ChemistrySelect
·
2026
·Vol. 11
·期 5
·e05063
·
IF 2
Yu Huai,Heyang Gong,Yueran Zhang,Hongbo Huang,Yan Gao,Yun Gao
As essential trace elements in the organism, Ag + plays crucial roles in living systems. Deficiency or excess of Ag + can induce various diseases. Notably, hypochlorite (ClO − ), as a critical component of reactive oxygen species, not only participates in fundamental metabolic processes such as thyroid hormone synthesis but also exerts a crucial function in immune regulation and antibacterial defense. In this study, a bifunctional probe ( BHZ ) based on benzimidazole was designed and constructed. In the presence of Ag + , the fluorescence wavelength of the probe experienced a slight redshift, accompanied by a decrease in fluorescence intensity. The mechanism is attributed to the ICT effect induced by the complexation of BHZ with Ag + , leading to changes in the fluorescence spectrum. Meanwhile, the probe selectively recognize ClO − via a fluorescence “OFF-ON” response, and the weak blue light of the probe turned into strong green light upon addition of ClO − . The mechanism of ClO − recognition involves addition reaction between ClO − and the probe, thereby inducing structural modifications in the probe that consequently modulated its optical properties. The detection limits of probe BHZ toward Ag + and ClO − were 1.57×10 −8 M and 4.28 nM, respectively. Mass spectrometry was utilized to investigate the response mechanisms of the probe toward Ag + and ClO − . By combining the smartphone color recognition, the rapid and real-time detection of Ag + by BHZ in real water samples was achieved by using fluorescence ratiometric recognition and test paper. Moreover, the probe BHZ has been effectively deployed for ClO − bioimaging in mice in vivo.
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Huajie Chen,Dai Li,Yutao Zheng,Kui wang,He zhang,Zhipeng Feng,Bolin Huang,Huiyun Wen,Jiyong Wu,Weiming Xue,Saipeng Huang
Hypochlorite (ClO - ) is an important redox regulator in reactive oxygen species, which play a considerable role in oxidative stress and related diseases. Hence, accurate and sensitive monitoring of ClO - concentration was urgently needed in the fields of life sciences, food and environment. Bright green fluorescent carbon quantum dots (G-CQDs) were synthesized utilizing one-step hydrothermal method with citric acid and acriflavine precursors. Through TEM, FTIR, XPS and zeta potential characterization procedures, G-CQDs illustrated uniformly dispersed and significant number of –NH 2 and –OH on the surface. Meanwhile, the fluorescence and colorimetric analysis exhibited wide linear range and low detection limit response to ClO - . The fluorescence changes of G-CQDs were identified via smartphone to realize mobile sensing of ClO - . Subsequently, G-CQDs was applied for visualization and quantitative detection of ClO - in drinking water samples with satisfactory recovery rate. More importantly, G-CQDs demonstrated good water solubility, optical stability and excellent biocompatibility, which offered a promising analysis approach in cell imaging and exogenous ClO - detection in living cells. G-CQDs illustrated bright prospect and great potential in practical application of ClO - associated disease prevention and early clinical diagnosis.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2017
·Vol. 55
·期 6
·1067-1076
·
IF 2.952
Dalong Zhai,Wei Shi,Yonghai Hui,Zhengfeng Xie
High-efficiency, mild-conditioned tandem Knoevenagel–Michael reaction was utilized to post-modify aldehyde-containing, triphenylamine-based precursor conjugated polymer ( CP1 ) to afford dimedone-decorated aimed polymer ( CP2) . The chemical structure of CP2 was verified by FTIR and 1 H NMR analyses. With the introduction of aqueous Hg 2+ , fluorescence of CP2 in THF-water mixture ( V THF / V water = 1/100) (buffered with 5 mM sodium dihydrogen phosphate-disodium hydrogen phosphate (PB), pH = 7.4) altered significantly, with the emission changed from blue to orange. Besides this, CP2 also displayed specific optical response to ClO − in another probing medium ( V THF / V water = 1/100, buffered with 50 mM PBS (with NaCl in PB, pH = 7.4). The detailed probing process and the plausible detection mechanism of CP2 to Hg 2+ and ClO − were systematically investigated here. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55 , 1067–1076
