CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Wenjie Zhao,Yujie Zhang,Haomiao Li,Yi Shen,Kangli Wang,Kai Jiang
Rechargeable Mg batteries with the merits of low cost, high safety and environmental compatibility are deemed as promising energy storage techniques for large-scale applications. However, the actual development of rechargeable Mg batteries is constantly hindered by the difficulty of finding suitable electrode materials to accommodate Mg 2+ . Cu 2-x Se has exceptionally high electrical conductivity and its unique crystal structure could be better compatible with Mg 2+ cations. Herein, a novel Cu 2-x Se hollow nanocube with extraordinarily high conductivity and unique structure was designed and synthesized by facile one-step template-directed selenation reaction methods. The excellent Mg electrochemical performance of Cu 2-x Se hollow nanocube cathodes was demonstrated based on rechargeable Mg batteries. The Cu 2-x Se NCs provide a high specific capacity of 232.5 mAh g - 1 at 100 mA g - 1 , superior cycling stability over 3700 cycles, and an excellent rate capacity of 163.1 mAh g - 1 at 3000 mA g - 1 . Furthermore, the two-step magnesiation/demagnesiation processes of the Cu 2-x Se NC cathodes were revealed, and the accelerating effects of the fast Mg 2+ diffusion in the unique hierarchical structure on magnesium storage performance were analyzed. The outcomes of this study not only provide simple methods for fabricating high-performance Cu 2-x Se cathodes but also propose valuable insights for exploring conversion-type Mg-storage materials.
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2026
·
IF 9.6
Meichan Wu,Puze Li,Xin Xin,Cheng Song,Xiangliang Yang,Qingxia Xu,Yan Liu,Yong Shen,Guoping Wang,Jun Hu
The activation and infiltration of cytotoxic T lymphocytes (CTLs) are the key of tumor immunotherapy. However, the suppressive tumor immune microenvironment usually inhibits the function of CTLs. Tumor-associated macrophages (TAMs) play an important role in remodeling the tumor immune microenvironment. In this work, probiotic Escherichia coli Nissle 1917 (EcN) is used as a bioreactor to achieve intracellular synthesis of copper selenide nanoparticles (Cu 2-x Se NPs), giving Cu 2-x Se@EcN, which effectively repolarize macrophages from pro-tumor M2 phenotype to anti-tumor M1 phenotype mainly through activating MAPK signaling pathway. The synthesized Cu 2-x Se NPs exhibited excellent photothermal performance, inducing hyperthermia-sensitized Fenton-like reaction to catalyze the generation of hydroxyl radical from H 2 O 2 , then resulted in immunogenic death effect of tumor cells and the repolarization of M2 macrophages. Combined with surface-expressed pathogen-associated molecular patterns (PAMPs) of bacteria, Cu 2-x Se@EcN synergistically promoted DCs maturation and TAMs reprogramming, eventually promoting the infiltration and activation of T cells. Therefore, the bacteria-inorganic hybrid nanomaterials showed satisfied effect in inhibiting tumor growth and recurrence.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2018
·Vol. 20
·期 28
·4020-4024
·
IF 3.304
Xin Huang,Yu Zou,Jian Hao,Jiang Jiang
Uniform ZnSe hollow nanospheres with face-centered cubic structure were synthesized via a post-synthetic chemical transformation reaction from solid Cu2−xSe nanocrystals, with the help of tributylphosphine at room temperature under an ambient atmosphere. The formation of ZnSe hollow structure was based on the synergetic effect of isotropic cation exchange from Cu2−xSe to ZnSe and concurrent selective etching of Cu2−xSe templates through anion extraction. The degree of hollowness could be adjusted by changing the feed molar ratio of Zn/Cu and reaction temperature which determined the extent of cation exchange. These ZnSe hollow nanospheres exhibited excellent catalytic activity and stability for the photodegradation of dyes.
