environments.
研究领域:
分析化学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2024
·
IF 4.4
Han Song,Jiasheng Fan,Shengkai Liu,Boyu Chen,Jin Huang,Yujie Fu,Zhiguo Liu
In this study, we synthesized DOX-loaded H-ZIF-8@CaCO 3 -PEG nanocarrier, which combined with calcium overload and photothermal therapy (PTT) for synergistic therapy. The nanocarrier comprised a PEG modified calcium carbonate (CaCO 3 ) shell and a hollow imidazolate zeolite skeleton (H-ZIF-8) core, in which the chemotherapy drug doxorubicin hydrochloride (DOX) and photosensitizer indocyanine green (ICG) were simultaneously co-loaded. In vitro cellular experiments revealed that the lethality of DOX&ICG@H-ZIF-8@CaCO 3 -PEG against tumor cells was significantly higher than that of the single chemotherapy owing to the combination with chemotherapy and photothermal therapy as well as calcium overloading. This drug-loaded nanocarrier exhibits notable characteristics such as exceptional stability, elevated drug loading capacity and efficient release of the loaded drug, which provides a promising perspective for efficient synergistic therapy.
研究领域:
纳米技术
·
药学
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2021
·
IF 3.512
Linzhi Li,Xing Liu,Saijun He,Hongmei Cao,Benchao Su,Tianzeng Huang,Qi Chen,Minghuan Liu,Da-Peng Yang
A novel ultrasensitive electrochemiluminescence (ECL) immunoassay based on Au/CaCO3 was proposed for detecting ochratoxin A (OTA) in coffee. Au/CaCO3 nanocomposites synthesized using waste eggshells as the template with a large surface area and excellent electrochemical properties were applied for immobilizing a large amount of Ru(bpy)32+ and conjugating a high-affinity nanobody (prepared by the phage display technique). Coupling of the Au/CaCO3 nanocomposites and nanobody technologies provided an ultrasensitive and highly selective ECL immunosensor for OTA detection in the range of 10 pg/mL–100 ng/mL with a low detection limit of 5.7 pg/mL. Moreover, the as-prepared ECL immunosensor showed excellent performance and high stability. Finally, the proposed ECL sensor was applied to analyze OTA in coffee samples, confirming the desirable accuracy and practical applicability potential. Overall, this work presents a new nanomaterial for fabricating the sensing interface of immunosensors by harnessing natural waste as the source and a method for detecting toxic OTA in foods.
研究领域:
分析化学
·
纳米技术
·
食品安全
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2020
·Vol. 35
·期 18
·2427-2440
·
IF 2.502
Tingyu Yang,Yu Wu,Xiaoqing Yue,Cuiyan Wang,Jianbin Zhang
The synthesis of antibacterial biomaterial with specific functions responsive to specific bacterial growth environments is of significant importance to achieve effective sterilization and reduce the resistant bacteria. Herein, inspired by biomineralization, we develop a one-pot, threonine (Thr)-mediated biomineralization method using a CO2 bubbling procedure to green, simply and quickly prepare vaterite CaCO3 microspheres as a platform for antibacterial Sanguinarine (SAN) delivery. The loading capacity of vaterite CaCO3 microspheres for SAN drugs reached 159.8 mg/g, corresponding to the loading efficiency of 83.7%. And for the first time, a novel Sanguinarine@calcium carbonate (SAN@CaCO3) organic–inorganic hybrid antibacterial biofilm was constructed by using vaterite CaCO3 microspheres with pH-responsive and high SAN drug-loading. Importantly, the film showed bacteria-triggered, pH-responsive SAN release properties and strong bactericidal ability (96.19%) for Staphylococcus aureus (S. aureus). Meanwhile, it also had antibacterial capabilities in real environments. In 7 days, it can significantly inhibit the adhesion and growth of bacteria in the air. The biomineralized synthetic vaterite CaCO3 microspheres and the application in the construction of pH-responsive antibacterial biofilm have bright future in resisting bacterial infections and reducing the production of resistant bacteria.
研究领域:
材料科学
·
生物技术
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）