研究领域:
高分子化学
·
材料科学
·
分析化学
·
环境监测
·
光学传感
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DOI
高影响因子
Journal of Analytical Methods in Chemistry
·
2023
·
IF 2.6
Qianchun Zhang,Haijiang Du,Siqi Xie,Fengling Tian,Xixi Long,Shan Liu,Yun Wu
Hypochlorite (ClO−) has received extensive attention owing to its significant roles in the immune defense and pathogenesis of numerous diseases. However, excessive or misplaced production of ClO− may pose certain diseases. Thus, to determine its biological functions in depth, ClO− should be tested in biosystems. In this study, a facile, one-pot synthesis of nitrogen-fluorine-doped carbon quantum dots (N, F-CDs) was developed using ammonium citrate tribasic, L-alanine, and ammonium fluoride as raw materials under hydrothermal conditions. The prepared N, F-CDs demonstrate not only strong blue fluorescence emission with a high fluorescence quantum yield (26.3%) but also a small particle size of approximately 2.9 nm, as well as excellent water solubility and biocompatibility. Meanwhile, the as-prepared N, F-CDs exhibit good performance in the highly selective and sensitive detection of ClO−. Thus, a wide concentration response range of 0–600 μM with a low limit of detection (0.75 μM) was favorably obtained for the N, F-CDs. Based on the excellent fluorescence stability, excellent water solubility, and low cell toxicity, the practicality and viability of the fluorescent composites were also successfully verified via detecting ClO− in water samples and living RAW 264.7 cells. The proposed probe is expected to provide a new approach for detecting ClO− in other organelles.
研究领域:
分析化学
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生物医学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2022
·
IF 4.889
Jiankun Li,Fang Xu,Keyu Wang,Juan He,Yixing Wang,Linfeng Lei,Minghui Zhu,Linzhou Zhuang,Zhi Xu
Regulating the electronic structure is of great importance for improving the performance, stability, and selectivity of seawater splitting catalysts. Herein, cobalt-based oxide and chalcogenide (Co 3 X 4 , X = O, S, and Se) are synthesized to investigate the effect of anions on the electronic structure, catalytic performance and selectivity of the seawater oxidation catalysts. The theoretical calculations predict the possible active sites of oxygen evolution reaction and hypochlorite evolution reaction. Then the experimental characterization and calculation results demonstrate that S and Se substitution could regulate the electronic structure and d-band center of Co site, enhance the metallicity of catalysts. Moreover, the energy barrier of Cl* conversion to ClO - could be modulated for preventing the formation of ClO - by anions regulating. Consequently, Co 3 S 4 could stably operate at a current density of 100 mA cm −2 in 0.1 M KOH + 0.6 M NaCl for 100 h and in neutral seawater for 20 h.
研究领域:
材料科学
·
电化学
·
催化
·
可再生能源
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产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Shu Wang,Shun-Hua Wu,Wen-Le Fang,Xiao-Feng Guo,Hong Wang
A facile and straightforward strategy was used to prepare carbon dots (CDs) using catechol as carbon source in one-pot hydrothermal method . The synthesis method is simple without any doping and modification and the prepared CDs do not require any post-processing. Characterizations of the obtained CDs indicated that they had high crystallinity and higher quantum yield (QY, 32%) than most non-functionalized and non-doped CDs. Noticeably, the fluorescence of CDs could be quenched with hypochlorite (ClO − ) by oxidation of the residual pyrocatechol groups on the surface to o -benzoquinone exhibiting high sensitivity and selectivity for ClO − . The assay covered a linear range from 0.1 to 10 μM with a low detection limit of 30 nM. The results showed that the CDs provided a promising potential tool for the detection of ClO − in real water samples.
研究领域:
材料科学
·
环境科学
·
分析化学
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DOI
高影响因子
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