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2017
·Vol. 10
·期 7
·3130-3143
·
IF 7.367
Shaohua Zhang,Qian Huang,Lijuan Zhang,Hao Zhang,Yaobao Han,Qiao Sun,Zhenxiang Cheng,Huizhu Qin,Shixue Dou,Zhen Li
The vacancies in the semiconductor nanocrystals not only induce unique properties, but also provide spaces for engineering them with multifunctions by the introduction of other elements. Herein, the vacancy of Cu2−xSe nanoparticles was tuned by doping with magnetic ferric ions (Fe3+) at room temperature, and the position and intensity of the near-infrared localized surface plasmon resonance (LSPR) in the resultant nanostructure can be finely controlled by altering the feeding amount of Fe3+ ions. The results of the density-functional theory (DFT) calculations show that both doping and replacement reactions are favourable. Owing to its tunable near-infrared absorption and magnetic property, the obtained hybrid nanostructure was demonstrated to be a novel nanotheranostic agent for effective deep-tissue photoacoustic imaging, magnetic resonance imaging, and photothermal therapy of cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jiaying Chang,Man Wang,Junrong Wang,Guoqing Zhu,Yulin Xie,Yanrong Qian,Qianqian Sun,Chunxia Li
Autologous tumor cells demonstrate considerable promise as individualized therapeutic vaccines owing to their endogenous neoantigen repertoire. Nevertheless, their suboptimal immunogenicity substantially impedes clinical translation. Herein, we engineered an innovative whole tumor cell vaccine platform utilizing photothermal Cu 2- x Se nanoparticles, which encapsulate comprehensive tumor-associated antigens and intrinsic immunostimulatory molecules to elicit a polyvalent antitumor immune response. In this work, Cu 2-x Se was applied to prepare the whole tumor cell vaccine for the first time. As a pyroptosis inducer, Cu 2-x Se triggered the expression of damage-associated molecular patterns (DAMPs) as endogenous adjuvants in 4T1 cells (mouse breast cancer cells) under near-infrared (NIR) irradiation. Repeated freeze-thaw cycles inactivated and lysed Cu 2-x Se-loaded 4T1 cells, releasing DAMPs for laser-activated Cu 2-x Se-based whole tumor cell vaccine (LC-TCV) preparation. Mild photothermal therapy (PTT) at the vaccination site by NIR irradiation effectively suppressed tumor growth. This efficacy was primarily attributed to the synergistic effects of multiple natural antigens and adjuvants in LC-TCV, which promoted dendritic cells (DCs) maturation and subsequent immune activation. Consequently, it potentiates the recruitment of cytotoxic T lymphocytes, elicits immunogenic cell death (ICD), and consequently initiates a potent antigen-specific immune cascade. Collectively, this study presents an innovative approach to unleash the potential of personalized whole tumor cell vaccines in cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Qiao Cu,Chaoqun Shang,Guofu Zhou,Xin Wang
The fabrication of freestanding electrodes for Na + storage is necessary to achieve high energy density. However, the large radius of Na + results in a large volume fluctuation and sluggish reaction kinetics of active materials, particularly at a high active material content, thereby impeding electrochemical performance with undesirable cycling performance or rate capability. In this study, a freestanding electrode based on the “NiSe grafted on Cu 2-x Se” heterostructure with double-carbon protective shells (NiSe/Cu 2-x Se@C@NCNFs) was successfully constructed for Na + storage. In this microstructure, N -doped carbon nanofibers (NCNFs) serve as the stem of the twinborn NiSe/Cu 2-x Se heterostructure with a built-in electric field, where NiSe improves Na + absorption and Cu 2-x Se enhances Na + diffusion. The “graft” design enabled the freestanding NiSe/Cu 2-x Se@C@NCNFs electrode with a high active mass content of 76.1 wt% to exhibit superior electrochemical performance for Na + storage (75 mAh g −1 at 2 A g −1 ) compared to those of Cu 2-x Se@C@NCNFs (26 mAh g −1 at 2 A g −1 ) and NiSe@C@NCNFs (9 mAh g −1 at 2 A g −1 ).
✓ 已验证
DOI
高影响因子
ANALYST
·
2018
·Vol. 144
·期 2
·716-721
·
IF 3.864
Qing Juan Guo,Zi Yu Pan,Chen Men,Wen Yi Lv,Hong Yan Zou,Cheng Zhi Huang
A simple protocol for in situ growth of Cu2−xSe nanoparticles on graphene oxide hybrids (Cu2−xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2−xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2−xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. The results showed that the Cu2−xSe/rGO hybrids could be the promising nanozyme mimetics for potential applications in bioanalytical fields.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2015
·Vol. 140
·期 12
·4121-4129
·
IF 4.107
Hong Yan Zou,Peng Fei Gao,Ming Xuan Gao,Cheng Zhi Huang
Full understanding and easy construction of specific biosensing principles is necessary for disease diagnostics and therapeutics in the hope of creating new types of biosensors. Herein, we developed a new conceptual nanobiosensing platform by coupling nanometal surface energy transfer (NSET) and photo-induced electron transfer (PET) with polydopamine-embedded Cu2−xSe nanoparticles (Cu2−xSeNPs@pDA) and DNA-conjugated fluorescent organic dyes. The new prepared Cu2−xSeNPs@pDA has intense and broad localized surface plasmon resonance (LSPR) absorption over UV to near infrared (NIR) wavelengths, with different affinities toward ssDNA versus dsDNA. It also exhibits a high multiplexed fluorescence quenching ability, and thus can act as an acceptor in the energy transfer and electron transfer interactions between Cu2−xSeNPs@pDA and fluorescent organic dyes. As a proof of concept, a new biosensing platform has been successfully developed to target biomacromolecules such as DNA and proteins, in which the NSET and PET interactions between Cu2−xSeNPs@pDA and three different DNA-conjugated fluorescent dyes have been identified using steady-state and time-resolved fluorescence. A simple mathematical model was further applied to simulate the respective contributions of the coexisting NSET and PET to the total quenching observed for each DNA-conjugated dye in this sensing system. This study highlights the importance of understanding the mechanistic details of NSET and PET coupling processes, and the disclosed coupling mechanism of NSET and PET (NSET©PET) in the systems of Cu2−xSeNPs@pDA with wide wavelength range dyes provides new opportunities for sensitive biosensing applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2017
·
IF 13.942
Yu Zou,Chao Sun,Wenbin Gong,Xianfeng Yang,Xin Huang,Ting Yang,Weibang Lu,Jiang Jiang
Integrating a plasmonic metal and a semiconductor at the nanoscale is of great importance for exploring their optical coupling properties. However, the synthesis and fine structural control of such nanostructures remain challenging. Herein we report the facile aqueous-phase Se-mediated overgrowth of metal selenides onto Au nanocrystals. Taking plasmonic Cu2–xSe as an example, the introduction of a Se template allows deposition of large Cu2–xSe crystalline grains onto Au nanocrystal seeds in various shapes, including spheres, rods, and plates. Moreover, the configuration of Au–Cu2–xSe hybrids can be tuned from core–shell to heterodimer structure by controlling the growth behavior of the Se template. Se overgrowth depends critically on the absorption strength of stabilizers on Au seeds: a strongly absorbing stabilizer inhibits isotropic overgrowth, which is in agreement with molecular dynamics simulations. The resultant Au–Cu2–xSe hybrid nanocrystals possess multiple surface plasmon resonance modes. Finally, our synthetic strategy can be extended to prepare other Au–metal selenide hybrids such as Au–Ag2Se and Au–CdSe with controllable morphologies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Tong Yang,Hong Yan Zou,Cheng Zhi Huang
A new heterogeneous catalytic composite composed of nonstoichiometric Cu2–xSe nanoparticles (NPs) with high copper deficiency and graphene oxide (GO) is prepared by coembedding in electrospun nanofibers of a poly(vinylpyrrolidone) (PVP) support, wherein GO in the nanofibers is converted into reduced GO (rGO) via heat treatment. The as-prepared composite Cu2–xSe/rGO/PVP nanofibers have demonstrated superior catalytic activity toward the reduction of a refractory organic compound by taking 4-nitrophenol (4-NP) as an example. In the presence of NaBH4, the Cu2–xSe/rGO/PVP nanofibers display a synergetic effect between Cu2–xSe and rGO in PVP nanofibers compared to their independent components or corresponding nanofibers. Furthermore, the Cu2–xSe/rGO/PVP nanofibers exhibit a favorable water-stable property via heat treatment to solidify the hydrophilic PVP matrix, which makes the composite display good reusability, stability in aqueous solution, and separability from a water medium. This work not only presents a direct, convenient, and effective approach to doping semiconductor nanomaterials into polymer nanofibers but also provides fundamental routes for further investigations about the synergetic effect between different materials based on the platform of electrospun nanofibers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Xu Chen,Mengjun Qiu,LiPing Liu,Qin Ji,Zushun Xu,Zhifan Xiong,Shengli Yang
A novel nanoplatform that supports multimodal imaging has been designed for deep tumor therapy. In this study, Bi 2 Se 3 @Cu 2−x Se heterojunction nanocomposites with tunable spectral absorption, effective electron–hole separation and high photothermal conversion efficiency were prepared for the combination therapy of phototherapy (PT), chemodynamic therapy (CDT) and radiotherapy (RT). By adjusting the doping ratio, the heterojunction nanoparticles show obvious tunable ability of local surface plasmon resonance and the ability to promote electron-hole separation with significantly enhanced reactive oxygen species production capacity. The band structure and charge density difference calculated by density functional theory further reveal that the change of band gap and the decrease of free carriers can regulate the spectral absorption of nanomaterials and promote electron-hole separation. In addition, the photothermal conversion properties of low carrier density semiconductors are related to their inherent deep level defects. The formation of heterojunctions making the Se atoms deviate from the Bi 2 Se 3 lattice, resulting in more deep level defects and stronger photothermal conversion properties. Meanwhile, this nanoplatform presented features similar to catalase activities and glutathione (GSH) consumption characteristics, which was capable of effectively alleviate the tumor-specific hypoxia environment to enhance the efficacy of O 2 -dependent photodynamic therapy (PDT) and radiotherapy (RT) and depletion GSH to prevent the reduction of therapeutic efficacy due to the clearance of reactive oxygen species. In addition to therapeutic enhancement, heterojunction nanomaterials have excellent nuclear magnetic resonance imaging (MRI), infrared thermal imaging (IR) and computed tomography (CT) properties due to their significant paramagnetism and excellent photothermal conversion and X-ray attenuation capacities. In conclusion, our findings provide a new strategy for designing multi-function and efficient nanoplatform to treat tumor.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2025
·
IF 2.5
Yang Yang,Hua Xie,Bi Zhou,Yuling Liu,Jiqing Hao
A single drug therapeutic approach fails to sufficiently eliminate tumors in clinics, owing to the tumoral complexity and heterogeneity. The integration of chemotherapy with novel treatment modalities offers a promising synergistic strategy for enhancing therapeutic outcomes. Herein, we successfully develop pH-triggered dynamic organic nanocomposite hydrogels for enhanced local tumor combination therapy, which are prepared through incorporation of Cu2-xSe nanoparticles (NPs) and lipophilic mixture (OPC) including orthoester compound, polycaprolactone and carboplatin into imine-crosslinked polysaccharide-based hydrogels. The dynamic imine linkages endow the hydrogels with favorable injectability and self-adaptability as well as tumoral extracellular pH-triggered degradation. OPC can enhance drug escape from hydrogels, tumor penetration and pH-responsive prolonged and sustained release of the drug. Cu2-xSe NPs endow the hydrogels with photothermal therapy (PTT), photodynamic therapy (PDT) and chemo-dynamic therapy (CDT). These superior physicochemical properties result in significant tumor growth inhibition while decreasing side effect on normal tissues. Therefore, the pH-responsive dynamic organic nanocomposite hydrogels have great potential for local tumor therapy in clinics.
研究领域:
肿瘤学
·
生物材料
·
纳米医学
·
药物递送
·
转化医学
·
光热治疗
·
化学动力学治疗
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）